[go: up one dir, main page]

WO2012177639A3 - Bioprocessing and bioproduction using avian cell lines - Google Patents

Bioprocessing and bioproduction using avian cell lines Download PDF

Info

Publication number
WO2012177639A3
WO2012177639A3 PCT/US2012/043148 US2012043148W WO2012177639A3 WO 2012177639 A3 WO2012177639 A3 WO 2012177639A3 US 2012043148 W US2012043148 W US 2012043148W WO 2012177639 A3 WO2012177639 A3 WO 2012177639A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioproduction
bioprocessing
cell lines
avian cell
avian
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/043148
Other languages
French (fr)
Other versions
WO2012177639A2 (en
Inventor
Gregory Hinkle
Brian Bettencourt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alnylam Pharmaceuticals Inc
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of WO2012177639A2 publication Critical patent/WO2012177639A2/en
Publication of WO2012177639A3 publication Critical patent/WO2012177639A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/05—Animals modified by non-integrating nucleic acids, e.g. antisense, RNAi, morpholino, episomal vector, for non-therapeutic purpose
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to compositions and methods of modulating the status, activity or expression of avian transcripts in the process of bioproduction. In one aspect, the invention provides for a method for producing a biological product from an avian host cell.
PCT/US2012/043148 2011-06-22 2012-06-19 Bioprocessing and bioproduction using avian cell lines Ceased WO2012177639A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161499757P 2011-06-22 2011-06-22
US61/499,757 2011-06-22
US201261639333P 2012-04-27 2012-04-27
US61/639,333 2012-04-27

Publications (2)

Publication Number Publication Date
WO2012177639A2 WO2012177639A2 (en) 2012-12-27
WO2012177639A3 true WO2012177639A3 (en) 2013-05-30

Family

ID=47423168

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/043148 Ceased WO2012177639A2 (en) 2011-06-22 2012-06-19 Bioprocessing and bioproduction using avian cell lines

Country Status (1)

Country Link
WO (1) WO2012177639A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12139617B2 (en) 2017-12-22 2024-11-12 North Carolina State University Polymeric fluorophores, compositions comprising the same, and methods of preparing and using the same

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE429927T1 (en) 2000-02-04 2009-05-15 Children S Hospital Res Founda USE OF LYSOSOMAL ACID LIPASE TO TREAT ATHEROSCLERosis AND SIMILAR DISEASES
EP2370577B1 (en) 2008-12-03 2019-08-28 Arcturus Therapeutics, Inc. Usirna complexes
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
KR101742346B1 (en) 2010-04-23 2017-06-15 시나게바 바이오파르마, 코포레이션 Lysosomal storage disease enzyme
CN105457018A (en) 2010-09-09 2016-04-06 辛那杰瓦生物制药股份有限公司 Use of lysosomal acid lipase for treating lysosomal acid lipase deficiency in patients
KR20140006037A (en) 2011-02-15 2014-01-15 시나게바 바이오파르마, 코포레이션 Methods for treating lysosomal acid lipase deficiency
US20140378533A1 (en) 2012-02-08 2014-12-25 Isis Pharmaceuticals, Inc. Modulation of rna by repeat targeting
AU2013226081B2 (en) 2012-02-27 2018-06-14 Becton, Dickinson And Company Compositions and kits for molecular counting
EP2831232A4 (en) 2012-03-30 2015-11-04 Univ Washington METHOD FOR MODULATING TAU EXPRESSION TO REDUCE PROBLEMS AND MODIFY A NEURODEGENERATIVE SYNDROME
RU2745324C2 (en) 2013-03-14 2021-03-23 Ионис Фармасьютикалз, Инк. Compositions and methods for modulating expression of tau
ES2649490T3 (en) 2013-03-14 2018-01-12 Alnylam Pharmaceuticals, Inc. Compositions of RNAi against component C5 of the complement and methods for its use
KR102712053B1 (en) 2013-05-01 2024-10-02 아이오니스 파마수티컬즈, 인코포레이티드 Compositions and methods for modulating hbv and ttr expression
TWI657819B (en) 2013-07-19 2019-05-01 美商Ionis製藥公司 Composition for regulating the expression of tau protein
SG10201806890VA (en) 2013-08-28 2018-09-27 Cellular Res Inc Massively parallel single cell analysis
PL3119888T3 (en) * 2014-03-19 2021-12-20 Ionis Pharmaceuticals, Inc. Compositions for modulating ataxin 2 expression
BR112016022711A2 (en) * 2014-04-01 2017-10-31 Monsanto Technology Llc compositions and methods for insect pest control
RU2739987C2 (en) 2014-05-23 2020-12-30 Джензим Корпорейшн Multiple oligonucleotide fragments on a peptide carrier
CA2960728C (en) * 2014-09-18 2023-06-06 The University Of British Columbia Allele-specific therapy for huntington disease haplotypes
CA2976445A1 (en) * 2015-02-13 2016-08-18 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
ES2934982T3 (en) 2015-03-30 2023-02-28 Becton Dickinson Co Methods for encoding with combinatorial barcodes
US10619186B2 (en) 2015-09-11 2020-04-14 Cellular Research, Inc. Methods and compositions for library normalization
WO2017100542A1 (en) 2015-12-10 2017-06-15 Alnylam Pharmaceuticals, Inc. Sterol regulatory element binding protein (srebp) chaperone (scap) irna compositions and methods of use thereof
WO2017117496A1 (en) 2015-12-31 2017-07-06 Ionis Pharmaceuticals, Inc. Methods for reducing ataxin-2 expression
CA3013797A1 (en) 2016-03-09 2017-09-14 Ionis Pharmaceuticals, Inc. Methods and compositions for inhibiting pmp22 expression
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
UY37376A (en) * 2016-08-26 2018-03-23 Amgen Inc ARNI CONSTRUCTIONS TO INHIBIT EXPRESSION OF ASGR1 AND METHODS FOR USE
KR102363716B1 (en) 2016-09-26 2022-02-18 셀룰러 리서치, 인크. Determination of protein expression using reagents having barcoded oligonucleotide sequences
JOP20190065A1 (en) 2016-09-29 2019-03-28 Ionis Pharmaceuticals Inc Compounds and Methods for Reducing the Expression of TAU
EP3533868A4 (en) * 2016-10-31 2019-12-11 Gifu University DOUBLE-STRANDED NUCLEIC ACID MOLECULE AND USE THEREOF
US11319583B2 (en) 2017-02-01 2022-05-03 Becton, Dickinson And Company Selective amplification using blocking oligonucleotides
CA3051839A1 (en) 2017-02-17 2018-08-23 Bristol-Myers Squibb Company Antibodies to alpha-synuclein and uses thereof
JOP20190215A1 (en) * 2017-03-24 2019-09-19 Ionis Pharmaceuticals Inc Modulators of pcsk9 expression
NO344051B1 (en) * 2017-05-04 2019-08-26 Patogen As Novel virus in Fish and Method for detection
US11643656B2 (en) 2017-05-24 2023-05-09 The Regents Of The University Of California Antisense therapies for treating cancer
CA3059559A1 (en) 2017-06-05 2018-12-13 Becton, Dickinson And Company Sample indexing for single cells
KR102399851B1 (en) * 2017-08-25 2022-05-19 더 가버닝 카운슬 오브 더 유니버시티 오브 토론토 Compositions and methods for detecting and treating insulin resistance
PE20251292A1 (en) 2018-03-08 2025-05-14 Incyte Corp DIOLIC AMINOPYRAZINE COMPOUNDS AS PI3K-GAMMA INHIBITORS
WO2019197845A1 (en) * 2018-04-12 2019-10-17 Mina Therapeutics Limited Sirt1-sarna compositions and methods of use
ES2945191T3 (en) 2018-05-03 2023-06-29 Becton Dickinson Co High-throughput multi-omics sample analysis
ES3014208T3 (en) 2018-05-03 2025-04-21 Becton Dickinson Co Molecular barcoding on opposite transcript ends
JPWO2019240164A1 (en) * 2018-06-13 2021-06-24 第一三共株式会社 Myocardial damage drug
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
AR115847A1 (en) 2018-07-25 2021-03-03 Ionis Pharmaceuticals Inc COMPOUNDS AND METHODS TO REDUCE THE EXPRESSION OF ATXN2
US12398402B2 (en) 2018-09-12 2025-08-26 Fred Hutchinson Cancer Center Reducing CD33 expression to selectively protect therapeutic cells
EP4471156A3 (en) 2018-10-01 2025-02-26 Becton, Dickinson and Company Determining 5' transcript sequences
JP7618548B2 (en) 2018-11-08 2025-01-21 ベクトン・ディキンソン・アンド・カンパニー Whole-transcriptome analysis of single cells using random priming
EP3894552A1 (en) 2018-12-13 2021-10-20 Becton, Dickinson and Company Selective extension in single cell whole transcriptome analysis
WO2020132558A1 (en) * 2018-12-21 2020-06-25 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing pmp22 expression
US20220072024A1 (en) * 2018-12-28 2022-03-10 Dicerna Pharmaceuticals, Inc. Compositions and methods for inhibiting hmgb1 expression
EP4242322B1 (en) 2019-01-23 2024-08-21 Becton, Dickinson and Company Oligonucleotides associated with antibodies
CN113454234B (en) 2019-02-14 2025-03-18 贝克顿迪金森公司 Heterozygote targeted and whole transcriptome amplification
DK3938542T3 (en) * 2019-03-13 2025-09-29 Goodgut S L IMPROVED METHOD FOR THE SCREENING, DIAGNOSIS AND/OR MONITORING OF COLORECTAL ADVANCED NEOPLASIA, ADVANCED ADENOMA AND/OR COLORECTAL CANCER
CN115806976A (en) * 2019-03-20 2023-03-17 中国科学院上海营养与健康研究所 Protein Translation Using Circular RNA and Its Applications
US20220333105A1 (en) * 2019-06-03 2022-10-20 Quralis Corporation Oligonucleotides and methods of use for treating neurological diseases
EP4004231B1 (en) 2019-07-22 2025-11-12 Becton, Dickinson and Company Single cell chromatin immunoprecipitation sequencing assay
CN114729350A (en) 2019-11-08 2022-07-08 贝克顿迪金森公司 Obtaining full-length V (D) J information for immunohistorian sequencing using random priming
EP4077666A1 (en) 2019-12-16 2022-10-26 Alnylam Pharmaceuticals, Inc. Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
CN115244184A (en) 2020-01-13 2022-10-25 贝克顿迪金森公司 Methods and compositions for quantification of protein and RNA
US12188010B2 (en) 2020-01-29 2025-01-07 Becton, Dickinson And Company Barcoded wells for spatial mapping of single cells through sequencing
EP3868884A1 (en) * 2020-02-19 2021-08-25 Aarhus Universitet Method for subtyping bladder cancer using aptamers
WO2021173719A1 (en) 2020-02-25 2021-09-02 Becton, Dickinson And Company Bi-specific probes to enable the use of single-cell samples as single color compensation control
EP4146807A4 (en) * 2020-05-08 2024-09-04 Takeda Pharmaceuticals U.S.A., Inc. Methods for the treatment of nucleotide repeat expansion disorders associated with msh3 activity
WO2021231779A1 (en) * 2020-05-14 2021-11-18 Becton, Dickinson And Company Primers for immune repertoire profiling
WO2021247593A1 (en) 2020-06-02 2021-12-09 Becton, Dickinson And Company Oligonucleotides and beads for 5 prime gene expression assay
AR122534A1 (en) 2020-06-03 2022-09-21 Triplet Therapeutics Inc METHODS FOR THE TREATMENT OF NUCLEOTIDE REPEAT EXPANSION DISORDERS ASSOCIATED WITH MSH3 ACTIVITY
EP4165185A4 (en) * 2020-06-11 2025-09-10 Genetic Intelligence Inc New York Ny COMPOSITIONS FOR FN GENE MODULATION AND METHODS THEREFOR
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
WO2022026909A1 (en) 2020-07-31 2022-02-03 Becton, Dickinson And Company Single cell assay for transposase-accessible chromatin
EP4247967A1 (en) 2020-11-20 2023-09-27 Becton, Dickinson and Company Profiling of highly expressed and lowly expressed proteins
CN116685850A (en) 2020-12-15 2023-09-01 贝克顿迪金森公司 Single cell secretome analysis
IL282597B (en) * 2021-04-22 2022-08-01 B G Negev Technologies And Applications Ltd At Ben Gurion Univ Birds for creating female offspring and methods for creating them
IL311872A (en) * 2021-10-15 2024-06-01 Codexis Inc Engineered terminal deoxynucleotidyl transferase variants
GB202117593D0 (en) * 2021-12-06 2022-01-19 Royal Veterinary College Methods
KR20250024748A (en) * 2022-04-08 2025-02-19 세카나 파머씨티컬스 지엠비에이치 엔 씨오. 케이지 Oligonucleotides for decreasing the expression of leucine rich repeat kinase 2 (LRRK2) and their use for preventing and/or treating human diseases
JP2025519286A (en) 2022-06-01 2025-06-25 イー－セラピューティクス・ピーエルシー Inhibitors of Expression and/or Function
CN115813944A (en) * 2022-07-01 2023-03-21 青岛市中心医院 Preparation with angiogenesis effect
WO2024023267A2 (en) * 2022-07-27 2024-02-01 E-Therapeutics Plc Nucleic acid compounds
WO2024023252A2 (en) * 2022-07-27 2024-02-01 E-Therapeutics Plc Nucleic acid compounds
EP4573198A2 (en) * 2022-08-18 2025-06-25 Alnylam Pharmaceuticals, Inc. Universal non-targeting sirna compositions and methods of use thereof
AU2024218976A1 (en) * 2023-02-06 2025-09-11 E-Therapeutics Plc Inhibitors of expression and/or function
WO2025007063A1 (en) 2023-06-30 2025-01-02 Avidity Biosciences, Inc. Compositions and methods of using pln-targeting antibody-oligonucleotide conjugates
CN120082549B (en) * 2024-08-22 2025-11-07 中国科学院动物研究所 A method for inhibiting rice virus replication by targeting viral small RNAs

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100305188A1 (en) * 2007-10-03 2010-12-02 Kyowa Hakko Kirin Co., Ltd. Nucleic acid capable of regulating the proliferation of cell
US20100306869A1 (en) * 2007-06-13 2010-12-02 Commwealth Scientific And Industrial Research Organization Modulating production traits in avians
WO2011005765A1 (en) * 2009-07-06 2011-01-13 Alnylam Pharmaceuticals, Inc. Bioprocessing
WO2011005786A2 (en) * 2009-07-06 2011-01-13 Alnylam Pharmaceuticals, Inc. Compositions and methods for enhancing production of a biological product
US20110111481A1 (en) * 2007-06-29 2011-05-12 Chiang Li ENABLING THE USE OF LONG dsRNA FOR GENE TARGETING IN MAMMALIAN AND OTHER SELECTED ANIMAL CELLS

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100306869A1 (en) * 2007-06-13 2010-12-02 Commwealth Scientific And Industrial Research Organization Modulating production traits in avians
US20110111481A1 (en) * 2007-06-29 2011-05-12 Chiang Li ENABLING THE USE OF LONG dsRNA FOR GENE TARGETING IN MAMMALIAN AND OTHER SELECTED ANIMAL CELLS
US20100305188A1 (en) * 2007-10-03 2010-12-02 Kyowa Hakko Kirin Co., Ltd. Nucleic acid capable of regulating the proliferation of cell
WO2011005765A1 (en) * 2009-07-06 2011-01-13 Alnylam Pharmaceuticals, Inc. Bioprocessing
WO2011005786A2 (en) * 2009-07-06 2011-01-13 Alnylam Pharmaceuticals, Inc. Compositions and methods for enhancing production of a biological product

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12139617B2 (en) 2017-12-22 2024-11-12 North Carolina State University Polymeric fluorophores, compositions comprising the same, and methods of preparing and using the same

Also Published As

Publication number Publication date
WO2012177639A2 (en) 2012-12-27

Similar Documents

Publication Publication Date Title
WO2012177639A3 (en) Bioprocessing and bioproduction using avian cell lines
BR112014004186A2 (en) enzymatic composition, method for producing an enzymatic composition, processes for degrading a cellulosic material, for synthesizing a fermentation product, and process for fermenting a cellulosic material
EP2577923A4 (en) Apparatus, method and computer program product for selecting beam group and subset of beams in communication system
BR112012032357A2 (en) “METHOD, SYSTEM FOR FERMENTATIVE PRODUCT PRODUCTION AND COMPOSITION”
IN2014DN09575A (en)
EP3494256A4 (en) Process for treating lignin
ZA201405478B (en) Method and composition for enzymatic treatment of fiber for papermaking, and paper products made therewith
EP2599848A4 (en) Water-and-oil repellant composition, functional textile product, and production method for functional textile product
WO2012168410A3 (en) Methods for treating lignocellulosic material
IL226423A0 (en) Novel method for the pre-or post -harvest treatment of plant products, using phosphonic acid and an essential oil
WO2010143149A3 (en) Method for treating pyropheophytin-containing compositions
EP2679664A4 (en) Reaction container and method for producing same
TWI563089B (en) Thermostable xylanase, production method and use thereof, and method for producing lignocellulosic glycation product
EP2669382A4 (en) Cellulosic biomass treatment method, method of producing sugar, alcohol or organic acid from cellulosic biomass
EP2657343A4 (en) Method for producing chemical by continuous fermentation
MX2014004055A (en) Process for the preparation of methoxymelonal.
EP2784156A4 (en) Method for producing cellulase, and apparatus for said method
EP2735612A4 (en) Mutant b-glucosidase, enzyme composition for decomposing biomass, and method for producing sugar solution
ZA201107891B (en) Emulsions,emulsifier,method of use and production process
EP2670890A2 (en) Electrolysis method, apparatus and product
WO2013038269A3 (en) Apparatus and methods for treating sugarcane stem cuttings
EP2636318A4 (en) Method for producing processed meats, and enzyme preparation for refining processed meats
EP2554675A4 (en) METHOD FOR THE PRODUCTION OF ZEAXANTHINE BY FERMENTATION
WO2012107445A3 (en) Soft substrate for cell culture and process for preparing the same
PL2749649T3 (en) Method for separating and purifying 1,4-diaminobutane from fermented solution

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12802215

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 12802215

Country of ref document: EP

Kind code of ref document: A2