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WO2013062266A2 - Procédé de fermentation-cataplasme utilisant une fleur médicinale, et composition associée à appliquer sur la peau - Google Patents

Procédé de fermentation-cataplasme utilisant une fleur médicinale, et composition associée à appliquer sur la peau Download PDF

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Publication number
WO2013062266A2
WO2013062266A2 PCT/KR2012/008541 KR2012008541W WO2013062266A2 WO 2013062266 A2 WO2013062266 A2 WO 2013062266A2 KR 2012008541 W KR2012008541 W KR 2012008541W WO 2013062266 A2 WO2013062266 A2 WO 2013062266A2
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Prior art keywords
skin
medicinal
flower
red
extract
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Korean (ko)
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WO2013062266A3 (fr
Inventor
심진섭
박준성
김현희
염명훈
조준철
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Amorepacific Corp
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Amorepacific Corp
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Priority to JP2014538700A priority Critical patent/JP6077554B2/ja
Priority to CN201280052868.5A priority patent/CN103906526B/zh
Publication of WO2013062266A2 publication Critical patent/WO2013062266A2/fr
Publication of WO2013062266A3 publication Critical patent/WO2013062266A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755—Gymnosperms [Coniferophyta]
    • A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]

Definitions

  • the present invention relates to a skin external preparation composition containing a fermented extract of ssam using medicinal flowers, and more particularly, to contain skin antioxidants, anti-aging, whitening and
  • the present invention relates to an external composition for skin having an excellent moisturizing effect.
  • Human skin is changed by a number of internal and external factors as it ages. That is, internally, the secretion of various hormones that regulate metabolism decreases, and the function of immune cells and the activity of cells decreases, thereby reducing the biosynthesis of immune proteins and constituent proteins necessary for living organisms. Due to the increase in the amount of ultraviolet rays that reach the surface of the sun's rays and further increase environmental pollution, free radicals and free radicals, such as free radicals, skin thickness is reduced, wrinkles are increased, elasticity is reduced only In addition, the color of the skin becomes dull, skin problems frequently occur, and various changes such as blemishes, freckles, and black mushrooms also increase.
  • cyclooxygenase-2 (Cox-2, cyclooxygenase), an enzyme that produces proinflammatory cytokine, which is known to cause inflammation, in most cells constituting the skin due to aging or ultraviolet rays.
  • MMP matrix metalloproteinase
  • free radicals generated by various physical, chemical and environmental factors such as enzymes, reducing metabolism, chemicals, pollutants and photochemical reactions in the body are non-selective and irreversible to cell components such as lipids, proteins, sugars and DNA. It has been known to cause various diseases including cell aging or cancer by performing a destructive action.
  • various peroxides in the body including lipid peroxides produced as a result of lipid peroxidation by these free radicals, also cause oxidative destruction of cells and cause various functional disorders.
  • antioxidants such as free radical scavengers or peroxide production inhibitors are expected as agents for inhibiting or treating aging and various diseases caused by these oxides.
  • the present inventors conducted a study to find a natural product extract having a superior performance than the existing natural products, as compared to the existing simple natural extracts and fermented extracts Ssam fermented extracts prepared by wrapping or fermenting natural products with medicinal flowers skin
  • the present invention has been found to be excellent in antioxidant, anti-aging, whitening and moisturizing effects.
  • the present invention provides a composition for external application for skin containing Ssam fermented extract prepared by fermentation by wrapping or covering natural products with medicinal flowers.
  • the present invention comprises the steps of boiling or steaming washed and dried natural products for 30 minutes to 2 hours;
  • Medicinal flower Ssam fermented extract according to the present invention exhibits excellent skin efficacy against antioxidant, anti-aging, whitening, and moisturizing, compared to natural extract or fermented extract of natural products before fermentation. It can be utilized.
  • the present invention provides a composition for external application of skin containing Ssam fermented extract prepared by fermentation by wrapping or covering natural products with medicinal flowers.
  • the present invention comprises the steps of boiling or steaming washed and dried natural products for 30 minutes to 2 hours;
  • Medicinal flowers that can be used in the present invention are brown, chrysanthemum, corolla, Kanto, lump, gold and silver, safflower, homegrown, nacho, magnolia, wheat dream, windproof, balsam, pomegranate, sundae, narcissus, calendula , God is at least one member selected from the group consisting of softening, Wonhwa, Takhwa, gunhwa, turmeric and safflower.
  • Gall flower means the flower of ⁇ . Gallulosis is used for headaches, fever and heavy chest feelings due to heavy drinking, which can cause your limbs not to stay still, thirst, anorexia, bloating and vomiting.
  • Chrysanthemum is a dried flower of Guam or White. Chrysanthemum has a fever in the chest and is effective for stuffy symptoms, pneumonia, bronchitis, headache, stiff shoulders, and high blood pressure. It is used for skin problems such as liver function, hyperemia, menstrual irregularities and acne.
  • Corolla is a flower of the perennial herbaceous Cockscomb (Celosia cristata L.). Flowers bloom in July-August in red, yellow, and white, and fruits are egg-shaped, with 3-5 black seeds. Coronary artery is used for hemostatic purposes for ophthalmic diseases, hypermenstrual, uterine bleeding, and hemorrhage.
  • Kanto Teussilago farfara L.
  • Kwanhwa is used for cough, expectorant, phlegm and pulmonary tuberculosis, lung abscess, and is used for external seawater, asthma and upper respiratory tract infections.
  • the pharmacological action has been reported to be effective for antitussive action, respiratory excitability and light anxiety, vasoconstriction, acute bronchitis in children, bronchial asthma and sore throat due to increased respiratory secretions.
  • a lump is a bud of the sophora japonica L. Necrosis is used to stop constipation, abortion, and hemostasis when eyeball hyperemia, intestinal bleeding, uterine bleeding, nosebleeds, bloody stool, and blood vomit due to liver fever. It is also effective for high blood pressure, headache, dizziness, arteriosclerosis, stroke, cerebral hemorrhage, and heartburn. Pharmacological actions include hemostasis, decreased capillary permeability, lowered blood pressure, lowered cholesterol, anticonvulsions, anti-ulcer, anti-radioactivity, frostbite treatment, and mild hypothermia.
  • Gold and silver coins refer to the buds of the Lonicera japonica Thunberg or the same plant. Gold and silver coins are used when the heat is lowered and the chest is thirsty and thirsty. It is good for inflammation, and it causes boils, skin toxins, organ inflammation, and pus. Also used for dysentery, skin tissue necrosis due to heat poisoning, mastitis. It is applied to colitis, gastric ulcer, cystitis, sore throat, tonsillitis, bronchitis, conjunctivitis and swelling, mumps and high fever, purulent infection. Pharmacological action has been reported antibacterial, anti-inflammatory, antipyretic, leukocyte phagocytosis, central nervous system excitability, serum cholesterol lowering, ulcer prevention effect.
  • a flower is a flower of the Prunus persica (L.) Batsch or P. davidiana (Carr.) Fr. It has the ability of diuresis, blood, and stool, and treats several species, each, faeces, and dysmenorrhea.
  • Cactus is a flower of Hirochloe odorata, a perennial herbaceous plant belonging to the flower family. It is used to stop vomiting blood and nosebleeds, and to injure the stool and iron to stop blood and pain.
  • Magnolia is the flower of the Hibiscus syriacus of the Mallow family. Magnolia cures intestinal bleeding, dysentery, whites and skin diseases. The ingredient contains sapononarin, and pharmacological action has been reported to have seaweed action.
  • Windproof flowers are flowers of the genus Windbreak (Saposhnikovia divaricata S.). Windproof flowers are white and hang on the end of the main stems and the branches of the branches. The flowering period is from July to August. Windproof shoes are used for the treatment of heart pain, extremity first aid, and fracture pain.
  • Balsam is a flower of the Impatiens balsamina L., an annual plant of the family Balsam.
  • Balsam contains a variety of anthocyanins, kaempferol, quercetin and naphthoquinone.
  • As a pharmacological action it is known to have an inhibitory effect on Staphylococcus aureus, Pseudomonas aeruginosa, Typhoid bacillus, and Ricci. It is mainly used for the treatment of urinary bleeding, post-birth blood, bruises, scabies, and intestines.
  • Pomegranate is a flower of the pomegranate (Punica granatum L.). Pomegranate is used for hemorrhage, bleeding due to nasal bleeding, otitis media, and bleeding.
  • Lilac is a flower of Inula britannica var. Japonica (Thunb.) Franch. & Sav. Seonhwa has a peculiar smell, taste is bitter, spicy and salty and slightly warm.
  • the abdomen circulates and releases clumps, sputum, cough, hiccups, belching, asthma, chronic bronchitis, acute pleurisy, and chest pains as if it's always full.
  • As a pharmacological action, anticonvulsant action, diuretic action of bronchus has been reported.
  • Daffodil is a flower of the perennial vine, Calystegia japonica C. Flowers bloom in June-August and pale red. It is used to nourish the face, get rid of freckles on the face, and improve the appearance of the face.
  • Calendula is the flower of the pine family Pinus densiflora S. et Z.
  • a male flower runs under several new branches of a male and female pine tree, elliptical, and brown.
  • Female flower runs 1 ⁇ 3 at the top and is ovate about 6mm long.
  • the pollen has a light yellow and sweet scent, and is mainly used to make food and smuggling.
  • a god is a magnolia (Magnolia denudata Desrousseaux) or a bud of the same plant. It is effective for treating cold energy and air congestion, sinusitis, runny nose, odorlessness, headache or lack of concentration, chills, fever, and sore cough. There is. Pharmacological action has been reported to be astringent, capillary dilatation, anti-inflammatory, hypotensive, analgesic, sedative, skin fungal and staphylococcal.
  • Softening is the flower of Nymphaea nelumbo L.
  • Lotus flower contains a variety of flavonoids such as quercetin, luteolin, isoquercetin, and kaempferol.
  • Lotus flower has the effect of bleeding, hemostasis, and moisturizing. It is used to treat bleeding and blisters caused by bruises.
  • the original painting refers to the buds of the Daphne genkwa Siebold et Zuccarini. Wonhwa is used for species to shed water in asthma, sea water and flanks. Also use only for abdominal swelling, boils, head rashes, urine, and stool. Pharmacological action was reported to increase urine, suppress the intestinal and uterine movement, and insecticidal action.
  • Quikhwa means the flower of the mallowaceae (Althaea rosea Cavanil) in Korea. Appearance yellow or light brown with 5 intact petals. Moisturization is used for white crabs, cold abdominal pain, inconspicuous pain, bleeding, uterine bleeding, burns, and redness of the nose. It has been reported that pharmacological action is effective against malaria.
  • Total flower is flower of Allium fistulosum L. Totalization is used for the treatment of abdominal pain with nasal pain.
  • the phoenix is the flower of the Typha orientalis C. Presl.
  • the pollen lowers blood fever, convergence, and hemostatic action, which is used for keratosis, hemostasis, nosebleeds, urine bleeding, and uterine bleeding, and improves blood circulation.
  • uterine excitement As pharmacological action, uterine excitement, lowering blood pressure, menstruation, shortening blood coagulation time, suppressing tuberculosis bacterium growth, lowering cholesterol, etc. have been reported.
  • the safflower is a flower of the Asteraceae (Carthamus tinctorius L.). Pharmacological action is known to be effective in the contraction of the uterus, intestines, etc. through the excitation of smooth muscle, effective in lowering blood pressure, antagonizing blood coagulation, bruises, sprains, hay fever. Safflower is effective in the use of blood, pain, pain, pain, aches and pains to treat amenorrhea, egg delivery, stillbirth, fish blood pain, carbuncles and bruises.
  • the natural products that can be used in the present invention are soybeans, cabbage, brown root, spicy meat, gamguk, dried Guangji, dried lacquer, licorice, health, nut, ginseng, red pepper, gobon, ginseng, gallweed, fruit fruit, gojija, gwakyang, baekbaek, tangerine, Gold Silver Coins, Gujeolcho, Chrysanthemum, Gil-Gyeong, Cucumber Tree, Locust, Male, Green Ginkgo Bridge, Mung Bean, Deer Antler, Twill, Poly, Donkey, Tangyuja, Daegye, Rhubarb, Hemp, Contrast, Daecheongcho, Rhubarb, Doin, Single Bowel, Cordyceps Sinensis , Tofu, ephedra, machi, manpyeongcho, ginseng, malt, mackmundong, quince, throat, cedar, mulee, bark,
  • Beans are also called soybeans. Widely cultivated as an edible crop, the fruit is edible, streaked, flat oval, with 1-7 seeds. When fully cooked, the pod bursts, dispersing the seeds. Seeds vary in size, including round, flat and round, depending on the variety. Seeds come in many varieties such as yellow, black, light brown, and green.
  • Caucasus removes the seeds from the mature fruit of the terminalia chebula Retzius and is a dried flesh used to treat diarrhea, dysentery, crayfish and prolapse.
  • Persimmon is a perennial herb and grows mainly in the mountains. In October, the flowers are dried and drunk, and young leaves are used as herbs. The flower has a rich scent and can be used for ornamental purposes. It is prescribed for the treatment of cold, pneumonia, bronchitis, headache, gastritis, enteritis, and boil in one shot.
  • Geonjiwang refers to the roots of dried Jihwang, the fever down, and writes medicines such as blood and hemostasis.
  • Dried lacquer is dried by collecting the lacquer gin and used for dysmenorrhea, blood, and roundworms.
  • Licorice is a medicinal plant and its root is sweet, so it is used as a sweetener and herbal medicine.
  • Health is used for the treatment of vomiting and diarrhea for the purpose of saying dried ginger in one shot.
  • Geunwoo refers to the seed of morning glory, which is bitter and full of character, and passes through urine. Used for the treatment of constipation, edema, extraction, back pain.
  • the deficiency refers to the seeds of the imperfection tea, which is a yearly herb.
  • the fruit bears a long, curved fruit, like a bow, the seed in which is a fault.
  • Gobon is a perennial herb of mountainous family, bears elliptical fruit, and its root is medicinal. In oriental medicine, roots are cut and dried in the fall and are prescribed for headache, joint pain, toothache, abdominal pain, diarrhea and eczema.
  • Ginseng is a perennial herb that is rooted in medicinal plants. Ginseng mainly refers to roots. It is used for jaundice, school work, and bleeding because of its bitter taste.
  • Goldamcho is a deciduous broad-leaved shrub of the legume, cultivated for ornamental purposes, and distributed in Korea and China.
  • Guruin is the seed of perennial vines of gourds, which is used to shed milk and faeces or to sink boils.
  • the wolfberry is the fruit of the wolfberry tree and is used as an antipyretic and tonic.
  • Gwakhyang is a perennial herb of Lamiaceae, which is used to treat digestive disorders and inflammation.
  • Kwonbaek is a perennial herb that is used to treat menstrual cramps and bleeding.
  • the tangerine peel refers to the peel of the tangerine and its warm properties help digestion, and it is effective in coughing, diarrhea and harvesting.
  • Gold and silver coin refers to the flower of honeysuckle, lowering the heat and acting to solve the poison is used in things like onggi.
  • Gujeolcho is a perennial herb of the Asteraceae family, and soaks flowers in liquor.
  • the herbal medicine Gujeolcho is dried stems and leaves.
  • oriental medicine and folk medicine the entire grass with flowers is prescribed for typhoons, gynecological diseases and gastrointestinal diseases.
  • Chrysanthemum is a perennial herb of the Asteraceae family, which mainly blooms in autumn, and has various flower shapes and colors.
  • Gilkyung is a perennial herbaceous plant with lanterns.
  • the roots are edible or used as medicinal herbs or Jinhae.
  • Kudji Mulberry is a deciduous tree of the Mulberry family and is known to be effective in treating tinnitus.
  • a moth is a seed of the radish or cognate of the cruciferous family. Used to pretend or to rule a wall.
  • Noggak Bridge is made of grass like an orphan with deer's horns. It has the effects of blood, hemostasis, and anxiety. It is used for low back pain, gonorrhea and crayfish.
  • Mung beans are used to treat skin diseases in the private sector and are antipyretic and detoxifying.
  • Deer antler is a soft horn of a newly sprouted deer that is used as a medicine to strengthen the musculature.
  • Twill is a fruit of perennial herbaceous fruit and edible.
  • Dacha is a green-yellow vegetable belonging to the cruciferous family and contains a lot of vitamins.
  • Carotene which is comparable to the effect of vitamin A, is twice the amount of spinach, and 100g of vitamins are enough to fill 80% of the daily needs, and it is rich in iron and calcium.
  • Angelica is the root of Seunggeumcho, a perennial herb of mountainous family. Mainly anti-inflammatory, analgesic action.
  • Sugar is an evergreen sub-tree, the fruit is used for the prevention and treatment of colds, and the treatment of liver disease.
  • Daegye is a perennial herb of the Asteraceae family, used as a hemostatic agent.
  • the rhubarb is the germination of the legume Glycine max Merrill. It is used for limb paralysis caused by summer humidity, limb tingling, swelling due to stagnation of water, and low urine. It is also used to reduce heat caused by colds and sweat.
  • Hemp is a perennial herb of the dicotyledon and moss plant.
  • the seeds and leaves are highly toxic, but the leaves are used for asthma tobacco.
  • Herbaceous herb is an outpost of Hygrophila salicifolia (Vahl) Nees. It is known to treat epidemic fever, jaundice, sputum sputum, coughing and hemorrhage (Chinese medicine dictionary). It contains about 25% oil and trace amounts of alkaloids, calcium phosphate and calcium chloride.
  • Rhubarb is a perennial herb that is used for medicinal purposes. Its roots are used for medicinal purposes, and it is used for feces, bullshit, drool, redistribution, gongga, and blood.
  • Doin refers to Jain (a relatively large granular body in the nucleus) in peach seeds, and is mainly used as a herbal medicine. It is used as a medicine for coughing, constipation, and blood.
  • Toxin is used for the treatment of muscle pain, paraplegia, headache and paraplegia.
  • Cordyceps sinensis is a term that refers to the mushrooms of the family Cordyceps sinensis, which means that what was cut in winter turns to grass in summer. It is effective in boosting immunity, anticancer and anti-aging.
  • Toothworm is a deciduous tree with Toothworm.
  • bark is used as a medicine tonic and tonic, to strengthen the cerebrum, and to control lung and knee ailment and hydration.
  • Folk in the leaves decoction is used for neuralgia, high blood pressure, is also taken by car.
  • Ephedra is an evergreen shrub with ephedra, which is effective in sweating, antipyretic, antitussive, diuretic and used to treat fever and asthma.
  • March is used as feed or medicine.
  • This herb has a soft, peculiar smell, mucus, tastes salty, and cold. It has antipyretic, detoxification, and hemostatic effects. It is used for bacterial dysentery, boils, hemorrhoids, cervical lymphadenitis, eczema, lobster, uterine bleeding, and urine.
  • As a pharmacological action, antimicrobial action, intestinal peristalsis due to the enhancement of uterine smooth muscle contractility, and diuretic action have been reported.
  • Manbyeongcho is an evergreen shrub of the Azalea family dicotyledon and used as a diuretic and tonic.
  • the ginseng is a vine perennial herb of the dicotyledon plant Campanula, which is used as an expectorant.
  • Malt is a grain of barley that germinates by acting moisture, temperature, and oxygen on the barley, and is used as a raw material for beer brewing, and is also used to prepare microorganism incubators. It contains sugars and vitamins such as starch, and has a strong amylase, which is used as a nutritional supplement, a digestive agent (diastatase, etc.), sometimes a livestock feed, and a raw material of maltose.
  • Macmundong is an evergreen of the monocotyledonous genus Liliumaceae. It is used as an anti-inflammatory, tonic, Jinhae, expectorant, and cardiac agent.
  • the quince is a medicinal herb that is medicinal and tastes warm. Used for muscle flexion disorders, keratin and sedimentary eggs.
  • the neck is a stem of the rake (Akebia quinata Decaisne) or other homologous plant, and is made by removing the bark and cutting it horizontally.
  • rake Alpha quinata Decaisne
  • red urine used for numb pain.
  • Mokhyang is a perennial herb of dicotyledon plant Campanula Asteraceae, used as perspiration, diuretic, expectorant and has insect repellent.
  • Mui is a dried medicinal herb of Ulmus macrocarpa, which belongs to the elm family. It is also used for intestinal bleeding, hemorrhoids, and severe wounds.
  • Peel is a medicinal herb made from peony root bark, menstrual irregularities caused by blood fever, dysmenorrhea, bruising, bleeding, nosebleed, spots, swelling due to fever, blood pressure, blood loss, bruises, anti-inflammatory It is used for pain relief, boil treatment, early appendicitis, and eliminates chest discomfort.
  • pharmacological action has been reported analgesic, sedation, antipyretic, anticonvulsion, anti-inflammatory, antithrombotic, anti-allergic, gastric secretion, uterine mucosa, antibacterial action.
  • Peppermint is a perennial root of dicotyledon and moss-planted nectar, and menthol of peppermint oil is used as a medicinal painkiller and insect repellent or as a refreshing or fragrance in toothpaste, jam, candy, and cosmetics.
  • Windproof is a medicinal herb made from the roots and rhizomes of Sapshnikovia divaricata Schiskin and is very important in treating wind diseases. External headaches, chills, fever, systemic pain, sore throat, etc. are effective for all symptoms.
  • Chinese cabbage is a biennial herb of the poppy family Mustard, and 100 g of Chinese cabbage contains vitamin I 33 IU, carotene 100 IU, vitamin B10.05 mg, vitamin B2 0.05 mg, nicotinic acid 0.5 mg, and vitamin C 40 mg.
  • the pale white part does not have vitamin A, and the blue part is a lot.
  • Baekgulchae is the ground part of the Chelidonium majus Linne. Pharmacological actions have been reported for anticonvulsions, intestinal linkage and salivation, antitumor, hepatitis, and antibacterial activity.
  • Baekduong refers to the roots of Pulsatilla koreana Nakai or the same plant in the country. It is used for dysentery due to moist heat, amoeba dysentery, cervical lymphadenitis and hemorrhoidal bleeding.
  • White rice is a medicinal herb made from the roots of Cynanchum atratum Bunge or the same plant of the Panaxia family.It cools the blood powder and consumes the blood and essence of the human body after the fever and postpartum. It heals and is used for fever, seawater from diarrhea, diuresis, boils, severe wounds, sore throat, and snake bites.
  • White is a medicinal herb that has dried orchid tubers. Efficacy is a hemostatic drug used for hemostasis caused by lung fever and hemorrhage caused by stomach fever. It is used for surgical diseases such as boils and helps to raise new flesh. In addition, local bleeding hemostasis, gastric and duodenal treatment, fungi, blood pressure increase, and anticancer activity were reported as pharmacological effects.
  • Sandalwood is an evergreen broad-leaved arboreous tree with sweet incense, and the inside of the tree has a yellowish, good fragrance, and is used in incense burners, medicines, and crafts.
  • Pleurotus is a word that reaches the root of a gae saw in one shot, and is used to treat window and burns.
  • Baekbokyeong is the dried core of Bokyeong, the taste is sweet and boring, the property is flat, there is a function to act and diuretic, but not strong. It has been used as a tonic since ancient times, and acts on menopause, parenteral, heart, nerve, and bladder to protect the spleen, sputum and stabilize the mind. The results of pharmacological experiments have been shown to act as a diuretic, lowering blood sugar, sedation, etc., and is also known as an immune resurrection.
  • White rich roots have strong poisons, but they are used as herbals and painkillers in oriental medicine.
  • White porcelain refers to the seeds of the cypress fruit. It stabilizes the mind and body and makes the intestines lubricate, so it is used for vigilance, worms, cold, constipation.
  • White flower is the outpost of the Oledenlandia diffusa (Willd.) Roxburgh. It is used for seawater, tonsillitis, and sore throat due to waste heat. It is also used for appendicitis, pelvic inflammatory disease, jaundice hepatitis and dysentery.
  • Earl is a perennial herb of the Buttercup family, and its roots are used for pain, dysfunction, and gynecological diseases.
  • White paper refers to the roots of the billiards, and is used for headaches, low back pain, and reflexes caused by colds.
  • Baekchul is a dried medicinal herb that removes inflorescences of the asteraceae or root stems of the baekryeok.It is weak when the function of the stomach is weak.It is good for news, boredom, yellowish face, thin stool or diarrhea. This helps to pour out water when it is swollen and indigestible. It is also used for coughing and clear phlegm, and for colds and limb pain with gastrointestinal disorders.
  • Bokbun is a medicinal herb made from unripe fruits of Bokbunja strawberry of Rosaceae. It has no smell, tastes sweet and warm. Enhancing the new function, it is used in oil wells, dreams, etc., it is used for weakening eyesight, lightens the body and makes the head black. It also makes the skin soft and beautiful. Pharmacological actions have been reported to anti-inflammatory, antioxidant and anti-Helicobacter pylori.
  • Bokryeong is a mushroom of the fungus of the fungus of Democracy mushroom, which is white. All herbal medicines are effective in tonic, diuretic and soothing, so they are used for kidney disease, cystitis and urethritis.
  • Daebokpi is a medicinal herb made from mature skin of Areca catechu L., which is used for swelling and swelling, and is effective in making faeces visible, and parasite control has been reported.
  • the rich man is a tuber of roots belonging to the buttercup family.
  • oriental medicine it is common to the excitement of the warmth, strong heart, pain, and diuretics such as gyeji, bokyeong, licorice, and never used in one side.
  • diuretics such as gyeji, bokyeong, licorice, and never used in one side.
  • it is used for cold, chills, numbness, pain, neuralgia, and rheumatoid arthritis.
  • Leek is a perennial plant of the family Liliaceae.
  • the scaly stem has short rhizomes underneath and black yellow fibers on the outside. Scales are used for dry stomach, burns, etc., and soft plants are eaten. Seeds are used in herbal medicine as urinary medicine.
  • the lake contains saponin and fatty oil in its roots and is used as a medicine for antipyretic, analgesic, tonic, respiratory, digestive and circulatory diseases.
  • Ice cubes refer to the crystals obtained from the brains. It is directional and is confused with strokes, phlegm and fever, and is used to treat sore throats.
  • Apple Lac is a delusional fiber and tube in the fruit of Luffa cylindrica Roemer. Edema of the customary arthritis, anti-inflammatory, redness in the redness, suppression of skin bacterial infection, etc. have been reported.
  • Samsam is a medicinal herb made from Adenophora triphylla var. Japonica Hara or the root of the same plant (Korea), and pharmacological action has been reported as expectorant, antibacterial, hemolytic and cardiovascular.
  • Wild ginseng is a kind of highly effective ginseng that grows in deep mountains. It tastes sweet and bitter, and its properties are slightly warm. Rain, menopause to refresh the effect is.
  • Sansa is a medicinal herb dried on the ripe fruits of the rapeseed (Crataegus pinnatifida Bunge var. Typica Schneider) and the same plant, and has been reported to have a cardiovascular effect, blood circulation improvement, and blood pressure lowering action.
  • Cornus is the fruit of the cornus tree, a deciduous tree of the dogwood family.
  • the pulp contains glycosides such as cornin, morroniside, loganin, tannin and saponin, and organic acids such as vitric acid, malic acid and tartaric acid. It also contains vitamin A and a large amount of sugar. From ancient times, herbal medicine was used as a medicine for headache, tinnitus, seawater disease, fever, excessive menstruation, and also used for folk remedies such as cold sweat and nocturnal enuresis.
  • Herbs are the roots of the vines of Deisocorea japonica or Deisocorea batatas belonging to the family Deisocoreaceae, which have the effect of strengthening rain and lungs.
  • Sanjoin is a medicinal herb made from jujube seeds and used for nervousness, insomnia, forgetfulness, cold sweat, etc., and strengthens the stomach and is effective for anemia.
  • Pharmacological action, sedation, hypnosis, lowering blood pressure, analgesic, lowering body temperature, antioxidant activity, immune hyperactivity, uterine excitement has been reported.
  • the gardenia is the fruit of the gardenia berry, and it is used as a medicine for fever, hemostasis, and diuresis.
  • Three hundred seconds is a perennial plant of the dicotyledonous pepper tree over three hundred, it is used when the body is swollen and urine does not come out well, respectively, jaundice, hepatitis is also used.
  • the shochu is a perennial herb of the dicotyledon plant Lantern Asteraceae, which is used as a medicine to create root stems. It is effective for sweating, diuresis, pain, and stomach, and is used for anorexia, indigestion, gastroenteritis, and cold.
  • Mistletoe mulberry (Loranthus parasticus Merr.) Or mistletoe (Viscum album L. var.coloratum Ohwi), which has the effect of lowering blood pressure, dizziness caused by hypertension It is used to strengthen the bones and muscles with bare feet and is used in the womb.
  • Sanbaekpi is a medicinal herb made of mulberry or the same plant's root bark.
  • Sanbaekpi treats seawater and asthma caused by waste heat and has a diuretic effect. It is used for acute pyelonephritis and fragile edema and has a blood pressure-lowering effect. It is also used for epidemic hepatitis. Pharmacological action is reported by Jinhae, diuresis, lowering blood pressure, sedation, analgesic, fever, jingyeong, antibacterial action.
  • Sangsan is a deciduous shrub with a dicotyledonous rat locust herbaceous rhyme, and the root is used as a medicinal herb, which treats seawater, fever, and sore throat caused by colds, and is effective in customary arthritis, dysentery, boils, and malaria.
  • the upper leaf is a dried herb of Morus alba L. or related plant of the same family. It is used for fever, headache, ocular hyperemia, seawater, browning and skin urticaria.
  • the boss is also called Hongdu.
  • the pods are used as arrow poisons because of the highly toxic abrin, and the leaves contain glycyrrhizin, which is sweetened like licorice and is a sweet drink.
  • Ginger roots are dried and used as a spice in bread, sweets, curry, sauces, and pickles. Peel, boil, and marinated in syrup. Ginger tea and ginger are also made.
  • dried root stem is used as a health medicine, which is effective for indigestion, vomiting and diarrhea, promotes blood circulation, and has anti-inflammatory and analgesic effects.
  • Seokchangpo is a perennial herb with monocotyledonous plant Chunnamseong Mok Cheonnamseong, and it uses root stem as a painkiller, sedative, and dry agent.
  • Seonhakcho is a perennial plant of the family Rosaceae, hemostatic, astringent action, hari, uterine bleeding, detoxification, hemostasis, urine bleeding, carbuncles, chemotherapy.
  • Seshin is a medicinal herb made from the roots of perennial plants belonging to the Rhododendron family. It is used for cold or windy pains in the head, stuffy nose, fever, phlegm, cough, and shortness of breath. Good for laryngitis, rhinitis, bronchitis.
  • Leaflets are perennial plants of Lamiaceae, leaves and stems are used as medicinal herbs and young leaves and seeds are edible.
  • Pine is an evergreen coniferous plant of the family Asteraceae, whose leaves are used as indigestion or tonic, flowers are dysentery, and rosin are used as raw materials of plaster.
  • Grenade uses the root of Jasminum floridum Bge., A plant of the ash family, and is used for wound healing.
  • Small fennel is a yearly herb that is also known as dill. Flowers, leaves, stems, and seeds are used as herbs because they have a unique scent throughout. Seeds are good for digestion, gusts, sedation and hypnosis, good for removing bad breath and preventing atherosclerosis, and can be used as a pillow for a good night's sleep.
  • Seed seed is a seed of the seed medicinal plant and uses oily debris for diuretics, laxatives, edema, ascites and food poisoning.
  • Oily debris for diuretics, laxatives, edema, ascites and food poisoning.
  • indigenous seeds are highly toxic and care should be taken.
  • Sokdan is a perennial herb of the dicotyledon and moss plant.
  • the thick root is used for gold spear and gynecological diseases.
  • Matsutake is an edible mushroom of the quince family with a unique aroma and taste that occurs on the pine forest land. It is edible as an advanced mushroom and is known for its anticancer effect.
  • Horseback riding is a perennial herb of the Ranunculus family, with roots used as antipyretics and antidote for oriental medicine. It has been reported that if you use a lot of heat with a cold, you will sweat and get fever.
  • Shiho is a perennial herb of the dicotyledonous plant Asteraceae, whose root contains saponin and fatty oil, and is used as a medicine for antipyretic, analgesic, tonic or respiratory, digestive and circulatory diseases in Chinese medicine.
  • the new song usually means a mixture of six medicines. Extinguishing the function of the digestive system and the action to help digestion has the effect of relaxing the inside. When you pretend, your chest is stuffy and full, vomiting and diarrhea, postpartum blood pain when the stomach is effective. Pharmacological experiments have been reported to have a health effect.
  • the night gate is a semi-tree of the dicotyledonous rosewood legume, which is used for the lack of yang, ulcer, premature ejaculation, cough, whooping cough, and snake bites.
  • seaweed action expectorant action
  • Pyeongcheon action action on the uterus, antibacterial action.
  • Yagyo refers to the stem of sesame, a vine perennial plant, with dicotyledonous plants, soybean, and effective for Jinhae, expectoration, arthritis, etc.
  • Eoseongcho refers to the terrestrial part of the flowering period of the weak wheat of more than three hundred. Echoseongcho is excellent for fever, drainage, cough due to lung abscess, pus, vomiting, pneumonia, acute pharyngitis, enteritis, urinary tract infections, boils, fever and urine can not be used. As a pharmacological action, antimicrobial action, immune enhancing action, anti-inflammatory action, diuretic action, antitussive action has been reported.
  • Yeonkyo lowers and detoxifies the fever and lowers the heart's fever in the early stages of fever, and is used for high fever and mental confusion, boils, rashes, appendicitis, lung abscesses, lymphadenitis, sore throat, and diuretic, anti-inflammatory.
  • pharmacological action antibacterial action, anti-inflammatory action, blood pressure drop, hemostatic action, liver treatment action, antipyretic effect, clay, diuretic effect have been reported.
  • Yanbab refers to the fruit of the lotus and is used for gynecological diseases.
  • Lotus is a seed of lotus and peeled and dried. It is a medicine that has been widely used because it helps the stomach and the spirit and energy, and when it is taken for a long time, it makes the body light, not old, hungry, and has a long life. Pharmacological action has been reported to inhibit nasal and throat cancer.
  • Yeochunhwa is also called a poppy flower, and in the folk, the fruit and plant of the poppy were separated and used for emergency diseases.
  • Smoking opium with cigarettes leads to anesthesia, dullness, and addiction when habitual, and even death.
  • Seed contains 45-50% fat, so it is used for food or industry. There is no anesthetic component.
  • Ganoderma lucidum is a semi-circular, kidney-type, or fan-shaped mushroom, which is effective in tonic, Jinhae, and small species in oriental medicine, and is used for nervous breakdown, heart disease, high blood pressure, and various cancers.
  • Odu is a tuber of roots belonging to the buttercup family, common in oriental medicine, strong heart, pain relief, diuretic, geyeji, bokyeong, licorice, etc., never used as a single. In addition to restoring extreme declines in metabolic function, it is used for colds, chills, numbness, pain, neuralgia, and rheumatoid arthritis.
  • Ogapi refers to the bark of the roots, stems and branches of the algae or the same plant. Ogapi strengthens the tendons and bones by keeping the liver and kidneys strong, so they are used for limb paralysis, cough, weakness in the lower back and knees, lower limbs, fractures, bruises, edema. Pharmacological action has been reported to enhance immune, antioxidant, anti-fatigue, anti-high temperature, anti-irritant, endocrine function, blood pressure control, anti-radioactivity, detoxification.
  • Schisandra chinensis is a fruit of Schisandra chinensis, which has five flavors: sweet, sour, bitter, salty, and spicy. It contains ingredients such as xanthrin, gomisin, citric acid, malic acid, and citric acid, which strengthens the heart, lowers blood pressure, and boosts immunity. Strong lung function, cough, expectorant action to help treat coughs and thirst.
  • the gall is an insect lump formed by the locusts of the cicada aphid and parasitic on the leaves of the Rhododendron.
  • oriental medicine it has the effect of astringent, hemostasis, detoxification, antibacterial, and is prescribed for diarrhea, prolapse, gastric ulcer, duodenal ulcer, cold, oil well, bloody stool, hematuria, stomatitis.
  • It contains 50 to 60% of the tannin component, and is a raw material for hair dyes and inks including tannins.
  • Osuyu is a deciduous arborescent of the dicotyledonous plant, Lichen Fructus, and is used as a dry, insect repellent, detoxification and diuretic in oriental medicine.
  • Ojak is a tuber of dried Cheontaejak, which is used for the treatment of heart pain, each one, and urinary emptying by making the qi well, removing Hansa, and warming the kidneys and bladder.
  • Okmisu refers to corn whiskers in Chinese medicine.
  • Adult diseases such as diabetes mellitus, blood pressure, cholesterol, diuresis, acute gastritis, nephritis, pregnant woman edema, fever, fever, hemostasis, stones, pleurisy, ascites, cystitis, urethritis, jaundice, hepatitis, gallbladder Used for cholecystitis, cirrhosis, arthritis, etc.
  • Okjuk refers to a dried herb root, and has the effect of clean and yin and yang.
  • Wasong is a perennial herb with dicotyledonous rosewood sedum, medicinal as a tonic for the whole grass, and leaves are used when squeezing juice and biting insects or getting burned. Excellent anti-cancer effect, effective for fever, hemostasis, hepatitis, eczema, dysentery, malignant tumors, burns.
  • Yonggyu is a yearly herb of the dicotyledon and moss-branching plant. It is prescribed for colds, chronic bronchitis, nephritis, high blood pressure, jaundice, boils, and cancer. In the private sector, the grass is crushed and glued to a diseased or injured place, or the decoction is used to wipe the affected area.
  • Gentian is a perennial herb with gentian, which is used for jaundice, dysentery, vaginal itch, cramps, eczema caused by hepatobiliary fever, and is compounded in hand and foot spasms due to high fever. Write on symptoms you can't hear.
  • the pharmacological action promotes the protection of liver function and promotes the secretion of bile, and relatively strong inhibitory effect has been reported on Pseudomonas aeruginosa, modified bacillus, meningitis diplococci and Staphylococcus aureus.
  • Longan meat refers to alfalfa of longan in Apatiaceae.
  • the texture is light, sticky, sweet, and has a unique scent.
  • Dragon meat is also used when the heart is beating irregularly or when forgetting, forgetfulness, insomnia, indigestion and loose stools. It is used when postpartum blood is weak and edema occurs when you are unable to control anemia, boredom and sweat after illness.
  • Pharmacological actions include scabies suppression, tonic action, antioxidant action, immune function activation.
  • the dew is the root of the knee or the dew with the amaranth. If you use raw materials to remove the blood and boils, if you boil the liver and gods to strengthen the muscles and skeleton. It is used for menstrual irregularities and postpartum abdominal pain by removing blood, supplementing bone marrow and making the penis well through arthritis, and treating rashes in the mouth and tongue caused by immunization sinus. In addition, pharmacological action, uterine excitement, cholesterol lowering action, diuretic action, hypoglycemic action, liver function improvement, and the like have been reported.
  • Wonji is a perennial herb of the dicotyledonous rat handiwork, and it is called as Wonji in oriental medicine, and it is used as an expectorant, tonic and gangjeong.
  • Wonhwa refers to the buds of the red azaleas of the Azalea family, and is used for species by lowering moisture staying in asthma, sea water and flanks. Also use only for abdominal swelling, boils, head rashes, urine, and stool. Pharmacological actions were reported to increase urine, suppress the intestinal and uterine movements, and kill insecticides.
  • Roots are used as a medicinal herb, and depending on the disease, leaves are used, and in the private sector, oil is used to make seeds for diabetes. Efficacy in antipyretic, anti-inflammatory, good roots for colds, sore throat, bronchitis, dermatitis, seed cough is effective in diabetes, hypertension, obesity, and suppresses excessive accumulation of lipid components, including cholesterol, is applied to hyperlipidemia.
  • the roots of elder bark are the bark of elm, and are effective on stomach ulcer, duodenal ulcer, small intestine ulcer, colon ulcer, edema, edema, gastric cancer, rectal cancer, uterine cancer, diuresis, sinusitis, rhinitis, swelling, boil, and swelling.
  • Rapeseed oil is consumed as oil after soybean oil as cooking oil, and is used as salty feed or fertilizer.
  • the fat oil separated from the seeds is used as a meat-based, oil-based solvent or machine lubricant.
  • Breeding is a medicinal herb made from breeding with fructose or other closely related plant species. It has a peculiar smell, tastes sweet, sour, salty, bitter and warm. It is used for breeding, and it is used for constipation caused by dry intestine, low back pain of the lack of sinyang, weak and weakness of the legs, tinnitus, amnesia, oil well, yuno, infertility, crayfish, lower abdominal cold, bleeding, sweating, and constipation. In addition, pharmacological actions have been reported to lower blood pressure, promote saliva secretion, and improve respiratory paralysis.
  • Eun Siho refers to the roots of the crabs of Sukju. It has no smell, is beautiful, tastes sweet, and is slightly cold. It is used for fever, fever due to overwork, cold sweat, fever, and bloating. Pharmacological action has been reported to prevent atherosclerosis, prevent cholesterol accumulation, antipyretic, killing action.
  • Eum Yanggwa is the terrestrial part of the trilobite or other cognate plants of the barberry family.
  • Eum yanggae is used for erectile dysfunction, oil well, cold uterus, cold limb, skin paralysis, gut wasabi, forgetfulness, paraplegia, back and knee weakness, hypertension, polio.
  • Pharmacological action promotes semen secretion, lowers blood pressure, increases coronary blood flow, lowers blood sugar, lowers cholesterol, boosts immune function, Jinhae, expectoration, Pyeongcheon, sedation, fungi, anti-inflammatory action, chicken femoral growth and protein polysaccharide activation Reported.
  • Uiin refers to the seed that has removed the seedling of the rice barley.
  • Uiyiin is a species, each, a stomach ulcer is a symptom of poor urine, diarrhea, edible use, etc. used for limb paralysis, pain, dyspnea and muscle pain, fever, drainage, appendicitis.
  • the drug action has been reported anti-cancer, skeletal muscle contraction suppression, intestinal uterus suppression, sedation, analgesic, antipyretic effect.
  • Motherwort is the medicinal herb dried on the ground when the motherwort blossoms.
  • Motherwort is amenorrhea, dysmenorrhea, postpartum uterine contraction, bleeding, abdominal pain when there is a blood removed to help the uterus contractions. It has a light diuretic effect when the amount of urine decreases and does not come out well. It is used when the body is swollen. It is used for eczema, itching, and boils.
  • Pharmacological action, uterine excitement, thrombolytic action, increased blood flow to the heart and coronary arteries, respiratory excitability, diuretic effect, skin fungal inhibitory action has been reported.
  • the ripe person refers to the ripe fruit of the ginger family. It is used when a runny nose flows due to abdominal bloating due to weakness of the stomach, weakness of the kidney due to weakness of the kidney function, frequent urination and weakness of feces, microurea, uterine bleeding during pregnancy, and spleen convergence. Pharmacological actions have been reported to increase cardiac contractility, suppression of ascites cancer cells, and ileal contractility.
  • Ginseng is a perennial herb of the dicotyledonous plant, Archaeaceae, and its root is medicinal. It is known as a medicinal herb from the ancient times.
  • Injin is a medicinal herb that dried the ground part of Asteraceae. Injin is used for jaundice due to moist heat, that is, acute hepatitis, fuming, systemic yellowness, red and low urine. It is also used for chronic hepatitis, cirrhosis, liver cancer, cholecystitis, and gallbladder stones. Eczema, scabies, ringworm, rubella, etc. It is also used for symptoms of fever and radiance due to skin diseases and spinal diseases. Pharmacological action has been reported to promote bile secretion, antipyretic, diuretic, antimicrobial, inhibitory effect of experimental cancer cells.
  • One-Dang-Dong-Gang is also called Japanese Donkey, Korean Dang-Dang-Gi, Cha-Dang-Gi-Gi, and Gai-Gang-Bow.
  • the root of the mature Angelica is used as a medicinal herb, and it has immunity and is used for anticancer drugs. It is used for anemia, menstrual irregularities, cold shoulder pain, physical pain, and tonic. Pharmacological action has been reported to lower blood pressure and diuretic action.
  • One lobe has the effect of blood, roots, dry muscle, pistil. It treats low back pain, limb paralysis, paraplegia, vulgaris, facial nerve palsy and polio after rheumatism.
  • Ilcheongung is a perennial herb of mountainous family, and it is effective for pain relief, jingyeong, foam, and blood.
  • Jawan is the root of the ant odor of the Asteraceae. It has a peculiar smell, it is a little bit sweet, bitter and sweet. Jawan softens the lungs and is used for seawater, sputum, asthma, ripening, and Pyeongcheon, especially for the treatment of blood mixing in old seawater and sputum. It is also used for sore throats and acute respiratory infections. As a pharmacological action, antitussive, expectorant, antibacterial and ascites cancer inhibitory activity has been reported.
  • Self-cultivation is a mushroom that grows on branches that extend above water such as lakes, ponds, and swamps.
  • Peony is a term used throughout the perennial herbaceous plant of the buttercup jabbi.
  • the flowers are large and beautiful, and are cultivated for ornamental purposes in the garden. It has a blue blood effect and eliminates blood, which is used for fever, blood, menopause, and bruises.
  • a twig is a perennial herb that is a dicotyledon plant, or as a planting agent for Jinhae, expectorant, antipyretic, tonic and pear.
  • Low root baekpi is a bark of the roots of the leather from the root of the horse, diarrhea, diarrhea, it is effective in the symptoms of blood mixed with feces.
  • He is a mushroom of the fungus of Democracy mushroom, which is used as a diuretic in oriental medicine.
  • Jeokbokyeong is a medicine made by removing the outer layer with the fungus nucleus of Jangyeongbi, which is parasitic on the root of pine. Do not urinate, edema of the stomach and whole body, soaking, sea water, vomiting, diarrhea when the nervousness caused by nerve hypersensitivity, used in the well, and also used for heart edema. Pharmacological actions include diuresis, fungi, intestinal relaxation, ulcer prevention effect, hypoglycemic action, increased cardiac contractility, immunopotentiation, and antitumor action.
  • Drip sewage refers to a dried medicinal herb. Used to protect the intestines and stop diarrhea.
  • Red cabbage is a type of cabbage belonging to the Cruciferaceae, and is one of the representative healthy vegetables that have effects such as gastric ulcer, anti-aging, and liver function recovery. Because of its beautiful color, it is often used as a decoration for salads and as a vegetable sprout. There are more nutrients such as fructose and glucose, vegetable protein lysine and vitamin C than ordinary white cabbage. In addition, it is rich in vitamin U and is effective in gastric ulcer, and it is also considered as a representative healthy vegetable because it is rich in selenium (selenium), which plays a role in preventing aging, mercury poisoning, and restoring liver function.
  • selenium selenium
  • the peony peony is a kind of peony and is called a peony because it turns red when the root is cut.
  • Jeonho is a perennial herb of mountainous family. It is used for headache, relieving and phlegm in oriental medicine.
  • Hole blood is the depigmentation of barberry, a deciduous arborescent of the dicotyledon, Leepanhwa, Rosaceae. It is effective in tonic, wind and Jinhae, and it treats physical weakness, pain in pain, stomach pain, customs pain, sea water and white hair.
  • Clove also called clove, is known for its good appetite because it is sweet and spicy.
  • a piece refers to the fruit of the legume juniper. Johyup has a strong expectorant effect and is used for pulmonary tuberculosis, lung abscess, and chronic bronchitis. It is also used for mental confusion due to a stroke, inability to greet, jeongan, and also used for boils, skin ulcers and constipation. The pharmacological effects of gastric mucosal irritation, respiratory tract endocrine secretion promotion, antibacterial action, and central nerve palsy have been reported.
  • Carver refers to the thorns of the legume juniper. Engraver is a strong drainage, anti-inflammatory action used to boil and release the skin poison. As a pharmacological action, antipyretic and anti-inflammatory effects of acute tonsillitis have been reported.
  • Jordae is bamboo with a monocotyledonous rice plant.
  • Jongyong also known as sarcoma, is a medicinal herb made using sarcoidoscopes of sarcoma or other related plant species. It is used for breeding, and it is used for constipation caused by dry intestine, low back pain of the lack of sinyang, weak and weakness of the legs, tinnitus, amnesia, oil well, yuno, infertility, crayfish, lower abdominal cold, bleeding, sweating, and constipation. Pharmacological actions have been reported to lower blood pressure, promote saliva secretion, and improve respiratory paralysis.
  • Phalanx is a medicinal herb dried from the roots of a wolfberry or other similar plant. Phalanges are good for cold sweats, sea water, asthma, hemorrhage, nosebleeds, urine bleeding, high blood sugar, high blood pressure, neuralgia, headache, shoulder pain, muscle pain, back pain, and back and knee weakness. Pharmacological action has been reported to reduce blood pressure and blood sugar of the cardiovascular system.
  • Earth tree is a stem bark of a barn tree. Earthwood has been reported to help blood circulation, release muscles, and hepatoprotective action as a pharmacological action.
  • Jimo is a monocotyledonous genus Limoaceae, whose root stem contains aponin and salsapokenin, which can be used as an ingredient in medicine.
  • the root stem is used as a medicinal herb, used as an antipyretic, and has been reported to be effective in chronic bronchitis and diabetes.
  • the brancher is the seed of the annual herb of the family Ming Dynasty.
  • the branch has been reported to be used as a tonic, diuretic and as a medicinal herb for hyperthyroidism and atopic symptoms.
  • Jisil refers to the young fruits of tanza trees, which are stagnant and full of chest and abdomen, swelling and swelling of the chest, tingling pain, swelling, indigestion, constipation, etc. It turned out. Pharmacological action, uterine contraction, gastrointestinal hyperactivity, cardiopulmonary action, diuretic effect has been reported.
  • Fat milk is the abbreviation of cucumber grass and is used for diarrhea, colitis, bleeding, swelling, and burns. Especially, it is used for bleeding various kinds of bleeding due to its strong hemostatic effect.
  • Jihwang is a plant of the Korean ginseng family, and in oriental herbs, raw jizohwang, dried dried geonjihwang, steamed dried sukjihwang is called.
  • Sukjihwang is used as a blood donor, menstrual disorders, weak constitution, children's developmental insufficiency, dementia, premature ejaculation, erectile dysfunction, raw jizohwang is used for weak constitution, bleeding, nosebleed, uterine bleeding, menstrual irregularity, constipation It has been reported to be effective for thirst caused by internal thirst and internal organ fever and to stop blood and nosebleeds.
  • Jin Bum is a plant of the genus Amanaceae, which is used as a medicinal herb in oriental medicine. It has been reported to be used for arthritis, spasms of muscles and bones, jaundice, and urine due to the effects of wind, pain, and diuresis.
  • Jingapi refers to a kind of ogapi. Outside to eliminate the customs and meridians to communicate well, has an analgesic action inside the liver and kidneys to strengthen the function of the muscles and bones.
  • Jinjucho is an annual herb that grows in fields or grasses, and is known to have chronic hepatitis, nephritis, enteritis, dysentery, and brightening eyes.
  • the dermis is the medicinal use of the fruit peel of tangerine trees.
  • the dermis relieves clumping and strengthens the function of fat to treat only the abdominal swelling, belching, vomiting, nausea, indigestion, flatulence, drowsiness, and diarrhea.
  • Pharmacological action has been reported that the essential oil components have digestive stimulation, digestion, expectoration, anti-ulcer, anti-gastric secretion, cardiac, blood pressure increase, anti-allergic, bile secretion, uterine smooth muscle suppression, antibacterial action.
  • the tea is the seed of plantain in one shot.
  • the teapot is used to urinate well, to control diarrhea, to clear eyes, and to stop coughing.
  • Changsha is the fruit of the Akomari of the Asteraceae.
  • Changsha is a medicinal herb that removes winds and is used for sinusitis, rhinitis, headache, fever, cough, quadriplegia, and discomfort, skin itching and otitis media.
  • Pharmacological actions have been reported in toxic reactions to essential oils and alkaloids, hypoglycemia, leukocyte reduction, cough, cardiac suppression.
  • Cheongung is an apiaceae plant that is effective in soothing roots, pain, and tonic in oriental medicine. It is used for headache, anemia, and gynecological diseases.
  • Cheonma refers to perennial herb of the monocotyledonous plant Orchidaceae Orchidaceae, and uses outpost for tonic, nervous breakdown, dizziness and headache.
  • Cheonmun-dong is a plant of the family Liliaceae. Its edible tender shoots are used for darkening, diuresis and tonic. It is reported that it is not recommended for people who are diarrhea due to cold body and bowel.
  • Cheoncho is a medicinal herb made by removing the seeds as much as possible from the bark of the Rhododendron or the same plant. Cheoncho is used for abdominal pain, diarrhea and toothache, asthma and low back pain caused by cold energy of the abdomen, and it is used for scabies, ringworm, vaginal itching, and scrotum eczema. Local anesthesia, intestinal linkage, and antibacterial activity have been reported as pharmacological action.
  • Chunyeoncho improves blood circulation and is effective in treating heart and stomach pain, antipyretic tablets, cough, dysentery, hemorrhoids, bronchial asthma, lack of sleep.
  • Cheon San Ryong uses herbal stems as a medicinal herb in Chinese medicine. Because it lowers, it is used for boils and skin rashes.
  • Cheonsan Seolyeon is a perennial herb of the Buttercup family, especially for men's rejuvenation, and has great efficacy on various women's diseases, cold diseases, kidneys, arthritis, diabetes, and customary uterus.
  • a cheonhwahwa refers to the roots peeled off of the halnut of the gourd or the yellow halnut. Heals thirst, boils and pus when the fluid is damaged by heat. Mainly lowers the heat of the lungs and stomach, making the essences to quench thirst and soothe the body. Pharmacological actions have been reported to inhibit malignant grapes and epithelial cell carcinoma, uterine smooth muscle excitability, hepatocarcinogenic effect, hypoglycemic activity, and bactericidal action.
  • Cheongho treats nausea, headaches and vomiting caused by schooling and summer heat, swelling of bones due to fever, symptoms of mild fever and summer cold. It is said to improve the color of the face and make white hair black.
  • a pharmacological action has been reported to inhibit agonists, hepatostomosis suppression, lowering blood pressure, antipyretic, skin fungal suppression, Jinhae, expectoration, asthma, bile secretion, immune regulation.
  • the excess is a plant of ginger family, and the excess fruit is used in Korea. Excess heats the stomach, dehumidifies, and is used for abdominal pain, abdominal swelling, nausea, vomiting and diarrhea.
  • Choo is a medicinal herb made from the lump root of the horticulture or the root of the same plant. Ciao is used for headaches, abdominal pain, boils, involuntary death, inability to greet, and guanwasa. It is used for the treatment of paralysis due to acupuncture, anxiety, rheumatoid arthritis, neuralgia, low back pain, tetanus, etc., and abdominal pain caused by cold stomach. Pharmacological effects include analgesic, sedation, anti-inflammatory, topical mitigating effects, and cardiomotor excitability has been reported with high doses.
  • Plantia refers to the fruit of gardenia, an evergreen shrub of the locust family. In oriental medicine, it has been reported to be effective in the treatment of insomnia and jaundice, anti-inflammatory, hemostatic and diuretic.
  • Blue box refers to the seeds of mandarin with amaranth, and blue box lowers the fever, so it is used for congestion, white convulsions, tears, light reluctance, high blood pressure, and headache. It is a pharmacological action used in eye diseases and applied to skin swelling.
  • Mokgyuhwa refers to the mallow flower of the mallow family, and it is used for the symptom of baekdaeha, lower abdomen, fecal incontinence, bleeding, uterine bleeding, burns and redness of the nose. It has been reported that pharmacological action is effective against malaria.
  • Acupuncture is an evergreen arboretum of Azalea, which is used as a medicinal herb in Chinese medicine. It has soothing, dry stomach, aeration, indigestion, anorexia, vomiting, bronchial asthma, premature ejaculation, vigor and lack of energy.
  • the talan is the above-ground part before the flowering of the easy-to-flower nectar.
  • Talanchoe is used for amenorrhea, menstrual cramps, postpartum abdominal pain and bruises caused by bleeding blood, and is effective for boils, liver dysfunction and postpartum urination.
  • the drugs that release the blood it does not damage the regular, it is applied to gynecology a lot. Strong action has been reported as a pharmacological action.
  • Taxi is reported to be used as a medicine for diuretics, species and gonorrhea in oriental medicine.
  • a tanza is the fruit of a tanza, which is fragrant and medicinal.
  • Tobokyeong refers to the roots of blue vines. Tobokyeong contains a lot of starch, constipation, syphilis, gonorrhea, poisoning, swelling, chronic dermatitis, mercury poisoning, cold, neuralgia is known to be effective.
  • Tosa is a seed of the annual ginseng, a vine plant belonging to the Coniferous family. Tosa is known as a medicine that mainly protects the liver and kidneys, brightens the eyes, helps yang, and strengthens the kidney function. Impaired sexual intercourse in men with weak kidneys, semen flowing spontaneously, it is effective for dreaming. It strengthens the bones and strengthens the strength of the lower back, and weak kidney function to heal the sore and sore back and knees. It has also been reported to be effective in the treatment of diabetes and diarrhea, and in treating diabetes.
  • Tocheongung is the medicinal root of Tounggung, which is used for the treatment of jingyeong, soothing, strengthening blood pressure, vasodilation, and antibacterial action.
  • Tongcho refers to the stem of the tree splinter of the family Arboraceae. Tongcho has been reported to promote gonorrhea, urethritis, cystitis and postpartum milk secretion by lowering heat and increasing urine volume.
  • Paegukcheon is also called noni, and leaves, stems, flowers, and fruit reps have been used in folk medicine. It contains ingredients such as anthraquinone and serotonin, which has been shown to help digestion, reduce pain, and have effects on high blood pressure and cancer.
  • Phadu is an evergreen broad-leaved shrub with the Great Sage, and in Chinese medicine it refers to its seed. Tasteful and eagerly poisonous medicinal herb that is filled with water and is used for constipation.
  • Pogongyoung refers to a dried herb of a dandelion or related plant. It is a medicine that reduces heat poisoning and dissipates boils. It is used for swelling, mastitis, sore throat, and carbuncles (sentitis, pulmonary abscess, peritonitis). As a pharmacological action, fungal action, immune function enhancement, bile secretion action, liver function protection action, and diuretic action have been reported.
  • Sulfur refers to the riches of the family or the pollen of the same plant. It is used to reduce blood fever, convergence, and topography, which is used for keratosis, hemostasis, nosebleeds, urine bleeding, and uterine bleeding, and improves blood circulation. It is used for heart pain, postpartum pain, and dysmenorrhea. As pharmacological action, uterine excitement, lowering blood pressure, menstruation, reducing blood coagulation time, suppressing tuberculosis bacterium growth, lowering cholesterol, etc.
  • Balloon orchid is a perennial herb of the orchid family Orchidaceae, with a rhizome of flesh and ellipsoid, with petioles and oval or oval-shaped leaves.
  • the fruit is capsule.
  • Sewage is native to China and has been cultivated as a medicinal plant.
  • oriental medicine it refers to a reddish brown tuber, which is used as a tonic, tonic, and emollient.
  • the leaves are made of herbs and attached to the fresh leaves to absorb pus.
  • the alliance has the effect of lowering heat, removing wind, and detoxification. It is used to treat colds, jaundice, dysentery, bloating, and dermatitis caused by wind.
  • a passerby is an apricot seed that is used in coughing, asthma, and constipation.
  • Hyangilgyu means sunflower seeds, lowers cholesterol levels and prevents cardiovascular disease and arteriosclerosis. In addition, it is rich in minerals such as calcium, potassium, iron, etc. It is also good for people with weak digestive, cold and weak. It also has excellent effects on hypertension and nervousness.
  • Hyangbuja is a perennial herb that is a perennial herb that contains essential oils and fatty oils at the end of roots, and is used in oriental medicine as headache, abdominal pain and menstrual irregularities, and as a pulmonary tuberculosis drug in the private sector.
  • Perfume has been reported to be used for the treatment of perspiration, antipyretic, diuretic, hemostatic as botanicals, as well as boils, varieties, species, gastritis, bleeding and bad breath.
  • Hyangchun is the fruit of oak. Hyangchun has the effects of swelling, acidity, and pain, and heals abundance, deep pain, rheumatic joint pain, and acid.
  • Hyangpo lowers the blood fever, convergence, hemostatic action is used in the bleeding, hemostasis, nosebleed, urine bleeding, uterine bleeding, improve blood circulation is used for heart pain, postpartum pain pain, dysmenorrhea, dysmenorrhea.
  • Pharmacological action has been reported, such as uterine excitement, lowering blood pressure, jingyeong, reduction of blood coagulation time, mycobacterium tuberculosis growth, cholesterol lowering action.
  • Hyunsam is a perennial herb of Hyunsam and it is reported that in oriental medicine, the root is used as antipyretic for sore throat, boil and lymphadenitis.
  • Local grass is a year-round grass with a rat's hand grass. It removes customs and communicates meridians to strengthen the skeleton and muscles, so it is used for limb pain, joint pain, and bruise. It is also effective for dysentery, chronic diarrhea and colic and enteritis. It is also effective for skin itching, scabies and swelling.
  • the hyungdae is the first year of the Lamiaceae, which means dried herbs in the oriental medicine, and is used when a cold causes a fever, headache, sore throat, or bleeding in the boil.
  • Hominein is a word that comes from a single shot of sesame seeds or black sesame seeds, and is known to be effective for people with swelling or gray hair.
  • Fenugreek is a perennial herb of Rosaceae, and fenugreek seeds are usually dried in the sun and medicinal. Seeds contain a very small amount of essential oils, which contain about 40 components: different types of alkaloids, proteins and fats. Because of its warm nature and no poison, it has been used to treat bladder and kidney disease in Africa, the Middle East, and India, and has been used to treat people with cold sweats or full stomach. Today, it is effective to maintain the balance between blood sugar and insulin in the body, and is known to be effective for weight control.
  • Pumpkin is a vine-like annual herb, which has the highest starch content among fruits and vegetables, and is known to be high in calories following potatoes, sweet potatoes and beans. It is usually used for cooking, and the berry contains a large amount of vitamin A and some vitamins B and C, which is very important as a vitamin source.
  • Hongmogapi refers to thorny ogapi whose thorn is reddish red.
  • Red ginseng is a red ginseng dried by steaming ginseng, which has sedative and excitatory effects on the central nervous system. It also acts on the circulatory system to prevent hypertension or arteriosclerosis. It also lowers hematopoietic and blood sugar levels, protects the liver, and acts indirectly on sexual and reproductive effects by acting on the endocrine system, has anti-inflammatory and anti-tumor effects, protects against radiation, and protects the skin. It also works to soften. The most important of the effects of red ginseng is the adaptogen effect, which has been scientifically proven to increase the ability of the living body to adapt more easily by protecting against various diseases such as leakage, stress, and other harmful effects from the environment.
  • Black tea mushrooms cultivate yeast with sugar-filled black tea, and are effective in inhibiting cancer, lowering cholesterol and blood pressure, and preventing hangovers.
  • Black tea herb is a soybean perennial herb, and in folk medicine, outpost was used as a diuretic, analgesic, digestive, sputum, and hemostatic medicine.
  • Safflower is used for women's diseases, pain and stomachache in oriental medicine.
  • the oil is squeezed from fruit and used for kerosene and edible oil.
  • the oil made from seeds contains linolic acid, which is good for the prevention and treatment of atherosclerosis caused by excess cholesterol.
  • Hwapi is located on the outside of the stamens and pistil to protect the stamens and pistil, also known as flower cover.
  • Gold is a perennial herb of Lamiaceae. In oriental medicine, roots are used as antipyretic, diuretic, branch, edam and anti-inflammatory agents.
  • Astragalus is a perennial herb of legumes. It is commonly cultivated as a herb, and it is harvested in autumn in oriental medicine to remove outcrops and roots, and dried in the sun. It is called Astragalus of medicinal herbs. It has the effects of tonic, cold, diuretic, swelling, etc. It has been reported to be prescribed for uterine dislocation, visceral sewage, cold sweat, and peripheral nerve.
  • Hwangjeong is a word that comes from the root of bamboo shoots.
  • Hwangmaemok refers to dried branches of gingko ginger tree, and is used as a medicine for fish blood, abdominal pain, postpartum pain and phlegm in oriental medicine.
  • Hwangbaek refers to dried bark of the anti-bark belonging to the Unhyang family, blood glucose lowering, pneumococcal, pneumococcal tuberculosis, staphylococcus, etc., while inhibiting the development of tumor cells, and inhibits the growth and sterilization.
  • palpation of gastric juice is promoted by palpation of taste reflexes, and also leads to edible hyperactivity.
  • General alkaloids do not have a systemic effect, so even if administered in high doses can be used as a formal agent as well as a stomach agent.
  • it since it does not develop resistance to various bacteria, it can also be used as a cleansing disinfectant when epidemic eye disease is in epidemic.
  • Thick leaf is an evergreen tree of the dicotyledonous plant of the genus Butteraceae, used for asthma and gastrointestinal diseases.
  • Black dog is a black seed of morning glory. It is used when the body is swollen, chronic pyelonephritis, liver cirrhosis, etc. due to strong hypothalamic action and diuretic action.
  • a rare rice is a medicinal herb made from the hairy chrysanthemum or the ground of the chrysanthemum. It is used to remove customs, and to write on arthritis, limb pain, paralysis, paralysis and paralysis, and to boil, rash, itching and eczema. Use for high blood pressure, headache, dizziness, acute hepatitis, etc. As pharmacological action, joint edema suppression and blood pressure lowering action have been reported.
  • Ssam fermentation extract using the medicinal flower of the present invention is boiled or steamed and dried natural products for 30 minutes to 2 hours; Cooling the boiled or steamed natural product at room temperature for 30 minutes to 1 hour; Wrapping or covering the cooled natural products with medicinal flowers and placing them on pottery for 4 to 7 days at room temperature in the shade; And removing and extracting medicinal flowers from fermented natural products.
  • the amount of the medicinal flower used during fermentation is not particularly limited, but may be preferably used in an amount of 1 to 40% by weight based on the weight of the natural product to be fermented.
  • water or an organic solvent may be used as the extraction solvent, and more specifically, one selected from the group consisting of purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, propylene glycol, dichloromethane and hexane alone. Or two or more kinds thereof can be mixed.
  • the extraction temperature is preferably 10 ⁇ 80 °C, it can be extracted for 6 to 24 hours. If the extraction temperature and extraction time is out of the extraction efficiency may decrease or change of components may occur.
  • Ssam fermented extract of the present invention is contained in an amount of 0.001 to 30% by weight based on the total weight of the composition. If it is less than 0.001% by weight, the desired effect cannot be expected. If it exceeds 30% by weight, the increase of the effect is insignificant compared to the increase in content, and the formulation stability may be deteriorated.
  • Ssam fermented extract using medicinal flowers according to the present invention is very excellent in skin antioxidant, anti-aging, whitening, moisturizing effect.
  • the external preparation composition for skin has a softening lotion, nourishing cream, massage cream, nourishing cream, essence, pack, gel, ampoule or skin adhesive type cosmetic formulation, lotion, ointment, gel, It is characterized by having a transdermal dosage form such as a cream, patch or spray.
  • the antioxidant capacity of the lotus leaf fermentation black soybean extract of Example 1 is significantly superior to the raw material extract (Comparative Example 1) and the extract of fermented black beans (Comparative Example 4) by mixing with lotus
  • the effect was much superior to trolox, a synthetic antioxidant used as a positive control.
  • the general fermented extract (Comparative Example 2) and medicinal flower alone fermented extract (Comparative Example 3) fermented black beans without medicinal flowers was found to have almost no antioxidant effect. Therefore, the medicinal flower ssam fermented extract according to the present invention was found to have an excellent antioxidant effect.
  • the collagenase production inhibitory ability of the extracts obtained in Comparative Examples 1 to 4 and Example 1 was measured in comparison with tocopherol and EGCG.
  • Tocopherol and EGCG are antioxidants and are known to have the function of regenerating the epidermal cells of the skin to prevent aging of the skin.
  • the test was performed by placing human fibroblasts at 5,000 cells / well in a 96-well microtiter plate containing Dulbecco's Modified Eagle's Media (DMEM) medium containing 2.5% fetal calf serum. Incubate until 90% growth. After incubation for 24 hours in serum-free DMEM medium, and then treated with each of the extracts, tocopherol and EGCG of Comparative Examples 1-4, Example 1 dissolved in serum-free DMEM medium for 24 hours at 10 -4 molarity. , Cell culture was collected.
  • DMEM Dulbecco's Modified Eagle's Media
  • the collected cell culture solution was measured for collagenase production using a commercially available collagenase measuring instrument (Amersham Pharma Co., Ltd., USA). First, the collected cell culture was placed in a 96-well plate uniformly coated with primary collagenase antibody, and the antigen-antibody reaction was performed in a thermostat for 3 hours.
  • the chromophore-bound secondary collagen antibody was placed in a 96-well plate and reacted for another 15 minutes. After 15 minutes, a color inducing substance was added to induce color development at room temperature for 15 minutes. Then, 1M sulfuric acid was added to stop the reaction (color development). The color of the reaction solution was yellow and the degree of yellow was different according to the progress of the reaction.
  • the absorbance of the yellowish 96-well plate was measured at 405 nm using an absorbance meter, and the degree of synthesis of collagenase was calculated by Equation 1 below.
  • the reaction absorbance of the collected cell culture medium of the group not treated with the composition was used as a control. That is, the expression level of collagenase in the non-treated group was set to 100, and the collagenase expression level in the group treated with the test substance was calculated.
  • Table 2 The results are shown in Table 2 below.
  • the medicinal flower ssam fermented extract according to the present invention was found to be excellent in anti-aging effect by effectively reducing the expression of collagenase by reducing collagen degradation in the skin.
  • Procollagen production ability of the extracts obtained in Comparative Examples 1 to 4 and Example 1 was measured by comparing with vitamin C.
  • Procollagen is a substance that induces collagen production and is necessary for collagen production and anti-aging, and vitamin C is known as an essential ingredient for collagen synthesis.
  • the test was performed by placing human fibroblasts at 5,000 cells / well in a 96-well microtiter plate containing Dulbecco's Modified Eagle's Media (DMEM) medium containing 2.5% fetal calf serum. Incubate until 90% growth. After incubation for 24 hours in serum-free DMEM medium, and then treated with each of the extracts of Comparative Examples 1-4, Example 1, vitamin C dissolved in serum-free DMEM medium at 10 -4 molarity for 24 hours, Cell culture was collected. After 24 hours, the amount of free collagen in the medium was measured using the procollagen type-1 C-peptide EIA kit (MK101, Takara, Japan).
  • DMEM Dulbecco's Modified Eagle's Media
  • the degree of procollagen production in the untreated group was set to 100, and procollagen production in the group treated with the test substance was calculated, and the results are shown in Table 3 below.
  • the medicinal flower ssam fermented extract according to the present invention was found to be excellent in the anti-aging effect by promoting the production of collagen in the skin by effectively promoting the production of procollagen.
  • the melanin production inhibitory ability of the extract obtained in Comparative Examples 1 to 4 and Example 1 was measured in comparison with hydroquinone.
  • Mel-Ab cells derived from C57BL / 6 mice (Dooley, TP et al, Skin pharmacol, 7, pp 188-200) in DMEM with 10% fetal placental serum, 100 nM 12-O-tetradecanoyl Incubated at 37 ° C. and 5% CO 2 in a medium to which phorbol (tetradecanoylphorbol) -13-acetate and 1 nM cholera toxin were added.
  • the cultured Mel-Ab cells were detached with 0.25% trypsin-EDTA, the cells were incubated at a concentration of 10 5 cells / well in 24-well plates, and then each test material was added for 3 consecutive days. And incubated.
  • hydroquinone and the extracts of Comparative Examples 1 to 4 and Example 1 were used at concentrations of 10 ppm each. At this time, the hydroquinone was used as a positive control group. Then, the culture solution was removed, washed with PBS, dissolved in 1N sodium hydroxide, and measured for absorbance at 400 nm. Then, the melanin production inhibition rate was calculated according to Equation 2 below and the results are shown in Table 4 below. Dooley's way).
  • Table 4 Test substance Melanin production inhibition rate (%) Untreated group 100 Hydroquinone (positive control) 41.4 Comparative Example 1 Black Bean Extract 97.2 Comparative Example 2 Normal Fermented Black Bean Extract 99.4 Comparative Example 3 General Fermented Lotus Extract 97.1 Comparative Example 4 Lotus Mixed Fermented Black Bean Extract 85.2 Example 1 Lotus Ssam Fermented Black Bean Extract 42.3
  • the lotus leaf fermented black soybean extract of the present invention was effectively inhibited the production of melanin than the extract extract (Comparative Example 4) fermented black soybean mixed with a raw product extract (Comparative Example 1) and lotus, It was confirmed that the melanin production inhibition rate similar to the known hydroquinone, a whitening substance.
  • the general fermentation extract (Comparative Example 2) and medicinal flower alone fermentation extract (Comparative Example 3) fermented black soybeans without medicinal flowers showed that the melanin production inhibitory ability is similar to that of the non-treated group, showing little whitening effect. there was.
  • the medicinal flower ssam fermented extract according to the present invention was found to have an excellent whitening effect by effectively inhibiting melanin production in the skin.
  • the lotus leaf fermented black soybean extract of the present invention has no irritant feeling unlike kojic acid and can provide a better feeling of use.
  • the human keratinocytes cultured in the primary cultures were attached to the bottom of the culture flasks in a test using absorbance, and then compared.
  • the extracts of Examples 1 and 2 and Example 1 were treated with the test substance of Table 6 at a concentration of 1 ppm, and then cultured for 5 days until the cells grew about 70 to 80% of the floor area.
  • the cells were harvested and washed with PBS (phosphate buffered saline), followed by 10 mM Tris-HCl (Tris-HCl) containing 2% Sodium Dodecyl Sulfate (SDS) and 20 mM Dithiothreitol (DTT). , pH 7.4) 1ml was added, and then boiled for 10 minutes after sonication (sonication) for 3 minutes. The precipitate was separated by centrifugation at 1200 rpm for 30 minutes and suspended again in 1 ml of PBS to measure absorbance at 340 nm.
  • PBS phosphate buffered saline
  • Tris-HCl Tris-HCl
  • SDS 2% Sodium Dodecyl Sulfate
  • DTT Dithiothreitol
  • the lotus leaf fermentation black soybean extract according to the present invention is Comparative Examples 1-4 It was found that more effectively promotes differentiation in keratinocytes.
  • the medicinal flower fermentation extract according to the present invention was found to enhance the barrier function of the skin and enhance the skin moisturizing ability.

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Abstract

Cette invention concerne une composition appliquée sur la peau, et contenant un extrait de fermentation-cataplasme utilisant une fleur médicinale. L'invention concerne en particulier une composition à appliquer sur la peau, et contenant un extrait de fermentation-cataplasme obtenu par fermentation d'un produit naturel en le recouvrant ou en l'enveloppant d'une fleur médicinale, ladite composition présentant d'excellents effets antioxydants, anti-âge, blanchissants et hydratants sur la peau. L'invention concerne également un procédé de préparation de la composition.
PCT/KR2012/008541 2011-10-25 2012-10-18 Procédé de fermentation-cataplasme utilisant une fleur médicinale, et composition associée à appliquer sur la peau Ceased WO2013062266A2 (fr)

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CN201280052868.5A CN103906526B (zh) 2011-10-25 2012-10-18 利用药用花的包裹发酵方法及利用其的皮肤外用剂组合物

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