[go: up one dir, main page]

WO2011069164A3 - Polypeptides chimériques et hybrides de facteur viii-fc, et procédés d'utilisation de ceux-ci - Google Patents

Polypeptides chimériques et hybrides de facteur viii-fc, et procédés d'utilisation de ceux-ci Download PDF

Info

Publication number
WO2011069164A3
WO2011069164A3 PCT/US2010/059136 US2010059136W WO2011069164A3 WO 2011069164 A3 WO2011069164 A3 WO 2011069164A3 US 2010059136 W US2010059136 W US 2010059136W WO 2011069164 A3 WO2011069164 A3 WO 2011069164A3
Authority
WO
WIPO (PCT)
Prior art keywords
chimeric
factor viii
methods
hybrid polypeptides
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2010/059136
Other languages
English (en)
Other versions
WO2011069164A2 (fr
Inventor
Jennifer A. Dumont
Susan Low
Alan J. Bitonti
Glenn Pierce
Alvin Luk
Haiyan Jiang
Byron Mckinney
Matt Ottmer
Jurg Ommer
Karen Nugent
Lian Li
Robert Peters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Biogen MA Inc
Original Assignee
Biogen Idec Inc
Biogen Idec MA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2010325787A priority Critical patent/AU2010325787B2/en
Priority to LTEP10835255.0T priority patent/LT2506868T/lt
Priority to NO10835255A priority patent/NO2506868T3/no
Priority to ES10835255.0T priority patent/ES2659888T3/es
Priority to CA2782424A priority patent/CA2782424C/fr
Priority to EP17194648.6A priority patent/EP3326643B1/fr
Priority to PL10835255T priority patent/PL2506868T3/pl
Priority to JP2012542240A priority patent/JP5903048B2/ja
Priority to HRP20180135TT priority patent/HRP20180135T1/hr
Priority to PL17194648T priority patent/PL3326643T3/pl
Priority to NZ600709A priority patent/NZ600709A/en
Priority to EP24152910.6A priority patent/EP4382170A3/fr
Priority to KR1020127017595A priority patent/KR101770849B1/ko
Priority to MX2018000089A priority patent/MX382693B/es
Priority to SG2012039640A priority patent/SG181130A1/en
Priority to MX2016000039A priority patent/MX353233B/es
Priority to CN2010800629507A priority patent/CN102791285A/zh
Priority to RS20180182A priority patent/RS56957B1/sr
Priority to BR112012013502A priority patent/BR112012013502A2/pt
Priority to EP10835255.0A priority patent/EP2506868B1/fr
Priority to SM20180099T priority patent/SMT201800099T1/it
Priority to DK10835255.0T priority patent/DK2506868T3/da
Priority to EP21161784.0A priority patent/EP3906937A1/fr
Application filed by Biogen Idec Inc, Biogen Idec MA Inc filed Critical Biogen Idec Inc
Priority to US13/513,424 priority patent/US9050318B2/en
Priority to EA201290443A priority patent/EA025416B1/ru
Priority to MEP-2018-40A priority patent/ME02964B/fr
Priority to MX2012006347A priority patent/MX336830B/es
Priority to SI201031628T priority patent/SI2506868T1/en
Publication of WO2011069164A2 publication Critical patent/WO2011069164A2/fr
Publication of WO2011069164A3 publication Critical patent/WO2011069164A3/fr
Priority to IL220204A priority patent/IL220204B/en
Anticipated expiration legal-status Critical
Priority to ZA2012/04874A priority patent/ZA201204874B/en
Priority to US13/793,783 priority patent/US9241978B2/en
Priority to US14/964,289 priority patent/US20160199455A1/en
Priority to AU2016213822A priority patent/AU2016213822B2/en
Priority to AU2017268648A priority patent/AU2017268648B2/en
Priority to CY20181100182T priority patent/CY1119919T1/el
Priority to IL260769A priority patent/IL260769B/en
Priority to US16/270,302 priority patent/US11266720B2/en
Priority to AU2019202969A priority patent/AU2019202969A1/en
Priority to AU2021202912A priority patent/AU2021202912B2/en
Priority to CY20211100615T priority patent/CY1124888T1/el
Priority to US17/587,941 priority patent/US20220265780A1/en
Priority to AU2024227757A priority patent/AU2024227757A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés d'administration de facteur VIII; des procédés d'administration de polypeptides chimériques et hybrides comprenant le facteur VIII; des polypeptides chimériques et hybrides comprenant le facteur VIII; des polynucléotides codant pour de tels polypeptides chimériques et hybrides; des cellules comprenant de tels polynucléotides; et des procédés de production de tels polypeptides chimériques et hybrides en utilisant de telles cellules.
PCT/US2010/059136 2009-12-06 2010-12-06 Polypeptides chimériques et hybrides de facteur viii-fc, et procédés d'utilisation de ceux-ci Ceased WO2011069164A2 (fr)

Priority Applications (42)

Application Number Priority Date Filing Date Title
EP21161784.0A EP3906937A1 (fr) 2009-12-06 2010-12-06 Polypeptides chimériques et hybrides de facteur viii-fc et leurs procédés d'utilisation
NO10835255A NO2506868T3 (fr) 2009-12-06 2010-12-06
ES10835255.0T ES2659888T3 (es) 2009-12-06 2010-12-06 Polipéptidos quiméricos e híbridos de Factor VIII-Fc, y métodos de uso de los mismos
CA2782424A CA2782424C (fr) 2009-12-06 2010-12-06 Polypeptides chimeriques et hybrides de facteur viii-fc, et procedes d'utilisation de ceux-ci
EP17194648.6A EP3326643B1 (fr) 2009-12-06 2010-12-06 Polypeptides chimériques et hybrides de facteur viii-fc et leurs procédés d'utilisation
PL10835255T PL2506868T3 (pl) 2009-12-06 2010-12-06 Chimeryczne i hybrydowe polipeptydy czynnika krzepnięcia viii-fc oraz sposoby ich stosowania
JP2012542240A JP5903048B2 (ja) 2009-12-06 2010-12-06 第ＶＩＩＩ−Ｆｃ因子キメラおよびハイブリッドポリペプチドならびにその使用法
HRP20180135TT HRP20180135T1 (hr) 2009-12-06 2010-12-06 Kimerni i hibridni polipeptidi čimbenika viii-fc, te postupci njihove upotrebe
PL17194648T PL3326643T3 (pl) 2009-12-06 2010-12-06 Chimeryczne i hybrydowe polipeptydy czynnika VIII-FC oraz sposoby ich zastosowania
NZ600709A NZ600709A (en) 2009-12-06 2010-12-06 Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof
EP24152910.6A EP4382170A3 (fr) 2009-12-06 2010-12-06 Polypeptides chimériques et hybrides de facteur viii-fc, et leurs procédés d'utilisation
LTEP10835255.0T LT2506868T (lt) 2009-12-06 2010-12-06 Faktoriaus viii-fc chimeriniai ir hibridiniai polipeptidai ir jų panaudojimo būdai
MX2018000089A MX382693B (es) 2009-12-06 2010-12-06 Polipéptidos híbridos y quiméricos del factor viii-fc, y métodos de uso de los mismos.
SG2012039640A SG181130A1 (en) 2009-12-06 2010-12-06 Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof
MX2016000039A MX353233B (es) 2009-12-06 2010-12-06 Polipéptidos híbridos y quiméricos del factor viii-fc, y métodos de uso de los mismos.
CN2010800629507A CN102791285A (zh) 2009-12-06 2010-12-06 因子VIII-Fc嵌合多肽和杂交多肽及其使用方法
RS20180182A RS56957B1 (sr) 2009-12-06 2010-12-06 Himerni i hibridni polipeptidi faktora viii-fc, i postupci za njihovu upotrebu
BR112012013502A BR112012013502A2 (pt) 2009-12-06 2010-12-06 "polipeptídeos quiméricos e híbridos de fator viii-fc, e métodos de uso dos mesmos".
EP10835255.0A EP2506868B1 (fr) 2009-12-06 2010-12-06 Polypeptides chimériques et hybrides de facteur viii-fc, et procédés d'utilisation de ceux-ci
SM20180099T SMT201800099T1 (it) 2009-12-06 2010-12-06 Polipeptidi chimerici e ibridi di fattore vii-fc e loro metodi di utilizzo
DK10835255.0T DK2506868T3 (da) 2009-12-06 2010-12-06 Kimæriske og hybride faktor viii-fc-polypeptider og fremgangsmåder til anvendelse deraf
AU2010325787A AU2010325787B2 (en) 2009-12-06 2010-12-06 Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof
KR1020127017595A KR101770849B1 (ko) 2009-12-06 2010-12-06 인자 ＦⅧ-Ｆｃ의 키메라 및 하이브리드 폴리펩티드, 및 그의 사용방법
US13/513,424 US9050318B2 (en) 2009-12-06 2010-12-06 Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof
EA201290443A EA025416B1 (ru) 2009-12-06 2010-12-06 Способ предотвращения или лечения эпизодов кровотечений с использованием химерного полипептида фактора viii длительного действия
MEP-2018-40A ME02964B (fr) 2009-12-06 2010-12-06 Polypeptides chimériques et hybrides de facteur viii-fc, et procédés d'utilisation de ceux-ci
MX2012006347A MX336830B (es) 2009-12-06 2010-12-06 Polipeptidos hibridos y quimericos del factor viii-fc, y metodos de uso de los mismos.
SI201031628T SI2506868T1 (en) 2009-12-06 2010-12-06 HYPER AND HYBRID POLYPETTIDES FACTOR VIII-FC AND METHODS FOR THEIR USE
IL220204A IL220204B (en) 2009-12-06 2012-06-06 Chimeric and hybrid factor fc–viii polypeptides and methods of using them
ZA2012/04874A ZA201204874B (en) 2009-12-06 2012-06-29 Factor vii-fc chimeric and hybrid polypeptides,and methods of use thereof
US13/793,783 US9241978B2 (en) 2009-12-06 2013-03-11 Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof
US14/964,289 US20160199455A1 (en) 2009-12-06 2015-12-09 Factor VIII-Fc Chimeric and Hybrid Polypeptides, and Methods of Use Thereof
AU2016213822A AU2016213822B2 (en) 2009-12-06 2016-08-11 Factor VIII-Fc Chimeric And Hybrid Polypeptides, And Methods Of Use Thereof
AU2017268648A AU2017268648B2 (en) 2009-12-06 2017-11-30 Factor VIII-Fc Chimeric And Hybrid Polypeptides, And Methods Of Use Thereof
CY20181100182T CY1119919T1 (el) 2009-12-06 2018-02-14 Χιμαιρικα και υβριδικα πολυπεπτιδια παραγοντα viii-fc kai meθοδοι χρησης αυτων
IL260769A IL260769B (en) 2009-12-06 2018-07-25 Factor viii–fc chimeric and hybrid polypeptides and methods of using them
US16/270,302 US11266720B2 (en) 2009-12-06 2019-02-07 Factor VIII-FC chimeric and hybrid polypeptides, and methods of use thereof
AU2019202969A AU2019202969A1 (en) 2009-12-06 2019-04-29 Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof
AU2021202912A AU2021202912B2 (en) 2009-12-06 2021-05-07 Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof
CY20211100615T CY1124888T1 (el) 2009-12-06 2021-07-07 Χιμαιρικα και υβριδικα πολυπεπτιδια παραγοντα viii-fc και μεθοδοι χρησεως αυτων
US17/587,941 US20220265780A1 (en) 2009-12-06 2022-01-28 Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof
AU2024227757A AU2024227757A1 (en) 2009-12-06 2024-10-30 Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US26707009P 2009-12-06 2009-12-06
US61/267,070 2009-12-06
US28505409P 2009-12-09 2009-12-09
US61/285,054 2009-12-09
US30159210P 2010-02-04 2010-02-04
US61/301,592 2010-02-04
US36306510P 2010-07-09 2010-07-09
US61/363,065 2010-07-09
US37311310P 2010-08-12 2010-08-12
US61/373,113 2010-08-12
US41092910P 2010-11-07 2010-11-07
US61/410,929 2010-11-07
US41967610P 2010-12-03 2010-12-03
US61/419,676 2010-12-03

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/513,424 A-371-Of-International US9050318B2 (en) 2009-12-06 2010-12-06 Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof
US13/793,783 Division US9241978B2 (en) 2009-12-06 2013-03-11 Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof

Publications (2)

Publication Number Publication Date
WO2011069164A2 WO2011069164A2 (fr) 2011-06-09
WO2011069164A3 true WO2011069164A3 (fr) 2011-07-28

Family

ID=44115536

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/059136 Ceased WO2011069164A2 (fr) 2009-12-06 2010-12-06 Polypeptides chimériques et hybrides de facteur viii-fc, et procédés d'utilisation de ceux-ci

Country Status (30)

Country Link
US (5) US9050318B2 (fr)
EP (4) EP4382170A3 (fr)
JP (8) JP5903048B2 (fr)
KR (1) KR101770849B1 (fr)
CN (1) CN102791285A (fr)
AU (6) AU2010325787B2 (fr)
BR (1) BR112012013502A2 (fr)
CA (2) CA3121739A1 (fr)
CO (1) CO6561782A2 (fr)
CY (2) CY1119919T1 (fr)
DK (1) DK2506868T3 (fr)
EA (2) EA038618B1 (fr)
ES (2) ES2659888T3 (fr)
HR (2) HRP20180135T1 (fr)
HU (1) HUE036233T2 (fr)
IL (2) IL220204B (fr)
LT (1) LT2506868T (fr)
ME (1) ME02964B (fr)
MX (3) MX382693B (fr)
MY (1) MY159135A (fr)
NO (1) NO2506868T3 (fr)
NZ (2) NZ703153A (fr)
PL (2) PL2506868T3 (fr)
PT (2) PT3326643T (fr)
RS (1) RS56957B1 (fr)
SG (3) SG181130A1 (fr)
SI (1) SI2506868T1 (fr)
SM (1) SMT201800099T1 (fr)
WO (1) WO2011069164A2 (fr)
ZA (1) ZA201204874B (fr)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6263355A (ja) * 1985-09-13 1987-03-20 Hitachi Ltd バツテリバツクアツプｒａｍのチエツク方法
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
ES2730800T3 (es) 2009-02-03 2019-11-12 Amunix Pharmaceuticals Inc Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
US20110046060A1 (en) 2009-08-24 2011-02-24 Amunix Operating, Inc., Coagulation factor IX compositions and methods of making and using same
EP4382170A3 (fr) * 2009-12-06 2024-09-04 Bioverativ Therapeutics Inc. Polypeptides chimériques et hybrides de facteur viii-fc, et leurs procédés d'utilisation
DK2591099T3 (da) 2010-07-09 2021-02-15 Bioverativ Therapeutics Inc Kimære koagulationsfaktorer
CA2807552A1 (fr) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Acides nucleiques modifies et leurs procedes d'utilisation
SMT202200321T1 (it) 2010-10-01 2022-09-14 Modernatx Inc Acidi ribonucleici contenenti n1-metil-pseudouracili e loro usi
CA2930801C (fr) 2010-11-05 2019-05-28 Rinat Neuroscience Corporation Conjugues de polypeptides obtenus par genie biologique, et procede de fabrication correspondants au moyen de transglutaminase
WO2012135805A2 (fr) 2011-03-31 2012-10-04 modeRNA Therapeutics Administration et formulation d'acides nucléiques génétiquement modifiés
PT2717898T (pt) 2011-06-10 2019-05-20 Bioverativ Therapeutics Inc Compostos pró-coagulantes e processos para a sua utilização
AU2012282875B2 (en) * 2011-07-08 2016-04-21 Bioverativ Therapeutics Inc. Factor VIII chimeric and hybrid polypeptides, and methods of use thereof
EP2737311B1 (fr) * 2011-07-25 2020-12-02 Bioverativ Therapeutics Inc. Dosages pour la surveillance de troubles hémostatiques
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
ES2911677T3 (es) 2011-10-03 2022-05-20 Modernatx Inc Nucleósidos, nucleótidos y ácidos nucleicos modificados, y sus usos
US20130156849A1 (en) 2011-12-16 2013-06-20 modeRNA Therapeutics Modified nucleoside, nucleotide, and nucleic acid compositions
ES2700583T3 (es) 2012-01-12 2019-02-18 Bioverativ Therapeutics Inc Procedimientos para reducir la inmunogenicidad contra el Factor VIII en individuos sometidos a terapia con Factor VIII
ES2753124T3 (es) * 2012-01-12 2020-04-07 Bioverativ Therapeutics Inc Polipéptidos quiméricos de factor VIII y usos de los mismos
DK2814840T3 (da) * 2012-02-15 2020-02-03 Bioverativ Therapeutics Inc Faktor viii-sammensætninger og fremgangsmåder til fremstilling og anvendelse deraf
EP2822577B1 (fr) 2012-02-15 2019-02-06 Bioverativ Therapeutics Inc. Protéines de facteur viii de recombinaison
EP2834260A4 (fr) 2012-04-02 2016-08-10 Moderna Therapeutics Inc Polynucléotides modifiés pour la production de protéines membranaires
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
EP2836518B1 (fr) 2012-04-11 2019-01-02 Bioverativ Therapeutics Inc. Procédés de détection de glycosaminoglycanes
WO2013185113A1 (fr) 2012-06-08 2013-12-12 Biogen Idec Ma Inc. Composés pro-coagulants
HK1207591A1 (en) 2012-06-08 2016-02-05 Biogen Ma Inc. Chimeric clotting factors
US10023628B2 (en) * 2012-07-06 2018-07-17 Bioverativ Therapeutics Inc. Cell line expressing single chain factor VIII polypeptides and uses thereof
DK2882450T3 (da) * 2012-07-11 2020-02-24 Bioverativ Therapeutics Inc Faktor viii-kompleks med xten og von willebrand-faktorprotein samt anvendelser deraf
US10001495B2 (en) 2012-07-25 2018-06-19 Bioverativ Therapeutics Inc. Blood factor monitoring assay and uses thereof
WO2014063108A1 (fr) 2012-10-18 2014-04-24 Biogen Idec Ma Inc. Procédés d'utilisation d'une dose fixe d'un facteur de coagulation
EP3943102A1 (fr) * 2012-10-30 2022-01-26 Bioverativ Therapeutics Inc. Procédé d'utilisation de polypeptide du facteur viii
HRP20220607T1 (hr) 2012-11-26 2022-06-24 Modernatx, Inc. Terminalno modificirana rna
US10717965B2 (en) 2013-01-10 2020-07-21 Gloriana Therapeutics, Inc. Mammalian cell culture-produced neublastin antibodies
FI2956477T4 (fi) * 2013-02-15 2024-04-24 Bioverativ Therapeutics Inc Optimoitu tekijä viii:n geeni
EP4122487A1 (fr) * 2013-03-15 2023-01-25 Bioverativ Therapeutics Inc. Formulations de polypeptide de facteur viii
US9090697B2 (en) * 2013-03-15 2015-07-28 Bayer Healthcare Llc Methods for treating bleeding disorders
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US10364288B2 (en) 2013-05-24 2019-07-30 Biogen Ma Inc. Anti-GPIIB/IIIA antibodies or uses thereof
TW201536811A (zh) * 2013-05-31 2015-10-01 Biogen Idec Inc 嵌合ｆｖｉｉ－ｘｔｅｎ分子及其用途
WO2017180807A1 (fr) 2016-04-15 2017-10-19 Baxalta Incorporated Méthode et appareil générant un schéma posologique pharmacocinétique
EP3309696A1 (fr) * 2013-06-20 2018-04-18 Baxalta Incorporated Fourniture d'un régime de dosage de médicaments pharmacocinétique
MX2015016567A (es) * 2013-06-28 2016-03-31 Biogen Ma Inc Enlazador escindible por trombina con xten y usos del mismo.
US20160229903A1 (en) * 2013-06-28 2016-08-11 Biogen Ma Inc. Thrombin cleavable linker
ES2804614T3 (es) 2013-07-31 2021-02-08 Rinat Neuroscience Corp Conjugados de polipéptidos manipulados usando transglutaminasa
WO2015023894A1 (fr) 2013-08-14 2015-02-19 Biogen Idec Ma Inc. Protéines de facteur viii de recombinaison
US10548953B2 (en) 2013-08-14 2020-02-04 Bioverativ Therapeutics Inc. Factor VIII-XTEN fusions and uses thereof
EP3048899B1 (fr) 2013-09-25 2021-09-08 Bioverativ Therapeutics Inc. Procédés d'inactivation de virus sur colonne
EP3052106A4 (fr) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucléotides codant des polypeptides de modulation immunitaire
EA201690675A1 (ru) 2013-10-03 2016-08-31 Модерна Терапьютикс, Инк. Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
US10584147B2 (en) 2013-11-08 2020-03-10 Biovertiv Therapeutics Inc. Procoagulant fusion compound
EP4332839A3 (fr) * 2013-12-06 2024-06-05 Bioverativ Therapeutics Inc. Outils pharmacocinétiques de population et leurs utilisations
US20160289633A1 (en) 2013-12-20 2016-10-06 Biogen Ma Inc. Use of Perfusion Seed Cultures to Improve Biopharmaceutical Fed-Batch Production Capacity and Product Quality
CA2935954A1 (fr) 2014-01-10 2015-07-16 Biogen Ma Inc. Proteines chimeriques de facteur viii et leurs utilisations
US20160347787A1 (en) 2014-02-04 2016-12-01 Biogen Ma Inc. Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications
WO2015148454A1 (fr) * 2014-03-28 2015-10-01 Asklepios Biopharmaceutical, Inc. Gènes du facteur viii modifiés et optimisés pour la thérapie génique
PL3134127T3 (pl) 2014-04-25 2020-07-27 Rinat Neuroscience Corp. Koniugaty przeciwciało-lek o dużym ładunku leku
US11008561B2 (en) 2014-06-30 2021-05-18 Bioverativ Therapeutics Inc. Optimized factor IX gene
WO2016061286A2 (fr) 2014-10-14 2016-04-21 Halozyme, Inc. Compositions d'adénosine désaminase-2 (ada2), variants de cette dernière et leurs procédés d'utilisation
MA40835A (fr) 2014-10-23 2017-08-29 Biogen Ma Inc Anticorps anti-gpiib/iiia et leurs utilisations
MA40864A (fr) 2014-10-31 2017-09-05 Biogen Ma Inc Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères
MA40861A (fr) 2014-10-31 2017-09-05 Biogen Ma Inc Anticorps anti-glycoprotéines iib/iiia
TWI741992B (zh) 2015-08-03 2021-10-11 美商百歐維拉提夫治療公司 因子ｉｘ融合蛋白以及其製備及使用方法
US11560418B2 (en) 2015-10-20 2023-01-24 The University Of North Carolina At Chapel Hill Methods and compositions for modified factor IX fusion proteins
NZ745831A (en) 2016-02-01 2025-07-25 Bioverativ Therapeutics Inc Optimized factor viii genes
TW201739448A (zh) * 2016-05-06 2017-11-16 安成生物科技股份有限公司 用於治療及/或預防血液相關疾病之方法及配方
EP3476937A4 (fr) 2016-06-24 2019-12-04 Mogam Institute for Biomedical Research Protéine chimère comprenant les facteurs fviii et vwf, et utilisation de celle-ci
CA3031735A1 (fr) 2016-08-05 2018-02-08 Medimmune, Llc Anticorps anti-o2 et utilisations associees
CN107759697B (zh) 2016-08-19 2023-03-24 安源医药科技（上海）有限公司 制备融合蛋白的方法
CN106279437B (zh) * 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
AU2017346488A1 (en) 2016-10-19 2019-05-30 Humabs Biomed Sa Anti-O1 antibodies and uses thereof
KR20240069834A (ko) 2016-12-02 2024-05-20 바이오버라티브 테라퓨틱스 인크. 키메라 응고 인자를 사용해 혈우병성 관절증을 치료하는 방법
EP3548063A1 (fr) * 2016-12-02 2019-10-09 Bioverativ Therapeutics Inc. Procédés d'induction de tolérance immunitaire à des facteurs de coagulation
CN108239151B (zh) * 2016-12-23 2020-07-03 海门晟斯生物制药有限公司 重组单链人FVIII-Fc融合蛋白及其应用
US10896749B2 (en) * 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
CR20190389A (es) 2017-01-31 2019-11-26 Bioverativ Therapeutics Inc Proteínas de fusión del factor ix y procedimientos de preparación y utilización de las mismas
CN112512555A (zh) 2018-05-18 2021-03-16 比奥维拉迪维治疗股份有限公司 治疗血友病a的方法
MX2020013036A (es) 2018-06-05 2021-02-26 Amgen Inc Modulacion de la fagocitosis celular dependiente de anticuerpos.
MA53603A (fr) 2018-09-11 2021-07-21 Amgen Inc Procédés de modulation de la cytotoxicité à médiation cellulaire dépendante des anticorps
WO2020086408A1 (fr) 2018-10-26 2020-04-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bioprocédé d'expression génique transitoire basé sur une perfusion à haut rendement
CA3121786A1 (fr) 2018-12-06 2020-06-11 Bioverativ Therapeutics Inc. Utilisation de vecteurs lentiviraux exprimant le facteur ix
CA3144630A1 (fr) 2019-06-19 2020-12-24 Bioverativ Therapeutics Inc. Methodes et compositions pour traiter l'hemophilie et la faible densite minerale osseuse a l'aide d'une proteine de facteur viii fc
TW202126284A (zh) 2019-09-30 2021-07-16 美商百歐維拉提夫治療公司 慢病毒載體配製物
TW202208619A (zh) 2020-06-24 2022-03-01 美商百歐維拉提夫治療公司 用於純化病毒載體之方法
CR20240525A (es) * 2022-04-28 2025-03-05 Biocad Joint Stock Co Ácido nucleico aislado que codifica una proteína de fusión basada en fviii-bdd y en un péptido señal heterólogo, y uso de la misma
CN114989307B (zh) * 2022-05-11 2023-08-01 华兰生物工程股份有限公司 一种重组人凝血因子Ⅷ-Fc融合蛋白及制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050260194A1 (en) * 2003-05-06 2005-11-24 Peters Robert T Immunoglobulin chimeric monomer-dimer hybrids

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235881A (en) * 1978-12-04 1980-11-25 Cort Joseph H Method for producing high potency factor VIII
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
WO1986006101A1 (fr) 1985-04-12 1986-10-23 Genetics Institute, Inc. Nouvelles proteines procoagulantes
KR910006424B1 (ko) 1985-08-21 1991-08-24 인코텍스 비.브이 편성브리프(brief) 제조방법
FI873796L (fi) 1986-01-03 1987-09-01 Genetics Inst Foerbaettrad metod foer produktion av proteiner av faktor viii:c-typ.
US5595886A (en) 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5543502A (en) 1986-06-24 1996-08-06 Novo Nordisk A/S Process for producing a coagulation active complex of factor VIII fragments
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
CA1331157C (fr) 1987-04-06 1994-08-02 Randal J. Kaufman Methode de production du facteur viii : proteines de type c
US6060447A (en) 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US6346513B1 (en) 1987-06-12 2002-02-12 Baxter Trading Gmbh Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
IL86693A (en) 1987-06-12 1994-06-24 Stichting Centraal Lab Proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them
DE3720246A1 (de) 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
FR2619314B1 (fr) 1987-08-11 1990-06-15 Transgene Sa Analogue du facteur viii, procede de preparation et composition pharmaceutique le contenant
US4994371A (en) 1987-08-28 1991-02-19 Davie Earl W DNA preparation of Christmas factor and use of DNA sequences
US5004803A (en) 1988-11-14 1991-04-02 Genetics Institute, Inc. Production of procoagulant proteins
SE465222C5 (sv) 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
CA2078721A1 (fr) 1991-09-24 1993-03-25 Hiroshi Yonemura Methode de preparation d'un complexe proteique du facteur viii de coagulation humaine
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US6376463B1 (en) 1992-04-07 2002-04-23 Emory University Modified factor VIII
US5364771A (en) 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
US5859204A (en) 1992-04-07 1999-01-12 Emory University Modified factor VIII
US5563045A (en) 1992-11-13 1996-10-08 Genetics Institute, Inc. Chimeric procoagulant proteins
SE504074C2 (sv) 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
US6818439B1 (en) 1994-12-30 2004-11-16 Chiron Corporation Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders
SE9503380D0 (sv) 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
CA2225189C (fr) 1997-03-06 2010-05-25 Queen's University At Kingston Gene et proteine du facteur viii du chien et methodes d'utilisation
AU4314801A (en) 2000-02-11 2001-08-20 Lexigen Pharm Corp Enhancing the circulating half-life of antibody-based fusion proteins
JP2003530839A (ja) 2000-04-12 2003-10-21 プリンシピア ファーマスーティカル コーポレイション アルブミン融合タンパク質
ES2301624T3 (es) * 2001-02-05 2008-07-01 Novo Nordisk Health Care Ag Uso combinado de polipeptidos de factor vii y polipeptidos de factor viii.
ES2425738T3 (es) 2001-12-21 2013-10-17 Human Genome Sciences, Inc. Proteínas de fusión de la albúmina
US7041635B2 (en) 2003-01-28 2006-05-09 In2Gen Co., Ltd. Factor VIII polypeptide
EP1444986A1 (fr) * 2003-02-07 2004-08-11 Aventis Behring GmbH Preparation pharmaceutique pour l'amélioration du traitement des maladies liées à une coagulation sanguine diminuée
DE602004022800D1 (de) 2003-05-06 2009-10-08 Syntonix Pharmaceuticals Inc Gerinnungsfaktor-fc chimere proteine zur behandlung von hämophilie
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
JP5114055B2 (ja) 2003-06-19 2013-01-09 ジェネンテック， インク． 障害に関連する凝固の治療用組成物および方法
US7211559B2 (en) 2003-10-31 2007-05-01 University Of Maryland, Baltimore Factor VIII compositions and methods
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
SI2363414T1 (sl) 2004-11-12 2022-09-30 Bayer Healthcare Llc Usmerjena modifikacija FVIII
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
WO2007103455A2 (fr) 2006-03-06 2007-09-13 Amunix, Inc. Materiels génétiques et utilisations correspondantes
KR20080108147A (ko) * 2006-03-31 2008-12-11 백스터 인터내셔널 인코포레이티드 페질화된 인자 ｖｉｉｉ
AU2007338298B2 (en) 2006-12-22 2013-02-07 Csl Behring Gmbh Modified coagulation factors with prolonged in vivo half-life
KR20100058541A (ko) 2007-08-15 2010-06-03 아뮤닉스 인코포레이티드 생물학적 활성 폴리펩티드의 특성을 변경하기 위한 조성물 및 방법
JP5619630B2 (ja) * 2008-02-27 2014-11-05 ノボ・ノルデイスク・エー／エス 結合型第ｖｉｉｉ因子分子
US8800831B2 (en) 2009-08-19 2014-08-12 Larry A. Gray Multi-purpose rack and method thereof
ES2730800T3 (es) 2009-02-03 2019-11-12 Amunix Pharmaceuticals Inc Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
CN102427823A (zh) * 2009-03-24 2012-04-25 拜耳医药保健有限公司 因子viii变体及使用方法
GB0908515D0 (en) 2009-05-18 2009-06-24 Apitope Technology Bristol Ltd Peptide
EP4382170A3 (fr) 2009-12-06 2024-09-04 Bioverativ Therapeutics Inc. Polypeptides chimériques et hybrides de facteur viii-fc, et leurs procédés d'utilisation
AU2012282875B2 (en) * 2011-07-08 2016-04-21 Bioverativ Therapeutics Inc. Factor VIII chimeric and hybrid polypeptides, and methods of use thereof
ES2700583T3 (es) * 2012-01-12 2019-02-18 Bioverativ Therapeutics Inc Procedimientos para reducir la inmunogenicidad contra el Factor VIII en individuos sometidos a terapia con Factor VIII
EP4122487A1 (fr) * 2013-03-15 2023-01-25 Bioverativ Therapeutics Inc. Formulations de polypeptide de facteur viii
JP6083911B2 (ja) 2014-12-19 2017-02-22 花王株式会社 吸収性物品

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050260194A1 (en) * 2003-05-06 2005-11-24 Peters Robert T Immunoglobulin chimeric monomer-dimer hybrids

Also Published As

Publication number Publication date
EP2506868A2 (fr) 2012-10-10
AU2016213822B2 (en) 2017-08-31
EA038618B1 (ru) 2021-09-23
EP3326643A1 (fr) 2018-05-30
ES2659888T3 (es) 2018-03-19
EA201290443A1 (ru) 2013-06-28
SG181130A1 (en) 2012-07-30
US9241978B2 (en) 2016-01-26
US11266720B2 (en) 2022-03-08
NZ703153A (en) 2015-02-27
AU2010325787B2 (en) 2016-05-12
EP4382170A2 (fr) 2024-06-12
AU2019202969A1 (en) 2019-05-16
NZ600709A (en) 2015-01-30
US9050318B2 (en) 2015-06-09
KR101770849B1 (ko) 2017-09-05
HUE036233T2 (hu) 2018-06-28
JP2020019821A (ja) 2020-02-06
JP6062459B2 (ja) 2017-01-18
ES2880038T3 (es) 2021-11-23
IL220204A0 (en) 2012-07-31
CY1124888T1 (el) 2023-01-05
SMT201800099T1 (it) 2018-03-08
ME02964B (fr) 2018-07-20
CY1119919T1 (el) 2018-06-27
CA2782424C (fr) 2021-07-27
HRP20180135T1 (hr) 2018-04-06
NO2506868T3 (fr) 2018-04-14
AU2010325787A1 (en) 2012-07-12
US20190262429A1 (en) 2019-08-29
MX353233B (es) 2018-01-08
KR20120129882A (ko) 2012-11-28
IL220204B (en) 2018-08-30
SG10201408049SA (en) 2015-02-27
JP2015083608A (ja) 2015-04-30
AU2017268648B2 (en) 2019-01-31
CN102791285A (zh) 2012-11-21
HK1253887A1 (en) 2019-07-05
MX2012006347A (es) 2012-10-03
EA025416B1 (ru) 2016-12-30
JP2017025098A (ja) 2017-02-02
EP3906937A1 (fr) 2021-11-10
DK2506868T3 (da) 2018-01-29
HRP20211010T1 (hr) 2021-09-17
US20130108629A1 (en) 2013-05-02
JP6641340B2 (ja) 2020-02-05
PT2506868T (pt) 2018-02-23
IL260769B (en) 2020-03-31
JP2018024706A (ja) 2018-02-15
AU2016213822A1 (en) 2016-09-01
US20160199455A1 (en) 2016-07-14
AU2010325787A2 (en) 2013-06-06
AU2021202912B2 (en) 2024-08-01
JP2022051964A (ja) 2022-04-01
AU2017268648A1 (en) 2017-12-21
LT2506868T (lt) 2018-02-26
US20130274194A1 (en) 2013-10-17
ZA201204874B (en) 2016-06-29
SG10201907152YA (en) 2019-09-27
CO6561782A2 (es) 2012-11-15
JP2025083451A (ja) 2025-05-30
PT3326643T (pt) 2021-07-12
CA2782424A1 (fr) 2011-06-09
CA3121739A1 (fr) 2011-06-09
EP3326643B1 (fr) 2021-04-07
AU2021202912A1 (en) 2021-06-03
US20220265780A1 (en) 2022-08-25
EP2506868B1 (fr) 2017-11-15
WO2011069164A2 (fr) 2011-06-09
BR112012013502A2 (pt) 2017-01-10
RS56957B1 (sr) 2018-05-31
MX382693B (es) 2025-03-13
PL3326643T3 (pl) 2021-10-25
JP6385410B2 (ja) 2018-09-05
EA201691109A1 (ru) 2017-01-30
AU2010325787A8 (en) 2012-07-19
JP2013512678A (ja) 2013-04-18
JP7244688B2 (ja) 2023-03-22
JP5903048B2 (ja) 2016-04-13
JP2023071969A (ja) 2023-05-23
EP2506868A4 (fr) 2013-07-24
PL2506868T3 (pl) 2018-06-29
AU2024227757A1 (en) 2024-11-21
MY159135A (en) 2016-12-15
EP4382170A3 (fr) 2024-09-04
SI2506868T1 (en) 2018-04-30
MX336830B (es) 2016-02-03

Similar Documents

Publication Publication Date Title
WO2011069164A3 (fr) Polypeptides chimériques et hybrides de facteur viii-fc, et procédés d'utilisation de ceux-ci
WO2012006624A3 (fr) Polypeptides du facteur ix et leurs méthodes d'utilisation
WO2013009627A3 (fr) Polypeptides chimériques et hybrides du facteur viii et leurs procédés d'utilisation
HK1213521A1 (zh) Fix多肽的應用
IL252561A0 (en) Antibodies against Siglac-15 polynucleotides encoding them, preparations containing them and their uses
WO2010034032A3 (fr) Procédés pour préparer des compositions de polypeptide purifié
WO2006105338A3 (fr) Variants fc presentant des proprietes optimisees
WO2013152351A3 (fr) Polypeptides de fusion et procédés pour les utiliser
EP4328304A3 (fr) Demi-domaines de clivage modifiés
PH12012500862B1 (en) Il-17a antagonists
WO2011075636A3 (fr) Épitopes et agents de liaison destinés à wise
WO2009126292A3 (fr) Macrocycles peptidomimétiques biologiquement actifs
WO2010132370A8 (fr) Peptides solubles de la famille trem-1 et procédés d'utilisation
WO2011005554A3 (fr) Bactéries éthanologènes recombinantes
HK1185266A (en) Factor ix polypeptides and methods of use thereof
HK40112150A (en) Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof
HK40091851A (en) Factor viii chimeric and hybrid polypeptides, and methods of use thereof
AU2009902652A0 (en) Methods of generating hybrid/chimeric cells, and uses thereof
WO2013102764A3 (fr) Oxydase alternative

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 201080062950.7

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10835255

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2782424

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: MX/A/2012/006347

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2012001463

Country of ref document: CL

Ref document number: 2012542240

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 1201002667

Country of ref document: TH

Ref document number: 220204

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2010325787

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 12109855

Country of ref document: CO

WWE Wipo information: entry into national phase

Ref document number: 5851/DELNP/2012

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 201290443

Country of ref document: EA

ENP Entry into the national phase

Ref document number: 20127017595

Country of ref document: KR

Kind code of ref document: A

REEP Request for entry into the european phase

Ref document number: 2010835255

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2010835255

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2010325787

Country of ref document: AU

Date of ref document: 20101206

Kind code of ref document: A

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112012013502

Country of ref document: BR

WWE Wipo information: entry into national phase

Ref document number: 13513424

Country of ref document: US

ENP Entry into the national phase

Ref document number: 112012013502

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20120604