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WO2011058373A3 - Drug combination with theobromine and its use in therapy - Google Patents

Drug combination with theobromine and its use in therapy Download PDF

Info

Publication number
WO2011058373A3
WO2011058373A3 PCT/GB2010/051895 GB2010051895W WO2011058373A3 WO 2011058373 A3 WO2011058373 A3 WO 2011058373A3 GB 2010051895 W GB2010051895 W GB 2010051895W WO 2011058373 A3 WO2011058373 A3 WO 2011058373A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapy
theobromine
drug combination
cough
sequential
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2010/051895
Other languages
French (fr)
Other versions
WO2011058373A2 (en
Inventor
John Brew
Robin Mark Bannister
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocopea Ltd
Original Assignee
Biocopea Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41509324&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2011058373(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to AU2010317667A priority Critical patent/AU2010317667B2/en
Priority to NZ599949A priority patent/NZ599949A/en
Priority to BR112012011227A priority patent/BR112012011227A2/en
Priority to CN2010800516299A priority patent/CN102753174A/en
Priority to RU2012124038/15A priority patent/RU2519086C2/en
Priority to CA2780703A priority patent/CA2780703A1/en
Priority to JP2012538415A priority patent/JP2013510841A/en
Priority to EP10825831A priority patent/EP2498777A2/en
Priority to PH1/2012/501369A priority patent/PH12012501369A1/en
Application filed by Biocopea Ltd filed Critical Biocopea Ltd
Priority to MX2012005532A priority patent/MX2012005532A/en
Priority to UAA201207164A priority patent/UA108993C2/en
Publication of WO2011058373A2 publication Critical patent/WO2011058373A2/en
Publication of WO2011058373A3 publication Critical patent/WO2011058373A3/en
Priority to US13/446,217 priority patent/US20120252824A1/en
Priority to IL219768A priority patent/IL219768A0/en
Anticipated expiration legal-status Critical
Priority to ZA2012/04248A priority patent/ZA201204248B/en
Priority to US14/287,017 priority patent/US10016437B2/en
Priority to US14/287,015 priority patent/US9308211B2/en
Priority to US14/287,014 priority patent/US9314465B2/en
Priority to US14/488,215 priority patent/US20150005325A1/en
Priority to US14/687,393 priority patent/US20150216869A1/en
Priority to US14/991,892 priority patent/US20160120899A1/en
Priority to US15/061,656 priority patent/US9700561B2/en
Priority to US15/063,465 priority patent/US9675618B2/en
Priority to US15/144,800 priority patent/US20160271197A1/en
Priority to US15/144,798 priority patent/US20160271136A1/en
Priority to US16/042,670 priority patent/US10420812B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

An agent comprises theobromine and another non-opiate antitussive, for simultaneous, sequential or separate use in therapy. Preferably, the therapy is of cough.
PCT/GB2010/051895 2009-06-16 2010-11-12 Drug combination with theobromine and its use in therapy Ceased WO2011058373A2 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
EP10825831A EP2498777A2 (en) 2009-11-13 2010-11-12 Drug combination with theobromine and its use in therapy
PH1/2012/501369A PH12012501369A1 (en) 2009-11-13 2010-11-12 Drug combination with theobromine and its use in therapy
BR112012011227A BR112012011227A2 (en) 2009-11-13 2010-11-12 theobromine and agent combined with another non-opioid antitussive and its therapeutic use
CN2010800516299A CN102753174A (en) 2009-11-13 2010-11-12 Pharmaceutical combinations of theobromine and their use in therapy
RU2012124038/15A RU2519086C2 (en) 2009-11-13 2010-11-12 Medical combination with theobromine and using it in treatment
CA2780703A CA2780703A1 (en) 2009-11-13 2010-11-12 Drug combination with theobromine and its use in therapy
JP2012538415A JP2013510841A (en) 2009-11-13 2010-11-12 Drug combination with theobromine and its use in therapy
AU2010317667A AU2010317667B2 (en) 2009-11-13 2010-11-12 Drug combination with theobromine and its use in therapy
MX2012005532A MX2012005532A (en) 2009-11-13 2010-11-12 Drug combination with theobromine and its use in therapy.
NZ599949A NZ599949A (en) 2009-11-13 2010-11-12 Drug combination with theobromine and its use in therapy
UAA201207164A UA108993C2 (en) 2009-11-13 2010-12-11 MEDICINAL COMBINATION WITH THEOBROMINE AND ITS APPLICATION IN Cough
US13/446,217 US20120252824A1 (en) 2009-06-16 2012-04-13 Drug Combinations and Uses in Treating a Coughing Condition
IL219768A IL219768A0 (en) 2009-11-13 2012-05-13 Drug combination with thebromine and its use in therapy
ZA2012/04248A ZA201204248B (en) 2009-11-13 2012-06-11 Drug combination with theobromine and its use in therapy
US14/287,014 US9314465B2 (en) 2009-06-16 2014-05-24 Drug combinations and uses in treating a coughing condition
US14/287,015 US9308211B2 (en) 2009-06-16 2014-05-24 Drug combinations and uses in treating a coughing condition
US14/287,017 US10016437B2 (en) 2009-06-16 2014-05-24 Drug combinations and uses in treating a coughing condition
US14/488,215 US20150005325A1 (en) 2009-06-16 2014-09-16 Drug Combinations and Uses in Treating a Coughing Condition
US14/687,393 US20150216869A1 (en) 2009-06-16 2015-04-15 Drug Combinations and Uses in Treating a Coughing Condition
US14/991,892 US20160120899A1 (en) 2009-06-16 2016-01-08 Drug Combinations and Uses in Treating a Coughing Condition
US15/061,656 US9700561B2 (en) 2009-06-16 2016-03-04 Drug combinations and uses in treating a coughing condition
US15/063,465 US9675618B2 (en) 2009-06-16 2016-03-07 Drug combinations and uses in treating a coughing condition
US15/144,800 US20160271197A1 (en) 2009-06-16 2016-05-02 Drug Combinations and Uses in Treating a Coughing Condition
US15/144,798 US20160271136A1 (en) 2009-06-16 2016-05-02 Drug Combinations and Uses in Treating a Coughing Condition
US16/042,670 US10420812B2 (en) 2009-06-16 2018-07-23 Drug combinations and uses in treating a coughing condition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0919889.6 2009-11-13
GBGB0919889.6A GB0919889D0 (en) 2009-11-13 2009-11-13 Drug composition and its use in therapy

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/GB2010/050997 Continuation-In-Part WO2010146394A1 (en) 2009-06-16 2010-06-15 Theobromine for the treatment of cough
PCT/GB2010/051896 Continuation-In-Part WO2011058374A1 (en) 2009-06-16 2010-11-12 Drug combination with theobromine and its use in therapy

Related Child Applications (3)

Application Number Title Priority Date Filing Date
PCT/GB2010/051896 Continuation-In-Part WO2011058374A1 (en) 2009-06-16 2010-11-12 Drug combination with theobromine and its use in therapy
PCT/GB2010/052056 Continuation-In-Part WO2011070363A1 (en) 2009-06-16 2010-12-09 Carbon and its use in blood cleansing applications
PCT/GB2010/052086 Continuation-In-Part WO2011073647A1 (en) 2009-06-16 2010-12-14 Therapeutic combinations of theobromine and an antihistamine

Publications (2)

Publication Number Publication Date
WO2011058373A2 WO2011058373A2 (en) 2011-05-19
WO2011058373A3 true WO2011058373A3 (en) 2011-07-07

Family

ID=41509324

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2010/051895 Ceased WO2011058373A2 (en) 2009-06-16 2010-11-12 Drug combination with theobromine and its use in therapy

Country Status (17)

Country Link
EP (1) EP2498777A2 (en)
JP (2) JP2013510841A (en)
CN (1) CN102753174A (en)
AU (1) AU2010317667B2 (en)
BR (1) BR112012011227A2 (en)
CA (1) CA2780703A1 (en)
CO (1) CO6551744A2 (en)
GB (1) GB0919889D0 (en)
IL (1) IL219768A0 (en)
MX (1) MX2012005532A (en)
NZ (1) NZ599949A (en)
PE (1) PE20130147A1 (en)
PH (1) PH12012501369A1 (en)
RU (1) RU2519086C2 (en)
UA (1) UA108993C2 (en)
WO (1) WO2011058373A2 (en)
ZA (1) ZA201204248B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0910375D0 (en) 2009-06-16 2009-07-29 Biocopea Ltd Drug composition and its use in therapy
US10016437B2 (en) 2009-06-16 2018-07-10 Infirst Healthcare Limited Drug combinations and uses in treating a coughing condition
GB201111485D0 (en) * 2011-07-05 2011-08-17 Biocopea Ltd Drug composition and its use in therapy
US9314465B2 (en) 2009-06-16 2016-04-19 Infirst Healthcare Limited Drug combinations and uses in treating a coughing condition
US9308211B2 (en) 2009-06-16 2016-04-12 Infirst Healthcare Limited Drug combinations and uses in treating a coughing condition
WO2017117347A1 (en) * 2015-12-30 2017-07-06 Markovitz M D Paul Method of treating schizophrenia

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998042322A2 (en) * 1997-03-26 1998-10-01 Korbonits Dezso Antitussive compositions
WO2008002514A2 (en) * 2006-06-26 2008-01-03 Levine Brian M Combination cough treatment compounds and method of treating common coughs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834479A (en) * 1993-03-05 1998-11-10 Mayer; David J. Method and composition for alleviating pain
ATE286885T1 (en) * 1996-11-25 2005-01-15 Procter & Gamble GUANIDYL HETEROCYCLIC COMPOUNDS AS ALPHA-2 ADRENOCEPTOR AGONISTS
US20030206942A1 (en) * 1998-09-25 2003-11-06 Neema Kulkarni Fast dissolving orally consumable films containing an antitussive and a mucosa coating agent
US6207674B1 (en) * 1999-12-22 2001-03-27 Richard A. Smith Dextromethorphan and oxidase inhibitor for weaning patients from narcotics and anti-depressants
EP1646428B1 (en) * 2003-05-29 2008-04-09 Unilever Plc Hair treatment compositions
US20060153926A1 (en) * 2005-01-10 2006-07-13 Bascom Charles C Compositions, products and methods for controlling weight in a mammal
US20080176955A1 (en) * 2007-01-16 2008-07-24 Victory Pharma, Inc. Combined administration of benzonatate and guaifenesin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998042322A2 (en) * 1997-03-26 1998-10-01 Korbonits Dezso Antitussive compositions
WO2008002514A2 (en) * 2006-06-26 2008-01-03 Levine Brian M Combination cough treatment compounds and method of treating common coughs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DICPINIGAITIS ET AL: "Currently available antitussives", PULMORNARY PHARMACOLOGY & THERAPEUTICS, ACADEMIC PRESS, GB, vol. 22, no. 2, 1 April 2009 (2009-04-01), pages 148 - 151, XP025971974, ISSN: 1094-5539, [retrieved on 20080819], DOI: DOI:10.1016/J.PUPT.2008.08.002 *

Also Published As

Publication number Publication date
EP2498777A2 (en) 2012-09-19
CO6551744A2 (en) 2012-10-31
RU2519086C2 (en) 2014-06-10
IL219768A0 (en) 2012-07-31
WO2011058373A2 (en) 2011-05-19
JP2016128439A (en) 2016-07-14
AU2010317667B2 (en) 2014-05-29
UA108993C2 (en) 2015-07-10
ZA201204248B (en) 2013-02-27
NZ599949A (en) 2013-08-30
BR112012011227A2 (en) 2017-06-13
CA2780703A1 (en) 2011-05-19
MX2012005532A (en) 2012-09-28
GB0919889D0 (en) 2009-12-30
RU2012124038A (en) 2013-12-20
CN102753174A (en) 2012-10-24
JP6118919B2 (en) 2017-04-19
JP2013510841A (en) 2013-03-28
AU2010317667A1 (en) 2012-06-07
PH12012501369A1 (en) 2012-10-22
PE20130147A1 (en) 2013-03-13

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