WO2009139657A1 - Inhalation method and a device for carrying out said method - Google Patents

Abstract

The invention relates to medicine. The inhalation method involves the intensive lung ventilation followed by a full inspiration and a breath holding. Then, a patient respires a xenon and oxygen mixture supplied by a closed circuit apparatus until the oxygen content in the mixture arrives at 20% and the gas effect becomes evident. Breathing of the gas mixture is carried out on an empty stomach and when the blood cholesterol is ≤ 5 mmol/l. Prior to inhalation, the patient drinks warm water and during the procedure lies on his back with the head end lowered. The device for carrying out said method comprises a gas distribution unit connected to the patient's breathing mask via an inspiration-expiration line and with a gas analyser, the sensors of which are placed inside the gas distribution unit which is in form of a monoblock with channels perforated therein for distributing the gas mixture and for supplying it to the inspiration-expiration line, the gas analyser sensors and to a collecting unit. A respiratory reservoir is disposed between the inspiration-expiration line and the gas distribution unit.

Description

 Method of inhalation and device for its implementation

Technical field

The invention relates to medicine and can be used in narcology, psychiatry, neurology, pulmonology, therapy, in the treatment of occupational diseases, preventive medicine, in the rehabilitation and restoration of the body after an illness, and also after stressful mental and physical stress.

The use of inert gases in medicine is currently becoming more widespread. It is well known to use the oxygen-helium mixture by inhalation for the treatment of lung diseases, warming the body during hypothermia (2), the oxygen-xenon mixture for the treatment of drug dependence (1,3), adaptogenic disorders (4).

At the same time, the main obstacle to the widespread adoption of noble gases in medical practice is the use of expensive equipment, the high cost of inert gases, especially xenon, which makes the inhalation procedure for treatment inaccessible to most of the population.

State of the art

A known method of autoanalgesia with a xenon-oxygen mixture, in which the patient is invited to inhale the xenon-oxygen mixture in a ratio of xenon to oxygen in vol. % from 30-70 to 50-50 before the relief of pain (RU patent N ° 2271815, op.20.03.2006)

This method does not provide for the preliminary preparation of the patient for the inhalation procedure. Experience shows that the use of a xenon-oxygen mixture in the ratio (50:50) of unprepared patients causes signs of clinical effect on average 3-4 minutes after the start of the procedure.

In addition, in the device used to implement this method, the breathing circuit is limited to 3 liters, and the absence of an additional outlet to increase the capacity to 5-6 liters leads to a greater consumption of xenon due to the additional supply of the mixture from the cylinder and dumping its excess from the circuit into atmosphere during the procedure.

The absence of a gas analyzer in the device that controls the content and oxygen consumption in the gas mixture can lead to patient hypoxia, especially if the patient is unconscious.

The device does not provide for other gas sources (for example, strippers, mini-balloons), there is no possibility of mixing therapeutic gases in the required proportions.

In addition, there is no possibility of collecting spent xenon, which eliminates the use of recycling technology.

A known method of increasing efficiency by inhalation of a xenon-oxygen gas mixture in a weight ratio of (5-50): (95-50) to a state of euphoria with a gas mixture consumption of not more than 0.1 l per lkg of body weight (RU patent N ° 2235563, op. 09/10/2004)

In this method of increasing the working capacity of athletes and individuals, due to their professional activities exposed to stressful loads, methods of preparation for the inhalation procedure are not used. The main metabolic conditions are not taken into account, as well as breathing characteristics that contribute to more complete ventilation of the lungs before the treatment mixture is supplied; there is no control over the flow rate and composition of the respiratory gas mixture, especially with respect to oxygen, which can lead to undesirable consequences. Also observed high consumption of the mixture, since breathing occurs along a half-open circuit. There is a gas effect on the doctor, there is no possibility of collecting xenon for regeneration. Failure to take all of this into account leads to greater xenon consumption during the inhalation procedure and a decrease in the therapeutic effect.

A known method of inhalation used in the treatment of drug addiction, including stopping the absorptive syndrome by anesthesia by inhalation of a mixture of oxygen with an inert gas xenon at a ratio of 50-50: 30-70 with the simultaneous use of drugs (patent RU JV216527O, op. 20.04.200 Ir). The method used the apparatus Polinarkon-2P.

The disadvantage of this method is the high consumption of xenon due to the supply of a gas mixture of xenon and oxygen in a large flow of 10-15 liters per procedure, which are mixed in the right proportions when gas is supplied through rotameters to the inhalation device, there is no preliminary preparation of the patient for the procedure.

A device is known for performing inhalation anesthesia with a gas mixture of xenon and oxygen (patent RU N ° 2183476, op. 20.06.2002). The device contains a gas supply unit with sources of compressed gases, a breathing circuit including a gas analyzer, a patient’s breathing mask, an inspiratory line, an exhalation line, disinfecting elements installed on the inspiratory line and the exhalation line, a CO ₂ and H ₂ O absorber. possible xenon losses due to design complexity. In addition, it is equipped with rotameters, a cryopump, a chromatograph, which requires special maintenance, makes the device expensive, bulky, this does not allow it to be used in the field, clinics, ambulances. The closest analogue adopted for the prototype in relation to the method is the inhalation method (RU N ° 2317112, op.28.02.2008), including intensive ventilation of the lungs with air, followed by the deepest possible exhalation of air into the environment and breath holding at an exhalation height, after which carry out breathing a gas mixture of xenon with oxygen from a closed breathing circuit until the oxygen content in the mixture is at least 20% and the onset of signs of gas exposure, when the conditions for breathing with a gas mixture of “pump” against a background of soda holding total cholesterol in the patient's blood <5 mmol / l.

The disadvantage of this method is the lack of adequate preparation of the patient for the xenon therapy procedure, namely, a preliminary assessment of the state of such blood parameters as cholesterol, blood hematocrit. In this method do not carry out procedures that correct these indicators in order to optimize them, which allows to reduce xenon consumption. Also, the method does not take into account the position of the patient during the procedure, the pharmacological support of this type of treatment, which also affects its effectiveness. The closest analogue adopted for the prototype in terms of the device is an inhalation device (RU for utility model N259415, op.27.12.2006) containing a gas supply unit connected to compressed gas sources, a capture unit, a closed breathing circuit connected to the supply unit gas and comprising a patient’s breathing mask, an inspiratory / expiratory line, a gas analyzer with sensors, a CO ₂ absorber, and at least one respiratory container.

The disadvantages of the device include a large internal volume of the respiratory chamber, which leads to a large gas flow, increase resistance to breathing, and the presence of elements for sterilization increases the bulkiness of the device, the location of the backup bags on the side opposite the respiratory circuit leads to an increase in breathing resistance. Disclosure of invention

The task to which this group of inventions is directed is to reduce xenon consumption, increase the efficiency of the inhalation procedure in the treatment of various diseases, reduce the time of the inhalation procedure, simplify the inhalation device.

To solve the problem in the inhalation method, in which intensive ventilation of the lungs with air is carried out, followed by the deepest possible exhalation of air into the environment and breath holding at an exhalation height, after which the gas mixture of xenon and oxygen is breathed from a closed loop apparatus until the oxygen content in the mixture is less than 20% and the onset of signs of gas exposure, when the conditions for breathing with a gas mixture of “pump” against the background of total cholesterol in the patient’s blood <5 mmol l / l, according to the invention, preliminarily, warm water is taken inward, while during the inhalation procedure the patient is lying on his back with his head down.

The intake of warm water inside is carried out in an amount of, preferably, 200-400 ml. The temperature of warm water is preferably 30-40 ⁰ C.

The patient is lying supine with the head down, preferably 5-10 °. The method is carried out against the background of pharmacotherapy with drugs that affect the level of cholesterol and blood flow in the brain, which are used, for example, nicotinic acid. In terms of the device, the task is solved as follows. A device for inhalation with a gas mixture of xenon with oxygen, comprising a gas supply unit connected to sources of compressed gas, a capture unit, a closed breathing circuit connected to a gas supply unit and including a patient respiratory mask, an inhalation / expiration line, a gas analyzer with sensors, a CO ₂ absorber , and at least one respiratory capacity, according to the invention, contains a gas distribution unit connected to the patient's respiratory mask through the inspiration / expiration line and with a gas analyzer, the sensors of which placed inside the gas distribution block, while the gas distribution block is made in the form of a monolith with channels for discharging the gas mixture and feeding it into the inhalation / exhalation line, to the sensors of the gas analyzer and to the recovery unit, and the respiratory capacity is installed on the inhalation / exhalation line between the mask and gas distribution unit. The inspiratory / expiratory line is made in the form of two respiratory lines equipped with inspiratory and expiratory valves.

The gas distribution unit is equipped with flaps for opening and closing the breathing circuit.

The internal volume of the gas distribution unit is preferably 20-200 ml.

The gas distribution unit is made in the form of a monolith, preferably in the form of a parallelepiped.

Figure l shows a schematic diagram of a device for inhalation Figure 2 - gas distribution unit, General view

In Fig.Z - gas distribution unit, section A-A in Fig.2

The inhalation device contains a closed breathing circuit, which includes a gas distribution unit 1 connected via an inhalation / exhalation line 2.3 to the patient’s breathing mask 4, and also connected to a gas analyzer 5, the xenon and oxygen sensors 7 of which are installed inside the gas distribution unit 1, mounted on inspiration / expiration lines 2.3, respiratory capacity in the form of a respiratory bag 8, absorber 9 CO _2. for example, a column with sorbents, namely soda lime. The inhalation device also contains a gas supply unit 10 and a capture unit 11. The main volume of the closed breathing circuit includes an inhalation / exhalation line 2.3 with a respiratory mask 4 of the patient, a breathing bag 8, an absorber 9 CO ₂ . The main volume of the closed respiratory circuit can be from 1.5 liters to 7 liters. The gas distribution unit 1 is connected to the gas supply unit 10, which has, for example, three channels: for supplying the finished mixture 12, for supplying oxygen 13, for supplying xenon 14. Five channels for supplying the gas mixture from the miniball 15, from the stripper 16 s are possible the possibility of supplying both the finished gas mixture and individual gases from the sources of compressed gases to the gas distribution unit 1. Each channel is equipped with a valve (not shown in the drawing) that opens during gas supply from the sources of compressed gas, which can be used Sources 12-16 are used. The body of the gas distribution unit 1 is made in the form of a monolith, for example, in the form of a parallelepiped with, for example, channels machined inside, for distributing the gas mixture coming from the gas supply unit 10 and supplying it to the inspiration / expiration line 2.3, to sensors 6.7 gas analyzer 5 and in the capture unit 11. The gas distribution unit 1 performs the function of the docking unit of the gas supply unit, gas analyzer sensors, xenon capture unit with the main volume of the respiratory circuit. The internal volume (channel volume) of the gas distribution unit is preferably from 20 to 200 ml. The gas distribution unit is minimally involved in the breathing process (due to the small volume) and is equipped with a relief valve 17. The relief valve is a safety measure to prevent overpressure in the apparatus circuit. In the event of hypoxia and hypercapnia conditions, a gas mixture is added to the breathing circuit, the valve automatically discharges excess gas, decreases exhalation resistance, and thereby prevents lung barotrauma. The CO ₂ absorber 9 and respiratory capacity 8 are installed on the inspiration / expiration line 2,3, while the CO ₂ absorber 9 is installed at the outlet of the gas distribution unit 1, and connected to the respiratory capacity 8, made, for example, in the form of a breathing bag, latex, from 1 to 5 liters.

The inhalation device contains a disinfecting element 18, which can be made in the form of a bacterial-viral filter installed between the mask 4 and respiratory capacity 8 on the inspiration / expiration line 2.3.

The inspiratory / expiratory breathing line 2,3 is made in the form of breathing tubes equipped with inspiratory and expiratory valves 19,20 installed between the disinfecting element 18 and the respiratory bag 8. At the exit from the gas distribution unit 1, the shutters 21 are installed on the inspiratory / expiratory 2,3 line , 22 to open and close the inhalation / exhalation line 2.3.

Desorber 16 may be equipped with a heating system — a chemical or electric heater (not shown), which can work both in stand-alone and in stationary modes.

The stripper 16 with the heating element is connected to the gas supply unit 10. Structurally, the option is possible when the stripper 16 is placed in the heating element, or the heating element is mounted in the bottom of the stripper.

Strippers 16 contain only xenon. When the stripper is heated, gas from it passes through the channel of the gas supply unit 10 to the gas distribution unit 1. At the same time, an additional effect of the heating device is achieved — inhalation of warm (hot) gases.

The capacity of the channels of the gas distribution unit 1 is from 20 to 200 ml. The possibility of using respiratory containers of 8 different sizes allows you to use this inhalation device for both children and adults with different lung capacities, which in adults can range from 2.5 liters to 7-8 liters (an athlete has a lung capacity of 7 liters, an ordinary person - 4 liters, children - 1 liter or less, elderly patients - less than three liters, tidal volume is reduced in the absence of one lung and pneumonia).

This is the main function of breathing bags. They also allow you to visually observe the degree of filling of the respiratory circuit with gas, the frequency and depth of breathing.

During inhalation, carbon dioxide-free gas enters the breathing bag 8 and is then inhaled by the patient through the inhalation line 2. At the same time, the inhalation valve 19 is open and the exhalation valve 20 closes, when exhaling, the valve 20 standing on the exhalation line 3 opens, and on inspiratory line 2 valve 19 is closed. The valves 19, 20 are a standard option and can be performed, for example, in the form of flap valves. The inhalation device is not seeded with microorganisms, thanks to the use of a bacterial-viral filter 18, and the gas distribution unit 1 is sterilized using standard sterilization methods (boiling, autoclaving, treatment with disinfectant solutions, etc.).

The respiratory mask 4 by the inhalation / exhalation line 2.3 through the bacterial-viral filter 18, valves 19.20, shutters 21.22, is connected to the gas distribution unit 1.

Shutters 21.22 for opening and closing the breathing circuit are located at the outlet of the gas distribution unit I and perform two functions - firstly, they prevent the loss of the gas mixture from the gas distribution unit 1 during depressurization of the respiratory circuit, the second function of the valves is that they open after the procedure, and is created the ability to collect the spent mixture from the respiratory. bag 8 and other components of the respiratory circuit in the block capture xenon 11 (BUK).

The gas analyzer 5 allows you to control the oxygen and xenon content in the gas mixture in the gas mixture preparation option in the gas distribution unit 1. And also, the gas analyzer allows you to control the oxygen and xenon consumption during the inhalation procedure. Sensors 6.7 of the gas analyzer are located directly inside the gas distribution unit 1 in the grooved channels, and not in the gas stream of the inhalation / expiration line, which provides less breathing resistance and makes the main external gas breathing circuit shorter.

An embodiment of the invention The method is as follows. The device is preparing for the procedure. To the gas distribution unit 1 is connected through the unit

10 gas supply sources with gases 12-16 necessary for the procedure. The gas distribution unit 1 and the breathing tank 8 are filled with a gas mixture with open shutters 21, 22 and a closed inspiratory valve 19 under the control of the gas composition of the mixture with a gas analyzer 5.

In the case of using cylinders separately with oxygen 13 and separately with xenon 14, the breathing circuit is preliminarily filled with the inspiratory valve 19 closed, first with oxygen and then with xenon under the control of the gas analyzer 5 to the xenon content: oxygen 70-10: 30-90%. After filling the gas distribution unit 1 and the breathing circuit with a gas mixture, close the valve of the gas supply unit 10.

The inhalation procedure is carried out on an empty stomach. When the total cholesterol content in the patient’s blood serum is more than 5.0 mmol / L, inhalation is carried out for 7-10 days with pharmacological drugs that reduce its level, for example, nicotinic acid, or others. The patient is prescribed a low lipid diet. For 15-45 minutes before inhalation, the patient takes 200-400 ml of warm water t = 30-40 °. The patient is given a horizontal position or a horizontal position with the head end lowered by 5-10 °.

Immediately before inhalation with a xenon-oxygen mixture, the patient for preferably 1 minute. independently carries out hyperventilation of the lungs by deep inhalation / exhalation, after which it produces a deep exhalation into the atmosphere. Then it holds the breath, while holding the breath, the patient is connected to the device (an anesthetic respiratory mask 4 is put on). Then, the inspiratory valve 19 immediately opens and the therapeutic gas mixture is supplied through the inspiratory / expiratory line 2.3.

The patient carries out independent breathing under the supervision of a physician. The doctor monitors the patient’s condition and when objective and subjective signs (nystagmus of the eyeballs (twitching), dizziness, paresthesia - a feeling of goosebumps, tingling, euphoria - a feeling of intoxication, redness of the skin of the face) occur, indicating a therapeutic gas mixture and a decrease oxygen content up to 20-23%, which is confirmed by the readings of the gas analyzer, stops the treatment procedure.

After the procedure, close the inspiratory valve 19, remove the mask 4, turn off the sources of the gas mixture 12-16. The spent mixture from the apparatus is sent to the xenon capture unit 1 1 for further processing (purification) and reuse of xenon.

Example 1

Patient K., 38 years old. Complaints of weakness, fatigue, decreased performance, lack of appetite, pain in the epigastric region. When examining a patient, pathology was not detected. Laboratory and instrumental studies: FGDS - the phenomenon of superficial gastritis; indicators of the autonomic nervous system - Kerdo index +8, Ashner test +1; hemogram - segmented neutrophils 69%, stab neutrophils 7%, eosinophils 2%, monocytes 3%, lymphocytes 19%, the total number of leukocytes 4,5 10 9 / l; hematocrit 49%; total cholesterol - 5.3 mmol / l.

Diagnosis: chronic fatigue syndrome, chronic stress. Appointed therapy by inhalation using a gas mixture of xenon and oxygen in a ratio of (50:50) 5 inhalations every other day. The first treatment session: the procedure was carried out 3 hours after a meal. Before treatment, the patient did not take warm water, was in a horizontal position with a raised head at 5-10 degrees, drug therapy was not carried out. Immediately before inhalation with a xenon-oxygen mixture, the patient for 1 min. he independently carried out hyperventilation of the lungs by deep inhalation / exhalation, after which he exhaled deeply into the atmosphere. He held his breath and at that time connected to the device through an anesthetic respiratory mask. Further, the patient carried out independent breathing under the supervision of a physician.

Objective and subjective signs of gas action (nystagmus of the eyeballs, dizziness, paresthesia - a feeling of goosebumps, tingling, euphoria - a feeling of intoxication, redness of the skin of the face appeared 180 seconds after the start of the procedure, by this time the oxygen content in the circuit had decreased to 20%. The procedure was discontinued.The patient was conscious, dizziness, nystagmus, euphoria within 3 minutes.

Second session: the procedure was performed on an empty stomach, 12 hours after a meal. Before treatment, the patient did not take warm water, was in a horizontal position with a raised head at 5-10 degrees, drug therapy was not carried out. The beginning of inhalation (see the description of the 1st session). Objective and subjective signs of gas action appeared 105 seconds after the start of the procedure, by the same time, the oxygen content in the circuit had decreased to 21%. The procedure is terminated. The patient was conscious, dizziness, nystagmus, euphoria passed within 3 minutes. Third session: the procedure was performed on an empty stomach, 12 hours after a meal. The patient took 200 ml of warm water (40 ^° C) 30 minutes before the procedure, was in a horizontal position with an elevated head of 5–10 °, and drug therapy was not carried out. Hematocrit after water intake 46%.

During the procedure, pronounced signs of gas exposure appeared 75 seconds after the start of the procedure, by this time the oxygen content in the circuit had decreased to 28%. The procedure is terminated. The patient was conscious, dizziness, nystagmus, euphoria passed within 3 minutes.

Fourth session: the procedure was performed on an empty stomach, 12 hours after a meal. The patient took 200 ml of warm water (4O ⁰ C) 30 minutes before the procedure, was in a horizontal position, his head was not raised, and pharmaceutical preparations were not carried out. During the xenon therapy procedure, pronounced signs of gas exposure appeared 60 seconds after its start, by this time the oxygen content in the circuit had decreased to 31%. The procedure is terminated. The patient was conscious dizziness, nystagmus, euphoria passed within a few minutes. Fifth session: the procedure was performed on an empty stomach, 12 hours after a meal. The patient took 400 ml of warm water (4O ⁰ C) 30 minutes before the procedure, was in a position with the tip of the head down at 10 °, and no drug therapy was carried out. The hematocrit after water intake was 44%. During the xenon therapy procedure, signs of the onset of pronounced xenon exposure appeared after 45 seconds, the oxygen in the circuit was 35%. The procedure is terminated. The patient was conscious dizziness, nystagmus, euphoria passed within 3 minutes. After 10 days of therapy, the patient's condition improved significantly, the pains in the epigastric region disappeared, appetite improved significantly, and working capacity increased. Kerdo index was - 6, Ashner test -2; hemogram - 56% segmented neutrophils, stab neutrophils 2%, eosinophils 4%, monocytes 3%, lymphocytes 35%, white blood cells 6.4 10 ⁹ L. Hematocrit - 47%. Total cholesterol - 5.1 mmol / L. Conclusion: Healthy.

An example shows that the duration of the procedure, its effectiveness, the xenon consumption has an effect: an empty stomach condition, which sharply reduces the time of the clinical effect, the level of hematocrit, at lower rates of which signs of saturation of the body with xenon are faster (Table 2.3). Also on the duration of the procedure and its effectiveness is the position of the patient (table 4). The best indicators (45 sec - the duration of the inhalation process) are recorded in patients provided that the fasting procedure is performed with the head down and after receiving warm water, which allows to reduce the hematocrit level. Example 2. Patient G. 45 years. Complaints of irritability, poor sleep, feelings of internal anxiety, periodic headaches, decreased performance. A laboratory and instrumental examination of pathological changes in internal organs and systems did not reveal blood pressure of 130/80 mm Hg, heart rate (heart rate) - 74 beats per minute. Assessment of reactive (PT) and personal anxiety (LT) according to Spielberg - Khanin: PT - 49 points (high); JIT - 43 points (moderate). Diagnosis: Almost healthy. Assigned inhalation of xenon oxygen mixture (50:50) five sessions every other day in order to improve the patient's condition.

The first treatment session: the procedure was carried out 1.5 hours after a meal. Before treatment, the patient did not take warm water, was in a horizontal position with a raised head at 5-10 degrees.

The device is filled with 3 liters of mixture. After hyperventilation of the lungs for 1 min and deep exhalation into the atmosphere through a mask, the patient is connected to the device and began to breathe in a closed circuit under the supervision of a doctor. The first signs of gas exposure (mild nystagmus, dizziness, mild euphoria) appeared after 170 seconds. After 2 minutes, the oxygen content in the circuit decreased to 20%, a feeling of suffocation appeared. 2 liters of the mixture are added to the circuit. Expressed. signs of gas effects (nystagmus of the eyeballs, dizziness, paresthesia - a feeling of goosebumps, tingling, euphoria - a feeling of intoxication, redness of the skin of the face) appeared 240 ^* seconds after the start of the procedure, by this time the oxygen content in the circuit had decreased to 20%. The procedure is terminated. The patient was conscious dizziness, nystagmus, euphoria passed within 3 minutes. Xenon consumption amounted to 5 liters.

Second session: the procedure was performed on an empty stomach 10 hours after a meal. Hematocrit 47%. Before treatment, the patient did not take warm water, was in a horizontal position with a raised head at 5-10 degrees.

The device is filled with 2.5 liters of gas mixture (50% xenon and 50% oxygen). Description of the technique for starting the procedure (see first session). The first signs of gas exposure (mild nystagmus, dizziness, mild euphoria) appeared after 50 seconds. After 2 minutes pronounced signs of exposure to gas. The duration of the procedure was 135 seconds. The oxygen concentration in the circuit is 25%. The patient was conscious of dizziness, nystagmus, euphoria passed within 2 minutes. Third session: The procedure was performed on an empty stomach 10 hours after a meal. Hematocrit 47%. The patient took 200 ml of warm water (t - 40 °) 30 minutes before the procedure, was in a horizontal position. The hematocrit was 44%. Total cholesterol 4.3 mmol / L. The device is filled with 3 liters of gas mixture (50% xenon and 50% oxygen). The first signs of gas exposure appeared after 40 seconds. After 90 seconds - pronounced signs of gas exposure. The duration of the procedure was 90 seconds. The oxygen concentration in the circuit is 24%. The patient was conscious dizziness, nystagmus, euphoria passed within 2 minutes 30 seconds. Fourth session: The procedure was performed on an empty stomach 10 hours after a meal. Hematocrit 48%. The patient took 200 ml of warm water (t ° - 4O ⁰ C) 30 minutes before the procedure, was in a horizontal position with the head end slightly down at Yugradusov. Hematocrit was 46%. The device is filled with 3 liters of gas mixture (50% xenon and 50% oxygen). The first signs of xenon exposure appeared after 30 seconds. After 60 seconds - pronounced signs of gas exposure. The duration of the procedure was 60 seconds. The oxygen concentration in the circuit is 27%. The patient was conscious, dizziness, nystagmus, euphoria passed within 2 minutes.

After the course, consisting of 5 inhalations, the sense of anxiety disappeared, sleep normalized, headaches did not bother, noted high performance. Spielberg-Khanin test after treatments: PT - 29 points (low), JIT - 40 points

(moderate). HELL - 1 10/70 mm Hg, heart rate - 68 beats. in 1 minute. Diagnosis: Healthy.

The example shows the effect of taking warm water on the hematocrit level and the effectiveness of the treatment gas inhalation procedure.

Example 3

Patient Ch. 28 years old. Complaints about a bad dream. Falls asleep for a long time, cannot sleep for more than an hour, wakes up early, sleep 4-5 hours a day. Reduced performance. From the anamnesis: due to its work, it often changes time zones for flights. Insomnia has been disturbing for 6 months. Frequent headaches. Blood pressure 140/90 mm Hg, heart rate -84 beats. in 1 minute. Diagnosis: Chronic stress, chronic insomnia. Therapy was prescribed - xenon inhalation every other day - 10 inhalations.

The first treatment session: the procedure was performed on an empty stomach. Before treatment, the patient did not take warm water, was in a horizontal position. During treatment, a modification of the gas distribution unit with an internal volume of 200 ml was used.

The device is filled with xenon-oxygen gas mixture in a ratio of 50:50. After hyperventilation of the lungs for 1 min and deep exhalation into the atmosphere through a mask, the patient is connected to the device and began to breathe in a closed circuit under the supervision of a doctor. The first signs of gas exposure (mild nystagmus, dizziness, mild euphoria) appeared after 60 seconds. After 90 seconds, the oxygen content in the circuit decreased to 25%, there were signs of a pronounced gas effect (eyeball nystagmus, dizziness, paresthesia - goosebumps, tingling, euphoria - feeling intoxication, redness of the skin of the face). The procedure is terminated. The consumption of the gas mixture was 3 liters of 400 ml., Xenon, respectively, 1 liter of 700 ml.

Second session: the procedure was performed on an empty stomach. Before treatment, the patient did not take warm water, was in a horizontal position.

During treatment, a modification of the gas distribution unit with an internal volume of 20 ml was used.

The device is filled with xenon-oxygen gas mixture in a ratio of 50:50. During the procedure, signs of pronounced xenon exposure appeared after 75 seconds. The oxygen content in the circuit decreased to 31%. The consumption of the gas mixture was 3 liters of 200 ml., Xenon, respectively, 1 liter of 600 ml.

In the second modification of the gas distribution unit, the consumption of xenon-oxygen mixture is 200 ml less, respectively, xenon 100. ml Given the high cost of xenon, this fact is significant from an economic point of view.

After the 4th session, he began to fall asleep faster - 15-20 minutes after going to bed. The sleep returned to normal by the end of the third week of xenon therapy. Headaches do not bother. An objective examination of the pathology was not detected. Efficiency returned to normal.

Blood pressure 110/70 mm Hg, ChCC-58 beats. in 1 minute.

Diagnosis: Almost healthy.

Example 4. Patient S. 54 years. Complaints of severe pain in the left half of the chest, aggravated by breathing. An ECG examination of the pathology of the heart was not detected. On palpation of the paravertebral points Th 5-Th 6, soreness and pain on palpation along the 5th intercostal space are noted on the left. HELL - 130/80 mm Hg, ChCC-72 strokes in 1 minute. When fluoroscopy of the organs of the chest cavity, pathologies of the heart and lungs were not detected, with radiography of the thoracic spine, the phenomena of osteochondrosis are determined. The content of total blood cholesterol is 6.4 mmol / L. Diagnosis: Osteochondrosis of the thoracic spine, neuralgia of the intercostal nerve Th 5 on the left.

Assigned xenon inhalation at a dose of 50:50 (xenon: oxygen) 1 time per day for 10 days. Nicotinic acid 0.1 g 4 times a day with a gradual increase in the daily dose to 3 g - treatment with a pharmaceutical product for 20 days.

The first treatment session: the procedure was performed on an empty stomach. The patient took 200 ml of warm water (t ° - 40 ° C) 30 minutes before the procedure, was in a horizontal position. The device is filled with 3 liters of mixture. After hyperventilation of the lungs for 1 min and deep exhalation into the atmosphere through a mask, the patient is connected to the device and began to breathe in a closed circuit under the supervision of a doctor.

The first signs of gas exposure (mild nystagmus, dizziness, mild euphoria) appeared after 120 seconds. The pain in breathing disappeared. After 150 seconds, the oxygen content in the circuit decreased to 21%, a therapeutic gas mixture was added to the circuit. Pronounced signs of gas exposure (eyeball nystagmus, dizziness, paresthesia - a feeling of goosebumps, tingling, euphoria - a feeling of intoxication, redness of the skin of the face) appeared 180 seconds after the start of the procedure. The procedure is terminated. The patient was conscious dizziness, nystagmus, euphoria passed within a few minutes. The flow rate of the gas mixture was 5.5 liters. The period during which the pain was mild was 3 hours, then over 8 hours the pain gradually intensified. The treatment was continued.

Fourth session: the procedure was performed on an empty stomach. The patient took 200 ml of warm water (t-40 ° C) 30 minutes before the procedure, was in a horizontal position. The content of total cholesterol is 5.6 mmol / L.

The device is filled with 3 liters of mixture. The first signs of gas exposure (mild nystagmus, dizziness, mild euphoria) appeared after 90 seconds. The pain in breathing disappeared. Pronounced signs of gas exposure 120 seconds after the start of the procedure. The procedure is terminated. The consumption of the gas mixture was 3 liters. The period during which the pain was absent was about 15 hours. There were no severe pains. The treatment was continued.

Seventh session: the procedure was performed on an empty stomach. The patient took 200 ml of warm water (t-40 ° C) 30 minutes before the procedure, was in a horizontal position. The content of total cholesterol is 5.0 mmol / l. The device is filled with 3 liters of mixture. The first signs of gas exposure (mild nystagmus, dizziness, mild euphoria) appeared after 75 seconds. Mild pain during breathing disappeared. Pronounced signs of gas exposure 100 seconds after the start of the procedure. The procedure is terminated. The consumption of the gas mixture was 3 liters. Respiratory pain did not bother. The treatment was continued.

After 10 sessions of xenon therapy, there were no complaints; there was no objective examination of pain during palpation of paravertebral points and along the fifth intercostal space on the left. The breath is painless, the dream is good.

Diagnosis: Osteochondrosis of the thoracic spine. Stage of remission. When viewed after three months, the patient has no complaints. The example shows that the duration of the xenon inhalation procedure and the consumption of xenon have a pronounced effect on total blood cholesterol. At rates of more than 5 mmol / L, the duration of the procedure increases, the consumption of xenon increases, and the effectiveness of treatment decreases.

As can be seen from the above, the use of the proposed method of inhalation and a device for its implementation has the following advantages and features.

The main differences of the proposed method and device, carried out in a closed breathing circuit are:

- moderately hyperoxic, passing into a moderately hypercapnic breathing pattern,

- preliminary preparation of the patient, both a few hours before the procedure and a few minutes, if necessary, a few days before the procedure,

- the position of the patient during the implementation of the therapy session.

All this provides a more efficient and economical mode of xenon consumption and a faster onset of clinical effects during the procedure. The device, due to the presence of a gas analyzer in it, allows you to exercise objective control over the consumption of oxygen and xenon, as well as prepare the desired treatment mixture in the circuit.

The gas analyzer, shutters, a closing valve on the inspiration / expiration line, and the presence of an outlet valve in the circuit allow more complete collection of xenon exhaled in the first minutes after the procedure into the gas recovery unit.

Reducing the internal volume of the gas distribution unit allows, before the procedure begins, to dilute with less nitrogen the air in the circuit, the therapeutic respiratory mixture. The condition on an empty stomach and preliminary preparation of the body, taking into account the state of the parameters of homeostasis (blood cholesterol, blood hematocrit values - tables 1,2,3) allows you to more quickly and more fully saturate the body with xenon. And preliminary therapy using, for example, nicotinic acid makes it possible to improve microcirculation of the brain (table 5), lower cholesterol, and ultimately increase the consumption of xenon by brain tissues. Which has a positive effect on the effectiveness of xenon treatment. Separation of the respiratory line on the inspiratory and expiratory lines, and the presence of an exhalation valve that opens during expiration and closes with increasing pressure in the circuit allows more efficient collection of xenon after the treatment procedure.

In the prototype, xenon in the blood is actively washed out with oxygen after the procedure, which leads to a decrease in the effect. therapy (1).

Placing a breathing bag on the inhalation / exhalation line between the mask and the gas distribution unit and supplying the inhalation device with the gas distribution unit and a small internal volume allows reducing the dead space of the device and breathing resistance, this also makes it possible to dilute the gas mixture less (residual atmospheric air in the circuit ) when working with a given gas mixture.

A significant role is played by the position of the patient during the procedure (table 4). A slight lowering of the head end of the patient by 5-10 degrees in a horizontal position leads to an increase in blood supply to the brain and to a more effective saturation of the patient's body with xenon. In addition, the inventive device is a mobile, multivariate, universal, quite structurally simple device.

Industrial applicability

The claimed group of inventions can be used in narcology, psychiatry, neurology, pulmonology, therapy, in the treatment of occupational diseases, preventive medicine, in the rehabilitation and recovery of the body after an illness, and also after stressful mental and physical stress.

Table 1

Effect of blood cholesterol on the duration of xenon therapy and xenon consumption (n = l 5)

table 2

The effect of hematocrit on the duration of xenon therapy and xenon consumption (n = 10)

Table 3

The effect of water intake on hematocrit and xenon therapy time (n = 10)

Таблица 4

Table 4

The influence of the position of the patient on the duration of the procedure and gas flow (n = 12)

Table 5

The effect of taking a vascular preparation (nicotinic acid 10 mg / ml - 1.0 s / c 30 minutes before the xenon therapy procedure) (n = 10)

Literature

1. Patent N "2165270 RF Method for the treatment of drug dependence. Vovk SM., Efimov B.B., Naumov CA. et al. 2000.20.04.200 l. Bull. JVeI 1

2. Pavlov B. H., Dyachenko A.I., Shulgin Yu.A. et al. Study of the physiological effects of breathing with heated oxygen-helium mixtures // Human Physiology.-2003.- T.29.-N ° 5. -P.69-73.

3. Naumov CA. et al. The role of xenon in the treatment of opium addiction // Issues of addiction. - 2002.- N "6. -P.13-18.

4. Patent N ° 2228739 The drug for adaptogenic therapy (options) and the method of its preparation. Butakov G.L., Roshchin I.N., Smetannikov V.P. et al. 2004, - 20.05.

Claims

Claim 1. An inhalation method in which intensive ventilation of the lungs with air is carried out, followed by the deepest possible exhalation of air into the environment and breath holding at the expiratory height, followed by breathing with a gas mixture of xenon and oxygen from a closed loop apparatus until the oxygen content in the mixture is at least 20% and the onset of signs of gas exposure, when the conditions for breathing with a gas mixture of “pump” against the background of total cholesterol in the patient’s blood <5 mmol / l, characterized in that tion is carried out inside the reception warm water, while during the inhalation procedure, the patient is in the supine position with the head end lowered. 2. The method of inhalation according to claim 1, characterized in that the intake of warm water inside is carried out in an amount of, preferably, 200-400 ml. 3. The inhalation method according to p. L, characterized in that the temperature of warm water is preferably 30-40 ⁰ C. 4. The method of inhalation according to claim 1, characterized in that the patient is lying on his back with his head down, preferably 5-10 degrees. 5. The method of inhalation according to claim 1, characterized in that it is administered against the background of pharmacotherapy with drugs that affect cholesterol and brain blood flow. 6. The inhalation method according to claim 1.4, characterized in that, for example, nicotinic acid is used as a drug that affects the cholesterol level and blood flow of the brain. 7. Device for inhalation with a gas mixture of xenon with oxygen, containing a gas supply unit connected to sources of compressed gases, a capture unit, a closed breathing apparatus a circuit connected to a gas supply unit and comprising a patient’s breathing mask, an inhalation / expiration line, a gas analyzer with sensors, a CO ₂ absorber, and at least one respiratory container, characterized in that it comprises a gas distribution unit connected to the patient’s breathing mask through the inhalation / exhalation line and with a gas analyzer, the sensors of which are located inside the gas distribution unit, while the gas distribution unit is made in the form of a monolith with channels for the distribution of gas mixture and and feed it into the inspiratory / expiratory line, the gas analyzer to aid in capturing unit, and respiratory line capacitance is set to the inspiratory / expiratory between the mask and the gas distribution unit. 8. The inhalation device according to claim 1, characterized in that the inspiratory / expiratory line is made in the form of two respiratory lines equipped with inspiratory and expiratory valves. 9. The inhalation device according to claim 1, characterized in that the gas distribution unit is equipped with shutters for opening and closing the respiratory circuit. 10. The inhalation device according to claim 1, characterized in that the internal volume of the gas distribution unit is preferably 20-200 ml. 11. The inhalation device according to p. L, characterized in that the gas distribution unit is made in the form of a monolith in the form of, for example, a parallelepiped.