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WO2009034975A1 - GLYCOLIDE/ ε -CAPROLACTONE COPOLYMER, SUTURES MADE BY USING THE SAME, AND PROCESSES FOR PRODUCTION OF BOTH - Google Patents

GLYCOLIDE/ ε -CAPROLACTONE COPOLYMER, SUTURES MADE BY USING THE SAME, AND PROCESSES FOR PRODUCTION OF BOTH Download PDF

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Publication number
WO2009034975A1
WO2009034975A1 PCT/JP2008/066278 JP2008066278W WO2009034975A1 WO 2009034975 A1 WO2009034975 A1 WO 2009034975A1 JP 2008066278 W JP2008066278 W JP 2008066278W WO 2009034975 A1 WO2009034975 A1 WO 2009034975A1
Authority
WO
WIPO (PCT)
Prior art keywords
glycolide
caprolactone
copolymer
units
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/066278
Other languages
French (fr)
Japanese (ja)
Inventor
Yoshitake Takahashi
Mitsutaka Matsuzaki
Toru Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gunze Ltd
Original Assignee
Gunze Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gunze Ltd filed Critical Gunze Ltd
Publication of WO2009034975A1 publication Critical patent/WO2009034975A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/78—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products
    • D01F6/84—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products from copolyesters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Textile Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

The invention provides a glycolide/ε-caprolactone copolymer which is excellent in strength and flexibility and which can give knots that are tight and little come undone (namely, that are excellent in ligation stability) when used as a suture; a process for the production of the same; and sutures made by using the copolymer. A glycolide/ε-caprolactone copolymer which comprises glycolide units and ε-caprolactone units at a mole ratio of 70:30 to 80:20, characterized in that in 1H-NMR (solvent: 1,1,1,3,3,3-hexafluoroisopropanol), the integrated signal value ratio (B/A) of a signal (B) in a δ range of 4.20 to 4.30 to a signal (A) in a δ range of 4.09 to 4.17 is 1 to 10 and that the copolymer contains a diol having five or fewer carbon atoms in an amount of 0.1 to 0.4% by mole based on the total molar amount of glycolide units and ε-caprolactone units.
PCT/JP2008/066278 2007-09-14 2008-09-10 GLYCOLIDE/ ε -CAPROLACTONE COPOLYMER, SUTURES MADE BY USING THE SAME, AND PROCESSES FOR PRODUCTION OF BOTH Ceased WO2009034975A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007239314A JP2011006496A (en) 2007-09-14 2007-09-14 SUTURE CONTAINING GLYCOLIDE/epsi-CAPROLACTONE COPOLYMER
JP2007-239314 2007-09-14

Publications (1)

Publication Number Publication Date
WO2009034975A1 true WO2009034975A1 (en) 2009-03-19

Family

ID=40451982

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/066278 Ceased WO2009034975A1 (en) 2007-09-14 2008-09-10 GLYCOLIDE/ ε -CAPROLACTONE COPOLYMER, SUTURES MADE BY USING THE SAME, AND PROCESSES FOR PRODUCTION OF BOTH

Country Status (2)

Country Link
JP (1) JP2011006496A (en)
WO (1) WO2009034975A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113881021A (en) * 2021-10-20 2022-01-04 广东粤港澳大湾区黄埔材料研究院 Terpolymer, suture line, preparation method and application thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022092014A1 (en) 2020-10-26 2022-05-05

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0343906B2 (en) * 1982-10-01 1991-07-04 Ethicon Inc
JPH04213320A (en) * 1990-02-06 1992-08-04 Ethicon Inc Segmental copolymer of epsilon-caprolactone and glycolide
JPH06277274A (en) * 1993-01-21 1994-10-04 Ethicon Inc Medical device of elastomer
US6498229B1 (en) * 2001-09-05 2002-12-24 Poly-Med, Inc. Direct synthesis of segmented glycolide copolymers and crystalline materials therefrom
JP2004131693A (en) * 2002-06-28 2004-04-30 Ethicon Inc Polymerization process for making quickly crystallizable polylactone copolymer by utilizing monofunctional and difunctional polymerization initiators
US20040084805A1 (en) * 2002-05-01 2004-05-06 Jonn Amy T. Continuous process for the preparation of absorbable monofilament fibers of block copolymers and the use thereof
JP3712849B2 (en) * 1996-12-10 2005-11-02 三井化学株式会社 Degradable monofilament and method for producing the same

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0343906B2 (en) * 1982-10-01 1991-07-04 Ethicon Inc
JPH03269013A (en) * 1982-10-01 1991-11-29 Ethicon Inc Manufacture of copolymer of glycolide with epsilon-caprolactone
JPH04213320A (en) * 1990-02-06 1992-08-04 Ethicon Inc Segmental copolymer of epsilon-caprolactone and glycolide
JPH06277274A (en) * 1993-01-21 1994-10-04 Ethicon Inc Medical device of elastomer
JP3712849B2 (en) * 1996-12-10 2005-11-02 三井化学株式会社 Degradable monofilament and method for producing the same
US6498229B1 (en) * 2001-09-05 2002-12-24 Poly-Med, Inc. Direct synthesis of segmented glycolide copolymers and crystalline materials therefrom
US20040084805A1 (en) * 2002-05-01 2004-05-06 Jonn Amy T. Continuous process for the preparation of absorbable monofilament fibers of block copolymers and the use thereof
JP2004131693A (en) * 2002-06-28 2004-04-30 Ethicon Inc Polymerization process for making quickly crystallizable polylactone copolymer by utilizing monofunctional and difunctional polymerization initiators

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113881021A (en) * 2021-10-20 2022-01-04 广东粤港澳大湾区黄埔材料研究院 Terpolymer, suture line, preparation method and application thereof
CN113881021B (en) * 2021-10-20 2023-05-02 广东粤港澳大湾区黄埔材料研究院 Terpolymer, suture and preparation method and application thereof

Also Published As

Publication number Publication date
JP2011006496A (en) 2011-01-13

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