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WO2009031576A1 - Procédé de fabrication de cristaux de chlorhydrate de valacyclovir - Google Patents

Procédé de fabrication de cristaux de chlorhydrate de valacyclovir Download PDF

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Publication number
WO2009031576A1
WO2009031576A1 PCT/JP2008/065859 JP2008065859W WO2009031576A1 WO 2009031576 A1 WO2009031576 A1 WO 2009031576A1 JP 2008065859 W JP2008065859 W JP 2008065859W WO 2009031576 A1 WO2009031576 A1 WO 2009031576A1
Authority
WO
WIPO (PCT)
Prior art keywords
valacyclovir hydrochloride
crystal
producing
hydrochloride crystal
thetav
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/065859
Other languages
English (en)
Japanese (ja)
Inventor
Tatsuya Ishikawa
Satoji Takahashi
Mayumi Sato
Makiya Ito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP2009531259A priority Critical patent/JPWO2009031576A1/ja
Publication of WO2009031576A1 publication Critical patent/WO2009031576A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cette invention porte sur un procédé de fabrication de cristaux de chlorhydrate de valacyclovir, qui permet d'obtenir simplement des cristaux anhydres de chlorhydrate de valacyclovir de pureté élevée, ayant des pics caractéristiques à des angles de diffraction (2ϑ) de 8,5 ± 0,2°, 16,3 ± 0,2°, 23,8 ± 0,2°, 26,1 ± 0,2°, et 32,2 ± 0,2° dans un motif de diffraction des rayons X fourni par une diffractométrie des rayons X sur poudre à l'aide d'un rayonnement Cu-Kα. Le procédé de production est caractérisé par le fait que l'on soumet des cristaux de chlorhydrate de valacyclovir hydraté à une transformation cristalline dans un N,N-diméthylformamide ou un solvant mixte composé d'un solvant organique et d'eau, les cristaux de chlorhydrate de valacyclovir hydraté ayant des pics caractéristiques à des angles de diffraction (2ϑ) de 3,6 ± 0,2°, 8,5 ± 0,2°, 9,4 ± 0,2°, 10,5 ± 0,2°, 10,8 ± 0,2°, 13,3 ± 0,2°, et 27,3 ± 0,2° dans un motif de diffraction des rayons X fourni par une diffractométrie des rayons X sur poudre à l'aide d'un rayonnement Cu-Kα.
PCT/JP2008/065859 2007-09-03 2008-09-03 Procédé de fabrication de cristaux de chlorhydrate de valacyclovir Ceased WO2009031576A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009531259A JPWO2009031576A1 (ja) 2007-09-03 2008-09-03 バラシクロビル塩酸塩結晶の製造方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007228275 2007-09-03
JP2007-228275 2007-09-03
US97357507P 2007-09-19 2007-09-19
US60/973,575 2007-09-19

Publications (1)

Publication Number Publication Date
WO2009031576A1 true WO2009031576A1 (fr) 2009-03-12

Family

ID=40428890

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065859 Ceased WO2009031576A1 (fr) 2007-09-03 2008-09-03 Procédé de fabrication de cristaux de chlorhydrate de valacyclovir

Country Status (2)

Country Link
JP (1) JPWO2009031576A1 (fr)
WO (1) WO2009031576A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010108417A1 (fr) * 2009-03-27 2010-09-30 浙江车头制药有限公司 Procédé de préparation d'hydrate d'aciclovir 2/3
CN110437231A (zh) * 2019-09-04 2019-11-12 上药康丽（常州）药业有限公司 一种盐酸伐昔洛韦无水晶型ⅰ的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998031683A1 (fr) * 1997-01-17 1998-07-23 Ajinomoto Co., Inc. Nouveaux cristaux de z-valacyclovir
JPH11503718A (ja) * 1995-01-20 1999-03-30 ザ、ウェルカム、ファンデーション、リミテッド グアニン誘導体
JP2000503310A (ja) * 1996-01-19 2000-03-21 グラクソ、グループ、リミテッド １日１回の投与による陰部ヘルペス治療用医薬の製造のためのバラシクロビールの使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04002192A (es) * 2001-09-07 2005-02-17 Teva Pharma Formas cristalinas de clorhidrato de valaciclovir.
US20040197396A1 (en) * 2001-11-05 2004-10-07 Fain Helen S Anhydrous crystal form of valaciclovir hydrochloride

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11503718A (ja) * 1995-01-20 1999-03-30 ザ、ウェルカム、ファンデーション、リミテッド グアニン誘導体
JP2000503310A (ja) * 1996-01-19 2000-03-21 グラクソ、グループ、リミテッド １日１回の投与による陰部ヘルペス治療用医薬の製造のためのバラシクロビールの使用
WO1998031683A1 (fr) * 1997-01-17 1998-07-23 Ajinomoto Co., Inc. Nouveaux cristaux de z-valacyclovir

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010108417A1 (fr) * 2009-03-27 2010-09-30 浙江车头制药有限公司 Procédé de préparation d'hydrate d'aciclovir 2/3
US9084792B2 (en) 2009-03-27 2015-07-21 Zhejiang Charioteer Pharmaceutical Co., Ltd. Method for preparing acyclovir 2/3 hydrate
CN110437231A (zh) * 2019-09-04 2019-11-12 上药康丽（常州）药业有限公司 一种盐酸伐昔洛韦无水晶型ⅰ的制备方法
CN110437231B (zh) * 2019-09-04 2022-04-29 上药康丽（常州）药业有限公司 一种盐酸伐昔洛韦无水晶型ⅰ的制备方法

Also Published As

Publication number Publication date
JPWO2009031576A1 (ja) 2010-12-16

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