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WO2009031576A1 - Process for producing valacyclovir hydrochloride crystal - Google Patents

Process for producing valacyclovir hydrochloride crystal Download PDF

Info

Publication number
WO2009031576A1
WO2009031576A1 PCT/JP2008/065859 JP2008065859W WO2009031576A1 WO 2009031576 A1 WO2009031576 A1 WO 2009031576A1 JP 2008065859 W JP2008065859 W JP 2008065859W WO 2009031576 A1 WO2009031576 A1 WO 2009031576A1
Authority
WO
WIPO (PCT)
Prior art keywords
valacyclovir hydrochloride
crystal
producing
hydrochloride crystal
thetav
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/065859
Other languages
French (fr)
Japanese (ja)
Inventor
Tatsuya Ishikawa
Satoji Takahashi
Mayumi Sato
Makiya Ito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP2009531259A priority Critical patent/JPWO2009031576A1/en
Publication of WO2009031576A1 publication Critical patent/WO2009031576A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention provides a process for producing a valacyclovir hydrochloride crystal which can simply produce a high-purity valacyclovir hydrochloride anhydride crystal having characteristic peaks at diffraction angles (2ϑ) of 8.5 ± 0.2°, 16.3 ± 0.2°, 23.8 ± 0.2°, 26.1 ± 0.2°, and 32.2 ± 0.2° in an X-ray diffraction pattern provided by a powdery X-ray diffractometry using a Cu-Kα radiation. The production process is characterized by subjecting a valacyclovir hydrochloride hydrate crystal to crystal transformation in an N,N-dimethylformamide or a mixed solvent composed of an organic solvent and water, the valacyclovir hydrochloride hydrate crystal having characteristic peaks at diffraction angles (2ϑ) of 3.6 ± 0.2°, 8.5 ± 0.2°, 9.4 ± 0.2°, 10.5 ± 0.2°, 10.8 ± 0.2°, 13.3 ± 0.2°, and 27.3 ± 0.2° in an X-ray diffraction pattern provided by a powdery X-ray diffractometry using a Cu-Kα radiation.
PCT/JP2008/065859 2007-09-03 2008-09-03 Process for producing valacyclovir hydrochloride crystal Ceased WO2009031576A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009531259A JPWO2009031576A1 (en) 2007-09-03 2008-09-03 Method for producing valaciclovir hydrochloride crystals

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007228275 2007-09-03
JP2007-228275 2007-09-03
US97357507P 2007-09-19 2007-09-19
US60/973,575 2007-09-19

Publications (1)

Publication Number Publication Date
WO2009031576A1 true WO2009031576A1 (en) 2009-03-12

Family

ID=40428890

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065859 Ceased WO2009031576A1 (en) 2007-09-03 2008-09-03 Process for producing valacyclovir hydrochloride crystal

Country Status (2)

Country Link
JP (1) JPWO2009031576A1 (en)
WO (1) WO2009031576A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010108417A1 (en) * 2009-03-27 2010-09-30 浙江车头制药有限公司 Method for preparing acyclovir 2/3 hydrate
CN110437231A (en) * 2019-09-04 2019-11-12 上药康丽（常州）药业有限公司 A kind of preparation method of valaciclovir hydrochlordide anhydrous crystal forms I

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998031683A1 (en) * 1997-01-17 1998-07-23 Ajinomoto Co., Inc. Novel z-valacyclovir crystals
JPH11503718A (en) * 1995-01-20 1999-03-30 ザ、ウェルカム、ファンデーション、リミテッド Guanine derivatives
JP2000503310A (en) * 1996-01-19 2000-03-21 グラクソ、グループ、リミテッド Use of valacyclobeer for the manufacture of a medicament for the treatment of genital herpes with once daily administration

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK1592004A3 (en) * 2001-09-07 2005-03-04 Teva Pharmaceutical Industries Ltd. Crystalline forms of valacyclovir hydrochloride
AU2002348022B2 (en) * 2001-11-05 2006-06-15 Glaxo Group Limited Anhydrous crystal form of valaciclovir hydrochloride

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11503718A (en) * 1995-01-20 1999-03-30 ザ、ウェルカム、ファンデーション、リミテッド Guanine derivatives
JP2000503310A (en) * 1996-01-19 2000-03-21 グラクソ、グループ、リミテッド Use of valacyclobeer for the manufacture of a medicament for the treatment of genital herpes with once daily administration
WO1998031683A1 (en) * 1997-01-17 1998-07-23 Ajinomoto Co., Inc. Novel z-valacyclovir crystals

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010108417A1 (en) * 2009-03-27 2010-09-30 浙江车头制药有限公司 Method for preparing acyclovir 2/3 hydrate
US9084792B2 (en) 2009-03-27 2015-07-21 Zhejiang Charioteer Pharmaceutical Co., Ltd. Method for preparing acyclovir 2/3 hydrate
CN110437231A (en) * 2019-09-04 2019-11-12 上药康丽（常州）药业有限公司 A kind of preparation method of valaciclovir hydrochlordide anhydrous crystal forms I
CN110437231B (en) * 2019-09-04 2022-04-29 上药康丽（常州）药业有限公司 Preparation method of valaciclovir hydrochloride anhydrous crystal form I

Also Published As

Publication number Publication date
JPWO2009031576A1 (en) 2010-12-16

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