[go: up one dir, main page]

WO2009075016A1 - 微小液滴操作デバイス及びそれを用いた反応処理方法 - Google Patents

微小液滴操作デバイス及びそれを用いた反応処理方法 Download PDF

Info

Publication number
WO2009075016A1
WO2009075016A1 PCT/JP2007/073774 JP2007073774W WO2009075016A1 WO 2009075016 A1 WO2009075016 A1 WO 2009075016A1 JP 2007073774 W JP2007073774 W JP 2007073774W WO 2009075016 A1 WO2009075016 A1 WO 2009075016A1
Authority
WO
WIPO (PCT)
Prior art keywords
flow passage
reaction vessel
base
vessel
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/073774
Other languages
English (en)
French (fr)
Inventor
Masakazu Akechi
Masaki Kanai
Naohiro Nishimoto
Nobuhiro Hanafusa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shimadzu Corp
Original Assignee
Shimadzu Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corp filed Critical Shimadzu Corp
Priority to JP2009545305A priority Critical patent/JP4962574B2/ja
Priority to PCT/JP2007/073774 priority patent/WO2009075016A1/ja
Priority to US12/746,749 priority patent/US8568668B2/en
Publication of WO2009075016A1 publication Critical patent/WO2009075016A1/ja
Anticipated expiration legal-status Critical
Priority to US14/052,299 priority patent/US10029253B2/en
Priority to US15/092,389 priority patent/US20160214109A1/en
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

反応容器内に微小液滴を精度よく注入する。 容器ベース３の一表面に反応容器５が形成されており、容器ベース３上には流路ベース１１が配置されている。流路ベース１１は容器ベース３との接合面に液体導入流路１２ａと反応容器エアー抜き流路１８ａを備えている。流路ベース１１は、反応容器５に対向して設けられ、液体導入流路１２ａの上面よりも上方側に凹んだ凹部２７も備えている。反応容器５と液体導入流路１２ａの接続部近傍において、上方から見て、凹部２７の肩部２６は反応容器５の肩部１６よりも反応容器５の中央側に配置されている。
PCT/JP2007/073774 2007-12-10 2007-12-10 微小液滴操作デバイス及びそれを用いた反応処理方法 Ceased WO2009075016A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2009545305A JP4962574B2 (ja) 2007-12-10 2007-12-10 微小液滴操作デバイス及びそれを用いた反応処理方法
PCT/JP2007/073774 WO2009075016A1 (ja) 2007-12-10 2007-12-10 微小液滴操作デバイス及びそれを用いた反応処理方法
US12/746,749 US8568668B2 (en) 2007-12-10 2007-12-10 Micro droplet operation device and reaction processing method using the same
US14/052,299 US10029253B2 (en) 2007-12-10 2013-10-11 Micro droplet operation device and reaction processing method using the same
US15/092,389 US20160214109A1 (en) 2007-12-10 2016-04-06 Micro droplet operation device and reaction processing method using the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/073774 WO2009075016A1 (ja) 2007-12-10 2007-12-10 微小液滴操作デバイス及びそれを用いた反応処理方法

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US11/746,749 A-371-Of-International US20070261956A1 (en) 2006-05-12 2007-05-10 Coating installation with carrier for substrate coating
US12/746,749 A-371-Of-International US8568668B2 (en) 2007-12-10 2007-12-10 Micro droplet operation device and reaction processing method using the same
US14/052,299 Division US10029253B2 (en) 2007-12-10 2013-10-11 Micro droplet operation device and reaction processing method using the same

Publications (1)

Publication Number Publication Date
WO2009075016A1 true WO2009075016A1 (ja) 2009-06-18

Family

ID=40755274

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/073774 Ceased WO2009075016A1 (ja) 2007-12-10 2007-12-10 微小液滴操作デバイス及びそれを用いた反応処理方法

Country Status (3)

Country Link
US (3) US8568668B2 (ja)
JP (1) JP4962574B2 (ja)
WO (1) WO2009075016A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011042334A1 (de) * 2009-10-06 2011-04-14 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Mikrofluidische struktur und verfahren zum positionieren eines flüssigkeitsvolumens in einem mikrofluidischen system
JP2013195075A (ja) * 2012-03-15 2013-09-30 Toyo Kohan Co Ltd バイオチップ用カバー、当該バイオチップ用カバーを備えるチップ装置、当該バイオチップ用カバーを用いた液体保持方法
CN103513045A (zh) * 2013-08-23 2014-01-15 宁波美康保生生物医学工程有限公司 试剂检测集成芯片
JP2014126517A (ja) * 2012-12-27 2014-07-07 Rohm Co Ltd マイクロチップ
WO2017199815A1 (ja) * 2016-05-20 2017-11-23 株式会社エンプラス 流体取扱装置
WO2021193265A1 (ja) * 2020-03-24 2021-09-30 京セラ株式会社 流路デバイス
WO2021193283A1 (ja) * 2020-03-24 2021-09-30 京セラ株式会社 流路デバイス

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2974360B1 (fr) * 2011-04-22 2014-09-12 Centre Nat Rech Scient Systeme microfluidique pour controler une carte de concentration de molecules susceptibles de stimuler une cible
WO2013029159A1 (en) 2011-08-30 2013-03-07 The Royal Institution For The Advancement Of Learning / Mcgill University Method and system for pre-programmed self-power microfluidic circuits
WO2013082316A1 (en) * 2011-11-29 2013-06-06 Caliper Life Sciences, Inc. Systems and methods for sampling of amplification products
US9689029B2 (en) 2011-12-02 2017-06-27 Caliper Life Sciences, Inc. Systems and methods for sampling of amplification products
WO2015021031A1 (en) * 2013-08-05 2015-02-12 Cam Med Llc Conformable patch pump
JP2015210242A (ja) * 2014-04-30 2015-11-24 キヤノン株式会社 流路デバイス、流路デバイスの製造方法、および検査方法
US10227556B2 (en) * 2015-09-04 2019-03-12 Wayne State University Cell culture devices for biomimetic and pathomimetic cell cultures
DE102016222040A1 (de) * 2016-11-10 2018-05-17 Robert Bosch Gmbh Mikrofluidische Vorrichtung
US11110457B2 (en) 2017-12-28 2021-09-07 Stmicroelectronics S.R.L. Analysis unit for a transportable microfluidic device, in particular for sample preparation and molecule analysis
US11511278B2 (en) * 2017-12-28 2022-11-29 Stmicroelectronics S.R.L. Solid reagent containment unit, in particular for a portable microfluidic device for sample preparation and molecule analysis
US11717825B2 (en) 2017-12-28 2023-08-08 Stmicroelectronics S.R.L. Magnetically controllable valve and portable microfluidic device having a magnetically controllable valve, in particular cartridge for sample preparation and molecule analysis
DE102020211697A1 (de) 2020-09-18 2022-03-24 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung
US12435357B2 (en) * 2022-12-22 2025-10-07 Kanso Diagnostics Ltd. Diagnostic device for detecting a target nucleic acid molecule in a biological sample

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006177850A (ja) * 2004-12-24 2006-07-06 Matsushita Electric Ind Co Ltd 流路と、この流路を用いた液体計量装置と、この液体計量装置を用いた液体分析装置と、その液体計量方法
JP2006349557A (ja) * 2005-06-17 2006-12-28 Toppan Printing Co Ltd 反応容器及びこれを用いた物質の検出方法
JP2007114162A (ja) * 2005-10-24 2007-05-10 Matsushita Electric Ind Co Ltd アッセイ方法、それを実施するためのセンサデバイス、およびセンサデバイス用測定装置
WO2007125642A1 (ja) * 2006-04-05 2007-11-08 Nikkiso Co., Ltd. 混合器、混合装置及び医療成分測定ユニット

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956150A (en) * 1985-11-27 1990-09-11 Alerchek Disposable microtiter stick
US6391578B2 (en) * 1997-04-09 2002-05-21 3M Innovative Properties Company Method and devices for partitioning biological sample liquids into microvolumes
US5869004A (en) * 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems
BR9909249B1 (pt) * 1998-03-11 2009-12-01 suporte de amostras.
AU3986501A (en) * 2000-02-23 2001-09-03 Zyomyx Inc Chips having elevated sample surfaces
EP1322949A2 (en) * 2000-10-05 2003-07-02 E.I. Du Pont De Nemours And Company Polymeric microfabricated fluidic device suitable for ultraviolet detection
JP3749991B2 (ja) 2001-10-18 2006-03-01 アイダエンジニアリング株式会社 微量液体秤取構造及び該構造を有するマイクロチップ
GB0321158D0 (en) * 2003-09-10 2003-10-08 Central Research Lab Ltd Apparatus and method for handling cells,embryos or oocytes
JP4374974B2 (ja) 2003-10-03 2009-12-02 三菱化学株式会社 微量液体操作方法を用いたタンパク質の結晶化方法
EP1547686A1 (en) 2003-12-22 2005-06-29 F.Hoffmann-La Roche Ag Microtiter plate, system and method for processing samples
US20070014695A1 (en) * 2005-04-26 2007-01-18 Applera Corporation Systems and Methods for Multiple Analyte Detection
US8337777B2 (en) * 2006-06-28 2012-12-25 Applied Biosystems, Llc Sample distribution devices and methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006177850A (ja) * 2004-12-24 2006-07-06 Matsushita Electric Ind Co Ltd 流路と、この流路を用いた液体計量装置と、この液体計量装置を用いた液体分析装置と、その液体計量方法
JP2006349557A (ja) * 2005-06-17 2006-12-28 Toppan Printing Co Ltd 反応容器及びこれを用いた物質の検出方法
JP2007114162A (ja) * 2005-10-24 2007-05-10 Matsushita Electric Ind Co Ltd アッセイ方法、それを実施するためのセンサデバイス、およびセンサデバイス用測定装置
WO2007125642A1 (ja) * 2006-04-05 2007-11-08 Nikkiso Co., Ltd. 混合器、混合装置及び医療成分測定ユニット

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011042334A1 (de) * 2009-10-06 2011-04-14 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Mikrofluidische struktur und verfahren zum positionieren eines flüssigkeitsvolumens in einem mikrofluidischen system
JP2013195075A (ja) * 2012-03-15 2013-09-30 Toyo Kohan Co Ltd バイオチップ用カバー、当該バイオチップ用カバーを備えるチップ装置、当該バイオチップ用カバーを用いた液体保持方法
JP2014126517A (ja) * 2012-12-27 2014-07-07 Rohm Co Ltd マイクロチップ
CN103513045A (zh) * 2013-08-23 2014-01-15 宁波美康保生生物医学工程有限公司 试剂检测集成芯片
WO2017199815A1 (ja) * 2016-05-20 2017-11-23 株式会社エンプラス 流体取扱装置
WO2021193265A1 (ja) * 2020-03-24 2021-09-30 京セラ株式会社 流路デバイス
WO2021193283A1 (ja) * 2020-03-24 2021-09-30 京セラ株式会社 流路デバイス
JPWO2021193283A1 (ja) * 2020-03-24 2021-09-30
JP6991407B1 (ja) * 2020-03-24 2022-01-13 京セラ株式会社 流路デバイス
JP7361884B2 (ja) 2020-03-24 2023-10-16 京セラ株式会社 流路デバイス

Also Published As

Publication number Publication date
US20140051160A1 (en) 2014-02-20
US20100294811A1 (en) 2010-11-25
JPWO2009075016A1 (ja) 2011-04-28
US8568668B2 (en) 2013-10-29
US10029253B2 (en) 2018-07-24
US20160214109A1 (en) 2016-07-28
JP4962574B2 (ja) 2012-06-27

Similar Documents

Publication Publication Date Title
WO2009075016A1 (ja) 微小液滴操作デバイス及びそれを用いた反応処理方法
WO2009072388A1 (ja) ソケット
EP2080978A3 (en) Liquid-cooled-type cooling device
WO2011028578A3 (en) Microfluidic interface
WO2008139867A1 (ja) 分析チップおよび分析装置
WO2009132374A3 (de) Vorrichtung zum eintragen von gasbläschen in eine flüssigkeit
WO2005091844A3 (en) Stackable container lid
WO2006083892A3 (en) Fluid sensor comprising a formed plastic body and a reagent, as well as a sensor package comprising a plurality of said sensors
WO2005011988A3 (en) Method and device for filling a printing-fluid container
WO2007125468A8 (en) Fluid sample transport device with reduced dead volume for processing, controlling and/or detecting a fluid sample
WO2008143319A1 (ja) 微小気泡発生装置および方法
WO2008089969A3 (en) Electronic device comprising differential sensor mems devices and drilled substrates
WO2007101174A3 (en) Digital magnetofluidic devices and methods
EP1795498A3 (en) Package for a semiconductor device
WO2010041230A3 (en) Microfluidic integrated device for sample processing
EP1901348A3 (en) Method for sealing microcomponent
WO2012089995A3 (en) Cone and plate fluidic oscillator inserts for use with a subterranean well
WO2006039225A3 (en) Proximity head substrate meniscus flow modulation
GB2438768A (en) Microfluidics package and method of fabricating the same
WO2012015811A3 (en) Pinned-contact, oscillating liquid-liquid lens and imaging systems
WO2011068777A3 (en) Slotted configuration for optimized placement of micro-components using adhesive bonding
WO2008139866A1 (ja) 電気泳動チップおよび電気泳動装置
WO2006083473A3 (en) Apparatus and methods for producing a beverage
CN108172444B (zh) 一种高冲击惯性微流体接电开关及其制造方法
EP1958517A3 (en) Method and device for dispensing a liquid

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07859759

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009545305

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 12746749

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 07859759

Country of ref document: EP

Kind code of ref document: A1