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WO2009066763A1 - 体表適用製剤、並びに、体表適用製剤保持シート - Google Patents

体表適用製剤、並びに、体表適用製剤保持シート Download PDF

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Publication number
WO2009066763A1
WO2009066763A1 PCT/JP2008/071224 JP2008071224W WO2009066763A1 WO 2009066763 A1 WO2009066763 A1 WO 2009066763A1 JP 2008071224 W JP2008071224 W JP 2008071224W WO 2009066763 A1 WO2009066763 A1 WO 2009066763A1
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Prior art keywords
body surface
application
preparation
end portion
target substance
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Ceased
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PCT/JP2008/071224
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English (en)
French (fr)
Inventor
Kanji Takada
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Bioserentach Co Ltd
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Bioserentach Co Ltd
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Application filed by Bioserentach Co Ltd filed Critical Bioserentach Co Ltd
Priority to CA2706404A priority Critical patent/CA2706404C/en
Priority to AU2008327083A priority patent/AU2008327083B2/en
Priority to EP08851780.0A priority patent/EP2213284B1/en
Priority to US12/734,755 priority patent/US8491534B2/en
Priority to CN200880117328A priority patent/CN101868229A/zh
Priority to JP2009542602A priority patent/JP5538897B2/ja
Publication of WO2009066763A1 publication Critical patent/WO2009066763A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

　より高い吸収率と薬理学的効果を実現することができる、自己溶解性の基剤からなるマイクロニードルとマイクロニードルアレイを提供することを目的とする。 　体表適用製剤１は挿入方向に分けられた２つの区分、すなわち先端部５と後端部６とを有している。先端部５は体表挿入端２を含む区分であり、基剤溶解性の目的物質を保持している。後端部６は押圧端３を含む区分であり、主として基剤のみから構成され、目的物質を保持していない。体表適用製剤１を皮膚等の体表に挿入した際に、その後端側の一部が体表内に挿入されずに残った場合でも、目的物質が先端部５に含まれているので、目的物質の実際の投与量が所望量より少なくなることがなく、高い吸収率と薬理学的効果を実現することができる。
PCT/JP2008/071224 2007-11-21 2008-11-21 体表適用製剤、並びに、体表適用製剤保持シート Ceased WO2009066763A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2706404A CA2706404C (en) 2007-11-21 2008-11-21 Preparation for body surface application and preparation for body surface application-holding sheet
AU2008327083A AU2008327083B2 (en) 2007-11-21 2008-11-21 Preparation for application to body surface and preparation holding sheet for application to body surface
EP08851780.0A EP2213284B1 (en) 2007-11-21 2008-11-21 Preparation for application to body surface and preparation holding sheet for application to body surface
US12/734,755 US8491534B2 (en) 2007-11-21 2008-11-21 Preparation for body surface application and preparation for body surface application-holding sheet
CN200880117328A CN101868229A (zh) 2007-11-21 2008-11-21 体表适用制剂和体表适用制剂保持片
JP2009542602A JP5538897B2 (ja) 2007-11-21 2008-11-21 体表適用製剤、並びに、体表適用製剤保持シート

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007302185 2007-11-21
JP2007-302185 2007-11-21
JP2008039814 2008-02-21
JP2008-039814 2008-02-21
JP2008-182525 2008-07-14
JP2008182525 2008-07-14

Publications (1)

Publication Number Publication Date
WO2009066763A1 true WO2009066763A1 (ja) 2009-05-28

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ID=40667585

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Application Number Title Priority Date Filing Date
PCT/JP2008/071224 Ceased WO2009066763A1 (ja) 2007-11-21 2008-11-21 体表適用製剤、並びに、体表適用製剤保持シート

Country Status (8)

Country Link
US (1) US8491534B2 (ja)
EP (1) EP2213284B1 (ja)
JP (1) JP5538897B2 (ja)
KR (1) KR101555391B1 (ja)
CN (1) CN101868229A (ja)
AU (1) AU2008327083B2 (ja)
CA (1) CA2706404C (ja)
WO (1) WO2009066763A1 (ja)

Cited By (31)

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WO2010140401A1 (ja) * 2009-06-03 2010-12-09 株式会社バイオセレンタック 多孔性基盤を用いたマイクロニードル・アレイとその製造方法
JP2011206178A (ja) * 2010-03-29 2011-10-20 Toray Eng Co Ltd マイクロニードルシート及びその製造方法
JP2012090767A (ja) * 2010-10-27 2012-05-17 Bioserentack Co Ltd ワクチン抗原表皮デリバリー用溶解性３層マイクロニードル・アレイ・パッチ
EP2379160A4 (en) * 2008-12-22 2012-08-22 Univ Queensland PIECE PRODUCTION
JP2012254952A (ja) * 2011-06-08 2012-12-27 Bioserentack Co Ltd 経皮吸収製剤
WO2013002331A1 (ja) 2011-06-28 2013-01-03 株式会社バイオセレンタック 皮膚治療用微細針集積型製剤
EP2548608A4 (en) * 2010-03-19 2013-10-09 Otsuka Pharma Co Ltd PROTEOGLYCAN CONTAINING MICRONADELARRAY
WO2014142135A1 (ja) 2013-03-12 2014-09-18 武田薬品工業株式会社 マイクロニードルパッチ
US8883015B2 (en) 2008-02-07 2014-11-11 The University Of Queensland Patch production
WO2015093452A1 (ja) 2013-12-16 2015-06-25 武田薬品工業株式会社 マイクロニードル
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
US9387000B2 (en) 2008-05-23 2016-07-12 The University Of Queensland Analyte detection using a needle projection patch
KR20160125420A (ko) 2014-03-12 2016-10-31 가부시키가이샤 바이오세렌택 진피 내 목적 물질 유치용 마이크로니들 제제 투여 부재 및 마이크로니들 제제 신속 투여 기구
JP2016195847A (ja) * 2012-11-13 2016-11-24 富士フイルム株式会社 経皮吸収シート
US9572969B2 (en) 2004-01-30 2017-02-21 The University Of Queensland Delivery device
JPWO2014196522A1 (ja) * 2013-06-03 2017-02-23 凸版印刷株式会社 針状体の製造方法及び製造装置
JP2017061447A (ja) * 2015-09-21 2017-03-30 ビーアンドエル バイオテック インコーポレイティッド 歯茎の屈曲に合うように柔軟な、歯科用物質伝達のためのマイクロニードルおよびその製作方法
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JP2018535236A (ja) * 2015-11-25 2018-11-29 パイアン エステティクス インコーポレイテッド 水溶性微細ニードル粉末とこれを含有する非水系化粧剤組成物
WO2019021954A1 (ja) * 2017-07-24 2019-01-31 株式会社バイオセレンタック ワクチンアジュバント及びマイクロニードル製剤
JP2020507422A (ja) * 2017-02-17 2020-03-12 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 活性成分を含むマイクロニードルアレイ
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
US11147954B2 (en) 2015-02-02 2021-10-19 Vaxxas Pty Limited Microprojection array applicator and method
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US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
US11254126B2 (en) 2017-03-31 2022-02-22 Vaxxas Pty Limited Device and method for coating surfaces
JP2022071044A (ja) * 2014-04-24 2022-05-13 ジョージア テック リサーチ コーポレイション マイクロニードル及びその製造方法
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
JP2023087755A (ja) * 2021-12-14 2023-06-26 国立大学法人 東京大学 卵巣刺激器具及び卵巣刺激方法
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JP5770055B2 (ja) * 2010-09-29 2015-08-26 富士フイルム株式会社 針状アレイ経皮吸収シートの製造方法
GB201107642D0 (en) * 2011-05-09 2011-06-22 Univ Cork Method
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CN104703651A (zh) 2012-05-01 2015-06-10 高等教育联邦系统-匹兹堡大学 用于经皮插入的尖端负载的微针阵列
JP2015521910A (ja) * 2012-06-29 2015-08-03 イーエルシー マネージメント エルエルシー １つ以上の封入された化粧品成分を含む可溶性マイクロニードル
CA2892587A1 (en) 2012-12-14 2014-06-19 Mindera Corporation Methods and devices for detection and acquisition of biomarkers
BR112015014969B1 (pt) 2012-12-21 2021-12-07 Corium, Inc Aparelho de microestruturas e método de fabricar um aparelho de microestruturas
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US20110028905A1 (en) 2011-02-03
JP5538897B2 (ja) 2014-07-02
JPWO2009066763A1 (ja) 2011-04-07
KR101555391B1 (ko) 2015-09-23
KR20100098406A (ko) 2010-09-06
CA2706404A1 (en) 2009-05-28
AU2008327083A1 (en) 2009-05-28
CA2706404C (en) 2017-04-11
EP2213284A1 (en) 2010-08-04
CN101868229A (zh) 2010-10-20
US8491534B2 (en) 2013-07-23
EP2213284B1 (en) 2017-11-15
EP2213284A4 (en) 2012-03-21

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