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WO2008130630A3 - Polymorphic form of rimonabant hydrochloride and processes for preparation thereof - Google Patents

Polymorphic form of rimonabant hydrochloride and processes for preparation thereof Download PDF

Info

Publication number
WO2008130630A3
WO2008130630A3 PCT/US2008/005022 US2008005022W WO2008130630A3 WO 2008130630 A3 WO2008130630 A3 WO 2008130630A3 US 2008005022 W US2008005022 W US 2008005022W WO 2008130630 A3 WO2008130630 A3 WO 2008130630A3
Authority
WO
WIPO (PCT)
Prior art keywords
processes
preparation
polymorphic form
rimonabant hydrochloride
rimonabant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/005022
Other languages
French (fr)
Other versions
WO2008130630A2 (en
WO2008130630A4 (en
Inventor
Eli Lancry
Marina Kalujny
Claude Singer
Sigalit Levi
Michal Rafilovich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Teva Pharmaceuticals USA Inc
Original Assignee
Teva Pharmaceutical Industries Ltd
Teva Pharmaceuticals USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd, Teva Pharmaceuticals USA Inc filed Critical Teva Pharmaceutical Industries Ltd
Publication of WO2008130630A2 publication Critical patent/WO2008130630A2/en
Publication of WO2008130630A3 publication Critical patent/WO2008130630A3/en
Publication of WO2008130630A4 publication Critical patent/WO2008130630A4/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Addiction (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Provided is a crystalline form of Rimonabant hydrochloride, processes for its preparation and pharmaceutical compositions containing such crystalline form of Rimonabant hydrochloride.
PCT/US2008/005022 2007-04-16 2008-04-16 Polymorphic form of rimonabant hydrochloride and processes for preparation thereof Ceased WO2008130630A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92383007P 2007-04-16 2007-04-16
US60/923,830 2007-04-16

Publications (3)

Publication Number Publication Date
WO2008130630A2 WO2008130630A2 (en) 2008-10-30
WO2008130630A3 true WO2008130630A3 (en) 2009-02-19
WO2008130630A4 WO2008130630A4 (en) 2009-04-16

Family

ID=39666000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/005022 Ceased WO2008130630A2 (en) 2007-04-16 2008-04-16 Polymorphic form of rimonabant hydrochloride and processes for preparation thereof

Country Status (1)

Country Link
WO (1) WO2008130630A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102206182B (en) * 2011-04-11 2013-03-13 中国药科大学 Method for synthesizing Rimonabant hydrochloride

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006087732A1 (en) * 2005-01-06 2006-08-24 Cadila Healthcare Limited An amorphous and three crystalline forms of rimonabant hydrochloride
WO2008000418A2 (en) * 2006-06-27 2008-01-03 Sandoz Ag New method for salt preparation
US20080004313A1 (en) * 2006-06-28 2008-01-03 Mai De Ltd. Preparation of crystalline polymorphs of rimonabant hydrochloride

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006087732A1 (en) * 2005-01-06 2006-08-24 Cadila Healthcare Limited An amorphous and three crystalline forms of rimonabant hydrochloride
WO2008000418A2 (en) * 2006-06-27 2008-01-03 Sandoz Ag New method for salt preparation
US20080004313A1 (en) * 2006-06-28 2008-01-03 Mai De Ltd. Preparation of crystalline polymorphs of rimonabant hydrochloride

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"RIMONABANT HYDROCHLORIDE ANTIOBESITY DRUG AID TO SMOKING CESSATION TREATMENT OF ALCOHOL DEPENDENCY CANNABINOID CB1 ANTAGONIST", DRUGS OF THE FUTURE, BARCELONA, ES, vol. 30, no. 2, 1 January 2005 (2005-01-01), pages 128 - 137, XP008059586, ISSN: 0377-8282 *

Also Published As

Publication number Publication date
WO2008130630A2 (en) 2008-10-30
WO2008130630A4 (en) 2009-04-16

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