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WO2009007747A3 - Hydantoin derivatives used as mmp12 inhibitors - Google Patents

Hydantoin derivatives used as mmp12 inhibitors Download PDF

Info

Publication number
WO2009007747A3
WO2009007747A3 PCT/GB2008/050545 GB2008050545W WO2009007747A3 WO 2009007747 A3 WO2009007747 A3 WO 2009007747A3 GB 2008050545 W GB2008050545 W GB 2008050545W WO 2009007747 A3 WO2009007747 A3 WO 2009007747A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydantoin derivatives
derivatives used
mmp12 inhibitors
mmp12
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2008/050545
Other languages
French (fr)
Other versions
WO2009007747A2 (en
Inventor
Balint Gabos
Af Rosenschoeld Magnus Munck
Lena Ripa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
AstraZeneca AB
Original Assignee
AstraZeneca UK Ltd
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca UK Ltd, AstraZeneca AB filed Critical AstraZeneca UK Ltd
Publication of WO2009007747A2 publication Critical patent/WO2009007747A2/en
Publication of WO2009007747A3 publication Critical patent/WO2009007747A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention provides novel hydantoin derivatives; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use as MMP12 inhibitors.
PCT/GB2008/050545 2007-07-11 2008-07-08 Hydantoin derivatives used as mmp12 inhibitors Ceased WO2009007747A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94900407P 2007-07-11 2007-07-11
US60/949,004 2007-07-11

Publications (2)

Publication Number Publication Date
WO2009007747A2 WO2009007747A2 (en) 2009-01-15
WO2009007747A3 true WO2009007747A3 (en) 2009-03-05

Family

ID=39829054

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/050545 Ceased WO2009007747A2 (en) 2007-07-11 2008-07-08 Hydantoin derivatives used as mmp12 inhibitors

Country Status (1)

Country Link
WO (1) WO2009007747A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201400957UA (en) * 2009-03-25 2014-09-26 Abbott Lab Antiviral Compounds And Uses Thereof
EP2907512A1 (en) 2014-02-14 2015-08-19 Commissariat A L'energie Atomique Et Aux Energies Alternatives Inhibitors of MMP-12 as antiviral Agents
CN110627827B (en) * 2019-09-11 2022-11-08 杭州澳赛诺生物科技有限公司 Synthesis method of 4-ethynyl-tetrahydropyrane or 4-ethynyl piperidine
CN115160151B (en) * 2022-08-04 2024-01-09 合肥星宇化学有限责任公司 Preparation method of N-alkyl-2-fluoroaniline

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074767A1 (en) * 2001-03-15 2002-09-26 Astrazeneca Ab Metalloproteinase inhibitors
WO2002074750A1 (en) * 2001-03-15 2002-09-26 Astrazeneca Ab Metalloproteinase inhibitors
WO2004024718A1 (en) * 2002-09-11 2004-03-25 Astrazeneca Ab Imidazolidinedione-derivatives and their use as metalloproteinase inhibitors
WO2006004533A1 (en) * 2004-07-05 2006-01-12 Astrazeneca Ab Compounds
WO2006004532A1 (en) * 2004-07-05 2006-01-12 Astrazeneca Ab Novel hydantoin derivatives for the treatment of obstructive airway diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074767A1 (en) * 2001-03-15 2002-09-26 Astrazeneca Ab Metalloproteinase inhibitors
WO2002074750A1 (en) * 2001-03-15 2002-09-26 Astrazeneca Ab Metalloproteinase inhibitors
WO2004024718A1 (en) * 2002-09-11 2004-03-25 Astrazeneca Ab Imidazolidinedione-derivatives and their use as metalloproteinase inhibitors
WO2006004533A1 (en) * 2004-07-05 2006-01-12 Astrazeneca Ab Compounds
WO2006004532A1 (en) * 2004-07-05 2006-01-12 Astrazeneca Ab Novel hydantoin derivatives for the treatment of obstructive airway diseases

Also Published As

Publication number Publication date
WO2009007747A2 (en) 2009-01-15

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