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WO2008120800A1 - ２－ハロイミダゾール化合物の製造方法 - Google Patents

２－ハロイミダゾール化合物の製造方法 Download PDF

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Publication number
WO2008120800A1
WO2008120800A1 PCT/JP2008/056593 JP2008056593W WO2008120800A1 WO 2008120800 A1 WO2008120800 A1 WO 2008120800A1 JP 2008056593 W JP2008056593 W JP 2008056593W WO 2008120800 A1 WO2008120800 A1 WO 2008120800A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
compounds
producing
general formula
compound represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/056593
Other languages
English (en)
French (fr)
Inventor
Takeshi Kumano
Yuichi Ikeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shikoku Chemicals Corp
Original Assignee
Shikoku Chemicals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shikoku Chemicals Corp filed Critical Shikoku Chemicals Corp
Priority to CN2008800113002A priority Critical patent/CN101652350B/zh
Priority to HK10107020.7A priority patent/HK1141010B/xx
Priority to EP08739704A priority patent/EP2141151B1/en
Priority to BRPI0809082-3A priority patent/BRPI0809082A2/pt
Publication of WO2008120800A1 publication Critical patent/WO2008120800A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

　一般式（II）で示される２－ハロイミダゾール化合物を、安価な原料を使用し、且つ簡便な操作により低コストで製造することができる製造方法を提供することを目的とする。 　一般式（I）で示される２，４－ジハロイミダゾール化合物と、ヨウ素化合物と、ケトン化合物、エステル化合物またはニトリル化合物から選択される１種もしくは２種以上とを反応させる。 （但し、Ｒは水素原子、アルキル基、アリール基、ニトロ基、シアノ基、ヒドロキシアルキル基、ホルミル基またはカルボキシル基を表し、Ｘはハロゲン原子を表す。）
PCT/JP2008/056593 2007-04-03 2008-04-02 ２－ハロイミダゾール化合物の製造方法 Ceased WO2008120800A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN2008800113002A CN101652350B (zh) 2007-04-03 2008-04-02 制造2-卤代咪唑化合物的方法
HK10107020.7A HK1141010B (en) 2007-04-03 2008-04-02 Method for producing 2-haloimidazole compound
EP08739704A EP2141151B1 (en) 2007-04-03 2008-04-02 Method for producing 2-haloimidazole compound
BRPI0809082-3A BRPI0809082A2 (pt) 2007-04-03 2008-04-02 Processo para produzir composto de 2-haloimidazol

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-097005 2007-04-03
JP2007097005 2007-04-03
JP2008-073511 2008-03-21
JP2008073511A JP5072675B2 (ja) 2007-04-03 2008-03-21 ２−ハロイミダゾール化合物の製造方法

Publications (1)

Publication Number Publication Date
WO2008120800A1 true WO2008120800A1 (ja) 2008-10-09

Family

ID=39808381

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056593 Ceased WO2008120800A1 (ja) 2007-04-03 2008-04-02 ２－ハロイミダゾール化合物の製造方法

Country Status (6)

Country Link
EP (1) EP2141151B1 (ja)
JP (1) JP5072675B2 (ja)
CN (1) CN101652350B (ja)
BR (1) BRPI0809082A2 (ja)
TW (1) TWI403504B (ja)
WO (1) WO2008120800A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012500183A (ja) * 2008-08-21 2012-01-05 デイナミート ノーベル ゲゼルシャフト ミット ベシュレンクテル ハフツング エクスプロジーフシュトッフ− ウント ジステームテヒニク ２−ハロ−４−ニトロイミダゾール及びその中間体の製造方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3443601A4 (en) * 2016-04-12 2020-02-19 Northwestern University SOFT PIEZOELECTRIC AND FERROELECTRIC HALOIMIDAZOLE CRYSTALS
CN111269183A (zh) * 2020-04-09 2020-06-12 成都睿智化学研究有限公司 一种4-溴-1-甲基-1h-咪唑-5-羧酸酰胺衍生物的合成方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06211846A (ja) 1991-05-16 1994-08-02 Glaxo Group Ltd ベンゾフラン誘導体
JP2004269500A (ja) * 2002-10-15 2004-09-30 Otsuka Pharmaceut Co Ltd １位置換−４−ニトロイミダゾール化合物及びその製造法
WO2006000552A1 (de) 2004-06-23 2006-01-05 Leica Geosystems Ag Scannersystem und verfahren zur erfassung von oberflächen
JP2006117628A (ja) 2004-02-18 2006-05-11 Otsuka Pharmaceut Co Ltd ４−ニトロイミダゾール化合物の製造法
JP2007097005A (ja) 2005-09-30 2007-04-12 Hitachi Ltd 可変利得増幅器
JP2008073511A (ja) 2006-09-22 2008-04-03 Aruze Corp ゲーミングターミナル、ゲーミングシステム及びゲーム制御方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3409606A (en) * 1965-12-30 1968-11-05 American Cyanamid Co Halogenated chloroimidazole compounds
CN1326840C (zh) * 2002-10-15 2007-07-18 大塚制药株式会社 1－取代的－4－硝基咪唑化合物及其制备方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06211846A (ja) 1991-05-16 1994-08-02 Glaxo Group Ltd ベンゾフラン誘導体
JP2004269500A (ja) * 2002-10-15 2004-09-30 Otsuka Pharmaceut Co Ltd １位置換−４−ニトロイミダゾール化合物及びその製造法
JP2006117628A (ja) 2004-02-18 2006-05-11 Otsuka Pharmaceut Co Ltd ４−ニトロイミダゾール化合物の製造法
WO2006000552A1 (de) 2004-06-23 2006-01-05 Leica Geosystems Ag Scannersystem und verfahren zur erfassung von oberflächen
JP2007097005A (ja) 2005-09-30 2007-04-12 Hitachi Ltd 可変利得増幅器
JP2008073511A (ja) 2006-09-22 2008-04-03 Aruze Corp ゲーミングターミナル、ゲーミングシステム及びゲーム制御方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EVANS D.A. ET AL.: "Selective Pd0-Mediated C-C Bond Constructions on the Imidazole Ring of L-Histidine: A Practical Approach to the Synthesis of Diphthamide and Related Histidine Analogues", ANGEW. CHEM. INT. ED. ENGL., vol. 32, no. 9, 1993, pages 1326 - 1327, XP008117137 *
J. CHEM. SOC., vol. 121, 1922, pages 947
JAIN R. ET AL.: "Synthesis of Ring-Halogenated Histidines and Histamines", TETRAHEDRON, vol. 54, no. 13, 1998, pages 3235 - 3242, XP004109100 *
See also references of EP2141151A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012500183A (ja) * 2008-08-21 2012-01-05 デイナミート ノーベル ゲゼルシャフト ミット ベシュレンクテル ハフツング エクスプロジーフシュトッフ− ウント ジステームテヒニク ２−ハロ−４−ニトロイミダゾール及びその中間体の製造方法

Also Published As

Publication number Publication date
HK1141010A1 (en) 2010-10-29
EP2141151A1 (en) 2010-01-06
CN101652350B (zh) 2012-05-09
TWI403504B (zh) 2013-08-01
BRPI0809082A2 (pt) 2014-09-09
TW200848408A (en) 2008-12-16
EP2141151B1 (en) 2013-03-20
CN101652350A (zh) 2010-02-17
JP2008273940A (ja) 2008-11-13
EP2141151A4 (en) 2011-08-31
JP5072675B2 (ja) 2012-11-14

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