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WO2008111631A1 - PROCÉDÉ DE PRODUCTION DE SEL D'α-MÉTHYLBENZYLAMINE - Google Patents

PROCÉDÉ DE PRODUCTION DE SEL D'α-MÉTHYLBENZYLAMINE Download PDF

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Publication number
WO2008111631A1
WO2008111631A1 PCT/JP2008/054567 JP2008054567W WO2008111631A1 WO 2008111631 A1 WO2008111631 A1 WO 2008111631A1 JP 2008054567 W JP2008054567 W JP 2008054567W WO 2008111631 A1 WO2008111631 A1 WO 2008111631A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydrate
producing
carboxylic acid
methylbenzylamine
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/054567
Other languages
English (en)
Japanese (ja)
Inventor
Taisuke Hamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP2009504077A priority Critical patent/JPWO2008111631A1/ja
Publication of WO2008111631A1 publication Critical patent/WO2008111631A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/64—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un intermédiaire de production important pour un dérivé [1] de phtalazinone optiquement actif, utile comme produit pharmaceutique, ou un sel pharmaceutiquement acceptable de celui-ci. Un procédé de production d'acide dicarboxylique optiquement actif [1] utilisant l'intermédiaire de préparation, et un procédé de production de phtalazinone ou d'un sel pharmaceutiquement acceptable de celui-ci utilisant le procédé de préparation de l'acide dicarboxyliques, sont également décrits. Les composés (1) à (4) suivants sont spécifiquement décrits : (1) un hydrate d'un sel constitué d'acide cis-(+)-6-(3,4-diméthoxybenzoyl)cycloheptyle-3-èn-1-dicarboxylique et de (+)-α-méthylbenzylamine; (2) l'hydrate de (1) qui est un monohydrate; (3) un hydrate d'un sel constitué d'acide cis-(-)-6-(3,4-diméthoxybenzoyl)cyclohex-3-èn-1-carboxylique et de (-)-α-méthylbenzylamine; (4) l'hydrate de (3) qui est un monohydrate.
PCT/JP2008/054567 2007-03-14 2008-03-13 PROCÉDÉ DE PRODUCTION DE SEL D'α-MÉTHYLBENZYLAMINE Ceased WO2008111631A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009504077A JPWO2008111631A1 (ja) 2007-03-14 2008-03-13 α−メチルベンジルアミン塩の製法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007065184 2007-03-14
JP2007-065184 2007-03-14

Publications (1)

Publication Number Publication Date
WO2008111631A1 true WO2008111631A1 (fr) 2008-09-18

Family

ID=39759562

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/054567 Ceased WO2008111631A1 (fr) 2007-03-14 2008-03-13 PROCÉDÉ DE PRODUCTION DE SEL D'α-MÉTHYLBENZYLAMINE

Country Status (2)

Country Link
JP (1) JPWO2008111631A1 (fr)
WO (1) WO2008111631A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59110656A (ja) * 1982-12-15 1984-06-26 Hiroyuki Nohira 光学活性な１―フェニル―２―（パラ―トリル）エチルアミンの製造方法
JP2002506856A (ja) * 1998-03-14 2002-03-05 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング フタラジノンｐｄｅｉｉｉ／ｉｖ阻害剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59110656A (ja) * 1982-12-15 1984-06-26 Hiroyuki Nohira 光学活性な１―フェニル―２―（パラ―トリル）エチルアミンの製造方法
JP2002506856A (ja) * 1998-03-14 2002-03-05 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング フタラジノンｐｄｅｉｉｉ／ｉｖ阻害剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VAN DER MEY M. ET AL.: "Novel Selective Phosphodiesterase (PDE4) Inhibitors. 4. Resolution, Absolute Configuration, and PDE4 Inhibitory Activity of cis-Tetra- and cis-Hexahydrophthalazinones", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 12, 2002, pages 2526 - 2533, XP002222829 *

Also Published As

Publication number Publication date
JPWO2008111631A1 (ja) 2010-06-24

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