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WO2008111631A1 - METHOD FOR PRODUCING α-METHYLBENZYLAMINE SALT - Google Patents

METHOD FOR PRODUCING α-METHYLBENZYLAMINE SALT Download PDF

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Publication number
WO2008111631A1
WO2008111631A1 PCT/JP2008/054567 JP2008054567W WO2008111631A1 WO 2008111631 A1 WO2008111631 A1 WO 2008111631A1 JP 2008054567 W JP2008054567 W JP 2008054567W WO 2008111631 A1 WO2008111631 A1 WO 2008111631A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydrate
producing
carboxylic acid
methylbenzylamine
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/054567
Other languages
French (fr)
Japanese (ja)
Inventor
Taisuke Hamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP2009504077A priority Critical patent/JPWO2008111631A1/en
Publication of WO2008111631A1 publication Critical patent/WO2008111631A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/64—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Disclosed is an important production intermediate for an optically active phthalazinone derivative [1], which is useful as a pharmaceutical product, or a pharmaceutically acceptable salt thereof. Also disclosed are a method for producing an optically active carboxylic acid [2] using the production intermediate, and a method for producing a phthalazinone derivative or a pharmaceutically acceptable salt thereof utilizing the production method of carboxylic acid. Specifically disclosed are the following (1)-(4). (1) A hydrate of a salt composed of cis-(+)-6-(3,4-dimethoxybenzoyl)cyclohex-3-en-1-carboxylic acid and (+)-α-methylbenzylamine (2) The hydrate of (1) which is a monohydrate (3) A hydrate of a salt composed of cis-(-)-6-(3,4-dimethoxybenzoyl)cyclohex-3-en-1-carboxylic acid and (-)-α-methylbenzylamine (4) The hydrate of (3) which is a monohydrate
PCT/JP2008/054567 2007-03-14 2008-03-13 METHOD FOR PRODUCING α-METHYLBENZYLAMINE SALT Ceased WO2008111631A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009504077A JPWO2008111631A1 (en) 2007-03-14 2008-03-13 Preparation of α-methylbenzylamine salt

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007065184 2007-03-14
JP2007-065184 2007-03-14

Publications (1)

Publication Number Publication Date
WO2008111631A1 true WO2008111631A1 (en) 2008-09-18

Family

ID=39759562

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/054567 Ceased WO2008111631A1 (en) 2007-03-14 2008-03-13 METHOD FOR PRODUCING α-METHYLBENZYLAMINE SALT

Country Status (2)

Country Link
JP (1) JPWO2008111631A1 (en)
WO (1) WO2008111631A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59110656A (en) * 1982-12-15 1984-06-26 Hiroyuki Nohira Optical resolution of 1-phenyl-2-(p-tolyl)ethylamine
JP2002506856A (en) * 1998-03-14 2002-03-05 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Phthalazinone PDEIII / IV inhibitor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59110656A (en) * 1982-12-15 1984-06-26 Hiroyuki Nohira Optical resolution of 1-phenyl-2-(p-tolyl)ethylamine
JP2002506856A (en) * 1998-03-14 2002-03-05 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Phthalazinone PDEIII / IV inhibitor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VAN DER MEY M. ET AL.: "Novel Selective Phosphodiesterase (PDE4) Inhibitors. 4. Resolution, Absolute Configuration, and PDE4 Inhibitory Activity of cis-Tetra- and cis-Hexahydrophthalazinones", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 12, 2002, pages 2526 - 2533, XP002222829 *

Also Published As

Publication number Publication date
JPWO2008111631A1 (en) 2010-06-24

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