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WO2008108177A1 - Phosphocoumarin derivative and fluorescent probe containing the same - Google Patents

Phosphocoumarin derivative and fluorescent probe containing the same Download PDF

Info

Publication number
WO2008108177A1
WO2008108177A1 PCT/JP2008/052938 JP2008052938W WO2008108177A1 WO 2008108177 A1 WO2008108177 A1 WO 2008108177A1 JP 2008052938 W JP2008052938 W JP 2008052938W WO 2008108177 A1 WO2008108177 A1 WO 2008108177A1
Authority
WO
WIPO (PCT)
Prior art keywords
phosphocoumarin
derivative
same
fluorescent probe
probe containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/052938
Other languages
French (fr)
Japanese (ja)
Inventor
Kazuya Kikuchi
Shin Mizukami
Shuji Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Osaka Industrial Promotion Organization
University of Osaka NUC
Original Assignee
Osaka University NUC
Osaka Industrial Promotion Organization
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osaka University NUC, Osaka Industrial Promotion Organization filed Critical Osaka University NUC
Priority to JP2009502510A priority Critical patent/JPWO2008108177A1/en
Publication of WO2008108177A1 publication Critical patent/WO2008108177A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

A compound which specifically reacts with a phosphatase, has sufficiently high fluorescence intensity, and gives a fluorescent spectrum or excitation spectrum having a sufficient shift in such a degree that a ratiometric measurement can be made. The compound is a phosphocoumarin derivative represented by the general formula (I) or a salt thereof. (I) In the formula, one of R1 and R2 is hydrogen and the other is a group represented by the formula (wherein n is an integer of 1-4).
PCT/JP2008/052938 2007-03-08 2008-02-21 Phosphocoumarin derivative and fluorescent probe containing the same Ceased WO2008108177A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009502510A JPWO2008108177A1 (en) 2007-03-08 2008-02-21 Phosphocoumarin derivatives and fluorescent probes containing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-059058 2007-03-08
JP2007059058 2007-03-08

Publications (1)

Publication Number Publication Date
WO2008108177A1 true WO2008108177A1 (en) 2008-09-12

Family

ID=39738074

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052938 Ceased WO2008108177A1 (en) 2007-03-08 2008-02-21 Phosphocoumarin derivative and fluorescent probe containing the same

Country Status (2)

Country Link
JP (1) JPWO2008108177A1 (en)
WO (1) WO2008108177A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020039708A1 (en) 2018-08-23 2020-02-27 国立大学法人九州大学 Organic electroluminescence element

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005206A1 (en) * 1985-02-27 1986-09-12 University Of Cincinnati Viable microorganism detection by induced fluorescence
JPH0223898A (en) * 1988-03-29 1990-01-26 Biocontrol Syst Inc Fast and highly sensitive low pressure enzyme detection and measurement system
CN1995029A (en) * 2006-12-14 2007-07-11 广州中医药大学 Cnidium lactone derivant and preparation method and application thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005206A1 (en) * 1985-02-27 1986-09-12 University Of Cincinnati Viable microorganism detection by induced fluorescence
JPH0223898A (en) * 1988-03-29 1990-01-26 Biocontrol Syst Inc Fast and highly sensitive low pressure enzyme detection and measurement system
CN1995029A (en) * 2006-12-14 2007-07-11 广州中医药大学 Cnidium lactone derivant and preparation method and application thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020039708A1 (en) 2018-08-23 2020-02-27 国立大学法人九州大学 Organic electroluminescence element

Also Published As

Publication number Publication date
JPWO2008108177A1 (en) 2010-06-10

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