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WO2008105445A1 - Transdermal pharmaceutical composition - Google Patents

Transdermal pharmaceutical composition Download PDF

Info

Publication number
WO2008105445A1
WO2008105445A1 PCT/JP2008/053376 JP2008053376W WO2008105445A1 WO 2008105445 A1 WO2008105445 A1 WO 2008105445A1 JP 2008053376 W JP2008053376 W JP 2008053376W WO 2008105445 A1 WO2008105445 A1 WO 2008105445A1
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
transdermal
transdermal pharmaceutical
eptazocine hydrobromide
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/053376
Other languages
French (fr)
Japanese (ja)
Inventor
Takayuki Furuishi
Kazuo Tomono
Toyofumi Suzuki
Toshiro Fukami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon University
Nippon Zoki Pharmaceutical Co Ltd
Original Assignee
Nihon University
Nippon Zoki Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon University, Nippon Zoki Pharmaceutical Co Ltd filed Critical Nihon University
Priority to JP2009501265A priority Critical patent/JP5230596B2/en
Publication of WO2008105445A1 publication Critical patent/WO2008105445A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Disclosed is a transdermal pharmaceutical composition characterized by blending eptazocine hydrobromide with a fatty acid ester, a glycerin fatty acid ester and a glycol or a pyrrolidone. Also disclosed is a method for enhancing the transdermal absorption of eptazocine hydrobromide. The transdermal pharmaceutical composition is significantly improved in absorption of eptazocine hydrobromide through the skin, and enables the penetration of a desired amount of eptazocine hydrobromide through the skin without the need of employing injection. Therefore, the transdermal pharmaceutical composition is highly useful as a pharmaceutical agent having an excellent analgesic effect.
PCT/JP2008/053376 2007-03-01 2008-02-27 Transdermal pharmaceutical composition Ceased WO2008105445A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009501265A JP5230596B2 (en) 2007-03-01 2008-02-27 Pharmaceutical composition for transdermal absorption

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007051171 2007-03-01
JP2007-051171 2007-03-01

Publications (1)

Publication Number Publication Date
WO2008105445A1 true WO2008105445A1 (en) 2008-09-04

Family

ID=39721270

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053376 Ceased WO2008105445A1 (en) 2007-03-01 2008-02-27 Transdermal pharmaceutical composition

Country Status (2)

Country Link
JP (1) JP5230596B2 (en)
WO (1) WO2008105445A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2500038A4 (en) * 2009-11-12 2015-03-11 Univ Nihon PHATMACEUTICAL COMPOSITION FOR EXTERNAL USE /

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04217920A (en) * 1990-03-30 1992-08-07 Morimoto Kazutoshi Percutaneously absorbable composition
JPH09143061A (en) * 1995-11-20 1997-06-03 Showa Denko Kk Percutaneous absorption preparation for analgesic
JPH09315957A (en) * 1996-05-28 1997-12-09 Hisamitsu Pharmaceut Co Inc Device for percutaneous therapy
WO2006085521A1 (en) * 2005-02-10 2006-08-17 Nihon University Medicinal composition for transdermal absorption containing opipid receptor antagonist, method of producing the same and method of promoting the transdermal absorption of the antagonist

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3243564B2 (en) * 1990-08-20 2002-01-07 リードケミカル株式会社 External patch
JPH0710754A (en) * 1993-06-28 1995-01-13 Sekisui Chem Co Ltd Percutaneous absorption plaster

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04217920A (en) * 1990-03-30 1992-08-07 Morimoto Kazutoshi Percutaneously absorbable composition
JPH09143061A (en) * 1995-11-20 1997-06-03 Showa Denko Kk Percutaneous absorption preparation for analgesic
JPH09315957A (en) * 1996-05-28 1997-12-09 Hisamitsu Pharmaceut Co Inc Device for percutaneous therapy
WO2006085521A1 (en) * 2005-02-10 2006-08-17 Nihon University Medicinal composition for transdermal absorption containing opipid receptor antagonist, method of producing the same and method of promoting the transdermal absorption of the antagonist

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FURUISHI T. ET AL.: "Shuka Suisosan Eptazocine no Keihi Kyushu ni Oyobosu Sokushinzai no Eikyo", THE PHARMACEUTICAL SOCIETY OF JAPAN DAI 127 NENKAI YOSHISHU, no. 3, 5 March 2007 (2007-03-05), pages 111 + ABSTR. NO. 29P1-AM202 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2500038A4 (en) * 2009-11-12 2015-03-11 Univ Nihon PHATMACEUTICAL COMPOSITION FOR EXTERNAL USE /
AU2010319065B2 (en) * 2009-11-12 2015-03-26 Nihon University Pharmaceutical composition for external use
US9050247B2 (en) 2009-11-12 2015-06-09 Nihon University Pharmaceutical composition for external use
KR101737960B1 (en) * 2009-11-12 2017-05-19 니혼 유니버서티 Pharmaceutical composition for external use

Also Published As

Publication number Publication date
JPWO2008105445A1 (en) 2010-06-03
JP5230596B2 (en) 2013-07-10

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