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WO2008105442A1 - スルホンアミド誘導体 - Google Patents

スルホンアミド誘導体 Download PDF

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Publication number
WO2008105442A1
WO2008105442A1 PCT/JP2008/053367 JP2008053367W WO2008105442A1 WO 2008105442 A1 WO2008105442 A1 WO 2008105442A1 JP 2008053367 W JP2008053367 W JP 2008053367W WO 2008105442 A1 WO2008105442 A1 WO 2008105442A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
hydrogen atom
atom
alkyl group
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/053367
Other languages
English (en)
French (fr)
Inventor
Koki Matsubara
Atsushi Iesato
Akifumi Oomura
Koh Kawasaki
Rintaro Yamada
Minoru Seto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Pharma Corp
Original Assignee
Asahi Kasei Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Pharma Corp filed Critical Asahi Kasei Pharma Corp
Priority to JP2009501263A priority Critical patent/JP5313125B2/ja
Priority to AU2008220104A priority patent/AU2008220104B2/en
Priority to EP08720915A priority patent/EP2130828A4/en
Priority to CN2008800064612A priority patent/CN101622243B/zh
Priority to CA002679263A priority patent/CA2679263A1/en
Publication of WO2008105442A1 publication Critical patent/WO2008105442A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

　Rho キナーゼを強力に阻害する式（１）［Ａは含窒素飽和環；ｍは０～２；ｎは１～４；Ｇ1 は水素原子、塩素原子、水酸基、アルコキシ基、又はアミノ基；Ｇ2 はハロゲン原子、水酸基、シアノ基、カルボキシ基、アルキル基、アルケニル基等；Ｇ3 は水素原子、ハロゲン原子、水酸基、シアノ基、カルボキシ基、アルキル基、アルケニル基等；Ｙは単結合、又は－Ｃ(Ｒ3)(Ｒ4)－（Ｒ3 及びＲ4 は水素原子、アルキル基、又は互いに結合して飽和炭化水素環基を形成する）；Ｇ4 は水酸基（但し、Ｙは単結合である）、又は－Ｎ(Ｒ1)(Ｒ2)（Ｒ1 及びＲ2 は水素原子、アルキル基、アラルキル基、アルケニル基等）を示し；Ｇ5 はＡの環構成炭素原子における置換基であり、水素原子、フッ素原子、又はアルキル基を示す］で表される化合物又はその塩、あるいはプロドラッグであるそれらの誘導体。
PCT/JP2008/053367 2007-02-28 2008-02-27 スルホンアミド誘導体 Ceased WO2008105442A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2009501263A JP5313125B2 (ja) 2007-02-28 2008-02-27 スルホンアミド誘導体
AU2008220104A AU2008220104B2 (en) 2007-02-28 2008-02-27 Sulfonamide derivative
EP08720915A EP2130828A4 (en) 2007-02-28 2008-02-27 sulfonamide
CN2008800064612A CN101622243B (zh) 2007-02-28 2008-02-27 磺酰胺衍生物
CA002679263A CA2679263A1 (en) 2007-02-28 2008-02-27 Sulfonamide compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007048280 2007-02-28
JP2007-048280 2007-02-28

Publications (1)

Publication Number Publication Date
WO2008105442A1 true WO2008105442A1 (ja) 2008-09-04

Family

ID=39721267

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053367 Ceased WO2008105442A1 (ja) 2007-02-28 2008-02-27 スルホンアミド誘導体

Country Status (7)

Country Link
US (1) US7964613B2 (ja)
EP (1) EP2130828A4 (ja)
JP (1) JP5313125B2 (ja)
CN (1) CN101622243B (ja)
AU (1) AU2008220104B2 (ja)
CA (1) CA2679263A1 (ja)
WO (1) WO2008105442A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010146881A1 (ja) * 2009-06-19 2010-12-23 株式会社デ・ウエスタン・セラピテクス研究所 置換されたイソキノリン誘導体
EP2413701A4 (en) * 2009-03-31 2012-10-03 Univ Vanderbilt SULFONYL-AZETIDIN-3-YL-METHYLAMINE AMIDE ANALOGUES AS GLYT1 INHIBITORS, METHODS OF MAKING THEM AND USE THEREOF IN THE TREATMENT OF PSYCHIATRIC DISORDERS
JP2017513919A (ja) * 2014-04-28 2017-06-01 メッドシャイン ディスカバリー インコーポレイテッド Ｒｈｏキナーゼ阻害剤としてのイソキノリンスルホン誘導体
JP2018070562A (ja) * 2016-11-04 2018-05-10 富士アミドケミカル株式会社 ４−フルオロイソキノリンの製法
JP2020502248A (ja) * 2016-12-21 2020-01-23 バイオアクソン バイオサイエンシーズ インコーポレイテッド Ｒｈｏキナーゼ阻害剤ＢＡ‐１０４９（Ｒ）及びその活性代謝物
US11701366B2 (en) 2015-01-26 2023-07-18 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
US11814361B2 (en) 2016-12-21 2023-11-14 BioAxone BioSciences, Inc. Rho kinase inhibitor BA-1049 (R) and active metabolites thereof

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
WO2007118853A1 (en) * 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and their use as blockers of calcium channels
TW200812963A (en) * 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
US8415372B2 (en) * 2007-02-27 2013-04-09 Asahi Kasei Pharma Corporation Sulfonamide compound
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
AU2008272396B2 (en) 2007-07-02 2011-09-08 Asahi Kasei Pharma Corporation Sulfonamide Compound and Crystal Thereof
WO2009040659A2 (en) * 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
CN102993178A (zh) * 2012-12-04 2013-03-27 天津红日药业股份有限公司 具有Rho激酶抑制活性的异喹啉类化合物、制备方法及用途
CN105085525B (zh) * 2014-04-28 2019-01-04 南京明德新药研发股份有限公司 作为rho激酶抑制剂的异喹啉磺酰衍生物
CN107564048B (zh) * 2017-09-25 2020-08-21 南通大学 基于分叉点特征配准方法
WO2019057121A1 (zh) * 2017-09-25 2019-03-28 南京明德新药研发股份有限公司 一种异喹啉磺酰衍生物的晶型及其制备方法
CN108558758A (zh) * 2018-04-12 2018-09-21 苏州康润医药有限公司 一种4-氟异喹啉-5-胺的合成方法
CN113906017B (zh) * 2019-06-21 2024-07-02 广州润尔眼科生物科技有限公司 作为rock蛋白激酶抑制剂的异喹啉酮的衍生物及其应用
CN114644618A (zh) * 2020-12-21 2022-06-21 广州润尔眼科生物科技有限公司 一种作为rock蛋白激酶抑制剂的异喹啉酮型化合物的盐型及其制备方法
WO2025247293A1 (zh) * 2024-05-28 2025-12-04 润尔眼科药物（广州）有限公司 一种一氧化氮供体型化合物及其应用

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JP2020502248A (ja) * 2016-12-21 2020-01-23 バイオアクソン バイオサイエンシーズ インコーポレイテッド Ｒｈｏキナーゼ阻害剤ＢＡ‐１０４９（Ｒ）及びその活性代謝物
JP7117306B2 (ja) 2016-12-21 2022-08-12 バイオアクソン バイオサイエンシーズ インコーポレイテッド Ｒｈｏキナーゼ阻害剤ＢＡ‐１０４９（Ｒ）及びその活性代謝物
JP2022141695A (ja) * 2016-12-21 2022-09-29 バイオアクソン バイオサイエンシーズ インコーポレイテッド Ｒｈｏキナーゼ阻害剤ＢＡ‐１０４９（Ｒ）及びその活性代謝物
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JP7461414B2 (ja) 2016-12-21 2024-04-03 バイオアクソン バイオサイエンシーズ インコーポレイテッド Ｒｈｏキナーゼ阻害剤ＢＡ‐１０４９（Ｒ）及びその活性代謝物
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CN101622243A (zh) 2010-01-06
AU2008220104A1 (en) 2008-09-04
US7964613B2 (en) 2011-06-21
EP2130828A1 (en) 2009-12-09
EP2130828A4 (en) 2010-12-29
US20090048223A1 (en) 2009-02-19
CA2679263A1 (en) 2008-09-04
JPWO2008105442A1 (ja) 2010-06-03

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