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WO2005094329A8 - Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor - Google Patents

Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor

Info

Publication number
WO2005094329A8
WO2005094329A8 PCT/US2005/010444 US2005010444W WO2005094329A8 WO 2005094329 A8 WO2005094329 A8 WO 2005094329A8 US 2005010444 W US2005010444 W US 2005010444W WO 2005094329 A8 WO2005094329 A8 WO 2005094329A8
Authority
WO
WIPO (PCT)
Prior art keywords
making
compouns
methods
compositions
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/010444
Other languages
French (fr)
Other versions
WO2005094329A2 (en
WO2005094329A3 (en
Inventor
Thais Sielecki
Vidal De La Cruz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytokine Pharmasciences Inc
Original Assignee
Cytokine Pharmasciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MXPA06010793A priority Critical patent/MXPA06010793A/en
Priority to CA2557166A priority patent/CA2557166C/en
Priority to EP05742932A priority patent/EP1727542A4/en
Priority to CN2005800098795A priority patent/CN101098697B/en
Priority to JP2007505270A priority patent/JP2007530598A/en
Priority to AU2005228417A priority patent/AU2005228417A1/en
Application filed by Cytokine Pharmasciences Inc filed Critical Cytokine Pharmasciences Inc
Priority to BRPI0507818-0A priority patent/BRPI0507818A/en
Publication of WO2005094329A2 publication Critical patent/WO2005094329A2/en
Publication of WO2005094329A8 publication Critical patent/WO2005094329A8/en
Anticipated expiration legal-status Critical
Publication of WO2005094329A3 publication Critical patent/WO2005094329A3/en
Ceased legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)

Abstract

The present invention provides a compound having Formula (I) or (II): wherein B, R, X, Ar, and Y are defined herein, pharmaceutically acceptable salts thereof and pharmaceutically acceptable prodrugs thereof. The present invention also provides methods of making and using the compound.
PCT/US2005/010444 2004-03-26 2005-03-28 Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor Ceased WO2005094329A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2557166A CA2557166C (en) 2004-03-26 2005-03-28 Compounds, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor
EP05742932A EP1727542A4 (en) 2004-03-26 2005-03-28 Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor
CN2005800098795A CN101098697B (en) 2004-03-26 2005-03-28 Compounds, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor
JP2007505270A JP2007530598A (en) 2004-03-26 2005-03-28 COMPOUND, COMPOSITION, MAKING PROCESS AND METHOD OF USE FOR INHIBITION OF MACROPHAGE MIGRATION INHIBITOR
AU2005228417A AU2005228417A1 (en) 2004-03-26 2005-03-28 Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor
MXPA06010793A MXPA06010793A (en) 2004-03-26 2005-03-28 Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor.
BRPI0507818-0A BRPI0507818A (en) 2004-03-26 2005-03-28 compound and inhibition methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55644004P 2004-03-26 2004-03-26
US60/556,440 2004-03-26

Publications (3)

Publication Number Publication Date
WO2005094329A2 WO2005094329A2 (en) 2005-10-13
WO2005094329A8 true WO2005094329A8 (en) 2006-01-05
WO2005094329A3 WO2005094329A3 (en) 2007-02-08

Family

ID=35064296

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/010444 Ceased WO2005094329A2 (en) 2004-03-26 2005-03-28 Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor

Country Status (9)

Country Link
US (3) US20050250826A1 (en)
EP (1) EP1727542A4 (en)
JP (1) JP2007530598A (en)
CN (1) CN101098697B (en)
AU (1) AU2005228417A1 (en)
BR (1) BRPI0507818A (en)
CA (1) CA2557166C (en)
MX (1) MXPA06010793A (en)
WO (1) WO2005094329A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1731512T1 (en) 2004-03-05 2015-01-30 Nissan Chemical Industries, Ltd. Isoxazoline-substituted benzamide compound and noxious organism control agent
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (en) 2005-12-30 2013-10-21 Du Pont Isoxazolines for controlling invertebrate pests
CA2647163C (en) * 2006-03-24 2016-06-21 The Feinstein Institute For Medical Research Modified macrophage migration inhibitory factor inhibitors
US8623875B2 (en) 2007-06-13 2014-01-07 E.I. Du Pont De Nemours And Company Isoxazoline insecticides
TWI430995B (en) 2007-06-26 2014-03-21 Du Pont Naphthalene isoxazoline invertebrate pest control agents
WO2009003075A1 (en) 2007-06-27 2008-12-31 E.I. Du Pont De Nemours And Company Animal pest control method
TWI461411B (en) 2007-08-17 2014-11-21 Du Pont Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives
BRPI0816564B8 (en) 2007-10-03 2022-12-06 Du Pont COMPOUND, COMPOSITION FOR PROTECTING AN ANIMAL FROM AN INVERTEBRATE PARASITIC PEST AND METHOD FOR PROTECTING AN ANIMAL FROM AN INVERTEBRATE PARASITIC PEST
TW201444787A (en) 2008-04-09 2014-12-01 Du Pont Method for preparing 3-trifluoromethylchalcone (CHALCONE)
US8691824B2 (en) 2008-08-04 2014-04-08 Chdi Foundation, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US9149465B2 (en) 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8927551B2 (en) 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8765735B2 (en) 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US20130172553A1 (en) * 2009-11-25 2013-07-04 Cpsi Stockholder Trust Chiral synthesis of isoxazolines, isoxazoline compounds, and uses thereof
WO2011091040A1 (en) * 2010-01-19 2011-07-28 Cytokine Pharmasciences, Inc. Use of isoxazoline compounds and compositions in bladder cancer
NZ603584A (en) 2010-05-27 2015-02-27 Du Pont Crystalline form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
WO2013010955A1 (en) 2011-07-15 2013-01-24 Morphosys Ag Antibodies that are cross-reactive for macrophage migration inhibitory factor (mif) and d-dopachrome tautomerase (d-dt)
BR112014004845A2 (en) 2011-08-30 2017-04-04 Chdi Foundation Inc at least one chemical entity; at least one compound; pharmaceutical composition; use of a therapeutically effective amount of at least one chemical entity; packaged pharmaceutical composition
KR102181011B1 (en) 2011-08-30 2020-11-20 씨에이치디아이 파운데이션, 인코포레이티드 Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
TW201348214A (en) * 2012-04-26 2013-12-01 Toyama Chemical Co Ltd Deuterated nitrogen-containing heterocyclic carboxamide derivatives
WO2013184884A1 (en) 2012-06-06 2013-12-12 Basf Corporation Improved methods for botanical and/or algae extraction
EP2944310B1 (en) 2014-05-16 2018-03-21 Mifcare MIF inhibitors for the acute or chronic treatment of pulmonary hypertension
AU2015289492B2 (en) 2014-07-17 2020-02-20 Chdi Foundation, Inc. Methods and compositions for treating HIV-related disorders
US11397182B2 (en) 2014-10-07 2022-07-26 Cornell University Methods for prognosing and preventing metastatic liver disease

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4933464A (en) * 1988-04-25 1990-06-12 W. R. Grace & Co.-Conn. Process for forming 3-phenylisoxazolines and 3-phenylisoxazoles
JP2787602B2 (en) * 1990-01-24 1998-08-20 大鵬薬品工業株式会社 Isoxazoline derivative
JP2738486B2 (en) * 1992-11-20 1998-04-08 ファイザー製薬株式会社 New isoxazolines as anti-inflammatory agents
JPH0741459A (en) * 1993-07-29 1995-02-10 Sumitomo Pharmaceut Co Ltd New elastase inhibitor
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
US5686434A (en) * 1993-11-26 1997-11-11 Pfizer Inc. 3-aryl-2-isoxazolines as antiinflammatory agents
CZ283564B6 (en) * 1993-11-26 1998-05-13 Pfizer Inc. 3-aryl-2-isoxazoline-5-hydroxamic acids and pharmaceutical compositions based thereon
CA2185019C (en) * 1994-03-09 2000-08-08 Pfizer Limited Isoxazoline compounds as inhibitors of tnf release
US6420188B1 (en) * 1996-02-16 2002-07-16 The Picower Institute For Medical Research Screening assay for the identification of inhibitors for macrophage migration inhibitory factor
US6492428B1 (en) * 2000-07-26 2002-12-10 The Picower Institute For Medical Research Compounds having MIF antagonist activity
US6335445B1 (en) * 1997-03-24 2002-01-01 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
FR2764889B1 (en) * 1997-06-20 2000-09-01 Sod Conseils Rech Applic NOVEL 2- (IMINOMETHYL) AMINO-PHENYL DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP2003513065A (en) * 1999-10-29 2003-04-08 ザ・ピコワー・インスティチュート・フォー・メディカル・リサーチ Compound having MIF antagonist activity
WO2002100332A2 (en) * 2001-06-08 2002-12-19 Cytokine Pharmasciences, Inc. Isoxazoline compounds having mif antagonist activity
US20050202010A1 (en) * 2003-08-29 2005-09-15 Giroir Brett P. Method of treatment and bioassay involving macrophage migration inhibitory factor (MIF) as cardiac-derived myocardial depressant factor
WO2005058845A2 (en) * 2003-12-19 2005-06-30 Novo Nordisk A/S Novel glucagon antagonists/inverse agonists

Also Published As

Publication number Publication date
CA2557166A1 (en) 2005-10-13
CN101098697B (en) 2010-11-10
JP2007530598A (en) 2007-11-01
MXPA06010793A (en) 2006-12-19
WO2005094329A2 (en) 2005-10-13
CA2557166C (en) 2015-06-30
US20050250826A1 (en) 2005-11-10
EP1727542A4 (en) 2009-08-05
CN101098697A (en) 2008-01-02
BRPI0507818A (en) 2007-07-10
US20130225586A1 (en) 2013-08-29
US20080113997A1 (en) 2008-05-15
WO2005094329A3 (en) 2007-02-08
EP1727542A2 (en) 2006-12-06
AU2005228417A1 (en) 2005-10-13

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