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WO2008105376A1 - グルクロン酸転移酵素測定用蛍光プローブ - Google Patents

グルクロン酸転移酵素測定用蛍光プローブ Download PDF

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Publication number
WO2008105376A1
WO2008105376A1 PCT/JP2008/053218 JP2008053218W WO2008105376A1 WO 2008105376 A1 WO2008105376 A1 WO 2008105376A1 JP 2008053218 W JP2008053218 W JP 2008053218W WO 2008105376 A1 WO2008105376 A1 WO 2008105376A1
Authority
WO
WIPO (PCT)
Prior art keywords
measurement
fluorescent probe
fluorescein
substituent
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/053218
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English (en)
French (fr)
Inventor
Tetsuo Nagano
Yasuteru Urano
Rie Tomiyasu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tokyo NUC
Original Assignee
University of Tokyo NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tokyo NUC filed Critical University of Tokyo NUC
Priority to US12/527,793 priority Critical patent/US8309319B2/en
Priority to JP2009501231A priority patent/JP5299920B2/ja
Publication of WO2008105376A1 publication Critical patent/WO2008105376A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Pyrane Compounds (AREA)

Abstract

　グルクロン酸転移酵素測定用蛍光プローブであって、フルオレセイン誘導体［ただし、該フルオレセイン誘導体は、フルオレセインのベンゼン環における2位のカルボキシ基が他の一価の置換基（ただし該置換基はスルホ基以外の置換基であり、該置換基はカルボキシ基又はスルホ基を有することはない）で置換されており、該フルオレセイン誘導体はベンゼン環上の2位以外の位置に任意の置換基を有していてもよく、該フルオレセイン誘導体はフルオレセインの2位及び/又は7位にアルコキシ基及びハロゲン原子からなる群から選ばれる置換基を有していてもよい］を含む蛍光測定用プローブ。
PCT/JP2008/053218 2007-02-27 2008-02-26 グルクロン酸転移酵素測定用蛍光プローブ Ceased WO2008105376A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/527,793 US8309319B2 (en) 2007-02-27 2008-02-26 Fluorescent probe for measurement of UDP-glucuronosyltransferase
JP2009501231A JP5299920B2 (ja) 2007-02-27 2008-02-26 グルクロン酸転移酵素測定用蛍光プローブ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90353407P 2007-02-27 2007-02-27
US60/903,534 2007-02-27

Publications (1)

Publication Number Publication Date
WO2008105376A1 true WO2008105376A1 (ja) 2008-09-04

Family

ID=39721208

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053218 Ceased WO2008105376A1 (ja) 2007-02-27 2008-02-26 グルクロン酸転移酵素測定用蛍光プローブ

Country Status (3)

Country Link
US (1) US8309319B2 (ja)
JP (1) JP5299920B2 (ja)
WO (1) WO2008105376A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015205841A (ja) * 2014-04-22 2015-11-19 住友化学株式会社 キサンテン化合物及びその用途
WO2023132337A1 (ja) * 2022-01-06 2023-07-13 国立大学法人大阪大学 蛍光染色方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180024136A1 (en) * 2015-02-11 2018-01-25 National University Of Singapore Development of ABCG2-Sensitive Fluorescent Probe For Isolation of ABCG2low Neural Stem/Progenitor Cells
CN112725408B (zh) * 2021-01-21 2024-01-26 上海中医药大学 一种ugt酶活性检测方法及其应用
CN113307799B (zh) * 2021-05-21 2022-07-19 大连医科大学 一种检测葡萄糖醛酸转移酶1a1荧光探针及其应用
KR102811319B1 (ko) * 2023-05-04 2025-05-28 재단법인대구경북과학기술원 저분자 형광물질을 이용한 면역세포의 검출방법 및 면역세포의 종류를 구별하는 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004068115A2 (en) * 2003-01-30 2004-08-12 Bellbrook Labs, Llc Assay method for group transfer reactions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7355010B2 (en) 2003-01-30 2008-04-08 Bellbrook Labs, Llc Assay method for group transfer reactions
US7378505B2 (en) 2003-01-30 2008-05-27 Bellbrook Labs Llc Assay method for group transfer reactions
US8178669B2 (en) 2005-11-14 2012-05-15 The University Of Tokyo Fluorescent probe for peroxynitrite

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004068115A2 (en) * 2003-01-30 2004-08-12 Bellbrook Labs, Llc Assay method for group transfer reactions

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
TANAKA K. ET AL.: "Rational design of fluorescein-based fluorescence probes. Mechanism-based design of a maximum fluorescence probe for singlet oxygen", J. AM. CHEM. SOC., vol. 123, no. 11, 2001, pages 2530 - 2536 *
UENO T. ET AL.: "Rational principles for modulating fluorescence properties of fluorescein", J. AM. CHEM. SOC., vol. 126, no. 43, 2004, pages 14079 - 14085 *
URANO Y. ET AL.: "Evolution of fluorescein as a platform for finely tunable fluorescence probes", J. AM. CHEM. SOC., vol. 127, no. 13, 2005, pages 4888 - 4894, XP002481573 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015205841A (ja) * 2014-04-22 2015-11-19 住友化学株式会社 キサンテン化合物及びその用途
WO2023132337A1 (ja) * 2022-01-06 2023-07-13 国立大学法人大阪大学 蛍光染色方法

Also Published As

Publication number Publication date
US20100297681A1 (en) 2010-11-25
JP5299920B2 (ja) 2013-09-25
US8309319B2 (en) 2012-11-13
JPWO2008105376A1 (ja) 2010-06-03

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