[go: up one dir, main page]

WO2009054497A1 - 新規アミロイド親和性化合物 - Google Patents

新規アミロイド親和性化合物 Download PDF

Info

Publication number
WO2009054497A1
WO2009054497A1 PCT/JP2008/069336 JP2008069336W WO2009054497A1 WO 2009054497 A1 WO2009054497 A1 WO 2009054497A1 JP 2008069336 W JP2008069336 W JP 2008069336W WO 2009054497 A1 WO2009054497 A1 WO 2009054497A1
Authority
WO
WIPO (PCT)
Prior art keywords
substituent
group
compound
amyloid
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/069336
Other languages
English (en)
French (fr)
Inventor
Shigeyuki Tanifuji
Daisaku Nakamura
Shinya Takasaki
Yuki Okumura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Medi Physics Co Ltd
Original Assignee
Nihon Medi Physics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Medi Physics Co Ltd filed Critical Nihon Medi Physics Co Ltd
Priority to US12/739,624 priority Critical patent/US8399672B2/en
Priority to AU2008314871A priority patent/AU2008314871A1/en
Priority to CN2008801216792A priority patent/CN101903383A/zh
Priority to EP08841078A priority patent/EP2213671A4/en
Priority to CA2704027A priority patent/CA2704027A1/en
Priority to JP2009538278A priority patent/JP5313158B2/ja
Publication of WO2009054497A1 publication Critical patent/WO2009054497A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

【課題】アミロイドを標的とした画像診断プローブとして有効な化合物及び該化合物を配合した生体組織に沈着したアミロイドの検出試薬を提供する。 【解決手段】下記式にて表される化合物及び該化合物を配合してなる生体組織に沈着したアミロイドの検出試薬。 式中、Ｒ１、Ｒ２、Ｒ３は、それぞれ独立に水素、水酸基、炭素数１～４のアルキル置換基、アルキル鎖の炭素数１～４のアルコキシ置換基、及びハロゲン置換基からなる群より選ばれる基（ただし、Ｒ１、Ｒ２、Ｒ３のうち、2以上の置換基が水素であるものを除く。）、Ｒ４は、水素、水酸基、アルキル鎖の炭素数が１～４のアルコキシ置換基、及びハロゲン置換基からなる群より選ばれる基、ｍは、１～４の整数である。ここで、Ｒ１、Ｒ２、Ｒ３及びＲ４のうちの少なくとも一つは、放射性ハロゲン置換基である。
PCT/JP2008/069336 2007-10-26 2008-10-24 新規アミロイド親和性化合物 Ceased WO2009054497A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US12/739,624 US8399672B2 (en) 2007-10-26 2008-10-24 Compound having affinity for amyloid
AU2008314871A AU2008314871A1 (en) 2007-10-26 2008-10-24 Novel compound having affinity for amyloid
CN2008801216792A CN101903383A (zh) 2007-10-26 2008-10-24 对淀粉样蛋白具有亲和性的新化合物
EP08841078A EP2213671A4 (en) 2007-10-26 2008-10-24 NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID
CA2704027A CA2704027A1 (en) 2007-10-26 2008-10-24 Novel compound having affinity for amyloid
JP2009538278A JP5313158B2 (ja) 2007-10-26 2008-10-24 新規アミロイド親和性化合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-278504 2007-10-26
JP2007278504 2007-10-26

Publications (1)

Publication Number Publication Date
WO2009054497A1 true WO2009054497A1 (ja) 2009-04-30

Family

ID=40579599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069336 Ceased WO2009054497A1 (ja) 2007-10-26 2008-10-24 新規アミロイド親和性化合物

Country Status (9)

Country Link
US (1) US8399672B2 (ja)
EP (1) EP2213671A4 (ja)
JP (1) JP5313158B2 (ja)
KR (1) KR20100072344A (ja)
CN (1) CN101903383A (ja)
AU (1) AU2008314871A1 (ja)
CA (1) CA2704027A1 (ja)
TW (1) TW200918101A (ja)
WO (1) WO2009054497A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009054496A1 (ja) * 2007-10-24 2011-03-10 日本メジフィジックス株式会社 新規アミロイド親和性化合物
WO2011108236A1 (ja) * 2010-03-01 2011-09-09 日本メジフィジックス株式会社 放射性ヨウ素標識有機化合物またはその塩
WO2012161116A1 (ja) * 2011-05-20 2012-11-29 日本メジフィジックス株式会社 新規アミロイド親和性化合物
US9211350B2 (en) 2011-06-24 2015-12-15 Nihon Medi-Physics Co., Ltd. Compound with amyloid affinity
US10508109B2 (en) * 2015-09-29 2019-12-17 Oncotherapy Science, Inc. Bicyclic compound and use thereof for inhibiting SUV39H2

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200803903A (en) * 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
ES2376491T3 (es) * 2006-05-19 2012-03-14 Nihon Medi-Physics Co., Ltd. Compuesto que tiene afinidad por amiloide.
KR20090025282A (ko) * 2006-06-21 2009-03-10 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물
JPWO2008056481A1 (ja) * 2006-11-09 2010-02-25 日本メジフィジックス株式会社 放射性画像診断剤
EP2098523A4 (en) * 2006-11-17 2011-09-21 Nihon Mediphysics Co Ltd NOVEL COMPOUNDS WITH AFFINITY FOR THE AMYLOID SUBSTANCE
CA2670436A1 (en) * 2006-11-30 2008-06-05 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
KR101485445B1 (ko) 2007-02-13 2015-01-22 니혼 메디피직스 가부시키가이샤 방사성 화상진단제의 제조 방법
CA2704172A1 (en) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
CN101909658A (zh) * 2007-10-30 2010-12-08 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
CN112079861B (zh) * 2020-10-13 2023-03-21 西北师范大学 一种荧光淬灭检测氟离子的分子探针及其制备方法

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074815A2 (en) * 2000-03-31 2001-10-11 Ortho Mcneil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
WO2001074813A2 (en) * 2000-03-31 2001-10-11 Ortho Mcneil Pharmaceutical, Inc. METHOD FOR USING 2- OR 3-ARYL SUBSTITUTED IMIDAZO[1,2-a] PYRIDINES AS H3 ANTAGONISTS
JP2002523383A (ja) 1998-08-20 2002-07-30 リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア βアミロイド斑及び神経原線維変化の標識方法
WO2003106439A1 (ja) 2002-06-12 2003-12-24 株式会社ビーエフ研究所 アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬
JP2004506723A (ja) 2000-08-24 2004-03-04 ユニバーシティー　オブ　ピッツバーグ アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体
JP2005504055A (ja) 2001-08-27 2005-02-10 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア スチルベン誘導体、およびアミロイド斑の結合および画像化のためのその使用
JP2005512945A (ja) 2001-04-23 2005-05-12 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア アミロイド斑凝集阻害剤および診断用造影剤
WO2007002540A2 (en) 2005-06-24 2007-01-04 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
WO2007063946A1 (ja) 2005-11-30 2007-06-07 Fujifilm Ri Pharma Co., Ltd. アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬
WO2007135890A1 (ja) * 2006-05-19 2007-11-29 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
WO2007148755A1 (ja) * 2006-06-21 2007-12-27 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
WO2008065785A1 (en) * 2006-11-30 2008-06-05 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727145A (en) * 1986-09-22 1988-02-23 Ortho Pharmaceutical Corporation 2- Or 3- aryl substituted imidazo [1,2-a]pyridines
US4791117A (en) * 1986-09-22 1988-12-13 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers
HUP9603001A3 (en) * 1996-10-30 1999-07-28 Richter Gedeon Vegyeszet Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same
AU2001251083A1 (en) * 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as h3 antagonists
TW200803903A (en) * 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
EP2213672A4 (en) * 2007-10-24 2012-05-02 Nihon Mediphysics Co Ltd NEW CONNECTION WITH AFFINITY TO AMYLOID
CA2704172A1 (en) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
TW200922629A (en) * 2007-10-30 2009-06-01 Nihon Mediphysics Co Ltd Utilization of novel compounds with amyloid affinity and method of producing the same

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002523383A (ja) 1998-08-20 2002-07-30 リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア βアミロイド斑及び神経原線維変化の標識方法
WO2001074815A2 (en) * 2000-03-31 2001-10-11 Ortho Mcneil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
WO2001074813A2 (en) * 2000-03-31 2001-10-11 Ortho Mcneil Pharmaceutical, Inc. METHOD FOR USING 2- OR 3-ARYL SUBSTITUTED IMIDAZO[1,2-a] PYRIDINES AS H3 ANTAGONISTS
JP2004506723A (ja) 2000-08-24 2004-03-04 ユニバーシティー　オブ　ピッツバーグ アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体
JP2005512945A (ja) 2001-04-23 2005-05-12 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア アミロイド斑凝集阻害剤および診断用造影剤
JP2005504055A (ja) 2001-08-27 2005-02-10 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア スチルベン誘導体、およびアミロイド斑の結合および画像化のためのその使用
WO2003106439A1 (ja) 2002-06-12 2003-12-24 株式会社ビーエフ研究所 アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑／びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬
WO2007002540A2 (en) 2005-06-24 2007-01-04 Kung Hank F Radiolabeled-pegylation of ligands for use as imaging agents
WO2007063946A1 (ja) 2005-11-30 2007-06-07 Fujifilm Ri Pharma Co., Ltd. アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬
WO2007135890A1 (ja) * 2006-05-19 2007-11-29 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
WO2007148755A1 (ja) * 2006-06-21 2007-12-27 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
WO2008065785A1 (en) * 2006-11-30 2008-06-05 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid

Non-Patent Citations (23)

* Cited by examiner, † Cited by third party
Title
BUU-HOI, N.P. ET AL.: "2-Arylpyrrocolines and 2- Aryl-pyrimidazoles", JOURNAL OF ORGANIC CHEMISTRY, vol. 19, 1954, pages 1370 - 1375, XP008134425 *
CHRISTOPHER H. CLARK ET AL.: "Imaging Amyloid with I123 IMPY SPECT", ALZHEIMER'S & DEMENTIA: THE JOURNAL OF THE ALZHEIMER'S ASSOCIATION, vol. 2, no. 1, 2006, pages S342
DOUGLAS D. DISCHINO ET AL., J. NUCL. MED., vol. 24, 1983, pages 1030 - 1038
ERIC D. AGDEPPA ET AL.: "2-Dialkylamino-6-Acylmalononitrile Substituted Naphthalenes (DDNP Analogs): Novel Diagnostic and Therapeutic Tools in Alzheimer's Disease.", MOLECULAR IMAGING AND BIOLOGY, vol. 5, 2003, pages 404 - 417
FURUMOTO Y ET AL.: "[11C]BF-227: A New 11C-Labeled 2-Ethenylbenzoxazole Derivative for Amyloid-? Plaques Imaging.", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 32, no. 1, 2005, pages 759
G. MCKHANN ET AL.: "Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alsheimer's Disease.", NEUROLOGY, vol. 34, 1984, pages 939 - 944
H. F. KUNG ET AL., J. AM. CHEM. SOC., vol. 123, 2001, pages 12740 - 12741
H. F. KUNG ET AL.: "Novel Stilbenes as Probes for amyloid plaques.", J. AMERICAN CHEMICAL SOCIETY, vol. 123, 2001, pages 12740 - 12741
HIROYUKI ARAL ET AL.: "11CJ-BF-227 AND PET to Visualize Amyloid in Alzheimer's Disease Patients", ALZHEIMER'S & DEMENTIA: THE JOURNAL OF THE ALZHEIMER'S ASSOCIATION, vol. 2, no. 1, 2006, pages S312
J. A. HARDY; G. A. HIGGINS: "Alzheimer's Disease: The Amyloid Cascade Hypothesis.", SCIENCE, vol. 256, 1992, pages 184 - 185
KING, L. CARROLL; OSTRUM, G. KENNETH, JOURNAL OF ORGANIC CHEMISTRY, vol. 29, no. 12, 1964, pages 3459 - 3461
MASAHIRO ONO ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 30, 2003, pages 565 - 571
MASAHIRO ONO ET AL.: "11C-labeled stilbene derivatives as A?-aggregate-specific PET imaging agents for Alzheimer's disease", NUCLEAR MEDICINE AND BIOLOGY, vol. 30, 2003, pages 565 - 571
NICOLAAS P. L. G. VERHOEFF ET AL.: "In-Vivo Imaging of Alzheimer Disease ?-Amyloid With [11C]SB-13 PET.", AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, vol. 12, 2004, pages 584 - 595
SANFILIPPO, P. ET AL.: "Synthesis of (Aryloxy) alkylamines. 2. Novel Imidazo-fused Heterocycles with Calcium Channel Blocking and Local Anesthetic Activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. LL, pages 2221 - 2227, XP002182515 *
See also references of EP2213671A4
SHAH, C. ET AL.: "Novel Human Histamine H3 Receptor Antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, 2002, pages 3309 - 3312, XP002353596 *
W. E. KLUNK: "Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.", ANN. NEUROL., vol. 55, 2004, pages 306 - 319
Z.-P. ZHUANG ET AL.: "Radioiodinated Styrylbenzenes and Thioflavins as Probes for Amyloid Aggregates.", J. MED. CHEM, vol. 44, 2001, pages 1905 - 1914
ZHI-PING ZHUANG ET AL., J. MED. CHEM, vol. 46, 2003, pages 237 - 243
ZHI-PING ZHUANG ET AL.: "Structure-Activity Relationship of Imidazo[1,2-a]pyridines as Ligands for Detecting ?-Amyloid Plaques in the Brain.", J. MED. CHEM, vol. 46, 2003, pages 237 - 243
ZHI-PING ZHUANG: "IBOX (2-(4'-dimethylaminophenyl)-6-iodobensoxazole) : a ligand for imaging amyloid plaques in the brain.", NUCLEAR MEDICINE AND BIOLOGY, vol. 28, 2001, pages 887 - 894
ZHI-PINQ ZHUANG ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 28, 2001, pages 887 - 894

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009054496A1 (ja) * 2007-10-24 2011-03-10 日本メジフィジックス株式会社 新規アミロイド親和性化合物
WO2011108236A1 (ja) * 2010-03-01 2011-09-09 日本メジフィジックス株式会社 放射性ヨウ素標識有機化合物またはその塩
JP5073871B2 (ja) * 2010-03-01 2012-11-14 日本メジフィジックス株式会社 放射性ヨウ素標識有機化合物またはその塩
US8476449B2 (en) 2010-03-01 2013-07-02 Nihon Medi-Physics Co., Ltd. Radioactive iodine labeled organic compound or salt thereof
WO2012161116A1 (ja) * 2011-05-20 2012-11-29 日本メジフィジックス株式会社 新規アミロイド親和性化合物
JP5272110B2 (ja) * 2011-05-20 2013-08-28 日本メジフィジックス株式会社 新規アミロイド親和性化合物
US9149546B2 (en) 2011-05-20 2015-10-06 Nihon Medi-Physics Co., Ltd. Compound having affinity for amyloid
US9211350B2 (en) 2011-06-24 2015-12-15 Nihon Medi-Physics Co., Ltd. Compound with amyloid affinity
US10508109B2 (en) * 2015-09-29 2019-12-17 Oncotherapy Science, Inc. Bicyclic compound and use thereof for inhibiting SUV39H2
AU2021201573B2 (en) * 2015-09-29 2022-02-17 Oncotherapy Science, Inc. Bicyclic compound and use thereof for inhibiting suv39h2

Also Published As

Publication number Publication date
AU2008314871A1 (en) 2009-04-30
US8399672B2 (en) 2013-03-19
CA2704027A1 (en) 2009-04-30
TW200918101A (en) 2009-05-01
KR20100072344A (ko) 2010-06-30
EP2213671A1 (en) 2010-08-04
JPWO2009054497A1 (ja) 2011-03-10
US20100292479A1 (en) 2010-11-18
JP5313158B2 (ja) 2013-10-09
CN101903383A (zh) 2010-12-01
EP2213671A4 (en) 2012-02-22

Similar Documents

Publication Publication Date Title
WO2009054497A1 (ja) 新規アミロイド親和性化合物
WO2009054496A1 (ja) 新規アミロイド親和性化合物
WO2009057578A1 (ja) 新規アミロイド親和性化合物の使用及び製造方法
NO20090233L (no) Ny sammensetning som har affinitet for amyloid
PT2192109E (pt) Derivado de -aminoácido bicíclico
WO2008087933A1 (ja) ＩκＢキナーゼβ阻害活性を有する新規インドール誘導体
TW200716619A (en) Heterocyclic compound
NO20074093L (no) Fremgangsmater for fremstilling av glukopyranosyl-substituerte benzyl-benzenderivater og mellomprodukter derav
WO2008028688A3 (en) Compounds and methods for 18f labeled agents
BRPI0711818A2 (pt) novo composto com afinidade pela amilóide
MA29539B1 (fr) Procedes de production de derives phenoliques 4-biphenylylazetidin -2-one
WO2008126831A1 (ja) ピロール誘導体のアトロプ異性体
TN2010000061A1 (en) Tricyclic bridged cyclopentanedione derivatives as herbicides
EA017861B9 (ru) Способ получения 4-оксохинолинового соединения
MX2010003576A (es) Nuevos compuestos como antagonistas de los receptores a1 de adenosina.
IL198995A0 (en) Novel compound having affinity for amyloid
WO2007103508A3 (en) Ligands for nematode nuclear receptors and uses thereof
NO20084897L (no) Ny forbindelse med affinitet til amuloid
TN2009000100A1 (en) Silicon derivatives for pet imaging
CR11084A (es) Compuesto biciclico y uso farmaceutico del mismo
WO2009057576A1 (ja) 新規アミロイド親和性化合物の使用及び製造方法
WO2008105376A1 (ja) グルクロン酸転移酵素測定用蛍光プローブ
WO2009057577A1 (ja) 新規アミロイド親和性化合物の使用及び製造方法
WO2008062167A3 (en) Melatonin derivatives and their use as antioxidants
WO2008063548A3 (en) 5, 6, or 7-substituted-s- (hetero)arylisoquinolinamine derivatives as antitumor agents

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880121679.2

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08841078

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009538278

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2704027

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 12739624

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2008841078

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 20107010119

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2008314871

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2008314871

Country of ref document: AU

Date of ref document: 20081024

Kind code of ref document: A