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WO2008010042A3 - Improved process for the preparation of cefepime intermediate - Google Patents

Improved process for the preparation of cefepime intermediate Download PDF

Info

Publication number
WO2008010042A3
WO2008010042A3 PCT/IB2007/001897 IB2007001897W WO2008010042A3 WO 2008010042 A3 WO2008010042 A3 WO 2008010042A3 IB 2007001897 W IB2007001897 W IB 2007001897W WO 2008010042 A3 WO2008010042 A3 WO 2008010042A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
cefepime
improved process
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/001897
Other languages
French (fr)
Other versions
WO2008010042A2 (en
Inventor
Sureshkumar Kanagaraj
Mohan Singaravel
Narayanan Arunkumar Lakshmi
Palanisamy Senth Udayampalayam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orchid Pharma Ltd
Original Assignee
Orchid Chemicals and Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals and Pharmaceuticals Ltd filed Critical Orchid Chemicals and Pharmaceuticals Ltd
Publication of WO2008010042A2 publication Critical patent/WO2008010042A2/en
Publication of WO2008010042A3 publication Critical patent/WO2008010042A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a process for the preparation of the compound of formula (I) wherein X represents iodo or chloro. The compound of formula (I) is an important intermediate in the preparation of Cefepime or its pharmaceutically acceptable salts.
PCT/IB2007/001897 2006-07-18 2007-07-09 Improved process for the preparation of cefepime intermediate Ceased WO2008010042A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1246/CHE/2006 2006-07-18
IN1246CH2006 2006-07-18

Publications (2)

Publication Number Publication Date
WO2008010042A2 WO2008010042A2 (en) 2008-01-24
WO2008010042A3 true WO2008010042A3 (en) 2008-06-12

Family

ID=38957140

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/001897 Ceased WO2008010042A2 (en) 2006-07-18 2007-07-09 Improved process for the preparation of cefepime intermediate

Country Status (1)

Country Link
WO (1) WO2008010042A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10568328B2 (en) 2013-03-15 2020-02-25 Monsanto Technology Llc Methods and compositions for weed control

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594131A (en) * 1992-07-24 1997-01-14 Bristol-Myers Squibb Company Process for preparing cephalosporin intermediates
WO2006008749A1 (en) * 2004-07-16 2006-01-26 Hetero Drugs Limited Process for preparing pure cephalosporine intermediates
WO2006075244A2 (en) * 2005-01-17 2006-07-20 Orchid Chemicals & Pharmaceuticals Ltd Improved process for the preparation of cephalosporin antibiotic intermediate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594131A (en) * 1992-07-24 1997-01-14 Bristol-Myers Squibb Company Process for preparing cephalosporin intermediates
WO2006008749A1 (en) * 2004-07-16 2006-01-26 Hetero Drugs Limited Process for preparing pure cephalosporine intermediates
WO2006075244A2 (en) * 2005-01-17 2006-07-20 Orchid Chemicals & Pharmaceuticals Ltd Improved process for the preparation of cephalosporin antibiotic intermediate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WALKER D.G. ET AL.: "Use of bistrimethylsilylated intermediates in the preparation of semisynthetic 7-amino-3-substituted cephems. Expedient syntheses of a new 3-[(1-methyl-1-pyrrolidinio)methyl]cephalosporin", J. ORG. CHEM., vol. 53, no. 5, 1988, pages 983 - 991 *

Also Published As

Publication number Publication date
WO2008010042A2 (en) 2008-01-24

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