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WO2008007321A3 - Cross-linked chitosan and process to cross-link - Google Patents

Cross-linked chitosan and process to cross-link Download PDF

Info

Publication number
WO2008007321A3
WO2008007321A3 PCT/IB2007/052659 IB2007052659W WO2008007321A3 WO 2008007321 A3 WO2008007321 A3 WO 2008007321A3 IB 2007052659 W IB2007052659 W IB 2007052659W WO 2008007321 A3 WO2008007321 A3 WO 2008007321A3
Authority
WO
WIPO (PCT)
Prior art keywords
cross
suspension
chitosan
link
chitosans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2007/052659
Other languages
French (fr)
Other versions
WO2008007321A2 (en
Inventor
Cosmo Mezzina
Giovanni Scapagnini
Ivo Volpato
Bernard Bizzini
Giovanni Franchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sirc SpA Natural & Dietetic Foods
Sirc SpA Natural & Dietetic Fo
Original Assignee
Sirc SpA Natural & Dietetic Foods
Sirc SpA Natural & Dietetic Fo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sirc SpA Natural & Dietetic Foods, Sirc SpA Natural & Dietetic Fo filed Critical Sirc SpA Natural & Dietetic Foods
Priority to EP07805070A priority Critical patent/EP2044127A2/en
Publication of WO2008007321A2 publication Critical patent/WO2008007321A2/en
Publication of WO2008007321A3 publication Critical patent/WO2008007321A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The present invention relates to Chitosans in crosslinked form wherein the crosslink derives from the reaction of said chitosans with a crosslinker chosen from among the group of aliphatic aldehydes, and to a Chitosan crosslinking process comprising the following stages: 1) suspend chitosan in a buffer solution having a pH that ranges between 7.5 and 9.5, preferably between 8.0 and 9.0, and more preferably between 8.1 and 8.3 (suspension 1); 2) place suspension (1) in contact with an aliphatic aldehyde as crosslinker and leave to react for 1 to 24 hours at a temperature of between 15- and 40 -C (suspension 2); and possibly: 3) treat suspension (2) with an organic amine compound.
PCT/IB2007/052659 2006-07-10 2007-07-06 Cross-linked chitosan and process to cross-link Ceased WO2008007321A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07805070A EP2044127A2 (en) 2006-07-10 2007-07-06 Cross-linked chitosan and process to cross-link

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20061335 ITMI20061335A1 (en) 2006-07-10 2006-07-10 RETICULATED CHITOSAN AND RETICULATION PROCESS
ITMI2006A001335 2006-07-10

Publications (2)

Publication Number Publication Date
WO2008007321A2 WO2008007321A2 (en) 2008-01-17
WO2008007321A3 true WO2008007321A3 (en) 2008-03-20

Family

ID=38846828

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/052659 Ceased WO2008007321A2 (en) 2006-07-10 2007-07-06 Cross-linked chitosan and process to cross-link

Country Status (3)

Country Link
EP (1) EP2044127A2 (en)
IT (1) ITMI20061335A1 (en)
WO (1) WO2008007321A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018119320A1 (en) * 2016-12-21 2018-06-28 Cresilon, Inc. Hemostatic compositions with antifibrinolytic agents

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4094743A (en) * 1975-04-10 1978-06-13 Societe D'assistance Technique Pour Produits Nestle S.A. Enzymes immobilized on chitosan
US5019509A (en) * 1988-04-20 1991-05-28 Genetics Institute, Inc. Method and compositions for the production of l-alanine and derivatives thereof
US5322935A (en) * 1993-04-27 1994-06-21 Alliedsignal Inc. Rigid materials having high surface area and low density
DE19920557A1 (en) * 1999-05-05 2000-11-16 Cognis Deutschland Gmbh Collagen-free cosmetic preparations
WO2003042250A1 (en) * 2001-11-15 2003-05-22 Biosyntech Canada Inc. Composition and method to homogeneously modify or cross-link chitosan under neutral conditions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4094743A (en) * 1975-04-10 1978-06-13 Societe D'assistance Technique Pour Produits Nestle S.A. Enzymes immobilized on chitosan
US5019509A (en) * 1988-04-20 1991-05-28 Genetics Institute, Inc. Method and compositions for the production of l-alanine and derivatives thereof
US5322935A (en) * 1993-04-27 1994-06-21 Alliedsignal Inc. Rigid materials having high surface area and low density
DE19920557A1 (en) * 1999-05-05 2000-11-16 Cognis Deutschland Gmbh Collagen-free cosmetic preparations
WO2003042250A1 (en) * 2001-11-15 2003-05-22 Biosyntech Canada Inc. Composition and method to homogeneously modify or cross-link chitosan under neutral conditions

Also Published As

Publication number Publication date
ITMI20061335A1 (en) 2008-01-11
EP2044127A2 (en) 2009-04-08
WO2008007321A2 (en) 2008-01-17

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