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WO2007084868A3 - Treatment of disorders by activation of the unfolded protein response - Google Patents

Treatment of disorders by activation of the unfolded protein response Download PDF

Info

Publication number
WO2007084868A3
WO2007084868A3 PCT/US2007/060527 US2007060527W WO2007084868A3 WO 2007084868 A3 WO2007084868 A3 WO 2007084868A3 US 2007060527 W US2007060527 W US 2007060527W WO 2007084868 A3 WO2007084868 A3 WO 2007084868A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
unfolded protein
protein response
disorders
activation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/060527
Other languages
French (fr)
Other versions
WO2007084868A2 (en
Inventor
Christian Hassig
Timothy C Gahman
Mark R Herbert
Angelina M Thayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kalypsys Inc
Original Assignee
Kalypsys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalypsys Inc filed Critical Kalypsys Inc
Publication of WO2007084868A2 publication Critical patent/WO2007084868A2/en
Publication of WO2007084868A3 publication Critical patent/WO2007084868A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention is directed to a novel method for the treatment of diseases by activating the unfolded protein response (UPR), or of inhibiting the expression of the inducible isoform of the nitric oxide synthase (iNOS) enzyme, or both. New methylpyrazole compounds which activate the UPR, downregulate iNOS, and reduce inflammatory markers are disclose herein, as are compositions comprising said compounds and their applications as pharmaceuticals for the treatment of disease.
PCT/US2007/060527 2006-01-17 2007-01-12 Treatment of disorders by activation of the unfolded protein response Ceased WO2007084868A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76104306P 2006-01-17 2006-01-17
US60/761,043 2006-01-17

Publications (2)

Publication Number Publication Date
WO2007084868A2 WO2007084868A2 (en) 2007-07-26
WO2007084868A3 true WO2007084868A3 (en) 2007-11-08

Family

ID=37873150

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/060527 Ceased WO2007084868A2 (en) 2006-01-17 2007-01-12 Treatment of disorders by activation of the unfolded protein response

Country Status (1)

Country Link
WO (1) WO2007084868A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008145681A2 (en) * 2007-05-31 2008-12-04 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists and uses thereof
KR101754698B1 (en) 2008-12-19 2017-07-26 센트렉시온 테라퓨틱스 코포레이션 Cyclic pyrimidin-4-carboxamides as CCR2 receptor antagonists for treatment of inflammation, asthma and COPD
HRP20141143T1 (en) 2009-12-17 2015-01-02 Boehringer Ingelheim International Gmbh NEW CCR2 RECEPTOR ANTAGONISTS AND THEIR USES
US8946218B2 (en) 2010-05-12 2015-02-03 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
WO2011141474A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2571870B1 (en) 2010-05-17 2015-01-21 Boehringer Ingelheim International GmbH Ccr2 antagonists and uses thereof
EP2576542B1 (en) 2010-05-25 2015-04-22 Boehringer Ingelheim International GmbH Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases
JP5721242B2 (en) 2010-06-01 2015-05-20 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel CCR2 antagonist
WO2012140516A2 (en) * 2011-04-13 2012-10-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Non human animal model for ulcerative colitis and its main complications
WO2013010839A1 (en) 2011-07-15 2013-01-24 Boehringer Ingelheim International Gmbh Novel and selective ccr2 antagonists
SG11201405761WA (en) 2012-03-16 2014-10-30 Axikin Pharmaceuticals Inc 3,5-diaminopyrazole kinase inhibitors
US9732067B2 (en) 2012-06-20 2017-08-15 University Of Kansas Compounds and methods for activating the apoptotic arm of the unfolded protein response
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
HUE049801T2 (en) 2014-12-23 2020-10-28 Sma Therapeutics Inc 3,5-diaminopyrazole kinase inhibitors
CN104725366B (en) * 2015-02-28 2018-06-19 南通大学 The preparation method and purposes of the trifluoromethyl pyrazol oxime derivatives of the thiadiazoles structure of alkoxy containing 5-
BR112017028492B1 (en) 2015-07-02 2023-12-26 Centrexion Therapeutics Corporation (4-((3R,4R)-3-METHOXITETRA-HYDRO-PYRAN-4- YLAMINO)PIPERIDIN-1-YL) CITRATE (5- METHYL-6-(((2R, 6S)-6-(P- TOLIL) TETRA-HYDRO-2H-PIRAN-2-IL)METHYLAMINO)PYRIMIDIN-4-IL) METHANONE, ITS USE AND ITS PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITION
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds
JP6400247B1 (en) * 2015-11-16 2018-10-03 ロンザ・リミテッド Process for the preparation of 1-methyl-3- (trifluoromethyl) -1H-pyrazol-5-ol
CN105712932B (en) * 2016-03-08 2019-01-22 南通大学 Preparation and application of a pyrazole oxime ether compound containing 1-methyl-3-aryl-4-chloropyrazole structure
WO2019230831A1 (en) * 2018-05-31 2019-12-05 クミアイ化学工業株式会社 Production method for fluorinated pyrazole derivative and intermediate thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052941A1 (en) * 1997-05-22 1998-11-26 G.D. Searle And Co. PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS
US20050130989A1 (en) * 2003-01-28 2005-06-16 Aventis Pharma S. A. N-arylheteroaromatic products compositions containing them and use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052941A1 (en) * 1997-05-22 1998-11-26 G.D. Searle And Co. PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS
US20050130989A1 (en) * 2003-01-28 2005-06-16 Aventis Pharma S. A. N-arylheteroaromatic products compositions containing them and use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARALDI P G ET AL: "DESIGN, SYNTHESIS, DNA BINDING, AND BIOLOGICAL EVALUATION OF WATER-SOLUBLE HYBRID MOLECULES CONTAINING TWO PYRAZOLE ANALOGUES OF THE ALKYLATING CYCLOPROPYLPYRROLOINDOLE (CPI) SUBUNIT OF THE ANTITUMOR AGENT CC-1065 AND POLYPYRROLE MINOR GROOVE BINDERS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 44, no. 16, 2 August 2001 (2001-08-02), pages 2536 - 2543, XP008049613, ISSN: 0022-2623 *
DENNY, WILLIAM A. ET AL: "Potential antitumor agents. 44. Synthesis and antitumor activity of new classes of diacridines: importance of linker chain rigidity for DNA binding kinetics and biological activity", JOURNAL OF MEDICINAL CHEMISTRY , 28(11), 1568-74 CODEN: JMCMAR; ISSN: 0022-2623, 1985, XP002427761 *

Also Published As

Publication number Publication date
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