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WO2008007390A3 - An improved process for purification of zolmitriptan - Google Patents

An improved process for purification of zolmitriptan Download PDF

Info

Publication number
WO2008007390A3
WO2008007390A3 PCT/IN2007/000267 IN2007000267W WO2008007390A3 WO 2008007390 A3 WO2008007390 A3 WO 2008007390A3 IN 2007000267 W IN2007000267 W IN 2007000267W WO 2008007390 A3 WO2008007390 A3 WO 2008007390A3
Authority
WO
WIPO (PCT)
Prior art keywords
zolmitriptan
purification
improved process
drug substance
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2007/000267
Other languages
French (fr)
Other versions
WO2008007390A2 (en
WO2008007390B1 (en
Inventor
Amala Kisham Kompella
Sreenivas Rachakonda
Kali Satya Bhujanga Adibhatla
Chowdary Nannapaneni Venkaiah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Natco Pharma Ltd
Original Assignee
Natco Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd
Publication of WO2008007390A2 publication Critical patent/WO2008007390A2/en
Publication of WO2008007390A3 publication Critical patent/WO2008007390A3/en
Publication of WO2008007390B1 publication Critical patent/WO2008007390B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to an improved and novel process for the purification of the Zolmitriptan (I) to get highly pure drug substance of greater than 99.8% purity. Zolmitriptan is a 5HT1-like receptor agonist useful in the treatment and prophylaxis of migraine and is chemically known as (S)-4-[(3-[2-(Dimethylamino) ethyl]-1H-indol-5-yl] methyl]-2-oxazolidinone. Formula (I). A novel method of purification of the drug substance Zolmitriptan (I) is developed and is described.
PCT/IN2007/000267 2006-07-10 2007-06-29 An improved process for purification of zolmitriptan Ceased WO2008007390A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1203/CHE/2006 2006-07-10
IN1203CH2006 2006-07-10

Publications (3)

Publication Number Publication Date
WO2008007390A2 WO2008007390A2 (en) 2008-01-17
WO2008007390A3 true WO2008007390A3 (en) 2008-03-06
WO2008007390B1 WO2008007390B1 (en) 2008-04-17

Family

ID=38670853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2007/000267 Ceased WO2008007390A2 (en) 2006-07-10 2007-06-29 An improved process for purification of zolmitriptan

Country Status (1)

Country Link
WO (1) WO2008007390A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008018090A2 (en) * 2006-08-09 2008-02-14 Matrix Laboratories Ltd An improved process for the preparation of zolmitriptan
CN103275075B (en) * 2013-06-24 2015-01-07 成都天台山制药有限公司 Zolmitriptan and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1227095A2 (en) * 1995-08-07 2002-07-31 AstraZeneca AB A process for the purification of (S)-4-((3-(dimethylamino)ethyl)-1H-indol-5yl)-methyl)-2-oxazolidinone
US20050245585A1 (en) * 2004-04-22 2005-11-03 Islam Aminul Process for preparing optically pure zolmitriptan

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1227095A2 (en) * 1995-08-07 2002-07-31 AstraZeneca AB A process for the purification of (S)-4-((3-(dimethylamino)ethyl)-1H-indol-5yl)-methyl)-2-oxazolidinone
US20050245585A1 (en) * 2004-04-22 2005-11-03 Islam Aminul Process for preparing optically pure zolmitriptan

Also Published As

Publication number Publication date
WO2008007390A2 (en) 2008-01-17
WO2008007390B1 (en) 2008-04-17

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