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WO2008126106A3 - Novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts - Google Patents

Novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts Download PDF

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Publication number
WO2008126106A3
WO2008126106A3 PCT/IN2008/000245 IN2008000245W WO2008126106A3 WO 2008126106 A3 WO2008126106 A3 WO 2008126106A3 IN 2008000245 W IN2008000245 W IN 2008000245W WO 2008126106 A3 WO2008126106 A3 WO 2008126106A3
Authority
WO
WIPO (PCT)
Prior art keywords
darifenacin
preparation
pharmaceutically acceptable
acceptable salts
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2008/000245
Other languages
French (fr)
Other versions
WO2008126106A8 (en
WO2008126106A2 (en
Inventor
Manne Satyanarayana Reddy
Srinivasan Thirumalai Rajan
Karamala Rama Subba Reddy
Mummadi Venkatesh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2008126106A2 publication Critical patent/WO2008126106A2/en
Publication of WO2008126106A8 publication Critical patent/WO2008126106A8/en
Anticipated expiration legal-status Critical
Publication of WO2008126106A3 publication Critical patent/WO2008126106A3/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts. Darifenacin is chemically known as 3 -(S)-(-)-(l -carbamoyl- 1,1 -diphenylmethyl)-l- [2- (2,3-dihydro benzofuran-5-yl)ethyl]pyrrolidine and represented by formula (II). The invention also relates to the novel polymorphs of the pharmaceutically acceptable salts of darifenacin and the methods for their preparation.
PCT/IN2008/000245 2007-04-16 2008-04-15 Novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts Ceased WO2008126106A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IN790/CHE/2007 2007-04-16
IN790CH2007 2007-04-16
IN2004/CHE/2007 2007-09-06
IN2004CH2007 2007-09-06
IN895/CHE/2008 2008-04-10
IN895CH2008 2008-04-10

Publications (3)

Publication Number Publication Date
WO2008126106A2 WO2008126106A2 (en) 2008-10-23
WO2008126106A8 WO2008126106A8 (en) 2009-04-30
WO2008126106A3 true WO2008126106A3 (en) 2011-07-14

Family

ID=39864466

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000245 Ceased WO2008126106A2 (en) 2007-04-16 2008-04-15 Novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts

Country Status (1)

Country Link
WO (1) WO2008126106A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009007853A2 (en) * 2007-06-08 2009-01-15 Actavis Group Ptc Ehf Novel polymorphs of darifenacin free base and its hydrobromide salt
AR068322A1 (en) * 2007-07-13 2009-11-11 Medichem Sa FORM AMORFA OF DARIFENACINE HYDROBROMIDE AND PROCEDURES FOR THEIR PREPARATION
JP2012041277A (en) * 2010-08-13 2012-03-01 Kaneka Corp Improved method for producing 1, 3-disubstituted pyrrolidine compound or salt thereof
CN101973971A (en) * 2010-09-26 2011-02-16 山东邹平大展新材料有限公司 Method for preparing 5-halogenated ethyl-2,3-dihydrobenzofuran
FI126118B (en) 2012-02-10 2016-06-30 Upm Kymmene Corp Cellulose pulp pretreatment method
CN110922294A (en) * 2019-12-11 2020-03-27 安徽至善新材料有限公司 Method for preparing organic bromide from organic chloride

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0178946A2 (en) * 1984-10-19 1986-04-23 A.H. Robins Company, Incorporated 1-(Aminoalkyl)-alpha, alpha-diaryl pyrrolidine-piperidine- and homopiperidine- acetamides and acetonitriles
EP0388054A1 (en) * 1989-03-17 1990-09-19 Pfizer Limited Pyrrolidine derivatives
WO2007076158A2 (en) * 2005-12-27 2007-07-05 Teva Pharmaceutical Industries Ltd. Processes for preparing darifenacin hydrobromide
WO2008029257A2 (en) * 2006-09-07 2008-03-13 Medichem, S.A. Improved method for preparing 1,3-disubstituted pyrrolidine compounds
WO2008100651A2 (en) * 2007-01-05 2008-08-21 Dr. Reddy's Laboratories Ltd. Preparation of darifenacin and its salts

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0178946A2 (en) * 1984-10-19 1986-04-23 A.H. Robins Company, Incorporated 1-(Aminoalkyl)-alpha, alpha-diaryl pyrrolidine-piperidine- and homopiperidine- acetamides and acetonitriles
EP0388054A1 (en) * 1989-03-17 1990-09-19 Pfizer Limited Pyrrolidine derivatives
WO2007076158A2 (en) * 2005-12-27 2007-07-05 Teva Pharmaceutical Industries Ltd. Processes for preparing darifenacin hydrobromide
WO2008029257A2 (en) * 2006-09-07 2008-03-13 Medichem, S.A. Improved method for preparing 1,3-disubstituted pyrrolidine compounds
WO2008100651A2 (en) * 2007-01-05 2008-08-21 Dr. Reddy's Laboratories Ltd. Preparation of darifenacin and its salts

Also Published As

Publication number Publication date
WO2008126106A8 (en) 2009-04-30
WO2008126106A2 (en) 2008-10-23

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