[go: up one dir, main page]

WO2008089436A3 - Crystalline forms of histone deacetylase inhibitors - Google Patents

Crystalline forms of histone deacetylase inhibitors Download PDF

Info

Publication number
WO2008089436A3
WO2008089436A3 PCT/US2008/051481 US2008051481W WO2008089436A3 WO 2008089436 A3 WO2008089436 A3 WO 2008089436A3 US 2008051481 W US2008051481 W US 2008051481W WO 2008089436 A3 WO2008089436 A3 WO 2008089436A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystalline forms
histone deacetylase
deacetylase inhibitors
compound
indazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/051481
Other languages
French (fr)
Other versions
WO2008089436A2 (en
Inventor
Patrick D Hayes
Paul Isbester
Bingidimi I Mobele
Grant Palmer
Jonathon S Salsbury
Xufeng Sun
Luckner Ulysse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda California Inc
Original Assignee
Takeda San Diego Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda San Diego Inc filed Critical Takeda San Diego Inc
Publication of WO2008089436A2 publication Critical patent/WO2008089436A2/en
Publication of WO2008089436A3 publication Critical patent/WO2008089436A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The application is related to polymorphs and salts of compounds having the formulae: Compound (I) N-(2-Aminophenyl)-4-((5,6-dimethoxy-2H-indazol-2-yl)methyl)benzamide Compound (II) 4-((6-Acetamido-2H-indazol-2-yl)methyl)-N-(2-aminophenyl)benzamide Compound (III) 1-(4-(2-Aminophenylcarbamoyl)benzyl)-N-ethyl-1H-pyrazole-4-carboxamide Also provided are novel methods for the preparation of the polymorphs of Compound (I), and kits and articles of manufacture of the compositions, and methods of using the compositions to treat various diseases.
PCT/US2008/051481 2007-01-18 2008-01-18 Crystalline forms of histone deacetylase inhibitors Ceased WO2008089436A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88561607P 2007-01-18 2007-01-18
US60/885,616 2007-01-18

Publications (2)

Publication Number Publication Date
WO2008089436A2 WO2008089436A2 (en) 2008-07-24
WO2008089436A3 true WO2008089436A3 (en) 2008-12-24

Family

ID=39591569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/051481 Ceased WO2008089436A2 (en) 2007-01-18 2008-01-18 Crystalline forms of histone deacetylase inhibitors

Country Status (4)

Country Link
AR (1) AR064971A1 (en)
CL (1) CL2008000150A1 (en)
TW (1) TW200911757A (en)
WO (1) WO2008089436A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2620027T3 (en) 2008-09-03 2017-06-27 Biomarin Pharmaceutical Inc. Compositions that include 6-aminohexanoic acid derivatives as HDAC inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US9540395B2 (en) 2011-02-28 2017-01-10 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
KR20150132345A (en) 2013-03-15 2015-11-25 바이오마린 파머수티컬 인크. Hdac inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004069823A1 (en) * 2003-02-04 2004-08-19 Methylgene, Inc. Inhibitors of histone deacetylase
WO2005092899A1 (en) * 2004-03-26 2005-10-06 Methylgene Inc. Inhibitors of histone deacetylase
WO2006066133A2 (en) * 2004-12-16 2006-06-22 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2006122319A2 (en) * 2005-05-11 2006-11-16 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2007011626A2 (en) * 2005-07-14 2007-01-25 Takeda San Diego, Inc. Histone deacetylase inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004069823A1 (en) * 2003-02-04 2004-08-19 Methylgene, Inc. Inhibitors of histone deacetylase
WO2005092899A1 (en) * 2004-03-26 2005-10-06 Methylgene Inc. Inhibitors of histone deacetylase
WO2006066133A2 (en) * 2004-12-16 2006-06-22 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2006122319A2 (en) * 2005-05-11 2006-11-16 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2007011626A2 (en) * 2005-07-14 2007-01-25 Takeda San Diego, Inc. Histone deacetylase inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAIRA M R: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 198, 1 January 1998 (1998-01-01), pages 163 - 208, XP001156954, ISSN: 0340-1022 *
VAISBURG ET AL: "N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 17, no. 24, 18 October 2007 (2007-10-18), pages 6729 - 6733, XP022339563, ISSN: 0960-894X *

Also Published As

Publication number Publication date
TW200911757A (en) 2009-03-16
CL2008000150A1 (en) 2008-03-14
AR064971A1 (en) 2009-05-06
WO2008089436A2 (en) 2008-07-24

Similar Documents

Publication Publication Date Title
WO2009109867A3 (en) Crystal form of phenylamino pyrimidine derivative
TNSN08104A1 (en) Pyrimidine amide compounds as pgds inhibitors
MY154895A (en) Pyrimidine hydrazide compounds as pgds inhibitors
WO2007056517A3 (en) Pharmaceutical salts and polymorphs of n- (5-chl0r0-2-pyridinyl) -2- [ [4- [ (dimethylamino) iminomethyl] benzoyl] amino] -5-meth oxy-benzamide, a factor xa inhibitor
CL2007002949A1 (en) CRYSTAL FORM OF THE COMPOUND 2-CHLORINE-5- (3,6-DIHIDRO-3-METHYL-2,6-DIOXO-4- (TRIFLUOROMETIL) -1- (2H) -PIRIMIDINIL) -4-FLUORO-N - (( METHYL (1-METHYLETY) AMINO) SULFONILE) BENZAMIDE; PROCESS FOR THE PREPARATION OF SUCH CRYSTAL FORM; PHYTOPROTECTOR COMPOSITION;
NZ596863A (en) Alkanoylamino benzamide aniline hdac inhibitor compounds
WO2006066133A3 (en) Histone deacetylase inhibitors
PE20110062A1 (en) N- (3- (3,5-DIMETOXIFENETTIL) -1H-PIRAZOL-5-IL) -4- (3,4-DIMETILPIPERAZIN-1-IL) BENZAMIDE AND SALTS OF THE SAME
WO2007026920A3 (en) Amide derivatives as rock inhibitors
WO2008075172A3 (en) Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases
NZ604035A (en) Glycine transporter-1 inhibitors, methods of making them, and uses thereof
EA200901514A1 (en) NEW SOLVATIVE AND CRYSTAL FORM OF CARBAMOILCYCLOGEXAN DERIVATIVES
SMT201300098B (en) Solid forms of N- (4- (7-azabicyclo [2.2.1] heptan-7-yl) -2- (trifluoromethyl) phenyl-4-oxo-5-trifluoromethyl) -1,4-dihydroquinoline-3-carboxamide
NO20076498L (en) Derivatives of 4- (2-amino-1-hydroxyethyl) phenol as agonists of the beta2-adrenergic receptor
WO2009016460A3 (en) Pyrazole compounds and their use as raf inhibitors
NO20092692L (en) MAPK / ERK kinase inhibitors
WO2008022286A3 (en) Small molecule inhibitors of kynurenine-3-monooxygenase
NO20074303L (en) 7- {4- [2- (2,6-dichloro-4-methylphenoxy) ethoxy] phenyl} -3,9-diazabicyclo [3.3.1] non-6-ene-6-karboksylsyresyklopropyl- (2,3- dimethylbenzyl) amide as a renin inhibitor for the treatment of hypertension
WO2007056219A3 (en) [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto
WO2010144499A3 (en) Urea derivatives as kinase inhibitors
ATE440833T1 (en) ANTITHRBOTIC DIAMIDES
MX2010002938A (en) (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1- carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating.
NO20083708L (en) 4-Phenyl-thiazole-5-carboxylic acid and 4-phenyl-thiazole-5-carboxylmides as PLK1 inhibitors
WO2008089436A3 (en) Crystalline forms of histone deacetylase inhibitors
MY149058A (en) N-(2-aminophenyl)-4-[n-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (ms-275) polymorph b

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08727929

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 08727929

Country of ref document: EP

Kind code of ref document: A2