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WO2008090770A1 - Ｌ－アミノ酸を生産する微生物及びｌ－アミノ酸の製造法 - Google Patents

Ｌ－アミノ酸を生産する微生物及びｌ－アミノ酸の製造法 Download PDF

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Publication number
WO2008090770A1
WO2008090770A1 PCT/JP2008/050246 JP2008050246W WO2008090770A1 WO 2008090770 A1 WO2008090770 A1 WO 2008090770A1 JP 2008050246 W JP2008050246 W JP 2008050246W WO 2008090770 A1 WO2008090770 A1 WO 2008090770A1
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Prior art keywords
amino acid
producing
production
microorganism capable
culture medium
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Ceased
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PCT/JP2008/050246
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English (en)
French (fr)
Inventor
Rie Takikawa
Yoshihiko Hara
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to ES08703110.0T priority Critical patent/ES2631360T3/es
Priority to BRPI0806790A priority patent/BRPI0806790B1/pt
Priority to CN200880002790.XA priority patent/CN101627110B/zh
Priority to KR1020097017482A priority patent/KR101730837B1/ko
Priority to JP2008555015A priority patent/JP5540504B2/ja
Priority to EP08703110.0A priority patent/EP2116595B1/en
Publication of WO2008090770A1 publication Critical patent/WO2008090770A1/ja
Priority to US12/497,918 priority patent/US7919284B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
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  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Ｌ－アミノ酸生産能を有し、かつ、ｋｄｐシステムが増強するように改変された腸内細菌科に属する微生物を培地で培養して、Ｌ－アミノ酸を該培地中又は菌体内に生成蓄積させ、該培地又は菌体よりＬ－アミノ酸を回収することにより、Ｌ－アミノ酸を製造する。
PCT/JP2008/050246 2007-01-22 2008-01-11 Ｌ－アミノ酸を生産する微生物及びｌ－アミノ酸の製造法 Ceased WO2008090770A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES08703110.0T ES2631360T3 (es) 2007-01-22 2008-01-11 Microorganismo que produce un L-aminoácido y procedimiento para producir un L-aminoácido
BRPI0806790A BRPI0806790B1 (pt) 2007-01-22 2008-01-11 microorganismo, e, método para produzir um l-aminoácido
CN200880002790.XA CN101627110B (zh) 2007-01-22 2008-01-11 生产l-氨基酸的微生物和l-氨基酸的生产方法
KR1020097017482A KR101730837B1 (ko) 2007-01-22 2008-01-11 Ｌ-아미노산을 생산하는 미생물 및 ｌ-아미노산의 제조법
JP2008555015A JP5540504B2 (ja) 2007-01-22 2008-01-11 Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
EP08703110.0A EP2116595B1 (en) 2007-01-22 2008-01-11 An l-amino acid-producing microorganism and a method for producing an l-amino acid
US12/497,918 US7919284B2 (en) 2007-01-22 2009-07-06 L-amino acid producing microorganism and a method for producing an L-amino acid

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-011392 2007-01-22
JP2007011392 2007-01-22
JP2007-131763 2007-05-17
JP2007131763 2007-05-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/497,918 Continuation US7919284B2 (en) 2007-01-22 2009-07-06 L-amino acid producing microorganism and a method for producing an L-amino acid

Publications (1)

Publication Number Publication Date
WO2008090770A1 true WO2008090770A1 (ja) 2008-07-31

Family

ID=39644345

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050246 Ceased WO2008090770A1 (ja) 2007-01-22 2008-01-11 Ｌ－アミノ酸を生産する微生物及びｌ－アミノ酸の製造法

Country Status (8)

Country Link
US (1) US7919284B2 (ja)
EP (1) EP2116595B1 (ja)
JP (1) JP5540504B2 (ja)
KR (1) KR101730837B1 (ja)
CN (1) CN101627110B (ja)
BR (1) BRPI0806790B1 (ja)
ES (1) ES2631360T3 (ja)
WO (1) WO2008090770A1 (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010027022A1 (ja) 2008-09-05 2010-03-11 味の素株式会社 Ｌ－アミノ酸生産菌及びｌ－アミノ酸の製造法
WO2011087139A2 (en) 2010-01-15 2011-07-21 Ajinomoto Co.,Inc. A BACTERIUM OF Enterobacteriaceae FAMILY PRODUCING L-ASPARTIC ACID OR L-ASPARTIC ACID-DERIVED METABOLITES AND A METHOD FOR PRODUCING L-ASPARTIC ACID OR L-ASPARTIC ACID-DERIVED METABOLITES
WO2015005406A1 (ja) 2013-07-09 2015-01-15 味の素株式会社 有用物質の製造方法
WO2015056813A1 (en) 2013-10-17 2015-04-23 Ajinomoto Co., Inc. Method for producing isoprene using bacterium
WO2015080273A1 (ja) 2013-11-28 2015-06-04 味の素株式会社 イソプレンモノマーの製造方法
WO2015147341A2 (en) 2014-03-28 2015-10-01 Ajinomoto Co., Inc. Method of producing isoprene monomer
WO2016104814A2 (en) 2014-12-26 2016-06-30 Ajinomoto Co., Inc. Method for producing dicarboxylic acid
WO2017073701A2 (en) 2015-10-27 2017-05-04 Ajinomoto Co., Inc. Method for producing aldehyde
WO2018030507A1 (ja) * 2016-08-10 2018-02-15 味の素株式会社 Ｌ－アミノ酸の製造法
WO2019194287A1 (ja) 2018-04-06 2019-10-10 味の素株式会社 １３－ヒドロキシ－９（ｚ）－オクタデセン酸の製造方法
EP4345166A2 (en) 2022-09-30 2024-04-03 Ajinomoto Co., Inc. Method for producing l-amino acid

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2004124226A (ru) 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
US7915018B2 (en) 2004-10-22 2011-03-29 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
WO2008133161A1 (ja) 2007-04-17 2008-11-06 Ajinomoto Co., Inc. カルボキシル基を有する酸性物質の製造法
ES2624913T3 (es) * 2008-09-08 2017-07-18 Ajinomoto Co., Inc. Microorganismo que produce un L-aminoácido y procedimiento para producir un L-aminoácido
US9611461B2 (en) * 2013-03-19 2017-04-04 National University Corporation NARA Institute of Science and Technology Enterobacteriaceae bacteria exhibiting increased L-cysteine producing ability
WO2021060438A1 (en) 2019-09-25 2021-04-01 Ajinomoto Co., Inc. Method for producing l-amino acids by bacterial fermentation
KR20250099654A (ko) * 2023-12-22 2025-07-02 씨제이제일제당 (주) 방향족 아미노산 트랜스포터의 활성이 강화된 미생물 및 이의 용도

Citations (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR356739A (fr) 1904-09-20 1905-12-07 Charles Glauser Perrin Mécanisme de remontoir et de mise à l'heure
JPS329393B1 (ja) 1954-12-25 1957-11-07
US3563857A (en) 1967-03-20 1971-02-16 Sanraku Ocean Co Process for producing l-glutamic acid by fermentation
JPS565099A (en) 1979-06-25 1981-01-20 Ajinomoto Co Inc Production of l-histidine through fermentation process and microorganism used therefor
US4278765A (en) 1978-06-30 1981-07-14 Debabov Vladimir G Method for preparing strains which produce aminoacids
GB2075056A (en) 1980-04-14 1981-11-11 Ajinomoto Kk L-proline-producing Microorganisms
JPS5771397A (en) 1980-08-22 1982-05-04 Ajinomoto Co Inc Preparation of l-tryptophan by fermentation method
US4346170A (en) 1979-07-23 1982-08-24 Ajinomoto Company, Incorporated Method for producing L-lysine by fermentation
DE3127361A1 (de) 1981-07-08 1983-02-03 Schering Ag, 1000 Berlin Und 4619 Bergkamen Herstellung und anwendung von plasmiden mit genen fuer die biosynthese von l-prolin
US4407952A (en) 1979-06-15 1983-10-04 Ajinomoto Company Incorporated Method for producing L-phenylalanine by fermentation
JPS6234397A (ja) 1985-08-08 1987-02-14 Mitsubishi Electric Corp ダイナミツクメモリ装置
JPS62244382A (ja) 1986-04-16 1987-10-24 Ajinomoto Co Inc 新規プロモーター及び該プロモーターを用いた遺伝子発現方法
KR890003681B1 (ko) 1987-03-26 1989-09-30 주식회사 미원 미생물에 의한 l-페닐 알라닌의 제조방법
JPH02458A (ja) 1987-10-12 1990-01-05 Ajinomoto Co Inc 発酵法によるｌ―イソロイシンの製造法
JPH02109985A (ja) 1988-02-22 1990-04-23 Eurolysine 細菌染色体上ヘの目的遺伝子の組み込み方法及び該方法によって得られた細菌
JPH02207791A (ja) 1989-02-07 1990-08-17 Ajinomoto Co Inc 微生物の形質転換法
US5168056A (en) 1991-02-08 1992-12-01 Purdue Research Foundation Enhanced production of common aromatic pathway compounds
US5175107A (en) 1988-10-25 1992-12-29 Ajinomoto Co., Inc. Bacterial strain of escherichia coli bkiim b-3996 as the producer of l-threonine
JPH057491A (ja) 1990-10-15 1993-01-19 Ajinomoto Co Inc 温度感受性プラスミド
JPH05130882A (ja) 1991-11-11 1993-05-28 Kyowa Hakko Kogyo Co Ltd 発酵法によるｌ−イソロイシンの製造法
JPH05244970A (ja) 1991-08-07 1993-09-24 Ajinomoto Co Inc 発酵法によるｌ−グルタミン酸の製造法
JPH05304969A (ja) 1992-02-25 1993-11-19 Kyowa Hakko Kogyo Co Ltd 発酵法によるアミノ酸の製造法
RU2003677C1 (ru) 1992-03-30 1993-11-30 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Штамм бактерий ESCHERICHIA COLI - продуцент L-гистидина
WO1994008031A1 (de) 1992-09-28 1994-04-14 Consortium für elektrochemische Industrie GmbH Mikroorganismen für die produktion von tryptophan und verfahren zu ihrer herstellung
EP0593792A1 (en) 1992-10-14 1994-04-27 Ajinomoto Co., Inc. Novel L-threonine-producing microbacteria and a method for the production of L-threonine
US5354672A (en) 1992-11-24 1994-10-11 Ian Fotheringham Materials and methods for hypersecretion of amino acids
US5376538A (en) 1991-09-04 1994-12-27 Kyowa Hakko Kogyo Co., Ltd. Process for producing L-threonine with strains of E coli resistant to phenylalanine and leucine
WO1996006926A1 (fr) 1994-08-30 1996-03-07 Ajinomoto Co., Inc. Procede pour produire de la l-valine et de la l-leucine
JPH0870879A (ja) 1994-06-30 1996-03-19 Kyowa Hakko Kogyo Co Ltd 発酵法によるｌ−ロイシンの製造法
US5573945A (en) 1994-01-10 1996-11-12 Ajinomoto Co., Inc. Mutant and method for producing L-glutamic acid by fermentation
EP0488424B1 (en) 1990-11-30 1997-03-05 Ajinomoto Co., Inc. Recombinant DNA sequences encoding feedback inhibition released enzymes, plasmids comprising the recombinant DNA sequences, transformed microorganisms useful in the production of aromatic amino acids, and a process for preparing aromatic amino acids by fermentation
WO1997008333A1 (fr) 1995-08-30 1997-03-06 Ajinomoto Co., Inc. Procede de production d'acides amines levogyres
US5658766A (en) 1991-05-30 1997-08-19 Ajinomoto Co., Inc. Strains of Escherichia coli which produce isoleucine or valine and a method for their production
US5705371A (en) 1990-06-12 1998-01-06 Ajinomoto Co., Inc. Bacterial strain of escherichia coli BKIIM B-3996 as the producer of L-threonine
US5756345A (en) 1995-09-05 1998-05-26 Degussa Aktiengesellschaft Production of tryptophan by the bacterium Escherichia coli
US5776736A (en) 1992-12-21 1998-07-07 Purdue Research Foundation Deblocking the common pathway of aromatic amino acid synthesis
RU2119536C1 (ru) 1997-01-21 1998-09-27 Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Штамм escherichia coli - продуцент l-гистидина
US5827698A (en) 1994-12-09 1998-10-27 Ajinomoto Co., Inc. Lysine decarboxylase gene and method of producing l-lysine
US5830716A (en) 1993-10-28 1998-11-03 Ajinomoto Co., Inc. Increased amounts of substances by modifying a microorganism to increase production of NADPH from NADH
WO1999003988A1 (en) 1997-07-18 1999-01-28 Ajinomoto Co., Inc. Process for producing purine nucleosides via fermentation
US5906925A (en) 1994-09-16 1999-05-25 Liao; James C. Microorganisms and methods for overproduction of DAHP by cloned pps gene
JPH11155571A (ja) 1997-11-25 1999-06-15 Ajinomoto Co Inc Ｌ−システインの製造法
US5939307A (en) 1996-07-30 1999-08-17 The Archer-Daniels-Midland Company Strains of Escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production
US5972663A (en) 1997-06-19 1999-10-26 Consortium Fur Elektrochemische Industrie Gmbh Microorganisms and processes for the fermentative preparation of L-cysteine, L-cystine, N-acetylserine or thiazolidine derivatives
EP0952221A2 (en) 1998-03-18 1999-10-27 Ajinomoto Co., Ltd. L-Glutamic acid-producing bacterium and method for producing L-glutamic acid
EP0955368A2 (en) 1998-03-18 1999-11-10 Ajinomoto Co., Ltd. L-glutamic acid-producing bacterium and method for producing l-glutamic acid
US5998178A (en) 1994-05-30 1999-12-07 Ajinomoto Co., Ltd. L-isoleucine-producing bacterium and method for preparing L-isoleucine through fermentation
US6040160A (en) 1993-12-08 2000-03-21 Ajinomoto Co., Inc. Method of producing L-lysine by fermentation
WO2000018935A1 (en) 1998-09-25 2000-04-06 Ajinomoto Co.,Inc. Process for constructing amino acid-producing bacterium and process for producing amino acid by fermentation method with the use of the thus constructed amino acid-producing bacterium
JP2000106869A (ja) 1998-03-18 2000-04-18 Ajinomoto Co Inc Ｌ―グルタミン酸生産菌及びｌ―グルタミン酸の製造法
EP0999282A2 (en) 1998-10-19 2000-05-10 Ajinomoto Co., Inc. L-glutamic acid producing bacterium and process for producing l-glutamic acid
EP1013765A1 (en) 1998-12-23 2000-06-28 Ajinomoto Co., Ltd. Gene and method for producing L-amino acids
EP1016710A2 (en) 1998-12-30 2000-07-05 Ajinomoto Co., Inc. Method for producing L-amino acids
JP2000189169A (ja) 1998-03-18 2000-07-11 Ajinomoto Co Inc Ｌ―グルタミン酸生産菌及びｌ―グルタミン酸の製造法
JP2000189175A (ja) 1998-10-19 2000-07-11 Ajinomoto Co Inc Ｌ―グルタミン酸生産菌及びｌ―グルタミン酸の製造法
US6124121A (en) 1997-10-29 2000-09-26 Ajinomoto Co., Inc. Method for producing L-leucine
JP2000270872A (ja) * 1999-03-25 2000-10-03 Ajinomoto Co Inc Ｌ−グルタミン酸の製造法
JP2000333769A (ja) 1999-05-31 2000-12-05 Ikeda Bussan Co Ltd シートバックフレーム
EP1078989A2 (en) 1999-08-20 2001-02-28 Ajinomoto Co., Ltd. Method for producing L-glutamic acid by fermentation accompanied by precipitation
EP1085087A2 (en) 1999-09-20 2001-03-21 Kyowa Hakko Kogyo Co., Ltd. Method for producing amino acids by fermentation using aminoquinoline resistant bacterial strains
US6218168B1 (en) 1995-10-26 2001-04-17 CONSORTIUM FüR ELEKTROCHEMISCHE INUDSTRIE GMBH Process for preparing O-acetylserine, L-cysteine and L-cysteine-related products
WO2001027307A1 (de) 1999-10-14 2001-04-19 Consortium für elektrochemische Industrie GmbH Verfahren zur fermentativen herstellung von l-cystein oder l-cystein-derivaten
US6258554B1 (en) 1998-07-03 2001-07-10 Kyowa Hakko Kogyo Co., Ltd. Method for producing metabolites biologically synthesized via phosphoribosyl pyrophosphate
US6303383B1 (en) 1999-03-16 2001-10-16 Ajinomoto Co., Inc. Temperature sensitive plasmid for coryneform bacteria
EP1149911A2 (en) 2000-04-26 2001-10-31 Ajinomoto Co., Ltd. Amino acid producing strains belonging to the genus Escherichia and method for producing amino acid
EP1170361A2 (en) 2000-06-28 2002-01-09 Ajinomoto Co., Inc. New mutant N-Acetylglutamate synthase and method for L-Arginine production
EP1170376A1 (en) 2000-07-05 2002-01-09 Ajinomoto Co., Inc. Method for producing substances utilizing microorganisms
EP1170358A1 (en) 2000-07-06 2002-01-09 Ajinomoto Co., Ltd. L-arginine producing Escherichia coli and method of producing L-arginine
EP1172433A1 (en) 2000-07-06 2002-01-16 Ajinomoto Co., Inc. Bacterium having ability to produce L-glutamic acid, L-proline or L-arginine and method for producing L-glutamic acid, L-proline or L-arginine
US6344347B1 (en) 1999-09-20 2002-02-05 Kyowa Hakko Kogyo Co., Ltd. Method for producing L-amino acids by fermentation
US20020025564A1 (en) 2000-08-24 2002-02-28 Ajinomoto Co., Inc. Method for producing basic amino acid
US20020058315A1 (en) 2000-09-26 2002-05-16 Ajinomoto Co., Inc. Bacterium having ability to produce L-glutamic acid, L-proline or L-arginine and method for producing L-glutamic acid, L-proline or L-arginine
US6403342B1 (en) 1999-07-09 2002-06-11 Anjinomoto Co., Inc. DNA coding for mutant isopropylmalate synthase L-leucine-producing microorganism and method for producing L-leucine
EP1233068A2 (en) 2001-02-20 2002-08-21 Ajinomoto Co., Inc. Method for producing L-glutamic acid
EP1233069A2 (en) 2001-02-20 2002-08-21 Ajinomoto Co., Inc. Method for producing L-glutamic acid
EP1239041A2 (en) 2001-02-13 2002-09-11 Ajinomoto Co., Inc. Method for producing L-amino acid using bacteria belonging to the genus Escherichia
EP1253195A1 (en) 2000-01-21 2002-10-30 Ajinomoto Co., Inc. Process for producing l-lysine
RU2000124295A (ru) 2000-09-26 2003-02-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Бактерия, обладающая способностью к продукции l-глутаминовой кислоты, l-пролина или l-аргинина, и способ получения l-глутаминовой кислоты, l-пролина или l-аргинина
US20030148473A1 (en) 2001-11-23 2003-08-07 Ajinomoto Co., Inc. Method for producing L-amino acid using bacteria belonging to the genus escherichia
US20030157667A1 (en) 2001-11-23 2003-08-21 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria belonging to the genus escherichia
JP2003274988A (ja) 2002-03-27 2003-09-30 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
WO2003097839A1 (en) 2002-05-15 2003-11-27 Cj Corporation Nucleotide sequence of threonine operon irrepressible by isoleucine and method for producing l-threonine using transformed host cell containing the same
WO2004111258A1 (ja) 2003-06-10 2004-12-23 Ajinomoto Co., Inc. Ｌ−グルタミン酸の製造法
WO2005010175A1 (en) 2003-07-29 2005-02-03 Ajinomoto Co., Inc. Method for producing l-lysine or l-threonine using escherichia bacteria having attnuated malic enzyme activity
RU2003121601A (ru) 2003-07-16 2005-02-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") (RU) Мутантная серинацетилтрансфераза
WO2005049808A1 (en) 2003-11-21 2005-06-02 Ajinomoto Co., Inc. Method for producing l-amino acid by fermentation
WO2005073390A2 (en) 2004-01-30 2005-08-11 Ajinomoto Co., Inc. L-amino acid-producing microorganism and method for producing l-amino acid
JP2005237379A (ja) * 2004-01-30 2005-09-08 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
WO2005085419A1 (en) 2004-03-04 2005-09-15 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing l-glutamic acid
JP2005278643A (ja) 2004-03-04 2005-10-13 Ajinomoto Co Inc Ｌ−グルタミン酸生産微生物及びｌ−グルタミン酸の製造法
WO2005103275A1 (ja) 2004-04-26 2005-11-03 Ajinomoto Co., Ltd. 発酵法によるｌ－トリプトファンの製造法
EP1624069A1 (en) 2003-05-07 2006-02-08 Ajinomoto Co., Inc. Process for producing l-glutamic acid
WO2006051660A1 (ja) 2004-11-09 2006-05-18 Ajinomoto Co., Inc. Ｌ－アミノ酸の製造法
JP2006129840A (ja) 2004-11-09 2006-05-25 Ajinomoto Co Inc Ｌ−グルタミン酸の製造法
US7090998B2 (en) 2002-07-12 2006-08-15 Ajinomoto Co., Inc. Method for producing target substance by fermentation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2215783C2 (ru) 2001-05-15 2003-11-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото - Генетика" МУТАНТНАЯ N-АЦЕТИЛГЛУТАМАТ СИНТАЗА (ВАРИАНТЫ), ФРАГМЕНТ ДНК, ШТАММ БАКТЕРИИ Escherichia coli - ПРОДУЦЕНТ АРГИНИНА (ВАРИАНТЫ) И СПОСОБ ПОЛУЧЕНИЯ L-АРГИНИНА
BR0304860A (pt) 2002-11-11 2004-08-31 Ajinomoto Kk Método para produzir uma substância alvo pela utilização de uma-bactéria pertencente ao gênero escherichia
RU2004124226A (ru) 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
US7915018B2 (en) 2004-10-22 2011-03-29 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
US7501282B2 (en) 2005-02-25 2009-03-10 Ajinomoto Co., Inc. Plasmid autonomously replicable in Enterobacteriaceae family

Patent Citations (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR356739A (fr) 1904-09-20 1905-12-07 Charles Glauser Perrin Mécanisme de remontoir et de mise à l'heure
JPS329393B1 (ja) 1954-12-25 1957-11-07
US3563857A (en) 1967-03-20 1971-02-16 Sanraku Ocean Co Process for producing l-glutamic acid by fermentation
US4278765A (en) 1978-06-30 1981-07-14 Debabov Vladimir G Method for preparing strains which produce aminoacids
US4407952A (en) 1979-06-15 1983-10-04 Ajinomoto Company Incorporated Method for producing L-phenylalanine by fermentation
US4388405A (en) 1979-06-25 1983-06-14 Ajinomoto Company Incorporated Method for producing L-histidine by fermentation
JPS565099A (en) 1979-06-25 1981-01-20 Ajinomoto Co Inc Production of l-histidine through fermentation process and microorganism used therefor
US4346170A (en) 1979-07-23 1982-08-24 Ajinomoto Company, Incorporated Method for producing L-lysine by fermentation
GB2075056A (en) 1980-04-14 1981-11-11 Ajinomoto Kk L-proline-producing Microorganisms
JPS5771397A (en) 1980-08-22 1982-05-04 Ajinomoto Co Inc Preparation of l-tryptophan by fermentation method
US4371614A (en) 1980-08-22 1983-02-01 Ajinomoto Co., Inc. E.Coli bacteria carrying recombinant plasmids and their use in the fermentative production of L-tryptophan
DE3127361A1 (de) 1981-07-08 1983-02-03 Schering Ag, 1000 Berlin Und 4619 Bergkamen Herstellung und anwendung von plasmiden mit genen fuer die biosynthese von l-prolin
JPS6234397A (ja) 1985-08-08 1987-02-14 Mitsubishi Electric Corp ダイナミツクメモリ装置
JPS62244382A (ja) 1986-04-16 1987-10-24 Ajinomoto Co Inc 新規プロモーター及び該プロモーターを用いた遺伝子発現方法
KR890003681B1 (ko) 1987-03-26 1989-09-30 주식회사 미원 미생물에 의한 l-페닐 알라닌의 제조방법
JPH02458A (ja) 1987-10-12 1990-01-05 Ajinomoto Co Inc 発酵法によるｌ―イソロイシンの製造法
JPH02109985A (ja) 1988-02-22 1990-04-23 Eurolysine 細菌染色体上ヘの目的遺伝子の組み込み方法及び該方法によって得られた細菌
US5175107A (en) 1988-10-25 1992-12-29 Ajinomoto Co., Inc. Bacterial strain of escherichia coli bkiim b-3996 as the producer of l-threonine
US5631157A (en) 1988-10-25 1997-05-20 Ajinomoto Co., Inc. Bacterial strain of Escherichia coli VNII genetika 472T23 as the producer of L-threonine
JPH02207791A (ja) 1989-02-07 1990-08-17 Ajinomoto Co Inc 微生物の形質転換法
US5705371A (en) 1990-06-12 1998-01-06 Ajinomoto Co., Inc. Bacterial strain of escherichia coli BKIIM B-3996 as the producer of L-threonine
JPH057491A (ja) 1990-10-15 1993-01-19 Ajinomoto Co Inc 温度感受性プラスミド
EP0488424B1 (en) 1990-11-30 1997-03-05 Ajinomoto Co., Inc. Recombinant DNA sequences encoding feedback inhibition released enzymes, plasmids comprising the recombinant DNA sequences, transformed microorganisms useful in the production of aromatic amino acids, and a process for preparing aromatic amino acids by fermentation
US5168056A (en) 1991-02-08 1992-12-01 Purdue Research Foundation Enhanced production of common aromatic pathway compounds
US5658766A (en) 1991-05-30 1997-08-19 Ajinomoto Co., Inc. Strains of Escherichia coli which produce isoleucine or valine and a method for their production
US5378616A (en) 1991-08-07 1995-01-03 Ajinomoto Co., Inc. Mutant Escherichia coli capable of enhanced L-glutamic acid production by fermentation
JPH05244970A (ja) 1991-08-07 1993-09-24 Ajinomoto Co Inc 発酵法によるｌ−グルタミン酸の製造法
US5376538A (en) 1991-09-04 1994-12-27 Kyowa Hakko Kogyo Co., Ltd. Process for producing L-threonine with strains of E coli resistant to phenylalanine and leucine
JPH05130882A (ja) 1991-11-11 1993-05-28 Kyowa Hakko Kogyo Co Ltd 発酵法によるｌ−イソロイシンの製造法
US5474918A (en) 1992-02-25 1995-12-12 Kyowa Kakko Kogyo Co., Ltd. Process for the production of L-threonine and L-isoleucine by fermentation of Escherichia coli
JPH05304969A (ja) 1992-02-25 1993-11-19 Kyowa Hakko Kogyo Co Ltd 発酵法によるアミノ酸の製造法
RU2003677C1 (ru) 1992-03-30 1993-11-30 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Штамм бактерий ESCHERICHIA COLI - продуцент L-гистидина
US6180373B1 (en) 1992-09-28 2001-01-30 Consortium f{umlaut over (u)}r elektrochemische Industrie GmbH Microorganisms for the production of tryptophan and process for the preparation thereof
WO1994008031A1 (de) 1992-09-28 1994-04-14 Consortium für elektrochemische Industrie GmbH Mikroorganismen für die produktion von tryptophan und verfahren zu ihrer herstellung
EP0593792A1 (en) 1992-10-14 1994-04-27 Ajinomoto Co., Inc. Novel L-threonine-producing microbacteria and a method for the production of L-threonine
US5354672A (en) 1992-11-24 1994-10-11 Ian Fotheringham Materials and methods for hypersecretion of amino acids
US5776736A (en) 1992-12-21 1998-07-07 Purdue Research Foundation Deblocking the common pathway of aromatic amino acid synthesis
US5830716A (en) 1993-10-28 1998-11-03 Ajinomoto Co., Inc. Increased amounts of substances by modifying a microorganism to increase production of NADPH from NADH
US6040160A (en) 1993-12-08 2000-03-21 Ajinomoto Co., Inc. Method of producing L-lysine by fermentation
US5573945A (en) 1994-01-10 1996-11-12 Ajinomoto Co., Inc. Mutant and method for producing L-glutamic acid by fermentation
US5998178A (en) 1994-05-30 1999-12-07 Ajinomoto Co., Ltd. L-isoleucine-producing bacterium and method for preparing L-isoleucine through fermentation
JPH0870879A (ja) 1994-06-30 1996-03-19 Kyowa Hakko Kogyo Co Ltd 発酵法によるｌ−ロイシンの製造法
WO1996006926A1 (fr) 1994-08-30 1996-03-07 Ajinomoto Co., Inc. Procede pour produire de la l-valine et de la l-leucine
US5906925A (en) 1994-09-16 1999-05-25 Liao; James C. Microorganisms and methods for overproduction of DAHP by cloned pps gene
US5827698A (en) 1994-12-09 1998-10-27 Ajinomoto Co., Inc. Lysine decarboxylase gene and method of producing l-lysine
US6319696B1 (en) 1995-08-30 2001-11-20 Ajinomoto Co., Inc. Process for producing L-amino acids
WO1997008333A1 (fr) 1995-08-30 1997-03-06 Ajinomoto Co., Inc. Procede de production d'acides amines levogyres
US5756345A (en) 1995-09-05 1998-05-26 Degussa Aktiengesellschaft Production of tryptophan by the bacterium Escherichia coli
US6218168B1 (en) 1995-10-26 2001-04-17 CONSORTIUM FüR ELEKTROCHEMISCHE INUDSTRIE GMBH Process for preparing O-acetylserine, L-cysteine and L-cysteine-related products
US5939307A (en) 1996-07-30 1999-08-17 The Archer-Daniels-Midland Company Strains of Escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production
RU2119536C1 (ru) 1997-01-21 1998-09-27 Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Штамм escherichia coli - продуцент l-гистидина
US5972663A (en) 1997-06-19 1999-10-26 Consortium Fur Elektrochemische Industrie Gmbh Microorganisms and processes for the fermentative preparation of L-cysteine, L-cystine, N-acetylserine or thiazolidine derivatives
WO1999003988A1 (en) 1997-07-18 1999-01-28 Ajinomoto Co., Inc. Process for producing purine nucleosides via fermentation
US6124121A (en) 1997-10-29 2000-09-26 Ajinomoto Co., Inc. Method for producing L-leucine
JPH11155571A (ja) 1997-11-25 1999-06-15 Ajinomoto Co Inc Ｌ−システインの製造法
US6331419B1 (en) 1998-03-18 2001-12-18 Ajinomoto Co., Inc. L-glutamic acid-producing bacterium and method for producing L-glutamic acid
JP2000106869A (ja) 1998-03-18 2000-04-18 Ajinomoto Co Inc Ｌ―グルタミン酸生産菌及びｌ―グルタミン酸の製造法
JP2000189169A (ja) 1998-03-18 2000-07-11 Ajinomoto Co Inc Ｌ―グルタミン酸生産菌及びｌ―グルタミン酸の製造法
EP0955368A2 (en) 1998-03-18 1999-11-10 Ajinomoto Co., Ltd. L-glutamic acid-producing bacterium and method for producing l-glutamic acid
EP0952221A2 (en) 1998-03-18 1999-10-27 Ajinomoto Co., Ltd. L-Glutamic acid-producing bacterium and method for producing L-glutamic acid
US6197559B1 (en) 1998-03-18 2001-03-06 Ajinomoto Co., Inc. L-glutamic acid-producing bacterium and method for producing L-glutamic acid
US6258554B1 (en) 1998-07-03 2001-07-10 Kyowa Hakko Kogyo Co., Ltd. Method for producing metabolites biologically synthesized via phosphoribosyl pyrophosphate
WO2000018935A1 (en) 1998-09-25 2000-04-06 Ajinomoto Co.,Inc. Process for constructing amino acid-producing bacterium and process for producing amino acid by fermentation method with the use of the thus constructed amino acid-producing bacterium
JP2000189175A (ja) 1998-10-19 2000-07-11 Ajinomoto Co Inc Ｌ―グルタミン酸生産菌及びｌ―グルタミン酸の製造法
EP0999282A2 (en) 1998-10-19 2000-05-10 Ajinomoto Co., Inc. L-glutamic acid producing bacterium and process for producing l-glutamic acid
EP1013765A1 (en) 1998-12-23 2000-06-28 Ajinomoto Co., Ltd. Gene and method for producing L-amino acids
EP1016710A2 (en) 1998-12-30 2000-07-05 Ajinomoto Co., Inc. Method for producing L-amino acids
US6303383B1 (en) 1999-03-16 2001-10-16 Ajinomoto Co., Inc. Temperature sensitive plasmid for coryneform bacteria
JP2000270872A (ja) * 1999-03-25 2000-10-03 Ajinomoto Co Inc Ｌ−グルタミン酸の製造法
JP2000333769A (ja) 1999-05-31 2000-12-05 Ikeda Bussan Co Ltd シートバックフレーム
US6403342B1 (en) 1999-07-09 2002-06-11 Anjinomoto Co., Inc. DNA coding for mutant isopropylmalate synthase L-leucine-producing microorganism and method for producing L-leucine
JP2001333769A (ja) 1999-08-20 2001-12-04 Ajinomoto Co Inc 析出を伴う発酵法によるｌ−グルタミン酸の製造法
EP1078989A2 (en) 1999-08-20 2001-02-28 Ajinomoto Co., Ltd. Method for producing L-glutamic acid by fermentation accompanied by precipitation
EP1085087A2 (en) 1999-09-20 2001-03-21 Kyowa Hakko Kogyo Co., Ltd. Method for producing amino acids by fermentation using aminoquinoline resistant bacterial strains
US6344347B1 (en) 1999-09-20 2002-02-05 Kyowa Hakko Kogyo Co., Ltd. Method for producing L-amino acids by fermentation
WO2001027307A1 (de) 1999-10-14 2001-04-19 Consortium für elektrochemische Industrie GmbH Verfahren zur fermentativen herstellung von l-cystein oder l-cystein-derivaten
EP1253195A1 (en) 2000-01-21 2002-10-30 Ajinomoto Co., Inc. Process for producing l-lysine
EP1149911A2 (en) 2000-04-26 2001-10-31 Ajinomoto Co., Ltd. Amino acid producing strains belonging to the genus Escherichia and method for producing amino acid
EP1170361A2 (en) 2000-06-28 2002-01-09 Ajinomoto Co., Inc. New mutant N-Acetylglutamate synthase and method for L-Arginine production
EP1170376A1 (en) 2000-07-05 2002-01-09 Ajinomoto Co., Inc. Method for producing substances utilizing microorganisms
EP1172433A1 (en) 2000-07-06 2002-01-16 Ajinomoto Co., Inc. Bacterium having ability to produce L-glutamic acid, L-proline or L-arginine and method for producing L-glutamic acid, L-proline or L-arginine
EP1170358A1 (en) 2000-07-06 2002-01-09 Ajinomoto Co., Ltd. L-arginine producing Escherichia coli and method of producing L-arginine
US20020025564A1 (en) 2000-08-24 2002-02-28 Ajinomoto Co., Inc. Method for producing basic amino acid
JP2002065287A (ja) 2000-08-24 2002-03-05 Ajinomoto Co Inc 塩基性アミノ酸の製造方法
US20020058315A1 (en) 2000-09-26 2002-05-16 Ajinomoto Co., Inc. Bacterium having ability to produce L-glutamic acid, L-proline or L-arginine and method for producing L-glutamic acid, L-proline or L-arginine
RU2000124295A (ru) 2000-09-26 2003-02-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Бактерия, обладающая способностью к продукции l-глутаминовой кислоты, l-пролина или l-аргинина, и способ получения l-глутаминовой кислоты, l-пролина или l-аргинина
EP1239041A2 (en) 2001-02-13 2002-09-11 Ajinomoto Co., Inc. Method for producing L-amino acid using bacteria belonging to the genus Escherichia
EP1233069A2 (en) 2001-02-20 2002-08-21 Ajinomoto Co., Inc. Method for producing L-glutamic acid
US6596517B2 (en) 2001-02-20 2003-07-22 Ajinomoto Co., Inc. Method for producing L-glutamic acid
EP1233068A2 (en) 2001-02-20 2002-08-21 Ajinomoto Co., Inc. Method for producing L-glutamic acid
RU2001112869A (ru) 2001-05-15 2003-03-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Новая мутантная n-ацетилглутамат синтаза и способ получения l-аргинина
US20030148473A1 (en) 2001-11-23 2003-08-07 Ajinomoto Co., Inc. Method for producing L-amino acid using bacteria belonging to the genus escherichia
US20030157667A1 (en) 2001-11-23 2003-08-21 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria belonging to the genus escherichia
JP2003274988A (ja) 2002-03-27 2003-09-30 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
WO2003097839A1 (en) 2002-05-15 2003-11-27 Cj Corporation Nucleotide sequence of threonine operon irrepressible by isoleucine and method for producing l-threonine using transformed host cell containing the same
US7090998B2 (en) 2002-07-12 2006-08-15 Ajinomoto Co., Inc. Method for producing target substance by fermentation
EP1624069A1 (en) 2003-05-07 2006-02-08 Ajinomoto Co., Inc. Process for producing l-glutamic acid
WO2004111258A1 (ja) 2003-06-10 2004-12-23 Ajinomoto Co., Inc. Ｌ−グルタミン酸の製造法
RU2003121601A (ru) 2003-07-16 2005-02-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") (RU) Мутантная серинацетилтрансфераза
WO2005010175A1 (en) 2003-07-29 2005-02-03 Ajinomoto Co., Inc. Method for producing l-lysine or l-threonine using escherichia bacteria having attnuated malic enzyme activity
WO2005049808A1 (en) 2003-11-21 2005-06-02 Ajinomoto Co., Inc. Method for producing l-amino acid by fermentation
JP2005237379A (ja) * 2004-01-30 2005-09-08 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
WO2005073390A2 (en) 2004-01-30 2005-08-11 Ajinomoto Co., Inc. L-amino acid-producing microorganism and method for producing l-amino acid
WO2005085419A1 (en) 2004-03-04 2005-09-15 Ajinomoto Co., Inc. L-glutamic acid-producing microorganism and a method for producing l-glutamic acid
JP2005278643A (ja) 2004-03-04 2005-10-13 Ajinomoto Co Inc Ｌ−グルタミン酸生産微生物及びｌ−グルタミン酸の製造法
WO2005103275A1 (ja) 2004-04-26 2005-11-03 Ajinomoto Co., Ltd. 発酵法によるｌ－トリプトファンの製造法
WO2006051660A1 (ja) 2004-11-09 2006-05-18 Ajinomoto Co., Inc. Ｌ－アミノ酸の製造法
JP2006129840A (ja) 2004-11-09 2006-05-25 Ajinomoto Co Inc Ｌ−グルタミン酸の製造法

Non-Patent Citations (45)

* Cited by examiner, † Cited by third party
Title
"Amino Acid Fermentation", 30 May 1986, GAKKAI SHUPPAN CENTER (LTD.), pages: 77 - 100
"Molecular Cloning", 2001, COLD SPRING HARBOR LABORATORY PRESS
ABSTRACTS OF THE 17TH INTERNATIONAL CONGRESS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY IN CONJUGATION WITH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 24 August 1997 (1997-08-24)
ARNOLD, A. ET AL., ANAL. BIOCHEM., vol. 71, 1976, pages 209
BACKMANN, B.J.: "Escherichia coli and Salmonella Cellular and Molecular Biology", 1996, AMERICAN SOCIETY FOR MICROBIOLOGY PRESS, article "Derivations and Genotypes of some mutant derivatives of Escherichia coli K-12", pages: 2460 - 2488
BIBB, M.J. ET AL., NATURE, vol. 274, 1978, pages 398 - 400
BIOCHEMISTRY, vol. 22, 1983, pages 5243 - 5249
BRUNSCHWIG, E.; DARZINS, A., GENE, vol. 111, no. 1, 1992, pages 35 - 41
CADWELL, R.C., PCR METH. APPL., vol. 2, 1992, pages 28
CANADIAN JOURNAL OF MICROBIOLOGY, vol. 43, 1997, pages 197
CHANG, S.; CHOEN, S.N., MOL. GEN. GENET., vol. 168, 1979, pages 111 - 115
CHO, E. H.; GUMPORT, R. I.; GARDNER, J. F., J. BACTERIOL., vol. 184, 2002, pages 5200 - 5203
DATSENKO, K.A.; WANNER, B.L., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6640 - 6645
DATSENKO, K.A.; WANNER, B.L., PROC. NATL. ACAD. SCI. USA., vol. 97, 2000, pages 6640 - 6645
DEHIO, M. ET AL., GENE, vol. 215, no. 2, 1998, pages 223 - 229
DUNCAN, C.H.; WILSON, G. A.; YOUNG, F. E., GENE, vol. 1, 1977, pages 153 - 167
GENE, vol. 27, 1984, pages 193 - 199
GOLDSTEIN ET AL.: "Prokaryotic promoters in biotechnology", BIOTECHNOL. ANNU. REV., vol. 1, 1995, pages 105 - 128, XP008038474
GUSYATINER ET AL., GENETIKA (IN RUSSIAN), vol. 14, 1978, pages 947 - 956
HINNEN, A.; HICKS, J.B.; FINK, G. R., PROC. NATL. SCI., USA, vol. 75, 1978, pages 1929 - 1933
INT. J. SYST. BACTERIOL., vol. 43, 1993, pages 162 - 173
INT. J. SYST. BACTERIOL., vol. 43, 1997, pages 1061 - 1067
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, vol. 39, July 1989 (1989-07-01), pages 337 - 345
J. BACTERIOL., vol. 174, no. 7, April 1992 (1992-04-01), pages 2152 - 59
J. BIOCHEM., vol. 95, 1984, pages 909 - 916
J. GEN. APPL. MICROBIOL., vol. 43, 1997, pages 355 - 361
KUNIHIKO AKASHI ET AL.: "Amino acid fermentation", 1986, JAPAN SCIENTIFIC SOCIETIES PRESS, pages: 195 - 215
L.J. REED; B.B. MUKHERJEE, METHODS IN ENZYMOLOGY, vol. 13, 1969, pages 55 - 61
LAIMINS L.A.: "Identification of the structural proteins of an ATP-driven potassium transport system in Escherichia coli", PROC. NATL. ACAD. SCI. USA, vol. 75, no. 7, 1978, pages 3216 - 3219, XP008110354 *
LAIMONIS A. LAIMINS, PROC. NATL. ACAD. SCI. USA, vol. 5, no. 7, 7 July 1978 (1978-07-07), pages 3216 - 19
LAIMONIS A. LAIMINS, PROC. NATL. ACAD. SCI. USA, vol. 8, no. 1, 7 January 1981 (1981-01-07), pages 464 - 68
MANDEL, M.; HIGA, A., J. MOL. BIOL., vol. 53, 1970, pages 159 - 162
MARK 0. WALDERHAUG, J. BACTERIOL., vol. 4, no. 7, 17 April 1992 (1992-04-17), pages 2152 - 59
MASHKO, S.V. ET AL., BIOTEKHNOLOGIYA (IN RUSSIAN), no. 5, 2001, pages 3 - 20
MICROBIOLOGY, vol. 140, 1994, pages 1817 - 1828
MILLERI, J. H.: "Experiments in Molecular Genetics", 1972, COLD SPRING HARBOR LABORATORY
MOL. GEN. GENET., vol. 218, 1989, pages 330 - 339
MOLECULAR MICROBIOLOGY, vol. 6, 1992, pages 317 - 326
PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6640 - 6645
SIEBERS, A. ET AL., EUR. J. BIOCHEM., vol. 178, 1988, pages 131
SKOROKHODOVA, A. YU ET AL., BIOTEKHNOLOGIYA (RUS), vol. 5, 2004, pages 3 - 21
STEMMER, W.P., NATURE, vol. 370, 1994, pages 389
THE 15TH MIAMI WINTER SYMPOSIUM, 1983, pages 34
WHITE, T.J. ET AL., TRENDS GENET., vol. 5, 1989, pages 185
ZHAO, H., NATURE BIOTECHNOL., vol. 16, 1998, pages 258

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WO2011087139A2 (en) 2010-01-15 2011-07-21 Ajinomoto Co.,Inc. A BACTERIUM OF Enterobacteriaceae FAMILY PRODUCING L-ASPARTIC ACID OR L-ASPARTIC ACID-DERIVED METABOLITES AND A METHOD FOR PRODUCING L-ASPARTIC ACID OR L-ASPARTIC ACID-DERIVED METABOLITES
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