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WO2008081897A1 - 蛍光内視鏡システム - Google Patents

蛍光内視鏡システム Download PDF

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Publication number
WO2008081897A1
WO2008081897A1 PCT/JP2007/075189 JP2007075189W WO2008081897A1 WO 2008081897 A1 WO2008081897 A1 WO 2008081897A1 JP 2007075189 W JP2007075189 W JP 2007075189W WO 2008081897 A1 WO2008081897 A1 WO 2008081897A1
Authority
WO
WIPO (PCT)
Prior art keywords
fluorescent
autofluorescence
excitation light
endoscope system
living tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/075189
Other languages
English (en)
French (fr)
Inventor
Hideyuki Takaoka
Koki Morishita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olympus Corp
Original Assignee
Olympus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Corp filed Critical Olympus Corp
Priority to EP07860410.5A priority Critical patent/EP2098157A4/en
Priority to US12/521,201 priority patent/US8214025B2/en
Publication of WO2008081897A1 publication Critical patent/WO2008081897A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002—Operational features of endoscopes
    • A61B1/00004—Operational features of endoscopes characterised by electronic signal processing
    • A61B1/00009—Operational features of endoscopes characterised by electronic signal processing of image signals during a use of endoscope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00186—Optical arrangements with imaging filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
    • A61B1/0638—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements providing two or more wavelengths

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Signal Processing (AREA)
  • Endoscopes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

　自家蛍光の影響を抑制して、蛍光プローブから発せられる蛍光による鮮明な蛍光画像により、癌細胞等の異常組織を正確かつ明瞭に判別することを可能とする。生体組織に付着または吸収させた蛍光色素からの蛍光を観察する蛍光内視鏡システム（１）であって、蛍光色素を励起する励起光を射出する励起光源（４）と、該励起光源（４）からの励起光を照射したときに生体組織から発せられる蛍光を撮影する撮像部（３）と、励起光を照射したときに生体組織から発せられる自家蛍光の信号強度を設定する自家蛍光信号設定部（５）と、撮像部（３）により取得された蛍光画像情報を、自家蛍光信号設定部（５）により設定された自家蛍光の信号強度に基づいて補償する画像補償部（６）とを備える蛍光内視鏡システム（１）を提供する。
PCT/JP2007/075189 2006-12-28 2007-12-27 蛍光内視鏡システム Ceased WO2008081897A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07860410.5A EP2098157A4 (en) 2006-12-28 2007-12-27 FLUORESCENT ENDOSCOPE SYSTEM
US12/521,201 US8214025B2 (en) 2006-12-28 2007-12-27 Fluorescence endoscope system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-356140 2006-12-28
JP2006356140A JP4954699B2 (ja) 2006-12-28 2006-12-28 蛍光内視鏡システム

Publications (1)

Publication Number Publication Date
WO2008081897A1 true WO2008081897A1 (ja) 2008-07-10

Family

ID=39588579

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/075189 Ceased WO2008081897A1 (ja) 2006-12-28 2007-12-27 蛍光内視鏡システム

Country Status (4)

Country Link
US (1) US8214025B2 (ja)
EP (1) EP2098157A4 (ja)
JP (1) JP4954699B2 (ja)
WO (1) WO2008081897A1 (ja)

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ATE336717T1 (de) 2001-05-17 2006-09-15 Xenogen Corp Verfahren und vorrichtung zur feststellung von zieltiefe, helligkeit und grösse in einer körperregion
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
ATE506000T1 (de) * 2008-06-04 2011-05-15 Fujifilm Corp Beleuchtungsvorrichtung zur verwendung in endoskopen
JP5216429B2 (ja) * 2008-06-13 2013-06-19 富士フイルム株式会社 光源装置および内視鏡装置
EP2526853B1 (en) * 2010-03-09 2014-01-08 Olympus Corporation Fluorescence endoscope device
JP5432793B2 (ja) * 2010-03-29 2014-03-05 オリンパス株式会社 蛍光内視鏡装置
JP2014039571A (ja) * 2010-12-27 2014-03-06 Olympus Corp 蛍光内視鏡装置
JP5926909B2 (ja) 2011-09-07 2016-05-25 オリンパス株式会社 蛍光観察装置
EP2863801B8 (en) 2012-06-21 2024-06-12 Stryker Corporation Quantification and analysis of angiography and perfusion
EP2976989A4 (en) * 2013-07-11 2017-03-15 Olympus Corporation Light source device
CN104274149B (zh) * 2013-07-12 2016-06-29 深圳先进技术研究院 光声-荧光双模成像内窥镜
EP3099325A4 (en) * 2014-01-31 2017-10-04 The General Hospital Corporation Dba Massachusetts General Hospital Methods of treating and imaging tumor micrometastases using photoactivatable immunoconjugates
CN106572792B (zh) * 2014-06-05 2020-03-06 海德堡大学 用于多光谱成像的方法和部件
CN107209118B (zh) 2014-09-29 2021-05-28 史赛克欧洲运营有限公司 在自体荧光存在下生物材料中目标荧光团的成像
AU2014408488B2 (en) 2014-10-09 2019-07-18 Stryker European Operations Limited Quantification of absolute blood flow in tissue using fluorescence-mediated photoplethysmography
KR101978838B1 (ko) * 2015-11-02 2019-05-16 재단법인 아산사회복지재단 다중 파장 내시경 시스템 및 이를 이용한 영상 처리 방법
JPWO2018008136A1 (ja) * 2016-07-07 2019-04-18 オリンパス株式会社 画像処理装置および画像処理装置の作動方法
US10610088B2 (en) 2016-10-18 2020-04-07 The Asan Foundation Multi-wavelength endoscopic system and image processing method using same
JP6931705B2 (ja) 2017-02-10 2021-09-08 ノバダック テクノロジーズ ユーエルシー オープンフィールドハンドヘルド蛍光イメージングシステムおよび方法
RU2665628C1 (ru) * 2018-01-25 2018-09-03 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) Устройство для спектрально-флуоресцентного исследования содержания флуорохромов
CN114098967B (zh) * 2021-12-01 2024-06-14 辽宁北镜医疗科技有限公司 一种具有辅助校准激光的荧光导航系统及方法
CN118787297B (zh) * 2024-09-11 2025-03-25 浙江华诺康科技有限公司 双荧光图像处理方法和内窥镜成像系统
CN119924755B (zh) * 2025-01-26 2025-11-21 苏州莱诺医疗器械有限公司 医用内窥镜荧光摄像系统

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JPH10201707A (ja) 1996-11-20 1998-08-04 Olympus Optical Co Ltd 内視鏡装置
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JP2006296635A (ja) * 2005-04-19 2006-11-02 Olympus Corp 内視鏡装置

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US7321791B2 (en) * 2003-09-23 2008-01-22 Cambridge Research And Instrumentation, Inc. Spectral imaging of deep tissue
EP2191774A3 (en) * 2004-12-06 2010-06-23 Cambridge Research & Instrumentation, Inc. Systems and methods for in-vivo optical imaging and measurement
JP4725952B2 (ja) 2005-02-14 2011-07-13 京セラミタ株式会社 画像形成方法
FR2882147B1 (fr) * 2005-02-14 2007-10-05 Commissariat Energie Atomique Dispositif d'imagerie de fluorescence par reflexion a deux longueurs d'onde
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Patent Citations (3)

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JPH10201707A (ja) 1996-11-20 1998-08-04 Olympus Optical Co Ltd 内視鏡装置
JP2006263044A (ja) * 2005-03-23 2006-10-05 Fuji Photo Film Co Ltd 蛍光検出システム
JP2006296635A (ja) * 2005-04-19 2006-11-02 Olympus Corp 内視鏡装置

Non-Patent Citations (1)

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Title
See also references of EP2098157A4

Also Published As

Publication number Publication date
EP2098157A4 (en) 2015-01-21
EP2098157A1 (en) 2009-09-09
JP2008161551A (ja) 2008-07-17
US20100016669A1 (en) 2010-01-21
JP4954699B2 (ja) 2012-06-20
US8214025B2 (en) 2012-07-03

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