[go: up one dir, main page]

WO2007011696A8 - Compositions et procedes pour le couplage d'une pluralite de composes a un squelette - Google Patents

Compositions et procedes pour le couplage d'une pluralite de composes a un squelette Download PDF

Info

Publication number
WO2007011696A8
WO2007011696A8 PCT/US2006/027310 US2006027310W WO2007011696A8 WO 2007011696 A8 WO2007011696 A8 WO 2007011696A8 US 2006027310 W US2006027310 W US 2006027310W WO 2007011696 A8 WO2007011696 A8 WO 2007011696A8
Authority
WO
WIPO (PCT)
Prior art keywords
scaffold
compositions
methods
compounds
coupling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/027310
Other languages
English (en)
Other versions
WO2007011696A3 (fr
WO2007011696A2 (fr
Inventor
M G Finn
Sayam Sen Gupta
Karl Barry Sharpless
Valery V Fokin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Priority to JP2008521631A priority Critical patent/JP2009501717A/ja
Priority to EP06787247A priority patent/EP1910497A4/fr
Priority to US11/995,523 priority patent/US20090181402A1/en
Publication of WO2007011696A2 publication Critical patent/WO2007011696A2/fr
Publication of WO2007011696A3 publication Critical patent/WO2007011696A3/fr
Anticipated expiration legal-status Critical
Publication of WO2007011696A8 publication Critical patent/WO2007011696A8/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Composite Materials (AREA)
  • Theoretical Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

La présente invention a trait à des compositions et des procédés pour le couplage d'une pluralité de composés à un squelette. L'invention a également trait à des compositions et des procédés pour la catalyse d'une réaction entre au moins un groupe fonctionnel alcyne terminal et au moins un groupe fonctionnel azide, dans laquelle un groupe fonctionnel est lié à un composé et l'autre groupe fonctionnel est lié au squelette, formant ainsi au moins un triazole.
PCT/US2006/027310 2005-07-14 2006-07-14 Compositions et procedes pour le couplage d'une pluralite de composes a un squelette Ceased WO2007011696A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008521631A JP2009501717A (ja) 2005-07-14 2006-07-14 複数の化合物を足場構造にカップリングさせるための組成物および方法
EP06787247A EP1910497A4 (fr) 2005-07-14 2006-07-14 Compositions et procedes pour le couplage d'une pluralite de composes a un squelette
US11/995,523 US20090181402A1 (en) 2005-07-14 2006-07-14 Compositions and methods for coupling a plurality of compounds to a scaffold

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69998505P 2005-07-14 2005-07-14
US60/699,985 2005-07-14
US11/486,646 US20070020620A1 (en) 2005-07-14 2006-07-13 Compositions and methods for coupling a plurality of compounds to a scaffold
US11/486,646 2006-07-13

Publications (3)

Publication Number Publication Date
WO2007011696A2 WO2007011696A2 (fr) 2007-01-25
WO2007011696A3 WO2007011696A3 (fr) 2007-04-26
WO2007011696A8 true WO2007011696A8 (fr) 2009-02-12

Family

ID=37669376

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/027310 Ceased WO2007011696A2 (fr) 2005-07-14 2006-07-14 Compositions et procedes pour le couplage d'une pluralite de composes a un squelette

Country Status (4)

Country Link
US (2) US20070020620A1 (fr)
EP (2) EP2452936A1 (fr)
JP (1) JP2009501717A (fr)
WO (1) WO2007011696A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9821071B2 (en) 2011-01-14 2017-11-21 Emory University Oligosaccharide conjugates for targeting bacteria and uses related thereto

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008510829A (ja) * 2004-08-25 2008-04-10 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン デンドリマーに基づく組成物およびそれらの使用法
US8071718B2 (en) 2004-12-22 2011-12-06 General Electric Company Selective radiolabeling of biomolecules
WO2007003054A1 (fr) 2005-07-06 2007-01-11 Shoichet Molly S Procede d'immobilisation de biomolecule sur des polymeres faisant intervenir des reactions chimiques du type rapide
EP1909846B1 (fr) 2005-08-05 2018-12-26 Syntarga B.V. Bras de liaison detachables contenant du triazole, conjugues de ceux-ci et procedes de preparation
US20070060658A1 (en) * 2005-08-31 2007-03-15 Diaz David D Stabilization of organogels and hydrogels by azide-alkyne [3+2] cycloaddition
US8158832B2 (en) 2005-11-09 2012-04-17 The Trustees Of Columbia University In The City Of New York Photochemical methods and photoactive compounds for modifying surfaces
US8734823B2 (en) 2005-12-14 2014-05-27 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US8682619B2 (en) 2005-12-14 2014-03-25 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US8278094B2 (en) 2005-12-14 2012-10-02 The Invention Science Fund I, Llc Bone semi-permeable device
US8658573B2 (en) * 2006-09-11 2014-02-25 The Trustees Of Columbia University In The City Of New York Photo-generated carbohydrate arrays and the rapid identification of pathogen-specific antigens and antibodies
EP2094721B1 (fr) * 2006-12-14 2018-02-14 Aileron Therapeutics, Inc. Systèmes de macrocyclisation bis-sulfhydryle
AU2008210434C8 (en) 2007-01-31 2014-03-27 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
ES2649941T3 (es) 2007-02-23 2018-01-16 Aileron Therapeutics, Inc. Aminoácidos sustituidos para preparar péptidos macrocíclicos unidos a triazol
KR20160061439A (ko) 2007-03-28 2016-05-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
US8927682B2 (en) * 2007-08-24 2015-01-06 Board Of Trustees Of Michigan State University Functionalization of polyglycolides by “click” chemistry
US8394914B2 (en) * 2007-08-24 2013-03-12 Board Of Trustees Of Michigan State University Functional polyglycolide nanoparticles derived from unimolecular micelles
US8563738B2 (en) * 2007-09-18 2013-10-22 The Scripps Research Institute Ligands for copper-catalyzed azide-alkyne cycloaddition reactions
WO2009053700A1 (fr) * 2007-10-23 2009-04-30 Cancer Research Technology Limited Modification d'entités biologiques contenant des acides nucléiques
EP2231201B1 (fr) * 2007-12-20 2018-02-14 General Electric Company Radiomarquage sélectif de biomolécules
US8252834B2 (en) * 2008-03-12 2012-08-28 The Regents Of The University Of Michigan Dendrimer conjugates
DE102008015526B4 (de) * 2008-03-25 2021-11-11 Merck Patent Gmbh Metallkomplexe
US8034396B2 (en) * 2008-04-01 2011-10-11 Tyco Healthcare Group Lp Bioadhesive composition formed using click chemistry
WO2009155431A1 (fr) * 2008-06-18 2009-12-23 University Of Louisville Research Foundation, Inc. Méthodes de détection et de traitement ciblés d'un cancer
GB0816783D0 (en) * 2008-09-15 2008-10-22 Carmeda Ab Immobilised biological entities
US8889635B2 (en) * 2008-09-30 2014-11-18 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010053993A1 (fr) 2008-11-04 2010-05-14 The Trustees Of Columbia University In The City Of New York Polymères hétérobifonctionnels et procédés de construction de films multicouches par superposition des couches
US9017644B2 (en) 2008-11-07 2015-04-28 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
US20100158850A1 (en) * 2008-12-23 2010-06-24 The Regents Of The University Of Michigan Dendrimer based modular platforms
BRPI1006139A2 (pt) 2009-01-14 2017-05-30 Aileron Therapeutics Inc macrociclos peptidomiméticos
EP2398523B1 (fr) 2009-02-21 2018-04-04 Covidien LP Dispositifs médicaux présentant des surfaces activées
WO2010095052A2 (fr) 2009-02-21 2010-08-26 Sofradim Production Composés et dispositifs médicaux activés par des lieurs solvophobes
US9523159B2 (en) 2009-02-21 2016-12-20 Covidien Lp Crosslinked fibers and method of making same using UV radiation
WO2010095053A2 (fr) 2009-02-21 2010-08-26 Sofradim Production Appareil et procédé d'obtention de polymères par exposition au rayonnement ultraviolet en vue de produire des dispositifs médicaux injectables
US8535477B2 (en) * 2009-02-21 2013-09-17 Sofradim Production Medical devices incorporating functional adhesives
AU2010215192B2 (en) 2009-02-21 2015-04-30 Sofradim Production Amphiphilic compounds and self-assembling compositions made therefrom
CA2753179A1 (fr) 2009-02-21 2010-08-26 Sofradim Production Fibres reticulees et leur procede de production par extrusion
US8512728B2 (en) 2009-02-21 2013-08-20 Sofradim Production Method of forming a medical device on biological tissue
US8663689B2 (en) * 2009-02-21 2014-03-04 Sofradim Production Functionalized adhesive medical gel
EP2398850B1 (fr) 2009-02-21 2018-08-22 Sofradim Production Dispositifs médicaux à revêtement activé
US8877170B2 (en) * 2009-02-21 2014-11-04 Sofradim Production Medical device with inflammatory response-reducing coating
US8968733B2 (en) * 2009-02-21 2015-03-03 Sofradim Production Functionalized surgical adhesives
CA2753217A1 (fr) 2009-02-21 2010-08-26 Sofradim Production Appareil et procede de reaction de polymeres passes au travers d'une matrice resineuse chelatee par ions metalliques pour produire des dispositifs medicaux injectables
WO2010096654A1 (fr) 2009-02-21 2010-08-26 Tyco Healthcare Group Lp Dispositifs médicaux présentant des surfaces activées
KR101742332B1 (ko) 2009-04-20 2017-05-31 갈렌바이오 인코포레이티드 생체분자로 세포를 형질감염시키기 위한 조성물
US8551749B2 (en) 2009-04-23 2013-10-08 The Invention Science Fund I, Llc Device including bone cage and method for treatment of disease in a subject
AU2010298338A1 (en) 2009-09-22 2012-04-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8741591B2 (en) 2009-10-09 2014-06-03 The Research Foundation For The State University Of New York pH-insensitive glucose indicator protein
EP2488172A4 (fr) 2009-10-13 2014-08-13 Univ Michigan Compositions de dendrimères et procédés de synthèse
US8912323B2 (en) 2009-10-30 2014-12-16 The Regents Of The University Of Michigan Multifunctional small molecules
GB201004101D0 (en) 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities
WO2011117744A2 (fr) 2010-03-25 2011-09-29 Sofradim Production Dispositifs médicaux incorporant des adhésifs fonctionnels
EP2550034B1 (fr) * 2010-03-25 2015-01-07 Sofradim Production Fixations chirurgicales et procédés pour fermer des plaies
WO2012006147A1 (fr) 2010-06-29 2012-01-12 Tyco Healthcare Group Lp Réacteur alimenté par micro-ondes et méthode de formation in situ d'implants
EP2588153A2 (fr) 2010-07-01 2013-05-08 Sofradim Production Dispositif médical comportant une intégration cellulaire activée prédéfinie
JP5773405B2 (ja) * 2010-07-09 2015-09-02 国立大学法人高知大学 細胞膜上分子と相互作用する化合物の検出方法
WO2012014080A2 (fr) * 2010-07-27 2012-02-02 Sofradim Production Fibres polymères ayant des éléments réactifs aux tissus
DK2603600T3 (da) 2010-08-13 2019-03-04 Aileron Therapeutics Inc Peptidomimetiske makrocyklusser
EA201390660A1 (ru) 2010-11-05 2013-11-29 Селекта Байосайенсиз, Инк. Модифицированные никотиновые соединения и связанные способы
US9006345B2 (en) 2011-03-25 2015-04-14 The Trustees Of Columbia University In The City Of New York Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials
EP2543671A1 (fr) * 2011-07-08 2013-01-09 cynora GmbH Liaison transversale et stabilisation de complexes métalliques organiques dans des réseaux
CN102336643B (zh) * 2011-07-13 2014-06-25 北京博源恒升高科技有限公司 苯酚类直接氧化合成苯醌类的工艺
RU2639523C2 (ru) 2011-10-18 2017-12-21 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы и их применение
WO2013085718A1 (fr) 2011-12-08 2013-06-13 The Regents Of The University Of Michigan Petites molécules multifonctionnelles
EP2807251B1 (fr) * 2012-01-26 2018-01-10 Life Technologies Corporation Méthodes pour augmenter la capacité d'infection des virus
SG11201404361UA (en) 2012-01-26 2014-09-26 Life Technologies Corp Methods for increasing the infectivity of viruses
CA2864120A1 (fr) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Macrocycles peptidomimetiques reticules par triazole et par thioether
RU2642299C2 (ru) 2012-02-15 2018-01-24 Эйлерон Терапьютикс, Инк. P53 пептидомиметические макроциклы
US8843229B2 (en) * 2012-07-20 2014-09-23 Biomet Manufacturing, Llc Metallic structures having porous regions from imaged bone at pre-defined anatomic locations
US9604919B2 (en) 2012-11-01 2017-03-28 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
US10071911B2 (en) 2013-03-05 2018-09-11 Prolume, Ltd. Self assembling beta-barrel proteins position nanotubes
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament
US20150368379A1 (en) * 2013-06-21 2015-12-24 The University Of Notre Dame Du Lac Synthesizing hyperbranched polymers with uniform structure in confined space
KR20160073372A (ko) * 2013-08-28 2016-06-24 아데노비르 파마 에이비 다가의 시알산 유도체
JP2018503595A (ja) 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその製剤
SG11201702223UA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2017004548A1 (fr) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
US10299916B2 (en) * 2016-01-07 2019-05-28 Medtronic Vascular, Inc. Bioprosthetic tissue repair and reinforcement
CN108659059B (zh) * 2017-04-01 2021-04-06 武汉博仁凯润药业有限公司 一种血型抗原a及其类似物的合成方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508151A (en) * 1994-12-22 1996-04-16 Eastman Kodak Company Processing of photographic elements using copper ligand complexes to catalyze peracid bleaching agents
WO2003101972A1 (fr) * 2002-05-30 2003-12-11 The Scripps Research Institute Ligation d'azides et d'acetylenes catalysee par le cuivre
WO2004009116A2 (fr) * 2002-07-18 2004-01-29 Cytos Biotechnology Ag Conjugues haptene-porteur et utilisations de ceux-ci
US7901461B2 (en) * 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US20090069561A1 (en) * 2004-06-30 2009-03-12 The Scripps Research Institute Click chemistry route to triazole dendrimers
WO2007003054A1 (fr) * 2005-07-06 2007-01-11 Shoichet Molly S Procede d'immobilisation de biomolecule sur des polymeres faisant intervenir des reactions chimiques du type rapide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9821071B2 (en) 2011-01-14 2017-11-21 Emory University Oligosaccharide conjugates for targeting bacteria and uses related thereto
US10646580B2 (en) 2011-01-14 2020-05-12 Emory University Oligosaccharide conjugates for targeting bacteria and uses related thereto

Also Published As

Publication number Publication date
EP2452936A1 (fr) 2012-05-16
US20070020620A1 (en) 2007-01-25
WO2007011696A3 (fr) 2007-04-26
US20090181402A1 (en) 2009-07-16
JP2009501717A (ja) 2009-01-22
WO2007011696A2 (fr) 2007-01-25
EP1910497A4 (fr) 2009-08-12
EP1910497A2 (fr) 2008-04-16

Similar Documents

Publication Publication Date Title
WO2007011696A3 (fr) Compositions et procedes pour le couplage d'une pluralite de composes a un squelette
EP2261218A3 (fr) Procédé pour la préparation d'imidazoles substitués par un groupe phényle, pyridinyle ou pyrimidinyle
WO2005074603A3 (fr) Utilisation d'aminobenzoxazoles comme agents therapeutiques
WO2009000441A8 (fr) Procédé de préparation de pyrazoles
WO2009016149A3 (fr) Procédé pour la fabrication de glycidol
WO2004087600A3 (fr) Composition de ciment
WO2007035629A3 (fr) Inhibiteurs de dipeptidylpeptidase
WO2008025027A3 (fr) Milieu de culture comprimé
WO2007061923A3 (fr) Activateurs de la glucokinase
WO2007109810A3 (fr) Procedes de preparation de composes contenant de l'imidazole
WO2009075890A8 (fr) Composés triazole qui modulent l'activité de hsp90
WO2007023295A3 (fr) Synthese chimique
WO2008040820A3 (fr) Composés fongicides et compositions fongicides
WO2005085236A3 (fr) Inhibiteurs de la caspase et leurs utilisations
WO2008034644A3 (fr) Procédé de fabrication d'anastrozole
WO2008074693A3 (fr) Procédé de préparation de 3,5-di-omicron-acyl-2-fluoro-2-c-méthyl-d-ribono-gamma-lactone
WO2007060448A3 (fr) Procédé chimique
WO2007066158A3 (fr) 17α-CYANOMETHYL-17β-HYDROXY-ESTRA-4,9-DIENE-3-ONE DE PURETE ELEVEE ET SON PROCEDE DE SYNTHESE
EP1831239A1 (fr) PROCÉDÉ DE SYNTHÈSE DE LA y-LACTONE DE L'ACID 17-HYDROXY-6 BETA, 7 BETA, 15 BETA, 16 BETA -BISMÉTHYLÈNE -17 ALPHA- PREGN-4- ÈNE-3-ONE-21 CARBOXYLIQUE ET INTERMÉDIARIES-CLÉS DE CE PROCÉDÉ
WO2008060366A3 (fr) Compositions d'agent générateur de gaz
WO2008015133A3 (fr) Procédé de fabrication d'amidrazones
WO2005080403A3 (fr) Procede chimique
WO2007085651A8 (fr) Procede de preparation de composes organiques
WO2008007391A3 (fr) Procédé amélioré de préparation du valsartan
WO2007039076A3 (fr) Composé de niobium

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2008521631

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006787247

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 11995523

Country of ref document: US