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WO2009075890A8 - Composés triazole qui modulent l'activité de hsp90 - Google Patents

Composés triazole qui modulent l'activité de hsp90 Download PDF

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Publication number
WO2009075890A8
WO2009075890A8 PCT/US2008/013671 US2008013671W WO2009075890A8 WO 2009075890 A8 WO2009075890 A8 WO 2009075890A8 US 2008013671 W US2008013671 W US 2008013671W WO 2009075890 A8 WO2009075890 A8 WO 2009075890A8
Authority
WO
WIPO (PCT)
Prior art keywords
synthesis
triazole compounds
hsp90 activity
modulate hsp90
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/013671
Other languages
English (en)
Other versions
WO2009075890A3 (fr
WO2009075890A2 (fr
Inventor
Dinesh U. Chimmanamada
Shijie Zhang
Chi-Wan Lee
Teresa Przewloka
Weiwen Ying
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synta Phamaceuticals Corp
Original Assignee
Synta Phamaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Phamaceuticals Corp filed Critical Synta Phamaceuticals Corp
Publication of WO2009075890A2 publication Critical patent/WO2009075890A2/fr
Publication of WO2009075890A3 publication Critical patent/WO2009075890A3/fr
Publication of WO2009075890A8 publication Critical patent/WO2009075890A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un nouveau procédé de synthèse de composés qui inhibent l'activité de Hsp90. Dans un mode de réalisation, la présente invention est un procédé de synthèse d'un composé de formule (IA), par cyclisation d'un composé de formule (II) : dans un mélange base/solvant, en produisant ainsi un composé de formule (IA). La définition des substituants et les conditions des réactions sont données ici.
PCT/US2008/013671 2007-12-12 2008-12-12 Composés triazole qui modulent l'activité de hsp90 Ceased WO2009075890A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US739107P 2007-12-12 2007-12-12
US61/007,391 2007-12-12

Publications (3)

Publication Number Publication Date
WO2009075890A2 WO2009075890A2 (fr) 2009-06-18
WO2009075890A3 WO2009075890A3 (fr) 2009-08-13
WO2009075890A8 true WO2009075890A8 (fr) 2009-10-01

Family

ID=40451133

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/013671 Ceased WO2009075890A2 (fr) 2007-12-12 2008-12-12 Composés triazole qui modulent l'activité de hsp90

Country Status (1)

Country Link
WO (1) WO2009075890A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
WO2012026931A1 (fr) * 2010-08-25 2012-03-01 Synta Pharmaceuticals Corp. Procédé de synthèse de 2-alkylphénols substitués
HRP20200690T1 (hr) 2015-05-20 2020-07-24 Amgen Inc. Agonisti triazola apj receptora
WO2017192485A1 (fr) 2016-05-03 2017-11-09 Amgen Inc. Composés triazole hétérocycliques utilisés en tant qu'agonistes du récepteur apj
WO2018093576A1 (fr) 2016-11-16 2018-05-24 Amgen Inc. Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj
US11020395B2 (en) 2016-11-16 2021-06-01 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
US10906890B2 (en) 2016-11-16 2021-02-02 Amgen Inc. Triazole phenyl compounds as agonists of the APJ receptor
US10736883B2 (en) 2016-11-16 2020-08-11 Amgen Inc. Triazole furan compounds as agonists of the APJ receptor
US11046680B1 (en) 2016-11-16 2021-06-29 Amgen Inc. Heteroaryl-substituted triazoles as APJ receptor agonists
EP3541803B1 (fr) 2016-11-16 2020-12-23 Amgen Inc. Composés de triazole pyridyle en tant qu'agonistes du récepteur apj
EP3704122B1 (fr) 2017-11-03 2021-09-01 Amgen Inc. Agonistes de triazole fusionnés du récepteur apj
EP3788037A1 (fr) 2018-05-01 2021-03-10 Amgen Inc. Pyrimidinones substituées en tant qu'agonistes du récepteur apj

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI490212B (zh) * 2006-05-25 2015-07-01 Synta Pharmaceuticals Corp 調節ｈｓｐ９０活性之三唑化合物
RS53446B (sr) * 2006-05-25 2014-12-31 Synta Pharmaceuticals Corp. Triazolska jedinjenja koja modulišu aktivnost hsp90

Also Published As

Publication number Publication date
WO2009075890A3 (fr) 2009-08-13
WO2009075890A2 (fr) 2009-06-18

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