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WO2006006268A1 - Reducteur de brillance - Google Patents

Reducteur de brillance Download PDF

Info

Publication number
WO2006006268A1
WO2006006268A1 PCT/JP2005/004061 JP2005004061W WO2006006268A1 WO 2006006268 A1 WO2006006268 A1 WO 2006006268A1 JP 2005004061 W JP2005004061 W JP 2005004061W WO 2006006268 A1 WO2006006268 A1 WO 2006006268A1
Authority
WO
WIPO (PCT)
Prior art keywords
shine
heat
gauri
inhibitor
sebum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2005/004061
Other languages
English (en)
Japanese (ja)
Inventor
Tsuyoshi Sakamoto
Toshihiko Tsuda
Junji Nagao
Yasuyuki Hasegawa
Yasufumi Itaya
Yuka Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kobayashi Pharmaceutical Co Ltd
Original Assignee
Kobayashi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kobayashi Pharmaceutical Co Ltd filed Critical Kobayashi Pharmaceutical Co Ltd
Publication of WO2006006268A1 publication Critical patent/WO2006006268A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a shine inhibitor that effectively suppresses skin shine. Furthermore, this invention relates to the foodstuff or pharmaceutical composition containing the said shine inhibitor.
  • Sebum secreted from the sebaceous glands of the skin plays a role of imparting smoothness to the skin and suppressing the entry of foreign substances from the outside of the body and the release of moisture from the skin.
  • sebum causes shininess on the skin, which causes cosmetic problems such as stickiness and collapse of makeup.
  • skin shine caused by excessive secretion of sebum promotes the growth of microorganisms and pathogens and can cause various skin abnormalities.
  • Patent Document 1 JP 2002-187811 A
  • Patent Document 2 JP 2002-278804 A
  • an object of the present invention is to provide a shining inhibitor that is highly safe and can be ingested or administered on a daily basis and is effective in suppressing skin shine. Furthermore, the present invention aims to provide foods and pharmaceuticals containing the shine inhibitor, and means for solving the problems
  • the present inventors have found that a heat-treated gourd obtained by drying a gourd and then heat-treating it has an action of suppressing skin shine.
  • the present invention has been developed based on further studies based on strong knowledge.
  • the present invention provides the following inventions:
  • a shine control agent comprising a heat-treated two-gauri product or an extract thereof as an active ingredient.
  • Item 2 The shine inhibitor according to Item 1, wherein the two-gauri heat-treated product is obtained by heating after drying -gouli.
  • a food for suppressing shine comprising the shine control agent according to Item 1 or 2.
  • Item 4 The food for suppressing shininess according to Item 3, which is in the form of powder, tablet, capsule, syrup, jelly, or beverage.
  • Item 5 A medicinal or quasi-drug for shining suppression containing the shining inhibitor according to Item 1 or 2.
  • the shine inhibitor of the present invention uses a bigauri heat-treated product as an active ingredient.
  • Nigauri is a cucurbitaceae plant with the scientific name Momordica charantia
  • Shishi Known as Shishi, it is native to tropical Asia and is cultivated in Japan in the offshore and Kyushu regions. Nigauri is also known as Goya Ralishi.
  • the gourd used in the present invention may be a wild species or an improved variety!
  • a fruit part of 2-gauri is used as the raw material of the heat-treated 2-gauri product that is the active ingredient of the present invention.
  • the fruit part includes fruit skin, fruit pulp, fruit juice, cotton, seeds, etc., but any of these parts may be used as a raw material for the two-gauri heat-treated product.
  • it is an edible part obtained by removing seeds and cotton from the fruit part, and more preferably pulp.
  • the two-gauri heat-treated product can be obtained by chopping or crushing two-gauri as necessary and, for example, heating it at 40 to 120 ° C for about 1 to 60 minutes.
  • the heating method is not particularly limited, but a roasting method is preferable.
  • the -gouli heat-treated product is preferably obtained by heating two-gauri after drying.
  • a method for preparing a gourd heat-treated product by drying and heating two gourds will be described.
  • the preparation of heat-treated cucumbers it is subjected to a step of drying the two gauli prior to the heat treatment of the gauri, but before the drying step, the two gaulis are chopped or crushed to an appropriate size. It is desirable to keep it. From the viewpoint of efficiently performing drying and heating, it is desirable to cut the two gourd into pieces of about 120 mm, preferably about 5-8 mm.
  • the dry weight of bigauri may be carried out until the weight is reduced to 120%, preferably 5-12% of the weight before drying.
  • the drying method and conditions are not particularly limited, and a drying method known or commonly used in the art may be employed.
  • Specific examples of the drying method include a method of drying by applying hot air of about 40 to 120 ° C, and a method of drying for 15 to 15 days, preferably about 3 days in the sun.
  • the dried bigauri is then subjected to a heat treatment (for example, roasting treatment).
  • About heating conditions it adjusts suitably according to heating temperature and heating time.
  • the heating temperature is usually set to 40-120 ° C, preferably 60-120 ° C.
  • the heating time varies depending on the heating temperature and cannot be specified uniformly, but is usually 1 to 60 minutes, preferably about 3 to 15 minutes.
  • the heating method is not particularly limited, and an example of a suitable heating method is a method of frying under the above temperature conditions.
  • the said heat processing can be implemented using a roasting machine etc., for example. By performing such heat treatment, a two-gauri heat-treated product is prepared.
  • the -gouli heat-treated product is usually reduced to a weight of 1-10%, preferably 5-7% of the weight of the -gouli before drying.
  • the ability to use the two-cucumber heat-treated product obtained by the above-described method as it is may be used.
  • the extract of the two-gauri heat-treated product is obtained by subjecting the two-gauli heat-treated product to room temperature or heating with an extraction solvent. It can be obtained by extracting below.
  • the extraction solvent include water; an organic solvent; or a mixed solution of water and an organic solvent.
  • the organic solvent used for extraction include methanol, ethanol, isopropanol, propylene glycol, 1,3-butylene glycol, acetone, ethyl acetate, chloroform, pentane, hexane, heptane, etc. A combination of more than one species can be mentioned.
  • the extraction solvent is preferably water; a lower alcohol such as methanol, ethanol or isopropanol; or a mixture of water and a lower alcohol, more preferably water, ethanol or a mixture of water and ethanol (5-50).
  • a water-weight ethanol solution particularly preferably water.
  • the above water includes warm water and hot water.
  • the extract of the two-gauri heat-treated product used for the shine inhibitor may be the same as the extract obtained by the above-described extraction process, or the extract liquid solids may be removed. It may be. If necessary, it may be further concentrated by vacuum distillation or the like, or may be dried by a drying treatment such as vacuum drying or freeze drying.
  • the intake or dose of the shine inhibitor of the present invention varies depending on the age, sex, expected effect, etc. of the subject, and cannot be defined uniformly, but the intake or dose per day for an adult
  • an amount in which the shine inhibitor (converted to the dry weight of the two-gauri heat-treated product) is 0.1 to 4 g, preferably 0.3 to 2 g, more preferably 0.7 to 2 g.
  • the shine inhibitor of the present invention can be provided as a food for suppressing skin shine by mixing with food, or prepared in the form of an internal medicine or quasi-drug to suppress skin shine. It can also be provided as a medicinal product or quasi-drug.
  • the above-mentioned food for suppressing skin shine is health functional foods (nutrient functional foods and foods for specified health use), so-called health foods, nutritional supplements or special-purpose foods (foods for the sick, etc.) Can be mentioned.
  • Examples of forms include powders, tablets, and capsules.
  • the extract of the heat-processed product obtained by using water as an extraction solvent can be used as it is, the extract itself, or a concentrated solution or a diluted solution thereof may be used as a beverage-type food.
  • the proportion of the shine inhibitor to be blended is appropriately set according to the daily intake of the agent, the form of the food, the expected effect, and the like. That's fine.
  • the shape of the pharmaceutical or quasi-drug for skin shine suppression is not particularly limited as long as it does not hinder the effects of the present invention.
  • Examples of the form of the pharmaceutical or quasi drug include tablets, powders, granules, capsules, pills, troches, liquids, extracts and the like.
  • the drug or quasi-drug is formulated with a pharmaceutically acceptable base or carrier, but if necessary, a binder, a disintegrant, a lubricant, a wetting agent, a buffering agent, a preservative. , And optionally contain pharmaceutically acceptable additives such as fragrances.
  • the ratio of the shinkari inhibitor contained in the medicinal product or quasi-drug for skin shine prevention is the dose per day of the agent, the age and sex of the subject, the drug or quasi-drug. It can be appropriately set according to the form, expected effect, and the like.
  • the shining inhibitor of the present invention can suppress skin shine caused by excessive secretion of sebum by ingestion or application.
  • the shining inhibitor of the present invention can be effectively used as a cosmetic means because it can effectively suppress the shining of the face where excessive sebum secretion tends to occur.
  • the shine inhibitor of the present invention it is possible to effectively suppress skin shine caused by excessive secretion of sebum, so that it is possible to maintain a healthy skin that is less prone to stickiness and makeup collapse. Become.
  • the shine inhibitor of the present invention has been conventionally used as a raw material for foods-it is prepared as a raw material, and thus is taken or administered daily as a highly safe food or internal medicine. It is possible.
  • the two-gauli heat-treated product obtained by heating after drying two-gauri does not have the bitterness peculiar to two-gauri and does not adversely affect the taste. It can be used without being limited by the type of product and the shape of the pharmaceutical or pharmaceutical composition, and can provide a wide variety of means for suppressing skin shine.
  • the thus-obtained heat-treated cucumber was added to boiling water immediately after boiling, and left to stand for 1 minute, and extracted to 100 g of the liquid-gouri-heat treated product to 0.2 g, followed by filtration.
  • the extract from which the solid residue was removed was used as a test sample.
  • the amount of sebum secreted in the forehead was measured by subjects who took the test sample under the conditions shown in Table 1 below. Specifically, the oil on the subject's forehead was sufficiently absorbed using oil blotting paper (trade name “Makeh Planetary Oil Blotting Paper”, manufactured by Orbit Co., Ltd., 100% natural hemp). Immediately thereafter, about 300 g of grilled meat was ingested. Two hours after the disclosure of the grilled meat intake, the oil on the left half of the subject's left forehead was thoroughly blotted using oil blotting paper. In addition, after 4 hours, the power to disclose the intake of grilled meat was again blotted with oil on the right half of the subject's forehead using oil blotting paper. The amount of sebum 2 and 4 hours after ingestion of yakiniku was calculated according to the following formula.
  • ⁇ The average score of subjects is 1 or more and less than 2
  • Sebum amount (g) (weight of oil blotting paper after absorbing sebum)
  • Table 2 shows the results obtained.
  • the rate of decrease in sebum secretion means the ratio (%) of the amount of sebum decreased relative to the amount of sebum in the control.
  • the heat-treated two-gauri product or its extract has an action of suppressing the increase in the amount of neutral fat in the blood. It became clear that it can improve to a new constitution.
  • Test Examples 1 and 2 show the average values of the results of all subjects.
  • Example 2 (capsule)
  • Gelatin 5g heated to 40-60 ° C was gradually added with stirring to dissolve.
  • the mixed solution was degassed under reduced pressure, and then appropriate amounts of titanium oxide and pigment were added and further mixed.
  • the body part of the capsule was prepared by the method described in Example 1 and filled with 200 mg of a gourd heat-treated product.
  • the cap part was bonded to prepare a capsule containing the two-gauri heat-treated product.
  • a soft drink having the following composition was prepared.
  • a jelly having the following composition was prepared.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Toxicology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L’invention porte sur un réducteur de brillance qui est extrêmement sûr, que l’on peut prendre ou administrer tous les jours, et qui est efficace pour réduire la brillance de la peau. Du melon amer traité thermiquement ou un extrait de celui-ci permet d’abaisser la teneur en graisse neutre dans le sang et sert d’ingrédient actif pour réduire la brillance.
PCT/JP2005/004061 2004-09-27 2005-03-09 Reducteur de brillance Ceased WO2006006268A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004280322 2004-09-27
JP2004-280322 2004-09-27

Publications (1)

Publication Number Publication Date
WO2006006268A1 true WO2006006268A1 (fr) 2006-01-19

Family

ID=35783630

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/004061 Ceased WO2006006268A1 (fr) 2004-09-27 2005-03-09 Reducteur de brillance

Country Status (1)

Country Link
WO (1) WO2006006268A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010053390A1 (en) * 1999-07-14 2001-12-20 Kaijun Ren Use of plant extracts for treatment of acne and furuncle
JP2002212050A (ja) * 2001-01-23 2002-07-31 Eikodo Honten:Kk 皮膚若しくは毛髪用化粧料
WO2003002277A1 (fr) * 2001-06-28 2003-01-09 Sms Demag Aktiengesellschaft Procede et dispositif de refroidisement et de lubrification de cylindres d'une cage de laminoir

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010053390A1 (en) * 1999-07-14 2001-12-20 Kaijun Ren Use of plant extracts for treatment of acne and furuncle
JP2002212050A (ja) * 2001-01-23 2002-07-31 Eikodo Honten:Kk 皮膚若しくは毛髪用化粧料
WO2003002277A1 (fr) * 2001-06-28 2003-01-09 Sms Demag Aktiengesellschaft Procede et dispositif de refroidisement et de lubrification de cylindres d'une cage de laminoir

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Araru Supasupa Kenko Shokuhin Net.", 11 April 2005 (2005-04-11), XP002994900, Retrieved from the Internet <URL:http://plaza.rakuten.co.jp/usa01/36000> *
WATANABE M ET AL: "Tonyo Rat no Shishitsu Taisha no Oyobosu Nigaru Funmatsu Choseiji ni Okeru Shori Hoho no Eikyo.", JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY., vol. 50, no. 3GA4, 2003, XP002996088 *

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