WO2006006268A1 - Shininess depressant - Google Patents

Abstract

[PROBLEMS] To provide a shininess depressant which is highly safe, can be taken or administered daily, and is effective in depressing the shininess of the skin. [MEANS FOR SOLVING PROBLEMS] Bitter melon treated with heating or an extract thereof functions to lower the neutral-fat content in the blood and is used as an active ingredient for a shininess depressant.

Description

 Specification

 Tekari inhibitor

 Technical field

 [0001] The present invention relates to a shine inhibitor that effectively suppresses skin shine. Furthermore, this invention relates to the foodstuff or pharmaceutical composition containing the said shine inhibitor.

 Background art

 [0002] Sebum secreted from the sebaceous glands of the skin plays a role of imparting smoothness to the skin and suppressing the entry of foreign substances from the outside of the body and the release of moisture from the skin. However, if sebum is excessively secreted, the sebum causes shininess on the skin, which causes cosmetic problems such as stickiness and collapse of makeup. In addition, skin shine caused by excessive secretion of sebum promotes the growth of microorganisms and pathogens and can cause various skin abnormalities.

 [0003] As a means for suppressing such skin shine, conventionally, a cosmetic suitable for suppressing skin shine has been proposed (for example, see Patent Document 1). However, all of the conventional shine prevention means are used by being applied transdermally, and ingredients that can suppress shine on the skin by daily use in the form of food or the like are known. Absent.

 [0004] By the way, it has been reported that pulverized Nigauri and its extract have an action of improving lipid metabolism (see Patent Document 2). However, simply crushed and dried two gourd-dried powder of gourd can reduce the amount of neutral fat in the liver, but it may cause skin shine! / There is no effect of reducing the above-mentioned effect (see paragraphs 0036 and 0046 of Patent Document 2). In addition, it is not known how the heat-treated product of digauri affects skin shine.

 Patent Document 1: JP 2002-187811 A

 Patent Document 2: JP 2002-278804 A

 Disclosure of the invention

Problems to be solved by the invention [0005] Accordingly, an object of the present invention is to provide a shining inhibitor that is highly safe and can be ingested or administered on a daily basis and is effective in suppressing skin shine. Furthermore, the present invention aims to provide foods and pharmaceuticals containing the shine inhibitor, and means for solving the problems

[0006] The inventors of the present invention diligently studied to solve the above-mentioned problems.

In particular, the present inventors have found that a heat-treated gourd obtained by drying a gourd and then heat-treating it has an action of suppressing skin shine. The present invention has been developed based on further studies based on strong knowledge.

[0007] That is, the present invention provides the following inventions:

 Item 1. A shine control agent comprising a heat-treated two-gauri product or an extract thereof as an active ingredient.

 Item 2. The shine inhibitor according to Item 1, wherein the two-gauri heat-treated product is obtained by heating after drying -gouli.

 Item 3. A food for suppressing shine, comprising the shine control agent according to Item 1 or 2.

 Item 4. The food for suppressing shininess according to Item 3, which is in the form of powder, tablet, capsule, syrup, jelly, or beverage.

 Item 5. A medicinal or quasi-drug for shining suppression containing the shining inhibitor according to Item 1 or 2.

 [0008] The present invention is described in detail below.

 [0009] The shine inhibitor of the present invention uses a bigauri heat-treated product as an active ingredient.

 [0010] Nigauri is a cucurbitaceae plant with the scientific name Momordica charantia

 Known as Shishi, it is native to tropical Asia and is cultivated in Japan in the offshore and Kyushu regions. Nigauri is also known as Goya Ralishi. The gourd used in the present invention may be a wild species or an improved variety!

[0011] As the raw material of the heat-treated 2-gauri product that is the active ingredient of the present invention, a fruit part of 2-gauri is used. The fruit part includes fruit skin, fruit pulp, fruit juice, cotton, seeds, etc., but any of these parts may be used as a raw material for the two-gauri heat-treated product. Preferably, it is an edible part obtained by removing seeds and cotton from the fruit part, and more preferably pulp. [0012] The two-gauri heat-treated product can be obtained by chopping or crushing two-gauri as necessary and, for example, heating it at 40 to 120 ° C for about 1 to 60 minutes. The heating method is not particularly limited, but a roasting method is preferable.

 [0013] The -gouli heat-treated product is preferably obtained by heating two-gauri after drying. Hereinafter, a method for preparing a gourd heat-treated product by drying and heating two gourds will be described. In the preparation of heat-treated cucumbers, it is subjected to a step of drying the two gauli prior to the heat treatment of the gauri, but before the drying step, the two gaulis are chopped or crushed to an appropriate size. It is desirable to keep it. From the viewpoint of efficiently performing drying and heating, it is desirable to cut the two gourd into pieces of about 120 mm, preferably about 5-8 mm. The dry weight of bigauri may be carried out until the weight is reduced to 120%, preferably 5-12% of the weight before drying. The drying method and conditions are not particularly limited, and a drying method known or commonly used in the art may be employed. Specific examples of the drying method include a method of drying by applying hot air of about 40 to 120 ° C, and a method of drying for 15 to 15 days, preferably about 3 days in the sun. The dried bigauri is then subjected to a heat treatment (for example, roasting treatment). About heating conditions, it adjusts suitably according to heating temperature and heating time. The heating temperature is usually set to 40-120 ° C, preferably 60-120 ° C. In addition, the heating time varies depending on the heating temperature and cannot be specified uniformly, but is usually 1 to 60 minutes, preferably about 3 to 15 minutes. The heating method is not particularly limited, and an example of a suitable heating method is a method of frying under the above temperature conditions. The said heat processing can be implemented using a roasting machine etc., for example. By performing such heat treatment, a two-gauri heat-treated product is prepared. The -gouli heat-treated product is usually reduced to a weight of 1-10%, preferably 5-7% of the weight of the -gouli before drying.

 [0014] In the present invention, as an active ingredient of the shine inhibitor, the ability to use the two-cucumber heat-treated product obtained by the above-described method as it is may be used.

[0015] The extract of the two-gauri heat-treated product is obtained by subjecting the two-gauli heat-treated product to room temperature or heating with an extraction solvent. It can be obtained by extracting below. Examples of the extraction solvent include water; an organic solvent; or a mixed solution of water and an organic solvent. Examples of the organic solvent used for extraction include methanol, ethanol, isopropanol, propylene glycol, 1,3-butylene glycol, acetone, ethyl acetate, chloroform, pentane, hexane, heptane, etc. A combination of more than one species can be mentioned. The extraction solvent is preferably water; a lower alcohol such as methanol, ethanol or isopropanol; or a mixture of water and a lower alcohol, more preferably water, ethanol or a mixture of water and ethanol (5-50). A water-weight ethanol solution); particularly preferably water. The above water includes warm water and hot water.

 [0016] The extract of the two-gauri heat-treated product used for the shine inhibitor may be the same as the extract obtained by the above-described extraction process, or the extract liquid solids may be removed. It may be. If necessary, it may be further concentrated by vacuum distillation or the like, or may be dried by a drying treatment such as vacuum drying or freeze drying.

 [0017] The intake or dose of the shine inhibitor of the present invention varies depending on the age, sex, expected effect, etc. of the subject, and cannot be defined uniformly, but the intake or dose per day for an adult As an example, there is exemplified an amount in which the shine inhibitor (converted to the dry weight of the two-gauri heat-treated product) is 0.1 to 4 g, preferably 0.3 to 2 g, more preferably 0.7 to 2 g.

 [0018] The shine inhibitor of the present invention can be provided as a food for suppressing skin shine by mixing with food, or prepared in the form of an internal medicine or quasi-drug to suppress skin shine. It can also be provided as a medicinal product or quasi-drug.

 [0019] Preferably, the above-mentioned food for suppressing skin shine is health functional foods (nutrient functional foods and foods for specified health use), so-called health foods, nutritional supplements or special-purpose foods (foods for the sick, etc.) Can be mentioned. Examples of forms include powders, tablets, and capsules.

, Syrup, jelly and the like. In addition, since the extract of the heat-processed product obtained by using water as an extraction solvent can be used as it is, the extract itself, or a concentrated solution or a diluted solution thereof may be used as a beverage-type food.

[0020] In the food for suppressing skin shine, the proportion of the shine inhibitor to be blended is appropriately set according to the daily intake of the agent, the form of the food, the expected effect, and the like. That's fine.

 [0021] The shape of the pharmaceutical or quasi-drug for skin shine suppression is not particularly limited as long as it does not hinder the effects of the present invention. Examples of the form of the pharmaceutical or quasi drug include tablets, powders, granules, capsules, pills, troches, liquids, extracts and the like. The drug or quasi-drug is formulated with a pharmaceutically acceptable base or carrier, but if necessary, a binder, a disintegrant, a lubricant, a wetting agent, a buffering agent, a preservative. , And optionally contain pharmaceutically acceptable additives such as fragrances.

 [0022] The ratio of the shinkari inhibitor contained in the medicinal product or quasi-drug for skin shine prevention is the dose per day of the agent, the age and sex of the subject, the drug or quasi-drug. It can be appropriately set according to the form, expected effect, and the like.

 [0023] The shining inhibitor of the present invention can suppress skin shine caused by excessive secretion of sebum by ingestion or application. In particular, the shining inhibitor of the present invention can be effectively used as a cosmetic means because it can effectively suppress the shining of the face where excessive sebum secretion tends to occur.

 The invention's effect

 [0024] According to the shine inhibitor of the present invention, it is possible to effectively suppress skin shine caused by excessive secretion of sebum, so that it is possible to maintain a healthy skin that is less prone to stickiness and makeup collapse. Become.

 [0025] In addition, the shine inhibitor of the present invention has been conventionally used as a raw material for foods-it is prepared as a raw material, and thus is taken or administered daily as a highly safe food or internal medicine. It is possible.

 [0026] Furthermore, the two-gauli heat-treated product obtained by heating after drying two-gauri does not have the bitterness peculiar to two-gauri and does not adversely affect the taste. It can be used without being limited by the type of product and the shape of the pharmaceutical or pharmaceutical composition, and can provide a wide variety of means for suppressing skin shine.

 BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the present invention will be described with reference to examples. However, the present invention is not limited to these examples. It is not something.

Example 1

 The following test was conducted and evaluated for the anti-shine effect of the two-gauri heat-treated product.

<Preparation of two-gauri heat-treated product>

 After removing the seeds and cotton from the fruit part of the bigauri, it was chopped to about 5-8 mm. Chopped-gouli lOOOOg was dried in a hot air dryer with hot air at 40-120 ° C until the weight was 120 g. Next, using a direct fire roaster, the iron plate temperature was gradually raised from 70 ° C. to 110 ° C. for 15 minutes and fried to obtain 60 g of a two-gauri heat-treated product.

 The thus-obtained heat-treated cucumber was added to boiling water immediately after boiling, and left to stand for 1 minute, and extracted to 100 g of the liquid-gouri-heat treated product to 0.2 g, followed by filtration. The extract from which the solid residue was removed was used as a test sample.

<Measurement of amount of sebum secreted in forehead>

 The amount of sebum secreted in the forehead was measured by subjects who took the test sample under the conditions shown in Table 1 below. Specifically, the oil on the subject's forehead was sufficiently absorbed using oil blotting paper (trade name “Makeh Planetary Oil Blotting Paper”, manufactured by Orbit Co., Ltd., 100% natural hemp). Immediately thereafter, about 300 g of grilled meat was ingested. Two hours after the disclosure of the grilled meat intake, the oil on the left half of the subject's left forehead was thoroughly blotted using oil blotting paper. In addition, after 4 hours, the power to disclose the intake of grilled meat was again blotted with oil on the right half of the subject's forehead using oil blotting paper. The amount of sebum 2 and 4 hours after ingestion of yakiniku was calculated according to the following formula.

Evaluation of degree of ¾ shine

(Evaluation criteria for the degree of shine)

Score 0: No shine

Grade 1: Slight shine on part of face

Score 2: shine is clearly recognized on part of face

Score 3: shine is clearly observed on the entire face

(Determining the degree of shine) A: The average score of subjects is less than 1

 ○: The average score of subjects is 1 or more and less than 2

 X: Average score of subjects is 2 or more

[0029] [Equation 1] Sebum amount (g) = (weight of oil blotting paper after absorbing sebum) (

 (Weight of oil blotting paper before absorbing sebum)

[0030] [Table 1]

 [0031] <Result>

 Table 2 shows the results obtained. In Table 2, the rate of decrease in sebum secretion means the ratio (%) of the amount of sebum decreased relative to the amount of sebum in the control. As a result, it was confirmed that by taking the extract of the two-gauri heat-treated product, facial shine was suppressed and the amount of sebum secreted in the forehead was also reduced. In particular, from the results of Test Example 2, it was confirmed that daily intake of the extract from the heat-treated 2-gauri product can effectively suppress the secretion of sebum and suppress the decay. It was.

 [0032] From the above results, the heat-treated two-gauri product or its extract has an action of suppressing the increase in the amount of neutral fat in the blood. It became clear that it can improve to a new constitution.

[0033] [Table 2] Test Example 1 Test Example 2

 Determining the degree of shine ◎ ◎

 0 indicates control (X) (X)

 Grilled meat intake Sebum amount (g) 0. 031 0. 015

 2 hours later 0 is within 1 hour (0. 246) (0. 254)

 Sebum secretion

 88 94

 Decrease rate (%)

 Determining the degree of shine ◎ ◎

 0 indicates control (X) (X)

 Grilled meat intake Sebum amount (g) 0. 030 0. 007

 4 hours later 0 within control (0. 133) (0. 153)

 Sebum secretion

 78 95

 Decrease rate (%)

 # The sebum amount and the decrease rate of sebum secretion in Test Examples 1 and 2 show the average values of the results of all subjects.

[0034] Example 2 (capsule)

 Gelatin 5g heated to 40-60 ° C was gradually added with stirring to dissolve. The mixed solution was degassed under reduced pressure, and then appropriate amounts of titanium oxide and pigment were added and further mixed. Then, after filling into a capsule-type bottle, it was dried until the moisture content was 15-18% by weight, and the body part of the capsule was prepared by the method described in Example 1 and filled with 200 mg of a gourd heat-treated product. Then, the cap part was bonded to prepare a capsule containing the two-gauri heat-treated product.

 [0035] Implementation 13 (Micro Capsenore)

 To 10 g of purified water heated to 40 ° C, 5 g of gelatin was gradually added with stirring and mixed and dissolved. Thereafter, 200 mg of a gourd heat-treated product prepared by the method described in Example 1, titanium oxide, glycerin and a dye were added in appropriate amounts and mixed to obtain a capsule. The capsule was then cooled and dehydrated until the water content was 15-18% by weight and further dried until the water content was 8.2 to 16% by weight. Then, it filtered and the microcapsule containing a two-gauri heat-processed material was prepared.

 [0036] Example 4 (cookies)

First, while stirring 70 g of unsalted butter, 80 g of sugar (granulated sugar) was gradually added thereto. After adding 1 broken egg to this, it was prepared by the method described in Example 1. 2 g of heat-treated product was added and further stirred. At the stage of sufficient mixing, 200 g of uniformly powdered flour was added and stirred at a low speed, and then lumped together. After sleeping in a low temperature room for about 30 minutes, it was uniformly stretched to a thickness of about 1 cm and extracted with a circular mold having a diameter of 5 cm. Next, the cut cookie dough was arranged on a top plate and heated in an oven preheated at 170 ° C. for 12-15 minutes to obtain a cookie containing a two-gauri heat-treated product.

 Example 5 (soft drink)

 A soft drink having the following composition was prepared.

 (Wt%)

Digauri heat-treated extract (prepared by the method described in Example 1) 0.5

Fructose dextrose liquid sugar 6.0

Sodium quenate 0.6

 L Asconolevic acid 3.0

 S. _

100% by weight

 Example 6 (jelly)

 According to a conventional method, a jelly having the following composition was prepared.

 (% By weight)

Digauri heat-treated extract (prepared by the method described in Example 1)

Gelatin 1.1

Sugar 22. 0

 L Tartaric acid 0.1

Sodium quenate 0.1

Quenic acid 0.1

 Dredging

100% by weight

Claims

The scope of the claims  [1] A shine inhibitor comprising the heat-treated two-gauri product or an extract thereof as an active ingredient. [2] The shine inhibitor according to claim 1, wherein the two-gauri heat-treated product is obtained by drying and heating two-gauri.  [3] A food for suppressing shine, comprising the shine inhibitor for use according to claim 1 or 2. [4] A medicinal or quasi-drug for shining suppression containing the shining inhibitor according to claim 1 or 2.