WO2006006269A1 - Blood-neutral-fat-lowering agent - Google Patents

Abstract

[PROBLEMS] To provide a blood-neutral-fat-lowering agent which is highly safe, can be taken or administered daily, and is effective in controlling the neutral-fat content in the blood. [MEANS FOR SOLVING PROBLEMS] Bitter melon treated with heating or an extract thereof functions to lower the neutral-fat content in the blood and is used as an active ingredient for a blood-neutral-fat-lowering agent.

Description

 Specification

 Blood neutral fat reducing agent

 Technical field

 [0001] The present invention relates to a blood neutral fat reducing agent capable of suppressing an increase in blood neutral fat and further reducing an increased blood neutral fatty acid content. Furthermore, the present invention relates to a food or pharmaceutical composition containing the blood neutral fat reducing agent.

 Background art

 [0002] In recent years, there has been a rapid increase in the number of people with so-called hyperlipidemia, in which blood neutral fat has exceeded normal levels due to overeating, lack of exercise, and increased intake of animal fat. Hyperlipidemia is known to cause diseases such as arterial stiffness, hypertension, myocardial infarction, and cerebrovascular disorder. In order to prevent these diseases, the amount of neutral fat in the blood It is important for modern people to suppress the increase in blood pressure and to lower the increased blood triglyceride level to the normal range. Therefore, it is desired to develop an edible material that can be ingested or administered on a daily basis and is effective in adjusting the neutral fat in the blood.

 [0003] By the way, it has been reported that pulverized Nigauri and its extract have an effect of improving lipid metabolism (see Patent Document 1). However, it was found that a dried two-gauri powder that had been crushed and dried with two-gauri could not reduce the amount of neutral fat in the blood even though it could reduce the amount of neutral fat in the liver. (See paragraphs 0036 and 0046 of Patent Document 1). In addition, it is not known how the heat-treated product of digauri affects the amount of neutral fat in the blood.

 Patent Document 1: Japanese Patent Laid-Open No. 2001-278804

 Disclosure of the invention

 Problems to be solved by the invention

[0004] Therefore, an object of the present invention is to provide a blood neutral fat reducing agent that is highly safe and can be taken or administered on a daily basis and is effective in adjusting blood neutral fat. . Furthermore, an object of the present invention is to provide foods and pharmaceuticals containing the blood neutral fat reducing agent. Means for solving the problem

 [0005] The inventors of the present invention diligently studied to solve the above-mentioned problems. As a result, the two-gauri heat-treated product, particularly the two-gauri-heat-treated product obtained by heat-treating the two-gauri after drying, It has been found that there is an effect of reducing the amount of neutral fat in the medium. The present invention has been developed through further studies based on such knowledge.

 That is, the present invention provides the following inventions:

 Item 1. A blood neutral fat reducing agent comprising heat-treated two-gauri or an extract thereof as an active ingredient.

 Item 2. The blood neutral fat reducing agent according to Item 1, wherein the two-gauri heat-treated product is obtained by drying and heating two-gauri.

 Item 3. A blood neutral fat reducing agent comprising the blood neutral fat reducing agent according to Item 1 or 2, Item 4. A powder, tablet, capsule, syrup, jelly, or beverage. Food for reducing blood neutral fat according to 3.

 Item 5. A pharmaceutical or quasi drug for reducing blood neutral fat, comprising the blood neutral fat reducing agent according to Item 1 or 2.

[0007] The present invention is described in detail below. In the blood triglyceride reducing agent of the present invention, a two-gauri heat-treated product is used as an active ingredient.

[0008] Nigauri is a cucurbitaceae plant known as the scientific name Momordica charantia and is native to tropical Asia. Nigauri is also known as Goyallreishi. The bigauri used in the present invention may be a wild species or an improved variety.

[0009] As a raw material of the heat-treated 2-gauri product which is the active ingredient of the present invention, a fruit part of 2-gauri is used. The fruit part includes fruit skin, fruit pulp, fruit juice, cotton, seeds, etc., but any of these parts may be used as a raw material for the two-gauri heat-treated product. Preferably, it is an edible part obtained by removing seeds and cotton from the fruit part, and more preferably pulp.

[0010] The two-gauri heat-treated product is chopped or crushed as necessary, for example, 40-1

It can be obtained by heating at 20 ° C for 1 to 60 minutes. Especially as a heating method Although not limited, a method of roasting is preferable.

 [0011] The two-gauri heat-treated product is preferably obtained by heating the two-gauli after drying. Hereinafter, a method for preparing a two-gauli heat-treated product by drying and heating the two-gauri will be described. In the preparation of heat-treated cucumber garlic, it is subjected to a process of drying garlic prior to heat treatment of garlic, but before the drying process, the garlic is shredded or crushed to an appropriate size. It is desirable to keep it. From the viewpoint of efficiently performing drying and heating, it is desirable to cut the two gourd into pieces of about 120 mm, preferably about 5-8 mm. The dry weight of bigauri may be carried out until the weight is reduced to 120%, preferably 5-12% of the weight before drying. The drying method and conditions are not particularly limited, and a drying method known or commonly used in the art may be employed. Specific examples of the drying method include a method of drying by applying hot air of about 40 to 120 ° C, and a method of drying for 15 to 15 days in the sun, preferably about 3 days. The dried bigauri is then subjected to a heat treatment (for example, roasting treatment). The calorific heat condition is appropriately adjusted according to the heating temperature and the heating time. The heating temperature is usually set to 40-120 ° C, preferably 60-120 ° C. In addition, the heating time varies depending on the heating temperature and cannot be specified uniformly, but is usually 1 to 60 minutes, preferably about 3 to 15 minutes. The heating method is not particularly limited, and an example of a suitable heating method is a method of frying under the above temperature conditions. The said heat processing can be implemented using a roasting machine etc., for example. By performing such heat treatment, a two-gauri heat-treated product is prepared. The heat-treated product of two-gauri is usually reduced to a weight of 1-10%, preferably 5-7% of the weight of 2-gauri before drying.

[0012] In the present invention, as an active ingredient of a blood neutral fat reducing agent, the ability to use the heat-treated bigauri heat-treated product obtained by the above method as it is, and further using the extract of the heat-treated bitter gourd heat Also good.

[0013] An extract of a heat-treated 2-gauli product can be obtained by extracting a heat-treated product of 2-gauri with an extraction solvent at room temperature or under heating. Examples of the extraction solvent include water; an organic solvent; or a mixed solution of water and an organic solvent. In addition, as an organic solvent used for extraction Examples include methanol, ethanol, isopropanol, propylene glycol, 1,3-butylene glycol, acetone, ethyl acetate, chloroform, pentane, hexane, heptane and the like alone or in combination of two or more. The extraction solvent is preferably water; a lower alcohol such as methanol, ethanol or isopropanol; or a mixture of water and a lower alcohol, more preferably water, ethanol or a mixture of water and ethanol (5-50). A water-weight ethanol solution); particularly preferably water. The above water includes warm water and hot water.

 [0014] The extract of the bigauri heat-treated product used in the blood neutral fat reducing agent may be the extract obtained by the above-described extraction treatment as it is, or a solid substance from the extract. (Insoluble matter) may be removed. Further, if necessary, it may be further concentrated by vacuum distillation or the like, or may be dried by a drying process such as vacuum drying or freeze drying.

 [0015] The intake or dose of the blood triglyceride reducing agent of the present invention varies depending on the age, sex, expected effect, etc. of the subject and cannot be uniformly defined, As an example of ingestion or dosage, 0.1 to 4 g, preferably 0 to 3 to 2 g, more preferably 0 to 7- An amount of 2g is illustrated.

 [0016] The blood triglyceride reducing agent of the present invention can also be provided as a food for reducing blood triglycerides by mixing with food, and can also be prepared in the form of pharmaceuticals or quasi drugs. Thus, it can also be provided as a pharmaceutical or quasi-drug for reducing blood neutral fat.

 [0017] The food for reducing blood neutral fat is preferably a health functional food (functional nutrition food and food for specified health use), so-called health food, dietary supplement or special food (food for patients, etc.) ) And the like. Examples of the form include powders, tablets, capsules, syrups, jelly and the like. In addition, since the extract of the two gourd heat-treated product obtained using water as an extraction solvent can be used as it is, the extract itself, or a concentrated or diluted solution thereof may be used as a beverage-type food.

[0018] In the food for reducing blood neutral fat, the ratio of the blood neutral fat reducing agent to be blended depends on the daily intake of the agent, the form of the food, the expected effect, etc. Appropriate settings may be made accordingly. [0019] The shape of the pharmaceutical or quasi-drug for reducing blood neutral fat is not particularly limited as long as the effect of the present invention is not hindered. Examples of the form of the pharmaceutical product or quasi drug include tablets, powders, granules, capsules, pills, troches, liquids, extracts and the like. The drug or quasi-drug is formulated with a pharmaceutically acceptable carrier or carrier, but if necessary, a binder, disintegrant, lubricant, wetting agent, buffer, storage Pharmaceutically acceptable additives such as agents and fragrances may be optionally contained.

 [0020] The ratio of the neutral fat-reducing agent contained in the above-mentioned pharmaceutical or quasi-drug for reducing blood neutral fat is the dose of the agent per day, the age and sex of the subject, the pharmaceutical or pharmaceutical It can be appropriately set according to the form of the quasi-drug, the expected effect, and the like.

 [0021] The blood triglyceride reducing agent of the present invention can suppress an increase in blood triglyceride and can further reduce the blood triglyceride content. Therefore, the blood neutral fat reducing agent of the present invention is useful as an agent for preventing or improving hyperlipidemia.

 [0022] The blood triglyceride reducing agent of the present invention is also useful as a preventive or ameliorating agent for diseases in which onset or deterioration of symptoms is expected due to abnormal blood triglyceride content. is there. Specific examples of powerful diseases include myocardial infarction, arteriosclerosis, angina pectoris, thrombosis, and cerebral infarction. Therefore, according to the blood neutral fat reducing agent of the present invention, it is possible to prevent sudden death due to myocardial infarction or arterial stiffness.

 [0023] Further, the blood neutral fat reducing agent of the present invention is useful as a sebum secretion inhibitor because it can suppress the secretion of sebum based on the effect of reducing blood neutral fat. is there. Therefore, the blood neutral fat reducing agent of the present invention can exert a facial shine prevention action based on suppression of sebum secretion in the face and a hair growth action based on suppression of sebum accumulation in the scalp.

 The invention's effect

 [0024] According to the blood triglyceride reducing agent of the present invention, an increase in blood triglyceride can be suppressed, and the elevated blood triglyceride content can be reduced. The amount of neutral fat can be adjusted. Therefore, the blood triglyceride reducing agent of the present invention is useful for the prevention and improvement of diseases caused by abnormal blood triglycerides.

[0025] The blood neutral fat reducing agent of the present invention has been conventionally used as a raw material for foods. It can be taken or administered on a daily basis as a highly safe food or pharmaceutical because it is prepared using gauri as a raw material.

 [0026] Furthermore, the two-gauli heat-treated product obtained by drying and heating two-gauri does not have the bitterness peculiar to two-gauri and does not adversely affect the taste. The reducing agent can be used without being limited by the type of food or the form of the pharmaceutical or pharmaceutical composition, and can provide a wide variety of means for reducing blood neutral fat.

 BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the present invention will be described with reference to examples, but the present invention is not limited to these examples. It is known that the amount of triglyceride in the blood is proportional to the amount of sebum secreted outside the body (for example, electronic technical information {"A certain spa spa health food net", [on line], Heisei 16 Search on September 23, 2013, Internet URL: http: 〃 plaza.rakuten.co.jp/usa01/36000>} etc.) Therefore, by measuring the amount of sebum secreted in the forehead, we evaluated how the two-gauri heat-treated product had an effect on the amount of neutral fat in the blood. Preparation of Kuni Gauri heat-treated product>

 After removing the seeds and cotton from the fruit part of the bigauri, it was chopped to about 5-8 mm. The chopped Nigauri lOOOOg was dried with a hot air dryer at 40 120 ° C hot air until the weight reached 120 g. Next, using a direct fire roaster, the iron plate temperature was gradually raised from 70 ° C. to 110 ° C. for 15 minutes and fried to obtain 60 g of a two-gauri heat-treated product.

 [0028] The 2-gauli heat-treated product thus obtained was added to hot water immediately after boiling, and left to stand for 1 minute, and extracted so that the 2-gauri-heat-treated product was 0.2 g per 100 g of the extract. Thereafter, an extract from which solid residue was removed by filtration was used as a test sample.

 <Measurement of amount of sebum secreted in forehead>

The amount of sebum secreted in the forehead was measured by subjects who took the test sample under the conditions shown in Table 1 below. Specifically, using oil blotting paper (trade name “Makeh Planetary Oil Blotting Paper”, manufactured by Orbit Co., Ltd., 100% natural hemp), the subject's forehead sebum is sufficient. Sucked up. Immediately thereafter, about 300 g of grilled meat was ingested. Two hours after the disclosure of the grilled meat intake, the oil on the left half of the subject's left forehead was thoroughly blotted using oil blotting paper. Furthermore, 4 hours after the disclosure of grilled meat intake, the oil on the right half of the subject's forehead was sufficiently absorbed using oil blotting paper again. The amount of sebum 2 and 4 hours after ingestion of yakiniku was calculated according to the following formula.

[0029] [Equation 1]

 Sebum amount (g) = (weight of oil blotting paper after absorbing sebum) (g)

 1 (weight of oil blotting paper before absorbing sebum) (g)

[0030] [Table 1]

 [0031] Results>

 Table 2 shows the results obtained. In Table 2, the rate of decrease in sebum secretion means the ratio (%) of the amount of sebum that has decreased relative to the amount of sebum in the control. As a result, it was found that the amount of sebum secreted in the forehead is reduced by ingesting the extract of the two-gauri heat-treated product. In particular, from the results of Test Example 2, it was confirmed that the amount of sebum secreted could be significantly reduced by daily intake of the extract of the heat-treated two gourd.

 [0032] From the above results, the heat-treated two-gauri food or its extract has an action of suppressing the increase in the amount of neutral fat in the blood. It became clear that it can be improved to a constitution with less fat.

[0033] [Table 2] 2 hours after ingestion of grilled meat 4 hours after ingestion of grilled meat Sebum volume (g) Sebum secretion Sebum volume (g) Sebum secretion

0 indicates control decrease rate (%) 0 indicates control decrease rate (%) Test Example 1

 88 78

 Test example 2

 94 95

 # The results of Test Examples 1 and 2 show the average of the results of all subjects.

[0034] Example 2 (capsule)

 While stirring, 5 g of gelatin heated to 40-60 ° C was gradually added and dissolved. The mixed solution was degassed under reduced pressure, and then appropriate amounts of titanium oxide and pigment were added and further mixed. Then, after filling into a capsule-type bottle and drying until the moisture content is 15 18% by weight, the capsule body part is filled with 200 mg of the two-gauli heat-treated product prepared by the method described in Example 1. Then, the cap part was combined to prepare a capsule containing the two-gauri heat-treated product.

 [0035] Example 3 (microcapsule)

 To 100 g of purified water heated to 40 ° C., 5 g of gelatin was gradually added with stirring and mixed and dissolved. Thereafter, 200 mg of a two-gauli heat-treated product prepared by the method described in Example 1, titanium oxide, glycerin and a dye were added in appropriate amounts and mixed to obtain a capsule. The capsule was then cooled, dehydrated until the water content was 15-18% by weight, and further dried until the water content was 8.2 to 16% by weight. Then, it filtered and the microcapsule containing a two-gauri heat-processed material was prepared.

 [0036] Example 4 (cookies)

First, while stirring 70 g of unsalted butter, 80 g of sugar (granulated sugar) was gradually added thereto. After adding one loose egg to this, 2 g of the heat-treated bittern prepared by the method described in Example 1 was added and further stirred. At the stage of sufficient mixing, 200 g of uniformly crushed flour was added and stirred at a low speed, and then lumped together. After sleeping in a low temperature room for about 30 minutes, it was uniformly stretched to a thickness of about 1 cm and extracted with a circular mold having a diameter of 5 cm. Next, the cut cookie dough is placed on a top plate and heated in an oven preheated at 170 ° C for 12 15 minutes. Thus, a cookie containing the two-gauri heat-treated product was obtained.

 Example 5 (soft drink)

 A soft drink having the following composition was prepared.

 (% By weight) Extract of Nigauri heat-treated product (prepared by the method described in Example 1) Fructose dextrose liquid sugar 6.0 Sodium citrate 0.6

L-asconolebic acid 3.0

 _ Total 100% by weight Example 6 (jelly)

 According to a conventional method, a jelly having the following composition was prepared.

 (% By weight) Extract from Nigauri heat-treated product (prepared by the method described in Example 1) Gelatin 1 · 1 Sugar 22.0

 L monotartaric acid 0.1 sodium citrate 0.1

 Drop volume

100% by weight

Claims

The scope of the claims  [1] A blood neutral fat reducing agent comprising a heat-treated two-gauri product or an extract thereof as an active ingredient. [2] The blood neutral fat reducing agent according to claim 1, wherein the two-gauri heat-treated product is obtained by drying and heating two-gauri. [3] A blood neutral fat-reducing food comprising the blood neutral fat reducing agent according to claim 1 or 2.  P  Po  [4] A pharmaceutical or quasi drug for reducing blood neutral fat, comprising the blood neutral fat reducing agent according to claim 1 or 2.