[go: up one dir, main page]

WO2006006270A1 - Agent ralentissant la chute des cheveux - Google Patents

Agent ralentissant la chute des cheveux Download PDF

Info

Publication number
WO2006006270A1
WO2006006270A1 PCT/JP2005/004063 JP2005004063W WO2006006270A1 WO 2006006270 A1 WO2006006270 A1 WO 2006006270A1 JP 2005004063 W JP2005004063 W JP 2005004063W WO 2006006270 A1 WO2006006270 A1 WO 2006006270A1
Authority
WO
WIPO (PCT)
Prior art keywords
hair loss
hair
heat
sebum
gauri
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2005/004063
Other languages
English (en)
Japanese (ja)
Inventor
Tsuyoshi Sakamoto
Toshihiko Tsuda
Junji Nagao
Yasuyuki Hasegawa
Yasufumi Itaya
Yuka Nakajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kobayashi Pharmaceutical Co Ltd
Original Assignee
Kobayashi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kobayashi Pharmaceutical Co Ltd filed Critical Kobayashi Pharmaceutical Co Ltd
Publication of WO2006006270A1 publication Critical patent/WO2006006270A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present invention relates to a hair loss improving agent that effectively improves hair loss symptoms. Furthermore, this invention relates to the foodstuff or pharmaceutical composition containing the said hair loss improving agent.
  • Sebaceous gland strength of the scalp Secreted sebum imparts appropriate oil, suppleness and strength to the hair, and also plays a role in suppressing the entry of foreign substances into the scalp and the release of moisture from the scalp. .
  • sebum will block the pores, which may cause or worsen hair loss symptoms!
  • Conventional hair restoration agents generally contain ingredients that contribute to blood circulation promotion, cleansing, anti-inflammatory, sterilization, cell activation, and the like.
  • the ingredients used in conventional hair restorers do not have the effect of suppressing the excessive secretion of sebum to the scalp or are weak, so that a sufficient hair-growth effect cannot be obtained.
  • Patent Document 1 Japanese Patent Laid-Open No. 2002-212050
  • Patent Document 2 JP 2002-278804 A Disclosure of the invention
  • An object of the present invention is to provide a hair loss improving agent that is highly safe and can be taken or administered on a daily basis and is effective in improving hair loss. Furthermore, an object of the present invention is to provide foods and pharmaceuticals containing the hair loss improving agent.
  • the inventors of the present invention have intensively studied to solve the above-described problems.
  • the scalp has a heat-treated product of two gourds, in particular, a heat-treated product after drying the gourd. It has been found that it suppresses the secretion of sebum and prevents or treats hair loss.
  • the present invention has been developed based on further studies and further studies.
  • the present invention provides the following inventions:
  • a hair loss-improving agent comprising a heat-treated two-gauri product or an extract thereof as an active ingredient.
  • Item 2 The hair loss improving agent according to Item 1, wherein the two-gauri heat-treated product is obtained by heating after drying -gouli.
  • a hair loss improving food comprising the hair loss improving agent according to Item 1 or 2.
  • Item 4 The food for improving hair loss according to Item 3, which is in the form of a powder, tablet, capsule, syrup, jelly, or beverage.
  • a pharmaceutical product or quasi-drug for hair loss improvement comprising the hair loss improving agent according to Item 1 or 2.
  • a two-gauri heat-treated product is used as an active ingredient.
  • Nigauri is a plant belonging to the cucurbitaceae family and has the scientific name Momordica charantia.
  • Shishi Known as Shishi, it is native to tropical Asia, and is often cultivated in the offshore and Kyushu regions in Japan.
  • Nigauri is also known as Goya Ralishi.
  • the gourd used in the present invention may be a wild species or an improved variety!
  • a fruit portion of 2-gauri is used as the raw material of the heat-treated 2-gauri product that is the active ingredient of the present invention.
  • the fruit part includes fruit skin, fruit pulp, fruit juice, cotton, seeds, etc., but any of these parts may be used as a raw material for the two-gauri heat-treated product.
  • the two-gauri heat-treated product can be obtained by chopping or crushing two-gauri as necessary, for example, by heating at 40 to 120 ° C for about 1 to 60 minutes.
  • the heating method is not particularly limited, but a roasting method is preferable.
  • the -gouli heat-treated product is obtained by heating two-gauri after drying.
  • a method for preparing a gourd heat-treated product by drying and heating two gourds will be described.
  • the preparation of heat-treated cucumbers it is subjected to a step of drying the two gauli prior to the heat treatment of the gauri, but before the drying step, the two gaulis are chopped or crushed to an appropriate size. It is desirable to keep it. From the viewpoint of efficiently performing drying and heating, it is desirable to cut the two gourd into pieces of about 120 mm, preferably about 5-8 mm.
  • the dry weight of bigauri may be carried out until the weight is reduced to 120%, preferably 5-12% of the weight before drying.
  • the drying method and conditions are not particularly limited, and a drying method known or commonly used in the art may be employed.
  • Specific examples of the drying method include a method of drying by applying hot air of about 40 to 120 ° C, and a method of drying for 15 to 15 days, preferably about 3 days in the sun.
  • the dried bigauri is then subjected to a heat treatment (for example, roasting treatment).
  • the calorific heat condition is appropriately adjusted according to the heating temperature and the heating time.
  • the heating temperature is usually set to 40-120 ° C, preferably 60-120 ° C.
  • the heating time varies depending on the heating temperature and cannot be specified uniformly, but is usually 1 to 60 minutes, preferably about 3 to 15 minutes.
  • the heating method is not particularly limited, and an example of a suitable heating method is a method of frying under the above temperature conditions.
  • the said heat processing can be implemented using a roasting machine etc., for example. By performing such heat treatment, a two-gauri heat-treated product is prepared.
  • the -gouli heat-treated product is usually reduced to a weight of 1-10%, preferably 5-7% of the weight of the -gouli before drying.
  • an extract of a heat-treated 2-gauli product can be obtained by extracting the heat-treated 2-gauli product with an extraction solvent at room temperature or under heating.
  • the extraction solvent include water; an organic solvent; or a mixed solution of water and an organic solvent.
  • the organic solvent used for extraction examples include methanol, ethanol, isopropanol, propylene glycol, 1,3-butylene glycol, acetone, ethyl acetate, chloroform, pentane, hexane, heptane, etc.
  • the extraction solvent is preferably water; a lower alcohol such as methanol, ethanol or isopropanol; or a mixture of water and a lower alcohol, more preferably water, ethanol or a mixture of water and ethanol (5-50).
  • a water-weight ethanol solution particularly preferably water.
  • the above water includes warm water and hot water.
  • the extract of the two-gauri heat-treated product used for the hair loss improving agent may be the extract obtained by the above-described extraction treatment as it is, or the extract liquid solids may be removed. It may be. If necessary, it may be further concentrated by vacuum distillation or the like, or may be dried by a drying treatment such as vacuum drying or freeze drying.
  • the amount or dose of the hair loss improving agent of the present invention varies depending on the age and sex of the subject, the degree of hair loss symptoms, the expected effect, etc., and cannot be uniformly defined, but per adult day
  • the amount of hair loss improver (converted to the dry weight of the two-gauri heat-treated product) is 0.1-4 g, preferably 0.3-2 g, more preferably 0.7-2 g. The quantity is illustrated.
  • the hair loss-improving agent of the present invention can also be provided as a food product for improving hair loss by blending it in foods, or it can be prepared in the form of an internal medicine or quasi-drug and used for improving skin hair loss. Or as a quasi-drug.
  • the above-mentioned food for improving hair loss includes health functional foods (nutrient functional foods and foods for specific health), so-called health foods, nutritional supplements or special-purpose foods (food for the sick, etc.). Can do.
  • Examples of the form include powders, tablets, capsules, syrups, jelly forms and the like.
  • the extract of the two gourd heat-treated product obtained using water as an extraction solvent can be used as it is, the extract itself, or its concentrated or diluted solution can be used as a beverage form food.
  • the ratio of the hair loss improving agent to be blended may be appropriately set according to the intake amount of the agent per day, the form of food, the expected effect, etc. Good.
  • the shape of the pharmaceutical product or quasi-drug for improving hair loss is not particularly limited as long as the effect of the present invention is not hindered.
  • Examples of the form of the pharmaceutical or quasi drug include tablets, powders, granules, capsules, pills, troches, liquids, extracts and the like.
  • the drug or quasi-drug is formulated with a pharmaceutically acceptable carrier or carrier, but if necessary, a binder, a disintegrant, a lubricant, a wetting agent, a buffer, a preservative. In addition, it may optionally contain pharmaceutically acceptable additives such as fragrances.
  • the ratio of the hair loss improving agent contained in the above-mentioned pharmaceutical product or quasi-drug for improving hair loss is the dosage of the agent per day, the age and sex of the subject, the form of the pharmaceutical product or quasi-drug, It can be set as appropriate according to the expected effect.
  • the hair loss improving agent of the present invention is useful as an edible hair restorer because it can prevent or treat hair loss by preventing the accumulation of sebum in the pores when taken or applied orally. It is. Moreover, the hair loss improving agent of the present invention is suitable for the ability to be effective against hair loss symptoms caused by any factor, particularly for the prevention or treatment of seborrheic alopecia.
  • the hair loss improving agent of the present invention may be used in combination with other hair growth agents that are applied transdermally or taken orally, and this may cause the effect of improving hair loss more remarkably.
  • the hair loss improving agent of the present invention it is possible to effectively suppress the accumulation of sebum in the pores, thus effectively preventing the occurrence of hair loss and symptom illness, and healthy scalp and hair. It is possible to maintain a stable state.
  • the hair loss improving agent of the present invention can be conventionally used as a raw material for foods-it is prepared as a raw material, and thus is taken or administered daily as a highly safe food or an internal medicine. It is possible.
  • the two-gauri heat-treated product obtained by drying and heating two-gauri does not have the bitterness peculiar to two-gauri and does not adversely affect the taste.
  • FIG. 1 A photograph of the condition of the scalp before ingesting the subject's grilled meat during the test of Test Example 1.
  • FIG. 2 A photograph of the condition of the scalp 2 hours after ingestion of the subject's grilled meat during the test of Test Example 1.
  • FIG. 3 is a photograph of the condition of the scalp before ingesting the subject's grilled meat during the control test in Test Example 1.
  • FIG. 4 is a photograph of the condition of the scalp taken 2 hours after ingesting the subject's grilled meat during the control test in Test Example 1.
  • hair loss symptoms can be improved by preventing the accumulation of sebum in the pores.
  • the amount of sebum secreted into the scalp (hair) is correlated with the amount of sebum secreted in the forehead. Therefore, by confirming the amount of sebum secreted in the scalp (hair part) and measuring the amount of sebum secreted in the forehead, what effect is exerted on the improvement of hair loss due to the treatment of two-gauri heat treatment? Evaluation was performed.
  • the degree of sebum accumulation in the scalp (hair) was evaluated by subjects who took the test sample under the conditions shown in Table 1 below, and the amount of sebum secreted in the forehead was measured. Specifically, first, the degree of sebum accumulation in the subject's scalp (hair) was confirmed by visual and photography, and oil blotting paper (trade name “Cosmetics Planet Oil Blotting Paper”, Orbit Co., Ltd.) 100% natural hemp) was used to fully absorb the subject's forehead sebum. Immediately thereafter, about 300 g of grilled meat was ingested.
  • the sebum amount after 2 and 4 hours of ingestion of yakiniku was calculated according to the following formula.
  • FIG. 14 shows the results of confirming the degree of sebum accumulation in the scalp by photography.
  • Fig. 1 shows the condition of the scalp before ingestion of the grilled meat of one subject in the test of Test Example 1;
  • Fig. 2 shows the condition of the scalp 2 hours after ingestion of the subject's grilled meat in the test of Test Example 1;
  • Fig. 4 shows the condition of the scalp before ingestion of the subject's grilled meat during the control test of Test Example 1;
  • Fig. 4 shows the condition of the scalp after 2 hours of ingestion of the subject's grilled meat during the control test of Test Example 1.
  • Table 2 shows the results obtained for the amount of sebum secreted in the forehead.
  • the rate of decrease in sebum secretion means the ratio (%) of the amount of sebum decreased relative to the amount of sebum in the control.
  • the amount of sebum secreted in the forehead was reduced by ingesting the extract of the two-gauri heat-treated product.
  • the amount of sebum secreted could be effectively suppressed by daily intake of the extract of the heat-treated two gourd.
  • the heat treatment product or extract thereof has the effect of suppressing the sebum secretion to the scalp and preventing the accumulation of sebum in the pores, resulting in hair loss symptoms. It became clear that it was useful for improvement.
  • Example 2 (capsule)
  • Gelatin 5g heated to 40-60 ° C was gradually added with stirring to dissolve.
  • the mixed solution was degassed under reduced pressure, and then appropriate amounts of titanium oxide and pigment were added and further mixed.
  • the body part of the capsule was prepared by the method described in Example 1 and filled with 200 mg of a gourd heat-treated product.
  • the cap part was bonded to prepare a capsule containing the two-gauri heat-treated product.
  • Example 5 soft drink
  • a soft drink having the following composition was prepared.
  • a jelly having the following composition was prepared.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne un agent ralentissant la chute des cheveux lequel est tout à fait sans danger, peut être pris ou administré quotidiennement et est efficace pour ralentir la chute des cheveux. De la margose traitée à la chaleur ou un extrait de celle-ci a un effet d'abaissement de la teneur en graisse neutre dans le sang et on l'utilise comme ingrédient actif pour un agent ralentissant la chute des cheveux.
PCT/JP2005/004063 2004-09-27 2005-03-09 Agent ralentissant la chute des cheveux Ceased WO2006006270A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004280634 2004-09-27
JP2004-280634 2004-09-27

Publications (1)

Publication Number Publication Date
WO2006006270A1 true WO2006006270A1 (fr) 2006-01-19

Family

ID=35783632

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/004063 Ceased WO2006006270A1 (fr) 2004-09-27 2005-03-09 Agent ralentissant la chute des cheveux

Country Status (1)

Country Link
WO (1) WO2006006270A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2127674A4 (fr) * 2007-02-19 2011-04-27 Nat Inst Of Advanced Ind Scien Promoteur de la repousse des cheveux
JP2012062294A (ja) * 2010-09-17 2012-03-29 National Institute Of Advanced Industrial Science & Technology 毛成長休止期短縮剤
WO2014107369A1 (fr) 2013-01-02 2014-07-10 Static Control Components, Inc. Systèmes et procédés pour composants d'imagerie universels

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010053390A1 (en) * 1999-07-14 2001-12-20 Kaijun Ren Use of plant extracts for treatment of acne and furuncle
JP2002212050A (ja) * 2001-01-23 2002-07-31 Eikodo Honten:Kk 皮膚若しくは毛髪用化粧料
WO2003002277A1 (fr) * 2001-06-28 2003-01-09 Sms Demag Aktiengesellschaft Procede et dispositif de refroidisement et de lubrification de cylindres d'une cage de laminoir
JP2003176213A (ja) * 2001-12-11 2003-06-24 National Institute Of Advanced Industrial & Technology 育毛剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010053390A1 (en) * 1999-07-14 2001-12-20 Kaijun Ren Use of plant extracts for treatment of acne and furuncle
JP2002212050A (ja) * 2001-01-23 2002-07-31 Eikodo Honten:Kk 皮膚若しくは毛髪用化粧料
WO2003002277A1 (fr) * 2001-06-28 2003-01-09 Sms Demag Aktiengesellschaft Procede et dispositif de refroidisement et de lubrification de cylindres d'une cage de laminoir
JP2003176213A (ja) * 2001-12-11 2003-06-24 National Institute Of Advanced Industrial & Technology 育毛剤

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Araru Supasupa Kenko Shokuhin Net.", 11 April 2005 (2005-04-11), XP002994900, Retrieved from the Internet <URL:http://plaza.rakuten.co.jp/usa01/36000> *
WATANABE M ET AL: "Tonyo Rat no Shishitsu Taisha no Oyobosu Nigaru Funmatsu Choseiji ni Okeru Shori Hoho no Eikyo.", JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY., vol. 50, no. 3GA4, 2003, pages 67, XP002996088 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2127674A4 (fr) * 2007-02-19 2011-04-27 Nat Inst Of Advanced Ind Scien Promoteur de la repousse des cheveux
JP2012062294A (ja) * 2010-09-17 2012-03-29 National Institute Of Advanced Industrial Science & Technology 毛成長休止期短縮剤
WO2014107369A1 (fr) 2013-01-02 2014-07-10 Static Control Components, Inc. Systèmes et procédés pour composants d'imagerie universels

Similar Documents

Publication Publication Date Title
US6416795B1 (en) Herbal extract composition for stress prevention and treatment
EP0930019A2 (fr) Composition pour traiter l&#39;obésité et aliments et boissons la comprenant
JP6294710B2 (ja) 糖代謝改善剤
JP4764518B1 (ja) 経口毛穴改善剤
KR100794446B1 (ko) 발모촉진제 및 제조방법
EP1583547B1 (fr) Ingredients anti-obesite obtenus a partir de plantes medicinales et leur composition
JP2008063332A (ja) 未成熟柿果実粉末組成物とその製造方法
JP3628999B2 (ja) 苦瓜茶及びその製造方法
TW201006389A (en) Formulations, methods and its use for reducing abdominal fat and waist circumference
JP2011020925A (ja) 内臓脂肪型肥満抑制剤及びその製造方法
WO2006006270A1 (fr) Agent ralentissant la chute des cheveux
JP2006117659A (ja) 脱毛改善剤
WO2014134833A1 (fr) Composition comestible, son procédé de préparation, et produit alimentaire comprenant la composition
JP2006117658A (ja) 血中中性脂肪低減剤
WO2006006268A1 (fr) Reducteur de brillance
JPH09187248A (ja) 抗アレルギー食品
JP7646740B2 (ja) 胃部不快感改善剤及び尿意抑制剤
JP2006117657A (ja) テカリ抑制剤
KR20000018977A (ko) 동아 녹즙 및 그 잔사를 사용하여 제조된 체중 및 혈당 조절용식품조성물 및 그 제조방법
WO2006006269A1 (fr) Agent abaissant le niveau de graisse neutre dans le sang
JP2002080385A (ja) 金属沈着抑制剤
JP7029697B2 (ja) 嚥下機能改善剤
WO2005094858A1 (fr) Composition antidiabetique
JP7421184B2 (ja) 皮膚水分量、皮膚油分量の増加及び／又は維持剤
JP7466174B2 (ja) コーヒーチェリー素材

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

NENP Non-entry into the national phase

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 05720335

Country of ref document: EP

Kind code of ref document: A1

122 Ep: pct application non-entry in european phase

Ref document number: 05720335

Country of ref document: EP

Kind code of ref document: A1

WWW Wipo information: withdrawn in national office

Ref document number: 5720335

Country of ref document: EP