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WO2006003989A1 - Composition de dentifrice - Google Patents

Composition de dentifrice Download PDF

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Publication number
WO2006003989A1
WO2006003989A1 PCT/JP2005/012075 JP2005012075W WO2006003989A1 WO 2006003989 A1 WO2006003989 A1 WO 2006003989A1 JP 2005012075 W JP2005012075 W JP 2005012075W WO 2006003989 A1 WO2006003989 A1 WO 2006003989A1
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WO
WIPO (PCT)
Prior art keywords
water
group
particle size
soluble polymer
feeling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2005/012075
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English (en)
Japanese (ja)
Inventor
Susumu Hiratsuka
Takaaki Komatsu
Takashi Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lion Corp
Original Assignee
Lion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corp filed Critical Lion Corp
Priority to KR1020077000046A priority Critical patent/KR101169939B1/ko
Priority to CN2005800248970A priority patent/CN1988876B/zh
Priority to JP2006528802A priority patent/JP4702561B2/ja
Publication of WO2006003989A1 publication Critical patent/WO2006003989A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

Definitions

  • the present invention relates to a dentifrice composition having an appropriate polishing force and having an excellent feeling of use due to a synergistic effect of granule brushing and excellent dentifrice dispersibility.
  • the polishing power of a dentifrice composition is considered to have a correlation with the hardness, particle size, and blending amount of the abrasive used. That is, relatively soft (a Mohs hardness of 2 to 3) Abrasives such as calcium hydrogen phosphate can be incorporated into a dentifrice composition in a relatively large amount. . However, in the case of a relatively hard abrasive such as caustic anhydride (Mohs hardness around 4-6), the particle size can be reduced and only a small amount can be blended.
  • the hardness, particle size and blending amount of the abrasive have a great influence on the feeling of use of the dentifrice composition. That is, the feeling of use (a feeling of brushing, dispersibility, etc.) of a dentifrice composition containing an abrasive having a large particle size and a dentifrice composition containing a large amount of abrasive is good.
  • the feeling of use of a dentifrice composition containing an abrasive with a small particle size and a dentifrice composition with a small amount of abrasive was required to improve the feeling of use due to poor brushing and dispersibility. .
  • a dentifrice composition containing a large amount of calcium hydrogen phosphate having a large particle size is a dentifrice composition having an appropriate polishing power and a good feeling of use, whereas an anhydrous case having a small particle size.
  • Heavy calcium carbonate is a relatively inexpensive abrasive, and its use has cost merit, but it is an abrasive that is relatively hard with a Mohs hardness of around 3 to 4, so it is suitable for polishing.
  • a dentifrice composition having strength it was necessary to reduce the particle size and to reduce the blending amount. Therefore, a dentifrice composition containing heavy calcium carbonate as an abrasive has been required to improve the feeling of use due to poor feeling of brushing and dispersibility. Disclosure of the invention
  • the present invention has been made in response to a strong demand, and an object of the present invention is to provide a heavy calcium carbonate-containing toothpaste composition having an appropriate polishing power and good usability. Means for solving the problem
  • the present inventor combined heavy calcium carbonate with an average particle diameter controlled to 5 to 15 m as an abrasive so as to obtain an appropriate polishing force.
  • Water-insoluble inorganic granules having a disintegration strength of 10 to 200 gZ, an average particle size of 50 to 150 111, and a difference between the 90% particle size and the average particle size of 100 m or less.
  • it can give a brushing feeling to the dentifrice, and at least one water-soluble polymer substance selected from the group (a) below and at least one kind selected from the group (b) below.
  • the dispersibility of the dentifrice is improved, and the brushing feeling of the dentifrice is further improved. Therefore, it has an appropriate polishing force and has a good feeling of use such as toothpaste dispersibility, brushing feeling and foreign body feeling, and toothpaste behavior. It was found that a dentifrice composition having a good feeling in use can be obtained.
  • the dentifrice composition of the present invention has an appropriate polishing power and has an excellent feeling of use due to a synergistic effect of the brushing feeling of granules and excellent dentifrice dispersibility.
  • the dentifrice composition of the present invention comprises (A) heavy calcium carbonate, (B) water-insoluble inorganic granules, and (C) a water-soluble polymer substance.
  • the heavy calcium carbonate of component (A) to be blended as an abrasive those having an average particle size of 5 to 15 m, preferably 7 to 13 ⁇ m are used. If the average particle size is too small, the tooth cleaning effect, which is the basic function of the dentifrice, cannot be sufficiently obtained, and the excellent feeling of use cannot be obtained due to poor dispersibility of the toothpaste. If the average particle size is too large, an unpleasant sensation may cause discomfort and the polishing power may be too high.
  • the average particle diameter is a value measured with a Microtrac particle size distribution analyzer (Model 7995 10, Type SRA, manufactured by Nikkiso Co., Ltd.), and is a value measured by adjusting the turbidity (dV value) of the specimen to 0.5. is there.
  • heavy calcium carbonate used in the present invention commercially available heavy calcium carbonate can be used, and examples are shown below, but the manufacturer, commodity, and grade are limited thereto. It is not something.
  • Heavy calcium carbonate [Heavy calcium carbonate RTT—21 (Bihoku Powder Co., Ltd .: average particle size 7-10 / ⁇ ⁇ ), Heavy calcium carbonate RTT—69 (China: Average particle size 8-13 / ⁇ ⁇ ), Whiteon F (manufactured by Shiraishi Calcium Co., Ltd .: average particle size 11-15 m)]
  • the component (B) blended in the present invention has a disintegration strength of 10 to 200 gZ, an average particle size of 50 to 150 ⁇ m, and a difference between the 90% particle size and the average particle size of 100 ⁇ m. m or less water-insoluble inorganic granules.
  • water-insoluble inorganic granules those produced by various methods can be used.
  • water-insoluble inorganic agglomerates are produced by pulverizing or water-insoluble inorganic powders are mixed with water to form a slurry and pressure. It can be granulated, dried and formed into granules.
  • the water-insoluble inorganic granules to be blended in the present invention are those produced by any method. Although it can be used, it was produced by the method of pulverizing the water-insoluble inorganic agglomerates described above, the method of adding water to a water-insoluble inorganic powder to form a slurry, granulating and drying by applying pressure. Granules are preferred.
  • Examples of the agglomerates and water-insoluble inorganic powders include dicalcium phosphate, triphosphate, insoluble calcium metaphosphate, anhydrous caustic acid, aluminum hydroxide, magnesium phosphate, bengara, calcium carbonate (heavy Or light calcium carbonate), calcium pyrophosphate, zeolite, aluminosilicate, magnesium carbonate, zirconosilicate, calcium sulfate, titanium oxide, aluminum oxide, and mixtures of these.
  • the main water-insoluble inorganic powders that occupy 70% by mass or more and 100% by mass or less of the water-insoluble inorganic granule, especially the anhydrous zeal and zola Those bets, selected calcium carbonate mosquito ⁇ al
  • the water-insoluble inorganic powder occupying 0 mass% or more and less than 30 mass% of the water-insoluble inorganic granule is particularly titanium oxide or aluminum oxide. Is preferred.
  • water-insoluble inorganic agglomerates and water-insoluble inorganic powders used in the present invention commercially available water-insoluble inorganic powders can be used, and examples are shown below. And the grade is not limited to this.
  • water-insoluble inorganic granules are adsorbed on the surface and blended with organic and inorganic surface coating agents and medicinal components, colorants, fragrance components and other excipients generally used in dentifrice. Monkey.
  • the water-insoluble inorganic granules used in the present invention have a disintegration strength of 10 to 200 gZ, preferably 20 to LOOgZ.
  • Granules with a disintegration strength of less than 10gZ may not have an excellent feeling of use due to the disintegration at the start of brushing, and condylar particles with a disintegration strength of more than 200gZ may cause foreign body sensation and discomfort in the oral cavity.
  • the disintegration strength is 20 to: LOOgZ, a very excellent feeling of use is obtained from the beginning of dentifrice, and the feeling of use lasts throughout the dentifrice action, so this is a preferable range.
  • the disintegration strength is the measured value of the automatic breaking strength of 30 granules (the load when the granules disintegrate when one granule is compressed under the conditions of a plunger diameter of 10 mm and a compression speed of lOmmZ. The measured value. ) Average value.
  • the water-insoluble inorganic granule has an average particle size of 50 to 150 ⁇ m, preferably an average particle size of 80 to 120 ⁇ m. Granules with an average particle size of less than 50 ⁇ m do not give a good feeling of use, and granules with an average particle size of more than 150 m may cause a foreign body sensation or discomfort in the oral cavity. When the average particle size is 80 to 120 m, a very excellent feeling of use with no foreign matter or discomfort is obtained from the beginning to the end of dentifrice.
  • the water-insoluble inorganic granule has a difference between the 90% particle size and the average particle size of 100 ⁇ m or less, and preferably the difference between the 90% particle size and the average particle size is 70 ⁇ m. m or less.
  • the difference between the 90% particle size and the average particle size is a factor that has a large influence on the particle size distribution of the granules, and in the case of granules whose difference between the 90% particle size and the average particle size exceeds 100 m, May cause a foreign body sensation or discomfort.
  • the difference between the 90% particle size and the average particle size is 70 ⁇ m or less, it is preferable that a feeling of foreign matter and discomfort are completely eliminated from the beginning to the end of dentifrice.
  • the lower limit of the difference between the 90% particle size and the average particle size is 0 ⁇ m or more.
  • the average particle diameter and the 90% particle diameter are measured values (m) measured using a microtrack particle size distribution measuring apparatus, that is, an apparatus using a particle size distribution measuring method based on the laser diffraction diffraction method.
  • a microtrack particle size distribution measuring apparatus that is, an apparatus using a particle size distribution measuring method based on the laser diffraction diffraction method.
  • it is a measurement value measured by adjusting the turbidity (dV value) of the sample to 0.5 using a Model7995-10, Type SRA manufactured by Nikkiso Co., Ltd.
  • the water-insoluble inorganic granules used in the present invention have low physical abrasiveness.
  • the RDA (Radioactive Dentin Abrasion) value for evaluating the abrasiveness of the granules is 30 or less, particularly 0 to 15. Preferably there is. If the RDA value exceeds 30, the polishing power of the dentifrice may become too high depending on the amount of granules.
  • the blending amount of the water-insoluble inorganic granules of the component (B) is preferably 0.1 to 20%, particularly preferably 0.5 to 10% of the entire composition. If the blending amount is less than 0.1%, an excellent feeling of use may not be obtained. If the blending amount exceeds 20%, a foreign body sensation or discomfort may occur in the oral cavity.
  • group (a) sodium alginate, carboxymethyl) Cellulose sodium, methenorescenellose, hydroxyethyl cellulose, xanthan gum, ⁇ -carrageenan, linear sodium polyacrylate
  • group (b) Greenan gum, agar) , ⁇ -carrageenan, t -carrageenan, gelatin, pectin, cross-linked sodium polyacrylate) and a mass ratio of (b) group to (b) group is 0.
  • the water-soluble polymer substance of group (a) in this case is generally a viscous solution in the form of an aqueous solution having a water-soluble polymer substance concentration of 1% and a propylene glycol concentration of 3%. It is a water-soluble polymeric substance that does not have gelling ability, and is sodium alginate, sodium carboxymethyl cellulose, methyl cellulose, hydroxyethyl cellulose, ⁇ -force laginan, linear sodium polyacrylate, and at least one selected from xanthan gum. It is a seed.
  • group (b) that has a great influence on the feeling of use of the dentifrice composition (especially dentifrice dispersibility).
  • the water-soluble polymer substance in group (b) is generally a water-soluble polymer substance having a gelling ability in an aqueous solution having a water-soluble polymer substance concentration of 1% and a propylene glycol concentration of 3%. It is a high molecular weight substance, and is at least one selected from dielan gum, agar, ⁇ -strength laginan, t- strength laginan, gelatin, pectin, and cross-linked sodium polyacrylate.
  • it is at least one selected from kappa laginane and cross-linked sodium polyacrylate.
  • xanthan gum is a water-soluble polymer substance having a gelling ability in the state of an aqueous solution having a water-soluble polymer substance concentration of 1% and a propylene glycol concentration of 3%. It is rich in elasticity and, as is clear from the results of the experimental examples described later, shows different results from the water-soluble polymer substance in group (b), and was classified as a water-soluble polymer substance in group (a).
  • water-soluble polymer substance used in the present invention commercially available water-soluble polymer substances can be used, and examples are shown below, but the manufacturer, product, and grade are limited thereto. It is not a thing. (a) group of water-soluble polymeric substances;
  • CMC Daicel (Daicel Chemical Industries, Ltd .: Viscosity (2% ⁇ 25. ⁇ Type ⁇ ⁇ . 2-20rpm) 100 ⁇ 1500mPa-s, etherity degree 0.8 ⁇ 1.5), Ernest Gum (Daicel Engineering Co., Ltd .: Viscosity (1% ⁇ 25 ° C ⁇ BH type ⁇ No. 2 ⁇ 20rpm) 100 ⁇ 1000mPa's, degree of etherification 1.5 or more), Sunrose F10LC (Nippon Paper Industries, Ltd.) : Viscosity (2% '25 ° C 'BH type ⁇ ⁇ .
  • Methylcellulose [(Metros SM (manufactured by Shin-Etsu Chemical Co., Ltd .: Viscosity (2% ⁇ 20 ° C ⁇ BH type ⁇ No. 2-20rpm) 150 ⁇ 4000mPa-s)]
  • HEC Daicel (Daicel Chemical Industries, Ltd .: Viscosity (1% ⁇ 25. C, BH type ⁇ ⁇ . 3, 30rpm) 2400 to 3000mPa, s, methoxykyl group 26.0 to 33.0% )
  • Linear sodium polyacrylate [Alonbis S (Nippon Pure Chemicals Co., Ltd .: Viscosity (2% ⁇ 25 ° C ⁇ BH type • No. 2-20rpm) 100 ⁇ 2000mPa-s)]
  • Xanthan gum [Monato Gum DA (CP Kelco: Viscosity (pharmaceutical additive standard) 1300 to 1700mPa.s), Keldent (CP Kelco: Viscosity (medicine supplement) 1200 to 1700mPa.s)]
  • the method for preparing the aqueous polymer solution and the method for measuring the viscosity when measuring the above-described viscosity are as follows.
  • the order in which the measurement conditions are described is (concentration of aqueous solution, measurement temperature, viscometer type, rotor number, rotation speed).
  • water-soluble polymer substance in group (b) In addition to the water-soluble polymer substance in group (b), another water-soluble polymer substance that has been subjected to gelation treatment such as heating, addition of a metal salt, pH adjustment, etc. It can be used as a water-soluble polymer substance belonging to It is also possible to use other water-soluble polymer substances as the water-soluble polymer substance in the group (a) that do not have the same gelling function as the water-soluble polymer substance in the group (a).
  • At least one water-soluble polymer substance in group (a) and at least one water-soluble polymer substance in group (b) are used in combination.
  • (b) Group mass ratio ((b) Group Z (Group a)) is set between 0.25 and 3, preferably between 0.3 and 2 It is desirable.
  • the mass ratio of the (b) group to the (a) group is less than 0.25, the dispersibility of the dentifrice composition is reduced and an excellent feeling of use cannot be obtained, and when it exceeds 3, the (b) group Gelling ability, which is a characteristic of water-soluble high-molecular substances, affects the properties immediately after the preparation of the dentifrice composition, and easily causes water separation.
  • the mass ratio of the group (b) to the group (a) is between 0.3 and 2, it is more preferable because the influence of other compounding ingredients is extremely small on the feeling and stability of the dentifrice composition. It becomes a range.
  • the total amount of the water-soluble polymer substances in the groups (a) and (b) is 0.5 to 1.5% of the entire composition, preferably 0.9 to 1.4. %.
  • the total amount of water-soluble polymer substances in groups (a) and (b) is less than 0.5%, water separation easily occurs in the properties immediately after the dentifrice composition is manufactured, and 1.5% If it exceeds 1, the dispersibility of the dentifrice composition decreases, and an excellent feeling of use cannot be obtained.
  • the total amount of water-soluble polymer substances is between 0.9 and 1.4%, the influence of other compounding ingredients on the feel and stability of the dentifrice composition is extremely small. This is a more preferable range.
  • the dentifrice composition of the present invention can be prepared into a dentifrice such as a toothpaste, a liquid dentifrice, and a moisturized dentifrice, and various base components used depending on the dosage form can be blended.
  • a dentifrice such as a toothpaste, a liquid dentifrice, and a moisturized dentifrice
  • various base components used depending on the dosage form can be blended.
  • abrasives other than heavy calcium carbonate, binders other than those described above, thickeners, foaming agents, sweeteners, fragrances and the like can be formulated at ordinary doses within the range that does not interfere with the effects of the present invention.
  • an abrasive usually blended in a dentifrice composition can be used.
  • an anhydrous carboxylic acid type such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, etc.
  • the blending amount of these abrasives is preferably 10 to 60% of the entire dentifrice composition as a total amount including heavy calcium carbonate as the component (A).
  • the binder is not limited to the effects of the present invention, and other than the above water-soluble polymer substance, for example, an inorganic binder such as a thickening anhydride, bee gum, or labonite. At least one can be added. These blending amounts are preferably 0.01 to 10% of the entire composition.
  • At least one polyhydric alcohol such as glycerin, sorbit, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, xylitol, manolecitol, and ratathitol can be blended (mixing amount is usually 1 to 1). 45%, particularly suitable 2-40%).
  • foaming agent examples include sodium lauryl sulfate, sodium myristyl sulfate, sodium N-lauroyl sarcosinate, sodium N-myristol sarcosinate, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, lauryl sulfo Anionic surfactants such as sodium acetate, sodium ⁇ -olefin sulfonate, ⁇ -acyl glutamate such as sodium palmitoylglutarate, ⁇ -methyl ⁇ -acyl taurate such as sodium taurate, Cationic surfactants, sucrose fatty acid esters such as sucrose fatty acid ester and maltose fatty acid ester, sugar alcohol fatty acid esters such as maltitol fatty acid ester and latator fatty acid ester, alkylol amide, Polyoxyethylene sorbitan fatty acid esters such as oxyethylene
  • ⁇ -alkyldiaminoethylglycine or ⁇ ⁇ ⁇ ⁇ —At least one amphoteric surfactant such as sodium alkyl-1-hydroxyethylimidazoline betaine Seeds can be blended.
  • the blending amount of the foaming agent is preferably 0.1 to 4% of the entire composition.
  • fragrance ingredients include menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, hi-TV neol, citronellyl acetate, cineol, linalool, ethyllinalool, ⁇ -lin, timonore, Perfume such as spearmint oil, peno-mint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, winter green oil, clove oil or eucalyptus oil alone Or they can be combined.
  • the blending amount of the fragrance component is preferably 0.5 to 1.5% of the entire composition.
  • At least one sweetener such as saccharin sodium, stepioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, perlartin, glycyrrhizin, thaumatin, and asparatylphenol-lanalanine methyl ester may be added.
  • the blending amount of the sweetener is preferably 0.05 to 1% of the entire composition.
  • the present invention includes phenolic compounds such as triclosan, hinokitiol, thymol, and piozole, and quaternary ammonium salts such as cetylpyridinum chloride, benzethonium chloride, and benzalkonium chloride.
  • phenolic compounds such as triclosan, hinokitiol, thymol, and piozole
  • quaternary ammonium salts such as cetylpyridinum chloride, benzethonium chloride, and benzalkonium chloride.
  • Enzymes such as dextranase, mutanase, lysozyme, amylase, protease, lytic enzyme, superoxide dimustase (SOD), alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate, sodium fluoride, fluoride Fluorides such as stannous, tranexamic acid, epsilon aminocaproic acid, allantoin, dihydrocholesterol, glycyrrhizic acids, glycyrrhetinic acid, glycephosphate, chlorophyll, sodium chloride, xylitol, zinc chloride, water-soluble Rinsani ⁇ product can Oubataekisu, chlorhexidine to chloro, vitamin A, vitamin B group, vitamin C, etc. vitamins and derivatives thereof such as vitamin E, be formulated at least one known active ingredient.
  • the active ingredient can be blended in an effective amount within a
  • the colorant at least one of Blue No. 1, Yellow No. 4, Green No. 3, titanium dioxide, alumina oxide and the like can be blended.
  • the dentifrice composition of the present invention is manufactured by a manufacturing apparatus capable of mixing under reduced pressure, and can be used by being filled into a tube laminated with aluminum foil, a plastic multilayer tube, a pump dispenser, a bottle container, or the like. .
  • Dentifrices containing the ingredients shown in Table 1 were prepared, and the effects of granule formulation were evaluated on the polishing power and feeling of use (toothpaste dispersibility, brushing feeling, foreign body feeling) by the following methods. The results are shown in Table 1.
  • polishing power was measured by the RDA method (1's place 0 to 4 were rounded down to 0, and 5 and above were rounded down to 5).
  • the RDA (Radioactive Dentin Abrasion) method is a method that uses a polishing tester to measure the radioactivity of a small amount of wear components by radiating neutrons to a person's extracted teeth, thereby improving the polishing performance.
  • ADA American Dental Association
  • the dentin polishing value (RDA value) is 100 when calcium pyrophosphate is used as the standard substance.
  • RDA the upper limit of RDA value by RDA method is 250 or less.
  • an appropriate RDA value was set to 80-130 in consideration of further safety and sufficient cleaning power.
  • the sensory test by 10 expert panelists was performed by absolute evaluation based on the following evaluation criteria, and the average score of 10 people was evaluated for the foreign body sensation during dentifrice behavior.
  • the polishing power is in the range of 80 to 130, the evaluation of the feeling of foreign matter is “ ⁇ ”, and in the evaluation of the feeling of use (toothpaste dispersibility 'brushing feeling) If the rating is “ ⁇ ”
  • ⁇ Within the range of polishing power of 80 to 130, the evaluation of the feeling of foreign matter is “ ⁇ ”, and in the evaluation of the feeling of use (toothpaste dispersibility 'brushing feeling) When the rating is “ ⁇ ” or “ ⁇ ” and “ ⁇ ”
  • Polishing power is in the range of 80 to 130, and feeling of use (toothpaste dispersibility ⁇ brushing feeling ⁇ foreign matter feeling
  • the toothpaste immediately after manufacture filled in a tube laminated with aluminum foil, a plastic multi-layer tube, a pump dispenser, a bottle container, etc. is made with straw half paper (Oji Extruded about 15 cm above the paper (manufactured by Shinko Co., Ltd.), and after 1 minute, a method of confirming the liquid oozing from the back of the straw half paper was used.
  • the granules used in each example are as follows.
  • a production method a method of pulverizing water-insoluble inorganic coagulum
  • a production method a production method (ii) a method of adding water to a water-insoluble inorganic powder to form a slurry, and applying pressure to granulate and dry
  • a production method iii
  • Other methods shall be used.
  • Granule A Caustic anhydride granule (INEOS BFG-10 production method (i))
  • Granule B Caustic anhydride granule (INEOS BFG-10 production method (i))
  • Granule D Keic anhydride granule (Rhodia Micropearl production method (iii))
  • Granule ⁇ Zeolite granule (COSITE COLITE-G production method (iii))
  • Granule F Caustic anhydride granule (INEOS BFG-10 production method (i))
  • Granule G Caustic anhydride granules (INEOS BFG-50 production method (i))
  • Granule H Caustic anhydride granule (INEOS BFG-50 production method (i))
  • the average particle size and 90% particle size should be MICROTRACK particle size distribution analyzer (Model 7995-10, Type SRA, manufactured by Nikkiso Co., Ltd.) !, and the sample strength (dV value) force ⁇ ). 5 Measured after adjusting to (rounded down).
  • Comparative Example 1 By adding the granules to Comparative Example 1, an attempt was made to improve the feeling of use, but it was not possible to obtain a satisfactory feeling of use with any of the granules. Among them, compared with Comparative Example 1, Comparative Examples 4 to 6 showed good results with a feeling of brushing out of the feeling of use. In Comparative Example 7, the disintegration strength was too weak, so that sufficient toothpaste dispersibility and a feeling of brushing were not obtained. In Comparative Example 8, since the breaking strength was too strong, there was a tendency for the polishing force to increase, and the feeling of use was too strong in the feeling of use, and a foreign object feeling was felt, making it unsuitable for comprehensive evaluation. .
  • Comparative Example 9 since the average particle diameter was too small, sufficient toothpaste dispersibility and a feeling of brushing were not obtained, which was inappropriate in the overall evaluation.
  • Comparative Example 10 since the average particle size was too large, the sense of use was too strong in the feeling of use, and a foreign object sensation was felt, which was inappropriate in the overall evaluation.
  • Comparative Example 11 the sense of use was too strong and a foreign object was felt, making it unsuitable for comprehensive evaluation.
  • the water-soluble polymer substances shown in Table 2 were uniformly dissolved in a 3% aqueous solution of propylene glycol under appropriate conditions in each water-soluble polymer substance to prepare a 1% solution. evaluated. Water-soluble polymer substances that were viscous solutions were classified as viscous polymer substances, and gelled water-soluble polymer substances were classified as gelling polymer substances. As the grouping, from the result of Experimental Example 3 described later, the viscous polymer substance and xanthan gum were classified as group (a), and the gelling polymer substance excluding xanthan gum was classified as group (b).
  • water-soluble polymer substance As the water-soluble polymer substance, the following commercially available ones were used.
  • Cross-linked sodium polyacrylate Rheological 250H viscosity (0.5% '25 ° C'BH type ⁇ ⁇ . 5-20rpm) 8220mPa-s made by Nippon Pure Chemical Co., Ltd.
  • Gelatin Nintendo gelatin Jelly strength (JIS K-6503) 235g
  • a dentifrice containing the ingredients shown in Tables 3 and 4 was prepared, and the effect of blending water-soluble polymer substances alone and in combination was determined from polishing power and feeling of use (toothpaste dispersibility, brushing feeling, foreign body feeling). evaluated. The results are shown in Tables 3 and 4.
  • the evaluation method was in accordance with Experimental Example 1.
  • Comparative Example 4 Depending on the use of the same viscous polymer as in Comparative Example 4 (Comparative Examples 12-14), the feeling of use (dentist dispersibility) cannot be improved. The overall evaluation was stronger than Comparative Example 4.
  • xanthan gum which is a gelling polymer material, had a tendency similar to that of a viscous polymer material with a water separation phenomenon.
  • xanthan gum When xanthan gum is used as a gelling polymer substance and combined with a viscous polymer substance (Comparative Examples 19, 21, and 22), the feeling of use (dentist dispersibility) is not improved, and the overall evaluation is The force was not able to exceed Comparative Example 4. Based on the results of single use and combination use, xanthan gum was classified into group (a) for viscous polymer substances and xanthan gum and group (b) for gelling polymer substances excluding xanthan gum.
  • a dentifrice composition containing the components shown in Tables 5 and 6 was prepared, and the mass ratio of the water-soluble high-molecular substances in the groups (a) and (b) [the water-soluble polymer substance in the (b) group] The amount (%) / (a) group of water-soluble polymer substance blending amount (%)] was evaluated from polishing power and feeling of use (dentist dispersibility, brushing feeling, foreign body feeling).
  • the evaluation method was in accordance with Experimental Example 1.
  • the water-soluble polymer substances shown in Table 7 are classified into viscous polymer substances and gelling polymer substances in the same manner as in Experimental Example 2, and the viscous polymer substances are classified into group (a).
  • the gelling polymer material was classified as (b) group.
  • water-soluble polymer substance As the water-soluble polymer substance, the following commercially available ones were used (the same applies hereinafter).
  • Methylcellulose Metrows SM viscosity (2% '20 ° C'BH type ⁇ ⁇ .2-20rpm) 2400m Pa-s Shin-Etsu Chemical Co., Ltd.
  • Hydroxyethyl cellulose HEC Daicel viscosity (1% '25 ° C'BH type ⁇ .3-30rp m) 2790mPa's, methoxykyl group 29.0% Made by Daicel Chemical Industries
  • Linear sodium polyacrylate Alonbis S viscosity (2% '25 ° C'BH type ⁇ ⁇ .2-20rp m) 973mPa-s made by Nippon Pure Chemical Co., Ltd.
  • Jelang gum G—100 Jelly strength (JIS K—6503) 635 g Kibun Food Chemifa Agar: Inagel Jelly strength CFISK— 6503) 603 g Ina Foods
  • a dentifrice composition having the composition shown in Table 9 was prepared and evaluated in the same manner as in the above experimental example. As a result, it was confirmed that both had excellent polishing power and feeling of use.
  • Granule I Caustic anhydride granule (BFG-10 production method (i) manufactured by INEOS)
  • Condylar fistula anhydrous silicate granules (manufactured by INEOS BFG-50 (i))
  • Toothbrush dispersibility ® ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ®
  • Feeling of use Printing feeling ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇
  • Foreign object feeling ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇

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Abstract

Composition de dentifrice comprenant (A) du carbonate de calcium lourd ayant un diamètre moyen de particule compris entre 5 et 15 µm, (B) des granules inorganiques non-solubles dans l'eau ayant un effort d'écrasement compris entre 10 et 200 g/granule, un diamètre moyen de particule compris entre 50 et 150 µm, et une différence d'au plus 100 µm entre 90% du diamètre de particule et le diamètre moyen de particule, et (C) un matériau polymérique soluble dans l'eau comprenant au moins un membre issu du Groupe (a) et au moins un membre issu du Groupe (b) et dont le rapport de masse (b)/(a) est compris entre 0,25 et 3, Groupe (a) : alginate de sodium, carboxyméthylcellulose de sodium, méthylcellulose, hydroxyéthylcellulose, Xanthomonas campestris, λ-carraghénine, et du polyacrylate de sodium à chaîne droite, et Groupe (b) : gomme gellane, gélose, κ-carraghénine, ι-carraghénine, gélatine, pectine, et du polyacrylate de sodium à chaîne croisée, et ayant une teneur totale de (a) et de (b) comprise entre 0,5 et 1,5 % par masse basée sur l'ensemble de la composition.
PCT/JP2005/012075 2004-07-06 2005-06-30 Composition de dentifrice Ceased WO2006003989A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007291021A (ja) * 2006-04-26 2007-11-08 Kao Corp 口腔用組成物
JP2011121916A (ja) * 2009-12-11 2011-06-23 Kao Corp 歯磨剤組成物
JP2012116772A (ja) * 2010-11-30 2012-06-21 Lion Corp 歯磨剤組成物
WO2012090571A1 (fr) * 2010-12-27 2012-07-05 ライオン株式会社 Composition de dentifrice
JP2012149035A (ja) * 2010-12-27 2012-08-09 Lion Corp 歯磨剤組成物
JP2013181012A (ja) * 2012-03-02 2013-09-12 Kao Corp 歯磨剤
JP2014105191A (ja) * 2012-11-28 2014-06-09 Lion Corp 不透明歯磨剤組成物
JP2014129305A (ja) * 2012-12-28 2014-07-10 Kao Corp 歯磨組成物
JP2015010044A (ja) * 2013-06-27 2015-01-19 花王株式会社 歯磨剤
CN108567582A (zh) * 2017-03-09 2018-09-25 狮王株式会社 洁齿剂组合物
JP2018203631A (ja) * 2017-05-30 2018-12-27 花王株式会社 歯磨剤組成物
WO2022145160A1 (fr) * 2020-12-28 2022-07-07 ライオン株式会社 Composition pour cavité buccale
JP7516439B2 (ja) 2022-02-21 2024-07-16 花王株式会社 練歯磨組成物

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SG10201805232UA (en) 2013-06-18 2018-08-30 Lg Household & Health Care Ltd Oral composition
JP7126811B2 (ja) * 2017-07-25 2022-08-29 株式会社ジーシー 歯面清掃用組成物
US11638684B2 (en) 2017-10-30 2023-05-02 Lg Household & Health Care Ltd. Pump-type toothpaste composition
KR101998594B1 (ko) * 2019-01-28 2019-07-10 주식회사 엘지생활건강 펌핑형 용기에 사용하기 위한 치약 조성물
KR102389707B1 (ko) * 2019-03-28 2022-04-22 주식회사 엘지생활건강 풀림성이 개선된 치약 조성물
WO2020197342A1 (fr) 2019-03-28 2020-10-01 주식회사 엘지생활건강 Composition de dentifrice
KR102044938B1 (ko) * 2019-05-07 2019-11-14 주식회사 엘지생활건강 펌핑형 용기에 사용하기 위한 치약 조성물
CN110180661B (zh) * 2019-05-17 2023-07-25 江苏群鑫粉体科技股份有限公司 一种制备丁腈手套使用的无机填料的制备方法
CN115645291B (zh) * 2022-09-29 2024-03-19 广东省九科生物科技有限公司 一种沸石牙膏
CN115778846A (zh) * 2022-12-16 2023-03-14 广州立白企业集团有限公司 一种电动牙刷用牙膏

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5862108A (ja) * 1981-10-09 1983-04-13 Lion Corp 口腔用組成物
JPH10316547A (ja) * 1997-05-20 1998-12-02 Kao Corp 歯磨剤組成物
JPH1135438A (ja) * 1997-07-17 1999-02-09 Lion Corp 口腔用組成物
JP2003128528A (ja) * 2001-10-24 2003-05-08 Lion Corp 口腔用組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4131732B2 (ja) * 1997-04-24 2008-08-13 サンスター株式会社 口腔用組成物
JP3484425B2 (ja) * 2001-03-14 2004-01-06 花王株式会社 歯磨剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5862108A (ja) * 1981-10-09 1983-04-13 Lion Corp 口腔用組成物
JPH10316547A (ja) * 1997-05-20 1998-12-02 Kao Corp 歯磨剤組成物
JPH1135438A (ja) * 1997-07-17 1999-02-09 Lion Corp 口腔用組成物
JP2003128528A (ja) * 2001-10-24 2003-05-08 Lion Corp 口腔用組成物

Cited By (18)

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Publication number Priority date Publication date Assignee Title
JP2007291021A (ja) * 2006-04-26 2007-11-08 Kao Corp 口腔用組成物
JP2011121916A (ja) * 2009-12-11 2011-06-23 Kao Corp 歯磨剤組成物
JP2012116772A (ja) * 2010-11-30 2012-06-21 Lion Corp 歯磨剤組成物
JP5907075B2 (ja) * 2010-12-27 2016-04-20 ライオン株式会社 歯磨剤組成物
WO2012090571A1 (fr) * 2010-12-27 2012-07-05 ライオン株式会社 Composition de dentifrice
JP2012149035A (ja) * 2010-12-27 2012-08-09 Lion Corp 歯磨剤組成物
JP2013181012A (ja) * 2012-03-02 2013-09-12 Kao Corp 歯磨剤
JP2014105191A (ja) * 2012-11-28 2014-06-09 Lion Corp 不透明歯磨剤組成物
JP2014129305A (ja) * 2012-12-28 2014-07-10 Kao Corp 歯磨組成物
JP2015010044A (ja) * 2013-06-27 2015-01-19 花王株式会社 歯磨剤
CN108567582A (zh) * 2017-03-09 2018-09-25 狮王株式会社 洁齿剂组合物
CN108567582B (zh) * 2017-03-09 2023-04-07 狮王株式会社 洁齿剂组合物
JP2018203631A (ja) * 2017-05-30 2018-12-27 花王株式会社 歯磨剤組成物
WO2022145160A1 (fr) * 2020-12-28 2022-07-07 ライオン株式会社 Composition pour cavité buccale
JP2022104291A (ja) * 2020-12-28 2022-07-08 ライオン株式会社 口腔用組成物
CN116710053A (zh) * 2020-12-28 2023-09-05 狮王株式会社 口腔用组合物
JP7523346B2 (ja) 2020-12-28 2024-07-26 ライオン株式会社 口腔用組成物
JP7516439B2 (ja) 2022-02-21 2024-07-16 花王株式会社 練歯磨組成物

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CN1988876B (zh) 2010-11-24
KR101169939B1 (ko) 2012-08-06
JP4702561B2 (ja) 2011-06-15
JPWO2006003989A1 (ja) 2008-04-17
CN1988876A (zh) 2007-06-27

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