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WO2006068011A1 - Composition de blanchiment des dents et ensemble de blanchiment des dents - Google Patents

Composition de blanchiment des dents et ensemble de blanchiment des dents Download PDF

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Publication number
WO2006068011A1
WO2006068011A1 PCT/JP2005/022918 JP2005022918W WO2006068011A1 WO 2006068011 A1 WO2006068011 A1 WO 2006068011A1 JP 2005022918 W JP2005022918 W JP 2005022918W WO 2006068011 A1 WO2006068011 A1 WO 2006068011A1
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WO
WIPO (PCT)
Prior art keywords
tooth
composition
teeth
tooth whitening
sodium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2005/022918
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English (en)
Japanese (ja)
Inventor
Shimako Inoue
Akira Uchiyama
Ikuko Toki
Noriko Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lion Corp
Original Assignee
Lion Corp
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Filing date
Publication date
Application filed by Lion Corp filed Critical Lion Corp
Priority to JP2006548869A priority Critical patent/JP4873155B2/ja
Publication of WO2006068011A1 publication Critical patent/WO2006068011A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/28—Zirconium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54—Polymers characterized by specific structures/properties
    • A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
    • A61K2800/5426—Polymers characterized by specific structures/properties characterized by the charge cationic

Definitions

  • the present invention relates to a tooth whitening composition and a tooth whitening set for making teeth whiter than the original color. More specifically, the present invention relates to a tooth whitening composition and a powder such as titanium dioxide applied or applied to a tooth. The present invention relates to a tooth whitening composition and a tooth whitening set which are fixed on the surface of a tooth for a certain period of time and make the teeth white by irregular reflection and exhibit a high whitening effect for a long time.
  • techniques for whitening teeth include (1) technology that removes coloring substances attached to the teeth and restores the whiteness of the original teeth, and (2) whitening the teeth even more than the original color.
  • technologies a physical removal method using a dentifrice or toothbrush and brushing with a polishing component contained in the dentifrice, a solubilizer such as polyethylene glycol or polyvinylpyrrolidone, an enzyme or a chelating agent Chemical methods such as decomposing colored materials are used, etc.
  • the method (2) is representative of bleaching using peroxides frequently used in Europe and the United States, and dental curing agents. Applying concealing agents or dental materials such as laminating wear have been used.
  • Such whitening techniques include shellac, vinyl acetate resin and acrylic resin coatings.
  • coating agents such as nail polish utilizing the forming ability (Japanese Patent Laid-Open No. 04-82821, Japanese Patent Laid-Open No. 05-58844, Japanese Patent Laid-Open No. 09-100215, Japanese Patent Laid-Open No. 09-20 2718, JP-A-09-151123), there was a problem with the rough feeling of use of the coating agent coated on the teeth.
  • the particle size of titanium oxide used in combination with a coating agent is preferably lOOnm or less (Japanese Patent Laid-Open No. 09-151123)
  • a titanium oxide tooth without a coating agent is disclosed. The adsorptive properties to water were not always sufficient.
  • the specific surface area of titanium oxide which is conventionally used as a pigment in dentifrices and the like, is 10 to
  • Japanese Patent Application Laid-Open No. 2003-183142 discloses a method for enhancing the adsorptivity to enamel by applying an activation treatment that increases the number of surface hydroxyl groups of a metal oxide, and a method for making the teeth whiter.
  • a composition is disclosed.
  • operability and safety because it is necessary to treat the metal oxide under high strength conditions as pretreatment.
  • an object of the present invention is a tooth whitening composition for making teeth whiter than the original color, and is applied or applied to the teeth, and a powder such as titanium dioxide is applied to the teeth for a certain period of time. Fixing to the surface, making the teeth white by diffuse reflection, and maintaining the powder on the tooth surface stably for a long time, greatly reducing color unevenness and peeling, and continuously exerting a high whitening effect It is to provide a tooth whitening composition and a tooth whitening set.
  • a whitening powder selected from titanium dioxide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide, and dinoleconium oxide, a gel
  • pullulan as a chemical agent
  • a cationic polymer selected from lysozyme, cationic cellulose, and polylysine
  • the present invention provides:
  • a tooth whitening composition characterized by containing one or more selected from lysozyme, cationized cellulose, and polylysine.
  • the present invention provides a tooth whitening set comprising an application tool that is detachably attached to a tooth while holding the above-mentioned tooth whitening composition.
  • the applicable tool includes a tape, a sheet, a Finolem, a mouth tray, a mouthpiece, a sponge, an imprint material, a pack material, or a tooth cover molded into a dentition.
  • the metal oxide powder having excellent adsorptivity to teeth can diffusely reflect light on the tooth surface and appear whiter than the original color. It is possible to stably hold the powder on the tooth surface and continuously exert a high whitening effect.
  • Component (A) used in the tooth whitening composition of the present invention is a metal oxide selected from titanium dioxide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide, and dinoleconium oxide, preferably dioxide dioxide. These are titanium, zinc oxide, aluminum oxide and zirconium oxide. One or more of these may be used, and a composite of these metal oxides may be used.
  • the metal oxide used in the present invention is not particularly limited in the presence or absence of surface treatment, but is preferably coated with silicon dioxide, alumina, or zirconium oxide for the purpose of suppressing the catalytic activity of the metal oxide. Used for.
  • the amount of the component (A) metal oxide used in the present invention is not particularly limited as long as a sufficient amount can be released from the tooth whitening composition to the tooth surface. 0.:! To 50% by mass, more preferably 0.5 to 20% by mass. When the blending amount is less than 0.1% by mass, a sufficient whitening effect cannot be obtained and exceeds 50% by mass. In some cases, depending on the application form to the tooth, the composition may be poorly usable.
  • the average particle diameter of the metal oxide used as the component (A) of the present invention is preferably 0.005 to 5 / im. Particularly preferred is 0.01-: l x m. If the average particle size is less than 0.005 zm, light cannot be sufficiently scattered, and the whitening effect may not be obtained. If the average particle size exceeds 5 x m, the whitening effect may not be sustained due to insufficient fixation to the teeth.
  • the average particle size is a value measured by a 50% particle size using a Microtrac particle size analyzer (Nikkiso Co., Ltd.).
  • the pullulan of component (B) used in the present invention is a high molecule in which maltotriose has 1-6 bonds, and has a weight average molecular weight of about 4 to 800,000. Of these, 100,000 to 500,000 are particularly preferred.
  • the weight average molecular weight of pullulan can be determined by gel permeation chromatography (GPC) using polyethylene oxide of known molecular weight as a standard substance and dimethylformamide with LiBr added as a solvent.
  • Punoreran is a polyacrylic acid or salt thereof, carboxyvinyl polymer, vinyl acetate, vinylpyrrolidone copolymer, cellulose derivatives such as sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, It can be used in combination with other water-soluble polymers such as xanthan gum, carrageenan, and alginate.
  • the blending amount of pullulan in the composition is preferably in the range of 0.:! To 20% by mass, particularly in the range of 0.3 to 15% by mass of the whole composition.
  • the weight average molecular weight of pullulan it is preferable to select the blending amount according to the molecular weight of pullulan, particularly 0.1 to 5% by weight is preferable when the weight average molecular weight is about 790,000, and more preferably 0.3 to 3% by weight. It is. In the case of a weight average molecular weight of about 400,000, 0 :! to 7% by mass is preferable, and more preferably 0.5 to 5% by mass. When the weight average molecular weight is about 200,000, 0.3 to 15% by mass is preferable, and more preferably 0.5 to 10% by mass. When the weight average molecular weight is about 47,000, 0.5 to 20% by mass is preferable, and 1 to 15% by mass is more preferable.
  • the preferred compounding amount for each weight average molecular weight is less than that, it is a metal oxide that reduces the adsorptivity and sustainability of the composition to the teeth even when combined with other water-soluble polymers. May not adhere to teeth for a long time.
  • the preferred blending amount in each weight average molecular weight In some cases, the viscosity of the product becomes high, and a sufficient amount of metal oxide cannot be adsorbed on the teeth.
  • the component (C) used in the present invention is one or more selected from lysozyme, cationized cellulose, and polylysine.
  • the lysozyme is preferably lysozyme chloride.
  • the amount of lysozyme is 0.1 to 10% by mass of the whole composition, and 0.5 to 5% by mass is more preferable.
  • the amount of lysozyme is less than 0.1% by mass, a metal oxide having a low adsorptivity and sustainability to the teeth may not be stably adsorbed on the teeth for a long time. If it exceeds 10% by mass, the bitterness unique to lysozyme becomes strong and the taste of the composition may deteriorate.
  • Cationized cellulose is composed of hydroxydimethylallyl ammonium chloride and
  • ⁇ 2-Hydroxy-1- (trimethylammonio) ⁇ propyl hydroxyethyl cellulose is preferably used.
  • a weight average molecular weight of about 300,000 to about 2 million is preferably used. If the weight average molecular weight is less than 300,000, the whitening effect may not be sustained due to insufficient fixation to the tooth, and if the weight average molecular weight is more than 2 million, the viscosity of the preparation increases and the operability is improved. It may be damaged.
  • the substitution degree of the cationic group is preferably 0.5 to 3% by mass as the nitrogen content.
  • the weight average molecular weight is a value determined by a gel permeation chromatograph (GPC) method using polyethylene glycol as a standard substance.
  • the nitrogen content is the value obtained by CHN organic element analysis.
  • Strength The blending amount of thiolated cellulose is preferably from 0.:! To 5% by mass of the whole composition, and more preferably from 0.5 to 3% by mass.
  • the compounding power of the cationized cellulose is less than 0.1% by mass, a metal oxide having a low adsorptivity and persistence to the tooth of the composition may not be stably adsorbed on the tooth for a long time.
  • the content exceeds 5% by mass, the viscosity of the composition becomes so high that a sufficient amount of metal oxide may not be adsorbed on the teeth.
  • polylysine polylysine alone, polylysine hydrochloride, polylysine hydride mouth bromide and the like can be used.
  • Polylysine having a number average molecular weight of 1,000 to 1,000,000 can be used, and 3,000 to 300,000 is particularly preferred. If the number average molecular weight is less than 100 0, the whitening effect may not be sustained due to insufficient fixation to the teeth. When the number average molecular weight force is greater than sioo million, the viscosity of the preparation increases, and the operability may be impaired.
  • the method for measuring the number average molecular weight is not particularly limited. For example, the number average molecular weight should be determined under the following conditions by the low-angle light scattering method (GPC-LALLS method) of gel permeation chromatography using polystyrene as a standard substance. Can do.
  • the blending amount of polylysine is preferably 0.01 to 20% by mass of the total composition, and more preferably 0.5 to 10% by mass.
  • the blending amount of polylysine is less than 0.01% by mass, a metal oxide having a low adsorptivity and persistence to the tooth may not be stably adsorbed on the tooth for a long time.
  • it exceeds 20% by mass the viscosity of the composition becomes high, and a sufficient amount of metal oxide may not be adsorbed on the teeth.
  • the tooth whitening composition of the present invention can further be applied to a tooth for a long time, and a gelling agent that prevents dissolution of the tooth whitening composition over the entire oral cavity according to its form. Can be blended.
  • the gelling agent used in the present invention is not particularly limited, but is polyacrylic acid or a salt thereof, a carboxyvinyl polymer, a vinyl acetate vinylpyrrolidone copolymer, carboxymethyl resorenolose sodium, hydroxye Cellulose derivatives such as chinorecenolose and hydroxypropenorescenellose, polyvinyl pyrrolidone, polybial alcohol, xanthan gum, carrageenan, and alginates are preferably used, and one or more selected from these are blended. obtain.
  • the blending amount of the gelling agent is preferably 0.1 to 10% by mass of the entire composition, and particularly preferably
  • the gelling agent may not be sufficiently dissolved, and the preparation may become non-uniform and may inhibit the preparation from adsorbing on the tooth surface.
  • the blending amount is less than 0.1% by mass, a feeling of strangeness such as stickiness in the mouth due to the dissolution of the gel may occur.
  • the tooth whitening composition of the present invention may further contain other components as necessary. You can.
  • anionic surfactants for the purpose of emulsification and dispersion, one or more of anionic surfactants, nonionic surfactants and zwitterionic surfactants can be used in combination.
  • anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate, sodium myristyl sulfate and sodium cetyl sulfate, sodium N-acyl glutamate such as sodium N-lauroyl glutamate and sodium N-palmitoyl glutamate.
  • Nonionic surfactants include glycerin fatty acid esters such as monoglyceryl stearate and decaglyceryl laurate, sucrose fatty acid esters, maltose fatty acid esters, sugar fatty acid esters such as malatose fatty acid esters, maltitol fatty acid esters , Sugar alcohol fatty acid esters such as ratathitol fatty acid esters, polyoxyethylene polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, fatty acid ethanolamides such as myristic mono- or diethanolamide, sorbitan fatty acid esters , Polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid Ester, or the like is used.
  • glycerin fatty acid esters such as monoglyceryl stearate and decaglyceryl laurate
  • Zwitterionic surfactants include alkyl dimethylamino acetate betaines such as lauryl dimethylamino acetate betaine, ⁇ -lauryl diaminoethyl glycine, ⁇ ⁇ ⁇ ⁇ -alkyldiaminoethyl glycine such as ⁇ -myristyl diaminoethyl glycine, ⁇ - Alkinole ⁇ — Carboxymethylammonium betaine, 2-alkyl 1-hydroxyethylimidazoline sodium betaine, etc. are used.
  • alkyl dimethylamino acetate betaines such as lauryl dimethylamino acetate betaine, ⁇ -lauryl diaminoethyl glycine, ⁇ ⁇ ⁇ -alkyldiaminoethyl glycine such as ⁇ -myristyl diaminoethyl glycine, ⁇ - Alkinole
  • enzymes such as dextranase, mutanase, amylase, protease, superoxide dismutase, water-soluble polyphosphate such as potassium pyrophosphate, sodium tripolyphosphate, sodium metaphosphate Salt, allantoin, dihydrocholestanol, glycyrrhizic acid, glycyrrhetinic acid, ⁇ -aminocaproic acid, tranexamic acid, bisabolol, isopropylmethylphenol, sodium chloride, trisan san, chlorhexidine salts, cetylpyridinium chloride, benzethonium chloride 1 or 2 or more of active ingredients such as herbal extracts such as benzalkcoumum chloride, ascorbic acid and its salts, tocopherol, ogon, obata, rosemary, chiioji, thyme, etc.
  • water-soluble polyphosphate such as potassium pyrophosphate, sodium tripolyphosphat
  • the composition for tooth whitening of the present invention further includes a fragrance such as vanitol, carvone, peppermint oil, and spearmint oil, a preservative such as benzoic acid and its sodium salt, parabens, red No. 3, red 104. No. 4, Yellow No. 4, Blue No. 1, Green No. 3, pigments or colorants such as titanium mica, petal, sweeteners such as saccharin and its sodium salt, stepioside, glycyrrhizin, aspartame and the like.
  • a fragrance such as vanitol, carvone, peppermint oil, and spearmint oil
  • a preservative such as benzoic acid and its sodium salt
  • parabens red No. 3, red 104. No. 4
  • Yellow No. 4 Blue No. 1, Green No. 3, pigments or colorants
  • titanium mica such as titanium mica, petal
  • sweeteners such as saccharin and its sodium salt
  • stepioside such as glycyrrhizin,
  • ⁇ of the tooth whitening composition is not particularly limited as long as it is within the range of safety in the oral cavity and the human body, but preferably the tooth whitening composition is diluted 10 times with purified water. ⁇ is 4 to 10 and more preferably ⁇ is 5.5 to 9. If it is less than ⁇ 4, there is a concern about decalcification depending on the application time. If it exceeds ⁇ , there is a concern about mucosal detachment when touching the gingiva.
  • acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citrate, phosphoric acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium tamate, sodium hydrogen citrate, sodium phosphate, phosphoric acid Sodium hydrogen or the like can be combined.
  • the tooth whitening composition is prepared in a paste form, a gel form, a liquid form, or the like, and depending on the form, it should be applied together with an application tool dedicated to holding and fixing to a tooth.
  • the application tool for holding and fixing to the tooth used in combination with the tooth whitening composition of the present invention assists the reliable application and fixation of the tooth whitening composition to the tooth. Inhibiting elution of the tooth whitening composition in use on the gums, tongue and oral mucosa, preventing unpleasant use and preventing the induction of saliva, as well as intrusion, occlusion, chewing and other physical stimuli It is used for the purpose of preventing the dilution of the tooth whitening composition and the separation of the tooth force.
  • the material and shape of the tool are not particularly limited as long as the above object can be achieved, but tape, sheet, Finolem, mouth tray, mouthpiece, sponge, impression material made of water-insoluble raw material.
  • a tooth cover molded into a pack material or a dentition is preferably used.
  • the thickness of the above-mentioned application tool is preferably 0.01 to 5 mm, which does not give a sense of incongruity when worn on the oral cavity, and is particularly preferably 0.01 to 2 mm for tapes, sheets and films.
  • polyethylene, foamed polyethylene, polypropylene, foamed polypropylene, polyester, polyurethane which have excellent fit when applied to the oral cavity and enable the formulation to be applied for a long time by suppressing the generation of saliva. It is preferable to use one or more of rayon, pulp, cotton, silk, paper, polysaccharide film, metal foil, etc.
  • the poorly water-soluble Punoreran film is a film of Punoreran and is not included in the pullulan component (B).
  • the saliva produced in the mouth is made by forming the material on the side that contacts the oral mucosa and the tongue with a hydrophilic or highly absorbent material such as woven or non-woven fabric using rayon, pulp, cotton, silk, paper, etc. It is preferable because it absorbs and retains water and has excellent usability.
  • a water-impermeable film such as polyethylene, polypropylene, polyester, polyurethane, etc. on the side holding the tooth whitening composition, it is possible to prevent the tooth whitening composition from adsorbing and penetrating into the application tool. You can also.
  • trays or mouthpieces made of thermoplastic resins such as silicone rubber and natural rubber and thermoplastic resins such as butyl acetate resin, acrylic resin, and ethylene-butyl acetate copolymer have a high degree of freedom of deformation. It is easy to fit in the user's dentition and tooth type, and therefore has excellent adhesion and fixability, and is suitable for the purpose of applying a tooth whitening composition to a tooth for a longer time.
  • the number of times of application, time, etc. are appropriately selected, but usually 1 to 6 times a day, especially:! To 3 times, once:! To 10 minutes, especially:! To 3 minutes. .
  • the pressure was reduced to 4 kPa and mixed until the composition became uniform to prepare a tooth whitening composition.
  • the pH was measured with a pH meter (HM-26S, manufactured by Toa DKKEI Co., Ltd.) after 1 minute at 25 ° C when diluted 10 times with purified water, and adjusted to pH 5.5 to 9.0. As needed, it adjusted using sodium hydroxide or hydrochloric acid.
  • Heated polyethylene film low density polyethylene, thickness 10 zm, manufactured by Tosoh Corporation, product grade; 212
  • a three-layer nonwoven fabric sheet having a thickness of 0.5 mm was prepared by fusing.
  • a sheet coated with the composition shown in Table 1 by the above method is placed on the extracted human tooth whose color difference L * a * b * has been measured in advance, and left in a thermostat at 37 ° C for 3 minutes. Thereafter, the sheet was peeled off, the gel was gently wiped with a tissue, washed with water, and then transferred into artificial saliva. After immersion in artificial saliva for 3 hours, the color difference L * a * b * was measured to determine ⁇ . The color difference was measured with a spectrocolorimeter (Minolta Co., Ltd., CM_2022).
  • the composition of artificial saliva is as follows.
  • ⁇ * (2) ((L * 2-L * 0) 2 + (a * 2- -a O) + (b 2 ⁇ b 0))
  • L * 0, a * 0, b * 0 represent the initial L * a * b * values, and similarly L * l, a * l, b * l, L * 2, a * 2, b * 2 Are the L * aV value after whitening and the L * aV value after immersion in artificial saliva, respectively.
  • Whitening effect ⁇ : ⁇ * (1) is 7.0 or more
  • ⁇ : ⁇ * (1) is more than 5.0 and less than 7.0
  • ⁇ : ⁇ * (1) is 3.0 or more and less than 5.0
  • ⁇ * (2) is 6.0 or more ⁇ : ⁇ (2) is 4.0 or more and less than 6.0
  • ⁇ : ⁇ * (2) is 3.0 or more and less than 4.0
  • Foamed polyethylene sheet (Sekisui Chemical Co., Ltd. Borara XL_IF08008, 15 mm X 60 mm X) that covers the lips of the front teeth left 3 to right 3 with 2.g of tooth whitening composition 1.
  • a thickness of 800 zm was applied to the labial surface of the tooth.
  • Titanium dioxide 3.0% (Ishihara Sangyo Co., Ltd. Typeter CR-50, average particle size 0 ⁇ 25 ⁇ )
  • Pullulan (Hayashibara Corporation, PF-2, weight average molecular weight 200,000)
  • Polylysine (Chisso Corporation, polylysine powder, number average molecular weight 4400)
  • Titanium dioxide 4.0%
  • a polyethylene film (Toray Co., Ltd., soft PE, 10 mm x 15 mm x 25 ⁇ m thick) with one tooth each coated with 0.2 g of the following tooth whitening composition 3 in advance is colored. Affixed only to the teeth of interest.
  • the whitening effect was ⁇ , and the persistence of the whitening effect was ⁇ .
  • Zirconium oxide (Nippon Denko, N—PC, average particle size 0 ⁇ 02 / im) 0.5% Titanium dioxide 3.0
  • Example 14 Apply the following tooth whitening composition 4 with 1. Og brush to the left lip of the front teeth 3rd to 3rd right, and from the top polypropylene film (Toray Industries soft PP, 15mm X 60mm X thickness 100 zm) was affixed. When evaluated in the same manner as in the above Examples:! To 10 and Comparative Examples 1 to 4, the whitening effect was ⁇ , and the persistence of the whitening effect was ⁇ .
  • the mouthpiece made of ethylene butyl acetate resin was warmed and softened with hot water, and the mouthpiece fitted with each tooth shape was made by massaging.
  • the mouthpiece was filled with 1. Og of the following tooth whitening composition 5 and attached.
  • the whitening effect was ⁇ , and the persistence of the whitening effect was ⁇ .
  • Silicon dioxide 1.0% (Huber, trade name Zeodentl l 3, average particle size 5 ⁇ 0 / im)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition de blanchiment des dents caractérisée en ce qu’elle comprend : (A) un, deux ou plus éléments sélectionnés dans le groupe constitué par le dioxyde de titane, le dioxyde de silicium, l’oxyde de zinc, l’oxyde d’aluminium, l’oxyde de magnésium et l’oxyde de zirconium, (B) du pullulane et (C) un, deux ou plus éléments sélectionnés dans le groupe constitué par le lysozyme, la cellulose cationisée et la polylysine. Dans l’utilisation de cette composition, un oxyde métallique en poudre qui excelle en adsorption sur les dents produit une réflexion diffuse de la lumière à la surface des dents, ce qui fait paraître cette surface plus blanche que sa couleur inhérente. En particulier, un tel effet de blanchiment peut être exercé de façon continue en réalisant une rétention stable de la poudre sur la surface des dents pour une période prolongée.
PCT/JP2005/022918 2004-12-22 2005-12-14 Composition de blanchiment des dents et ensemble de blanchiment des dents Ceased WO2006068011A1 (fr)

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JP2006548869A JP4873155B2 (ja) 2004-12-22 2005-12-14 歯牙美白用組成物及び歯牙美白用セット

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JP2004-371093 2004-12-22
JP2004371093 2004-12-22

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008162936A (ja) * 2006-12-28 2008-07-17 Lion Corp 歯の化粧用加圧転写シール
KR100870232B1 (ko) 2006-12-07 2008-11-24 재단법인서울대학교산학협력재단 치아용 미백기능성 물질 전달시스템
JP2010523526A (ja) * 2007-04-05 2010-07-15 グラクソ グループ リミテッド 新規の使用
WO2010114638A1 (fr) 2009-03-30 2010-10-07 E. I. Du Pont De Nemours And Company Réactifs à base de peptides pour blanchissement des dents
JP2012116768A (ja) * 2010-11-29 2012-06-21 Kao Corp 液体口腔用組成物
US8475772B2 (en) 2003-09-08 2013-07-02 E I Du Pont De Nemours And Company Peptide-based oral care surface reagents for personal care
CN103421329A (zh) * 2013-08-21 2013-12-04 华南理工大学 一种抗菌可食用膜材料的制备方法
WO2017172955A1 (fr) 2016-03-29 2017-10-05 Safewhite, Inc. Colles dentaires polyélectrolytiques pour le blanchiment des dents et de composants dentaires
KR20220052899A (ko) 2019-08-27 2022-04-28 라이온 가부시키가이샤 구강용 조성물
CN116898741A (zh) * 2023-08-18 2023-10-20 广州品硬生物科技有限公司 一种含溶菌酶和益生菌的牙龈修复牙膏及其制备方法

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KR102012409B1 (ko) * 2013-11-20 2019-10-21 주식회사 엘지생활건강 고형 치아 미백용 도포제

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JPS63250318A (ja) * 1987-04-06 1988-10-18 Fujimoto Seiyaku Kk 口腔内に適用する製剤
JPH0217108A (ja) * 1988-07-05 1990-01-22 Sunstar Inc 歯科用コーティング組成物
JPH0482821A (ja) * 1990-07-23 1992-03-16 Jun Kawai 歯の美容剤
JPH0558844A (ja) * 1991-08-27 1993-03-09 Jun Kawai 歯科美容用組成物
EP0716845A2 (fr) * 1994-12-13 1996-06-19 Mitsubishi Pencil Kabushiki Kaisha Liquide pour le revêtement des dents
JPH09151123A (ja) * 1995-11-30 1997-06-10 Mitsubishi Pencil Co Ltd 歯の塗布液
JPH10298048A (ja) * 1997-04-30 1998-11-10 Lion Corp 歯周病細菌内毒素中和剤、歯周病原因菌付着抑制剤及び口腔用組成物
WO1999015131A1 (fr) * 1997-09-19 1999-04-01 Kao Corporation Composition s'appliquant sur les dents
JPH11130645A (ja) * 1997-10-29 1999-05-18 Lion Corp 歯周疾患治療用シート
JP2001316235A (ja) * 2000-05-02 2001-11-13 Lion Corp グルカナーゼ配合液体口腔用組成物
JP2003137756A (ja) * 2001-11-06 2003-05-14 Kenji Nakamura 歯の漂白用貼付材

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8475772B2 (en) 2003-09-08 2013-07-02 E I Du Pont De Nemours And Company Peptide-based oral care surface reagents for personal care
KR100870232B1 (ko) 2006-12-07 2008-11-24 재단법인서울대학교산학협력재단 치아용 미백기능성 물질 전달시스템
JP2008162936A (ja) * 2006-12-28 2008-07-17 Lion Corp 歯の化粧用加圧転写シール
JP2010523526A (ja) * 2007-04-05 2010-07-15 グラクソ グループ リミテッド 新規の使用
WO2010114638A1 (fr) 2009-03-30 2010-10-07 E. I. Du Pont De Nemours And Company Réactifs à base de peptides pour blanchissement des dents
US8354381B2 (en) 2009-03-30 2013-01-15 E I Du Pont De Nemours And Company Peptide compositions for oral care systems
US8481678B2 (en) 2009-03-30 2013-07-09 E I Du Pont De Nemours And Company Peptide-based tooth whitening reagents
JP2012116768A (ja) * 2010-11-29 2012-06-21 Kao Corp 液体口腔用組成物
CN103421329A (zh) * 2013-08-21 2013-12-04 华南理工大学 一种抗菌可食用膜材料的制备方法
WO2017172955A1 (fr) 2016-03-29 2017-10-05 Safewhite, Inc. Colles dentaires polyélectrolytiques pour le blanchiment des dents et de composants dentaires
EP3435961A4 (fr) * 2016-03-29 2019-04-10 SafeWhite, Inc. Colles dentaires polyélectrolytiques pour le blanchiment des dents et de composants dentaires
KR20220052899A (ko) 2019-08-27 2022-04-28 라이온 가부시키가이샤 구강용 조성물
CN116898741A (zh) * 2023-08-18 2023-10-20 广州品硬生物科技有限公司 一种含溶菌酶和益生菌的牙龈修复牙膏及其制备方法

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