WO2006068011A1 - Tooth whitening composition and tooth whitening set - Google Patents

Abstract

A tooth whitening composition characterized by containing: (A) one or two or more members selected from among titanium dioxide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide and zirconium oxide, (B) pullulan, and (C) one or two or more members selected from among lysozyme, cationized cellulose and polylysine. In the use of this composition, metal oxide powder excelling in adsorption onto the teeth performs diffuse reflection of light on the teeth surface to thereby cause the same to look whiter than the inherent color. In particular, such a high whitening effect can be persistently exerted by realizing stable retention of the powder on the teeth surface for a prolonged period of time.

Description

 Specification

 Tooth whitening composition and tooth whitening set

 Technical field

 [0001] The present invention relates to a tooth whitening composition and a tooth whitening set for making teeth whiter than the original color. More specifically, the present invention relates to a tooth whitening composition and a powder such as titanium dioxide applied or applied to a tooth. The present invention relates to a tooth whitening composition and a tooth whitening set which are fixed on the surface of a tooth for a certain period of time and make the teeth white by irregular reflection and exhibit a high whitening effect for a long time.

 Background art

 [0002] Conventionally, techniques for whitening teeth include (1) technology that removes coloring substances attached to the teeth and restores the whiteness of the original teeth, and (2) whitening the teeth even more than the original color. Broadly divided into technologies. As the method of (1), a physical removal method using a dentifrice or toothbrush and brushing with a polishing component contained in the dentifrice, a solubilizer such as polyethylene glycol or polyvinylpyrrolidone, an enzyme or a chelating agent Chemical methods such as decomposing colored materials are used, etc., and the method (2) is representative of bleaching using peroxides frequently used in Europe and the United States, and dental curing agents. Applying concealing agents or dental materials such as laminating wear have been used.

 [0003] In recent years, with the improvement of oral hygiene awareness and desire for aesthetics, the need for whitening teeth is shifting from “cleaning” in (1) to “whitening” in (2). However, bleaching with peroxide can cause gingival irritation and regression, and it is extremely dangerous for consumers without expertise to use it without permission. On the other hand, nail polish and other coating agents are not sustainable because they are peeled off by eating and drinking. In addition, the laminating belay method can only be performed by a dentist, and it is necessary to sharpen the surface of the teeth with a sufficient force. Even if the patient is not satisfied with the results, the original tooth after surgery I can't go back to it.

 In view of the above, in the field of “whitening”, it has been desired to develop a tooth whitening technique that has good aesthetics, is simple, and has high safety.

[0005] Such whitening techniques include shellac, vinyl acetate resin and acrylic resin coatings. There have been proposed coating agents such as nail polish utilizing the forming ability (Japanese Patent Laid-Open No. 04-82821, Japanese Patent Laid-Open No. 05-58844, Japanese Patent Laid-Open No. 09-100215, Japanese Patent Laid-Open No. 09-20 2718, JP-A-09-151123), there was a problem with the rough feeling of use of the coating agent coated on the teeth. Further, although it has been disclosed that the particle size of titanium oxide used in combination with a coating agent is preferably lOOnm or less (Japanese Patent Laid-Open No. 09-151123), a titanium oxide tooth without a coating agent is disclosed. The adsorptive properties to water were not always sufficient.

 [0006] The specific surface area of titanium oxide, which is conventionally used as a pigment in dentifrices and the like, is 10 to

Even if a metal oxide with a specific surface area in this range is 20m ² Zg and applied to a tooth without a support such as a coating agent, it exhibits a sufficient whitening effect with low adsorptivity to the tooth. I couldn't.

 [0007] On the other hand, Japanese Patent Application Laid-Open No. 2003-183142 discloses a method for enhancing the adsorptivity to enamel by applying an activation treatment that increases the number of surface hydroxyl groups of a metal oxide, and a method for making the teeth whiter. A composition is disclosed. However, there is a problem in operability and safety because it is necessary to treat the metal oxide under high strength conditions as pretreatment.

 Disclosure of the invention

 Problems to be solved by the invention

 [0008] Therefore, an object of the present invention is a tooth whitening composition for making teeth whiter than the original color, and is applied or applied to the teeth, and a powder such as titanium dioxide is applied to the teeth for a certain period of time. Fixing to the surface, making the teeth white by diffuse reflection, and maintaining the powder on the tooth surface stably for a long time, greatly reducing color unevenness and peeling, and continuously exerting a high whitening effect It is to provide a tooth whitening composition and a tooth whitening set.

 Means for solving the problem

[0009] As a result of intensive studies to solve the above problems, the present inventors have found that a whitening powder selected from titanium dioxide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide, and dinoleconium oxide, a gel By combining pullulan as a chemical agent with a cationic polymer selected from lysozyme, cationic cellulose, and polylysine, the whitening powder is stably fixed to the tooth surface for a long time, and color unevenness and peeling are greatly reduced. High whitening It has been found that the effect is sustained, and the present invention has been made.

 [0010] Therefore, the present invention provides:

 (A) one or more selected from titanium dioxide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide, dinoleconium oxide,

 (B) Pullulan,

 (C) A tooth whitening composition characterized by containing one or more selected from lysozyme, cationized cellulose, and polylysine.

 [0011] Further, the present invention provides a tooth whitening set comprising an application tool that is detachably attached to a tooth while holding the above-mentioned tooth whitening composition. In this case, the applicable tool includes a tape, a sheet, a Finolem, a mouth tray, a mouthpiece, a sponge, an imprint material, a pack material, or a tooth cover molded into a dentition.

 The invention's effect

 [0012] According to the present invention, the metal oxide powder having excellent adsorptivity to teeth can diffusely reflect light on the tooth surface and appear whiter than the original color. It is possible to stably hold the powder on the tooth surface and continuously exert a high whitening effect.

 BEST MODE FOR CARRYING OUT THE INVENTION

[0013] Component (A) used in the tooth whitening composition of the present invention is a metal oxide selected from titanium dioxide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide, and dinoleconium oxide, preferably dioxide dioxide. These are titanium, zinc oxide, aluminum oxide and zirconium oxide. One or more of these may be used, and a composite of these metal oxides may be used.

 [0014] The metal oxide used in the present invention is not particularly limited in the presence or absence of surface treatment, but is preferably coated with silicon dioxide, alumina, or zirconium oxide for the purpose of suppressing the catalytic activity of the metal oxide. Used for.

[0015] The amount of the component (A) metal oxide used in the present invention is not particularly limited as long as a sufficient amount can be released from the tooth whitening composition to the tooth surface. 0.:! To 50% by mass, more preferably 0.5 to 20% by mass. When the blending amount is less than 0.1% by mass, a sufficient whitening effect cannot be obtained and exceeds 50% by mass. In some cases, depending on the application form to the tooth, the composition may be poorly usable.

 [0016] The average particle diameter of the metal oxide used as the component (A) of the present invention is preferably 0.005 to 5 / im. Particularly preferred is 0.01-: l x m. If the average particle size is less than 0.005 zm, light cannot be sufficiently scattered, and the whitening effect may not be obtained. If the average particle size exceeds 5 x m, the whitening effect may not be sustained due to insufficient fixation to the teeth. In the present invention, the average particle size is a value measured by a 50% particle size using a Microtrac particle size analyzer (Nikkiso Co., Ltd.).

[0017] The pullulan of component (B) used in the present invention is a high molecule in which maltotriose has 1-6 bonds, and has a weight average molecular weight of about 4 to 800,000. Of these, 100,000 to 500,000 are particularly preferred. The weight average molecular weight of pullulan can be determined by gel permeation chromatography (GPC) using polyethylene oxide of known molecular weight as a standard substance and dimethylformamide with LiBr added as a solvent. Punoreran is a polyacrylic acid or salt thereof, carboxyvinyl polymer, vinyl acetate, vinylpyrrolidone copolymer, cellulose derivatives such as sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, It can be used in combination with other water-soluble polymers such as xanthan gum, carrageenan, and alginate. The blending amount of pullulan in the composition is preferably in the range of 0.:! To 20% by mass, particularly in the range of 0.3 to 15% by mass of the whole composition. In this case, it is preferable to select the blending amount according to the molecular weight of pullulan, particularly 0.1 to 5% by weight is preferable when the weight average molecular weight is about 790,000, and more preferably 0.3 to 3% by weight. It is. In the case of a weight average molecular weight of about 400,000, 0 :! to 7% by mass is preferable, and more preferably 0.5 to 5% by mass. When the weight average molecular weight is about 200,000, 0.3 to 15% by mass is preferable, and more preferably 0.5 to 10% by mass. When the weight average molecular weight is about 47,000, 0.5 to 20% by mass is preferable, and 1 to 15% by mass is more preferable. Formulation power of Punoreran If the preferred compounding amount for each weight average molecular weight is less than that, it is a metal oxide that reduces the adsorptivity and sustainability of the composition to the teeth even when combined with other water-soluble polymers. May not adhere to teeth for a long time. In addition, when exceeding the preferred blending amount in each weight average molecular weight, In some cases, the viscosity of the product becomes high, and a sufficient amount of metal oxide cannot be adsorbed on the teeth.

 [0018] The component (C) used in the present invention is one or more selected from lysozyme, cationized cellulose, and polylysine.

 [0019] The lysozyme is preferably lysozyme chloride. The amount of lysozyme is 0.1 to 10% by mass of the whole composition, and 0.5 to 5% by mass is more preferable. When the amount of lysozyme is less than 0.1% by mass, a metal oxide having a low adsorptivity and sustainability to the teeth may not be stably adsorbed on the teeth for a long time. If it exceeds 10% by mass, the bitterness unique to lysozyme becomes strong and the taste of the composition may deteriorate.

 [0020] Cationized cellulose is composed of hydroxydimethylallyl ammonium chloride and

 {2-Hydroxy-1- (trimethylammonio)} propyl hydroxyethyl cellulose is preferably used. A weight average molecular weight of about 300,000 to about 2 million is preferably used. If the weight average molecular weight is less than 300,000, the whitening effect may not be sustained due to insufficient fixation to the tooth, and if the weight average molecular weight is more than 2 million, the viscosity of the preparation increases and the operability is improved. It may be damaged. The substitution degree of the cationic group is preferably 0.5 to 3% by mass as the nitrogen content. If the nitrogen content is less than 0.5% by mass, the whitening effect may not be sustained due to insufficient fixation to the teeth, and if the nitrogen content exceeds 3% by mass, the taste will deteriorate and the feeling of use will be reduced. May decrease. The weight average molecular weight is a value determined by a gel permeation chromatograph (GPC) method using polyethylene glycol as a standard substance. The nitrogen content is the value obtained by CHN organic element analysis. Strength The blending amount of thiolated cellulose is preferably from 0.:! To 5% by mass of the whole composition, and more preferably from 0.5 to 3% by mass. When the compounding power of the cationized cellulose is less than 0.1% by mass, a metal oxide having a low adsorptivity and persistence to the tooth of the composition may not be stably adsorbed on the tooth for a long time. On the other hand, when the content exceeds 5% by mass, the viscosity of the composition becomes so high that a sufficient amount of metal oxide may not be adsorbed on the teeth.

[0021] As polylysine, polylysine alone, polylysine hydrochloride, polylysine hydride mouth bromide and the like can be used. Polylysine having a number average molecular weight of 1,000 to 1,000,000 can be used, and 3,000 to 300,000 is particularly preferred. If the number average molecular weight is less than 100 0, the whitening effect may not be sustained due to insufficient fixation to the teeth. When the number average molecular weight force is greater than sioo million, the viscosity of the preparation increases, and the operability may be impaired. The method for measuring the number average molecular weight is not particularly limited. For example, the number average molecular weight should be determined under the following conditions by the low-angle light scattering method (GPC-LALLS method) of gel permeation chromatography using polystyrene as a standard substance. Can do.

 Column: Tosoh Biosep G5000 PW, 7.8mm X 30cm

 XL

 Moving bed: 0. ImolZL sodium phosphate buffer (pH 7.0)

 Flow rate: 0.5mL / min

 Column temperature: 40 ° C

 [0022] The blending amount of polylysine is preferably 0.01 to 20% by mass of the total composition, and more preferably 0.5 to 10% by mass. When the blending amount of polylysine is less than 0.01% by mass, a metal oxide having a low adsorptivity and persistence to the tooth may not be stably adsorbed on the tooth for a long time. On the other hand, if it exceeds 20% by mass, the viscosity of the composition becomes high, and a sufficient amount of metal oxide may not be adsorbed on the teeth.

 [0023] In addition to the above components, the tooth whitening composition of the present invention can further be applied to a tooth for a long time, and a gelling agent that prevents dissolution of the tooth whitening composition over the entire oral cavity according to its form. Can be blended.

 [0024] The gelling agent used in the present invention is not particularly limited, but is polyacrylic acid or a salt thereof, a carboxyvinyl polymer, a vinyl acetate vinylpyrrolidone copolymer, carboxymethyl resorenolose sodium, hydroxye Cellulose derivatives such as chinorecenolose and hydroxypropenorescenellose, polyvinyl pyrrolidone, polybial alcohol, xanthan gum, carrageenan, and alginates are preferably used, and one or more selected from these are blended. obtain.

 [0025] The blending amount of the gelling agent is preferably 0.1 to 10% by mass of the entire composition, and particularly preferably

 5-5 mass% is desirable. If the compounding amount exceeds 10% by mass, the gelling agent may not be sufficiently dissolved, and the preparation may become non-uniform and may inhibit the preparation from adsorbing on the tooth surface. When the blending amount is less than 0.1% by mass, a feeling of strangeness such as stickiness in the mouth due to the dissolution of the gel may occur.

[0026] The tooth whitening composition of the present invention may further contain other components as necessary. You can.

 For example, for the purpose of emulsification and dispersion, one or more of anionic surfactants, nonionic surfactants and zwitterionic surfactants can be used in combination.

 In this case, anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate, sodium myristyl sulfate and sodium cetyl sulfate, sodium N-acyl glutamate such as sodium N-lauroyl glutamate and sodium N-palmitoyl glutamate. N-lauroyl sarcosine sodium, N-mysyl sarcosine sodium N-acyl sarcosine sodium, N-lauroyl methyl taurine sodium, N-myristoyl methyl taurine sodium N-methyl _N_acyl taurine sodium, N-methyl Mono N-acylalanine sodium, sodium lauryl benzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, α-olefin Sodium sulfonate, sodium lauryl ΡΟΕ sulfate, Raurinore ΡΟΕ sodium acetate, sodium lauryl ΡΟΕ phosphate, stearyl ΡΟΕ sodium phosphate and the like are needed use.

 [0027] Nonionic surfactants include glycerin fatty acid esters such as monoglyceryl stearate and decaglyceryl laurate, sucrose fatty acid esters, maltose fatty acid esters, sugar fatty acid esters such as malatose fatty acid esters, maltitol fatty acid esters , Sugar alcohol fatty acid esters such as ratathitol fatty acid esters, polyoxyethylene polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, fatty acid ethanolamides such as myristic mono- or diethanolamide, sorbitan fatty acid esters , Polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid Ester, or the like is used.

[0028] Zwitterionic surfactants include alkyl dimethylamino acetate betaines such as lauryl dimethylamino acetate betaine, Ν-lauryl diaminoethyl glycine, ア ル キ ル -alkyldiaminoethyl glycine such as Ν-myristyl diaminoethyl glycine, Ν- Alkinole Ν— Carboxymethylammonium betaine, 2-alkyl 1-hydroxyethylimidazoline sodium betaine, etc. are used.

[0029] Further, in the present invention, as an active ingredient, enzymes such as dextranase, mutanase, amylase, protease, superoxide dismutase, water-soluble polyphosphate such as potassium pyrophosphate, sodium tripolyphosphate, sodium metaphosphate Salt, allantoin, dihydrocholestanol, glycyrrhizic acid, glycyrrhetinic acid, ε-aminocaproic acid, tranexamic acid, bisabolol, isopropylmethylphenol, sodium chloride, trisan san, chlorhexidine salts, cetylpyridinium chloride, benzethonium chloride 1 or 2 or more of active ingredients such as herbal extracts such as benzalkcoumum chloride, ascorbic acid and its salts, tocopherol, ogon, obata, rosemary, chiioji, thyme, etc. The

 [0030] The composition for tooth whitening of the present invention further includes a fragrance such as vanitol, carvone, peppermint oil, and spearmint oil, a preservative such as benzoic acid and its sodium salt, parabens, red No. 3, red 104. No. 4, Yellow No. 4, Blue No. 1, Green No. 3, pigments or colorants such as titanium mica, petal, sweeteners such as saccharin and its sodium salt, stepioside, glycyrrhizin, aspartame and the like.

 [0031] ρΗ of the tooth whitening composition is not particularly limited as long as it is within the range of safety in the oral cavity and the human body, but preferably the tooth whitening composition is diluted 10 times with purified water. ΡΗ is 4 to 10 and more preferably ρΗ is 5.5 to 9. If it is less than ρΗ4, there is a concern about decalcification depending on the application time. If it exceeds ρΗΙΟ, there is a concern about mucosal detachment when touching the gingiva. As pH adjusters, acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citrate, phosphoric acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium tamate, sodium hydrogen citrate, sodium phosphate, phosphoric acid Sodium hydrogen or the like can be combined.

[0032] The tooth whitening composition is prepared in a paste form, a gel form, a liquid form, or the like, and depending on the form, it should be applied together with an application tool dedicated to holding and fixing to a tooth. Although it is preferable, the application tool for holding and fixing to the tooth used in combination with the tooth whitening composition of the present invention assists the reliable application and fixation of the tooth whitening composition to the tooth. Inhibiting elution of the tooth whitening composition in use on the gums, tongue and oral mucosa, preventing unpleasant use and preventing the induction of saliva, as well as intrusion, occlusion, chewing and other physical stimuli It is used for the purpose of preventing the dilution of the tooth whitening composition and the separation of the tooth force. The material and shape of the tool are not particularly limited as long as the above object can be achieved, but tape, sheet, Finolem, mouth tray, mouthpiece, sponge, impression material made of water-insoluble raw material. A tooth cover molded into a pack material or a dentition is preferably used.

 [0033] The thickness of the above-mentioned application tool is preferably 0.01 to 5 mm, which does not give a sense of incongruity when worn on the oral cavity, and is particularly preferably 0.01 to 2 mm for tapes, sheets and films.

 [0034] With regard to the materials of the above-mentioned devices, polyethylene, foamed polyethylene, polypropylene, foamed polypropylene, polyester, polyurethane, which have excellent fit when applied to the oral cavity and enable the formulation to be applied for a long time by suppressing the generation of saliva. It is preferable to use one or more of rayon, pulp, cotton, silk, paper, polysaccharide film, metal foil, etc. Especially polyethylene, foamed polyethylene, polypropylene, foamed polypropylene, polyester, polyurethane, rayon, Good water-insoluble pullulan film. The poorly water-soluble Punoreran film is a film of Punoreran and is not included in the pullulan component (B). Furthermore, the saliva produced in the mouth is made by forming the material on the side that contacts the oral mucosa and the tongue with a hydrophilic or highly absorbent material such as woven or non-woven fabric using rayon, pulp, cotton, silk, paper, etc. It is preferable because it absorbs and retains water and has excellent usability. In this case, by adhering a water-impermeable film such as polyethylene, polypropylene, polyester, polyurethane, etc. on the side holding the tooth whitening composition, it is possible to prevent the tooth whitening composition from adsorbing and penetrating into the application tool. You can also.

 On the other hand, trays or mouthpieces made of thermoplastic resins such as silicone rubber and natural rubber and thermoplastic resins such as butyl acetate resin, acrylic resin, and ethylene-butyl acetate copolymer have a high degree of freedom of deformation. It is easy to fit in the user's dentition and tooth type, and therefore has excellent adhesion and fixability, and is suitable for the purpose of applying a tooth whitening composition to a tooth for a longer time.

[0036] Furthermore, when a gel composition having a low viscosity and a low adhesiveness to teeth is used in combination, a sponge impregnated with the preparation, or a water-absorbing resin such as rayon, cotton, pulp, etc., is used. It is possible to apply an appropriate amount of gel composition to the teeth by laying on the inside and keeping biting it.

 [0037] The number of times of application, time, etc. are appropriately selected, but usually 1 to 6 times a day, especially:! To 3 times, once:! To 10 minutes, especially:! To 3 minutes. .

 Example

 Hereinafter, the present invention will be specifically described with reference to examples and comparative examples. However, the present invention is not limited to the following examples. In addition, all% in each example is the mass%. In the following examples, the average particle diameter, weight average molecular weight, number average molecular weight, and nitrogen content are measured as described above. Further, in the following examples and comparative examples, there is an example using Chisso Co., Ltd. polylysine powder, which is 50% powder, and the blending amount is shown as a pure conversion.

 Formulation preparation

 After all the raw materials were weighed and put into a kneader, the pressure was reduced to 4 kPa and mixed until the composition became uniform to prepare a tooth whitening composition. In addition, the pH was measured with a pH meter (HM-26S, manufactured by Toa DKKEI Co., Ltd.) after 1 minute at 25 ° C when diluted 10 times with purified water, and adjusted to pH 5.5 to 9.0. As needed, it adjusted using sodium hydroxide or hydrochloric acid.

[0039] Fabrication of sheet

Heated polyethylene film (low density polyethylene, thickness 10 zm, manufactured by Tosoh Corporation, product grade; 212), polypropylene nonwoven fabric (100% polypropylene, spunbond, basis weight 40 g / m ² , surface embossing, Idemitsu Petrochemical Product grade; Idemitsu RN2 040) and rayon / polypropylene nonwoven fabric (rayon / polypropylene = 70/30, spun lace, basis weight 40gZm ² , product made by Shingo Co., Ltd., product grade; 7140-6) A three-layer nonwoven fabric sheet having a thickness of 0.5 mm was prepared by fusing. Rayon Z polypropylene nonwoven fabric side of this three-layer nonwoven fabric sheet and Faisin film (polyethylene terephthalate 100%, single-sided silicon coat, thickness 50 μΐη, manufactured by Toray Film Co., Ltd., product grade; Therapy BK (S) Tooth whitening composition was applied between the silicon coated surfaces of # 50) using a spreader (manufactured by Kaei Machinery Co., Ltd., roll sand coater) so that the total thickness was lmm. . Then, left and right of the upper and lower jaws:! ~ The tooth coated with a tooth whitening composition so that the size (60mm X 25mm) can cover the lip and tongue of the teeth of No. 3 A sheet that can be applied to the dentition was prepared.

 [Example:! To 10, Comparative example:! To 4]

 A sheet coated with the composition shown in Table 1 by the above method is placed on the extracted human tooth whose color difference L * a * b * has been measured in advance, and left in a thermostat at 37 ° C for 3 minutes. Thereafter, the sheet was peeled off, the gel was gently wiped with a tissue, washed with water, and then transferred into artificial saliva. After immersion in artificial saliva for 3 hours, the color difference L * a * b * was measured to determine ΔΕ. The color difference was measured with a spectrocolorimeter (Minolta Co., Ltd., CM_2022). The composition of artificial saliva is as follows.

 Salty Calcium 'Dihydrate 0, 2205g

 Jin Jin Henji! ^ Power]; Kum 0.6805g

 Salty natrium 5. 8440g

 Acetic acid 6. Og

 NaOH (pH adjuster)

 A

 Total 1, OOOmL

 • Whitening effect

 2, 1/2

△ E * (1) = ((L * 1— L * 0) ² + (a * l_ -a O) + (b 1-b 0))

 'Durability of whitening effect

 2 ヽ 1/2

ΔΕ * (2) = ((L * 2-L * 0) ² + (a * 2- -a O) + (b 2− b 0))

 L * 0, a * 0, b * 0 represent the initial L * a * b * values, and similarly L * l, a * l, b * l, L * 2, a * 2, b * 2 Are the L * aV value after whitening and the L * aV value after immersion in artificial saliva, respectively.

Longan

 Whitening effect ◎: ΔΕ * (1) is 7.0 or more

 ○: ΔΕ * (1) is more than 5.0 and less than 7.0

 Δ: ΔΕ * (1) is 3.0 or more and less than 5.0

 X: ΔΕ * (1) is less than 3.0

Persistence of whitening effect ◎: ΔΕ * (2) is 6.0 or more ◯: ΔΕ (2) is 4.0 or more and less than 6.0

 Δ: ΔΕ * (2) is 3.0 or more and less than 4.0

 x: ΔΕ * (2) is less than 3.0

 The results are shown in Table 1.

[table 1]

 [Example 11]

 Foamed polyethylene sheet (Sekisui Chemical Co., Ltd. Borara XL_IF08008, 15 mm X 60 mm X) that covers the lips of the front teeth left 3 to right 3 with 2.g of tooth whitening composition 1. A thickness of 800 zm) was applied to the labial surface of the tooth. When evaluated in the same manner as in the above-mentioned Examples:! To 10 and Comparative Examples 1 to 4, the whitening effect was 、 and the whitening effect was sustained.

 T, paste

Titanium dioxide 3.0% (Ishihara Sangyo Co., Ltd. Typeter CR-50, average particle size 0 · 25 μΐη) Pullulan (Hayashibara Corporation, PF-2, weight average molecular weight 200,000)

 Polylysine (Chisso Corporation, polylysine powder, number average molecular weight 4400)

 Sodium carboxymethylcellulose 0.5

 (Product name: CMC Daicel — 1150, manufactured by Daicel Chemical Industries, Ltd.)

70 ^ο / ο Sonorevi, 卜 1 Nore 30. 0

 Propylene glycol 3.0

 Saccharin sodium 0.2

 Methylparaben 0.1

 Fragrance 1.0

 Purified water balance

 Total 100. 0%

 [Example 12]

 2. Polyurethane film (made by Seadam Co., DUS2124-CDB, 15mm x 60mm x thickness 50) with the following tooth whitening composition 2 pre-coated with 2. Og and covering the lip of the left 3rd to right 3rd teeth μΐη) was affixed to the lip surface of the tooth. When evaluated in the same manner as in the above-mentioned Examples:! To 10 and Comparative Examples 1 to 4, the whitening effect was 、, and the persistence of the whitening effect was ◯. Tooth whitening composition 2 (gel)

 Titanium dioxide 4.0%

 (Ishihara Techno Co., Ltd. TTO-51 (A), average particle size 0 · 02 μΐη)

 Pullulan (Shokko Tsusho Co., Ltd., P-800, weight average molecular weight 790,000) 3 · 0 Cationized Senorelose 0.3

 (Japan NSC Co., Ltd., nitrogen content 2%, weight average molecular weight 300,000)

 Xanthan gum 0.2

 (Made by Saneigen F FF Eye Co., Ltd., trade name Sanace NXG_S)

 Sodium polyacrylate 0.6

 (Nippon Pure Chemicals Co., Ltd., trade name Aalunbis SS)

Butylparaben 0.1 70 ^ο / _ο Sonorevi, 卜 1 Nore 23. 0

 Propylene glycol 5.0

 Sodium benzoate 0.2

 Fragrance 1.0

 Purified water balance

 Total 100. 0%

 [Example 13]

 A polyethylene film (Toray Co., Ltd., soft PE, 10 mm x 15 mm x 25 μm thick) with one tooth each coated with 0.2 g of the following tooth whitening composition 3 in advance is colored. Affixed only to the teeth of interest. When evaluated in the same manner as in the above Examples:! To 10 and Comparative Examples 1 to 4, the whitening effect was ◎, and the persistence of the whitening effect was ◎.

T,) 3 (gel)

 Zirconium oxide (Nippon Denko, N—PC, average particle size 0 · 02 / im) 0.5% Titanium dioxide 3.0

 (Ishihara Techno Co., Ltd. TTO-51 (A), average particle size 0 · 02 μΐη)

 Pullulan (Shoko Tsusho Co., Ltd., P-400, weight average molecular weight 400,000) 5 · 0 Lysozyme (Wako Pure Chemical Industries, Ltd., lysozyme, molecular weight 14400) 0.1 Polylysine (Chisso Corporation, polylysine powder, number (Average molecular weight 4400) 1.5

 Glycerin 15.0

 Polyoxyethylene (60 mol) hydrogenated castor oil 1.0

 Xanthan gum 0.2

 (Made by Saneigen F FF Eye Co., Ltd., trade name Sanace NXG_S)

 Sodium fluoride 0.2

 Fragrance 1.0

 Saccharin sodium 0.1

 Purified water balance

 Total 100. 0%

[Example 14] Apply the following tooth whitening composition 4 with 1. Og brush to the left lip of the front teeth 3rd to 3rd right, and from the top polypropylene film (Toray Industries soft PP, 15mm X 60mm X thickness 100 zm) was affixed. When evaluated in the same manner as in the above Examples:! To 10 and Comparative Examples 1 to 4, the whitening effect was ◎, and the persistence of the whitening effect was ◎. Aluminum oxide 2.0%

 (Meller, trade name: pure alumina powder, average particle size 0.06 x m)

 Pullulan (Hayashibara Corporation, PF_2, weight average molecular weight 200,000) 3.0 Cationic senorelose 1.5

 (Japan NSC Co., Ltd., nitrogen content 2%, weight average molecular weight 300,000)

 Carrageenan 0.1

 (Product name: GELRICH No. 3 manufactured by San-Ei Gen F "F-I")

 Polyoxyethylene (60 mol) hydrogenated castor oil 1.0

 Sodium benzoate 0.3

 Methylparaben 0 · 1

 Quenic acid 0.1

 Sodium quenate 0 · 3

 Fragrance 0.5

 Saccharin 0 · 02

 Purified water balance

 Total 100. 0%

 [Example 15]

 The mouthpiece made of ethylene butyl acetate resin was warmed and softened with hot water, and the mouthpiece fitted with each tooth shape was made by massaging. The mouthpiece was filled with 1. Og of the following tooth whitening composition 5 and attached. When evaluated by the same method as in the above-mentioned Examples:! To 10 and Comparative Examples 1 to 4, the whitening effect was ◎, and the persistence of the whitening effect was ◯.

T,) 5 (gel)

Silicon dioxide 1.0% (Huber, trade name Zeodentl l 3, average particle size 5 · 0 / im)

Pullulan (Shoko Tsusho Co., Ltd., P-50, weight average molecular weight 47,000) 5.0 Polylysine 1.2

 (Wako Pure Chemical Industries, Ltd., poly L lysine hydrobromide, number average molecular weight of 300,000 or more) Sodium carboxymethylcellulose 0.3

 (Product name: CMC Daicel — 1150, manufactured by Daicel Chemical Industries, Ltd.)

Force Lagenan 0.2

 (Product name: GELRICH No. 3 manufactured by San-Ei Gen F "F-I")

Sonorebit 20. 0

Xyrit 10.0

Propylene glycol 3.0

Methylparaben 0. 05

Fragrance 1.0

Saccharin sodium 0.15

Purified water balance

Total 100. 0%

Claims

The scope of the claims  [1] (A) Titanium dioxide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide, one or more selected from dinoleconium oxide,  (B) Pullulan,  (C) A composition for whitening teeth, comprising one or more selected from lysozyme, cationized cellulose, and polylysine.  [2] The tooth whitening composition according to claim 1 and the application for holding the tooth whitening composition and detachably attaching to the tooth while holding the tooth whitening composition A set for teeth whitening characterized by comprising a tool. [3] The tooth whitening set according to claim 2, wherein the application tool is a tape, a sheet, a film, a mouth tray, a mouthpiece, a sponge, an impression material, a pack material, or a tooth cover molded into a dentition. .