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WO2005097168A3 - Synthetic chemokines, methods of manufacture, and uses - Google Patents

Synthetic chemokines, methods of manufacture, and uses Download PDF

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Publication number
WO2005097168A3
WO2005097168A3 PCT/US2005/010212 US2005010212W WO2005097168A3 WO 2005097168 A3 WO2005097168 A3 WO 2005097168A3 US 2005010212 W US2005010212 W US 2005010212W WO 2005097168 A3 WO2005097168 A3 WO 2005097168A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthetic chemokines
methods
manufacture
chemokines
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/010212
Other languages
French (fr)
Other versions
WO2005097168A2 (en
Inventor
James A Bradburne
Leslie P Miranda
Xavier Paliard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gryphon Therapeutics Inc
Original Assignee
Gryphon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gryphon Therapeutics Inc filed Critical Gryphon Therapeutics Inc
Priority to CA002561171A priority Critical patent/CA2561171A1/en
Priority to AU2005231338A priority patent/AU2005231338A1/en
Priority to EP05732998A priority patent/EP1732942A4/en
Publication of WO2005097168A2 publication Critical patent/WO2005097168A2/en
Anticipated expiration legal-status Critical
Publication of WO2005097168A3 publication Critical patent/WO2005097168A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to synthetic chemokines, methods of manufacture and uses thereof. The synthetic chemokines of the invention include one or more amino acid deletions at the C-terminus relative to the corresponding wild type chemokine, which also can include one or more covalently attached polymers, as well one or more additional amino acid changes or chemical modifications. The invention also provides synthetic chemokines in a substantially purified oligomeric form, such as, in a monomer or dimer form. Further provided are methods for synthesizing the synthetic chemokines of the invention, pharmaceutical formulations and kits thereof, and their use as research tools and medicaments.
PCT/US2005/010212 2004-03-30 2005-03-25 Synthetic chemokines, methods of manufacture, and uses Ceased WO2005097168A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002561171A CA2561171A1 (en) 2004-03-30 2005-03-25 Synthetic chemokines, methods of manufacture, and uses
AU2005231338A AU2005231338A1 (en) 2004-03-30 2005-03-25 Synthetic chemokines, methods of manufacture, and uses
EP05732998A EP1732942A4 (en) 2004-03-30 2005-03-25 SYNTHETIC CHEMOKINES, METHODS OF PRODUCTION THEREOF, AND USES THEREOF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55740004P 2004-03-30 2004-03-30
US60/557,400 2004-03-30

Publications (2)

Publication Number Publication Date
WO2005097168A2 WO2005097168A2 (en) 2005-10-20
WO2005097168A3 true WO2005097168A3 (en) 2006-10-05

Family

ID=35125616

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/010212 Ceased WO2005097168A2 (en) 2004-03-30 2005-03-25 Synthetic chemokines, methods of manufacture, and uses

Country Status (6)

Country Link
EP (1) EP1732942A4 (en)
CN (1) CN101006096A (en)
AU (1) AU2005231338A1 (en)
CA (1) CA2561171A1 (en)
WO (1) WO2005097168A2 (en)
ZA (1) ZA200608279B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006325214A1 (en) * 2005-12-15 2007-06-21 Laboratoires Serono S.A. New chemokine antagonists

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050089970A1 (en) * 2000-07-12 2005-04-28 Bradburne James A. Polymer-modified bioactive synthetic chemokines, and methods for their manufacture and use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0713495B1 (en) * 1993-06-08 2003-11-05 Smithkline Beecham Corporation Methods of enhancing bioactivity of chemokines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050089970A1 (en) * 2000-07-12 2005-04-28 Bradburne James A. Polymer-modified bioactive synthetic chemokines, and methods for their manufacture and use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHAKRAVARTY L. ET AL.: "Lysine 58 and Histidine 66 at the C-terminal a-Helix of Monocyte Chemoattractant Protein-1 Are Essential for Glycosaminoglycan Binding", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 5, 1998, pages 29641 - 29647, XP002250021, DOI: doi:10.1074/jbc.273.45.29641 *
See also references of EP1732942A4 *

Also Published As

Publication number Publication date
EP1732942A4 (en) 2008-12-03
EP1732942A2 (en) 2006-12-20
CN101006096A (en) 2007-07-25
CA2561171A1 (en) 2005-10-20
ZA200608279B (en) 2007-12-27
AU2005231338A1 (en) 2005-10-20
WO2005097168A2 (en) 2005-10-20

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