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WO2005095591A3 - Novel genes from a biosynthesis gene cluster for aminoglycoside antibiotic synthesis and the thus obtained novel aminoglycoside antibiotics - Google Patents

Novel genes from a biosynthesis gene cluster for aminoglycoside antibiotic synthesis and the thus obtained novel aminoglycoside antibiotics Download PDF

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Publication number
WO2005095591A3
WO2005095591A3 PCT/DE2005/000499 DE2005000499W WO2005095591A3 WO 2005095591 A3 WO2005095591 A3 WO 2005095591A3 DE 2005000499 W DE2005000499 W DE 2005000499W WO 2005095591 A3 WO2005095591 A3 WO 2005095591A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel
aminoglycoside
genes
gene cluster
biosynthesis gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2005/000499
Other languages
German (de)
French (fr)
Other versions
WO2005095591A2 (en
Inventor
Andreas Vente
Wolfgang Piepersberg
Udo Wehmeier
Heike Schmidt-Beissner
Khaled Mohammed Anwa Aboshanab
Katrin Welzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merlion Pharmaceuticals GmbH
Original Assignee
Combinature Biopharm AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combinature Biopharm AG filed Critical Combinature Biopharm AG
Publication of WO2005095591A2 publication Critical patent/WO2005095591A2/en
Publication of WO2005095591A3 publication Critical patent/WO2005095591A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention relates to novel genes obtainable from aminoglycoside-producing microorganisms, to novel gene clusters formed from the novel and/or known genes of said microorganisms, to the expression products of the genes, the transport vehicles thereof or of the gene clusters and to transformed cells containing said genes or gene clusters. Said invention also relates to methods for biologically producing aminoglycosides, methods for combinatory synthesis of aminoglycoside derivatives, to novel aminoglycosides, to the use thereof and to pharmaceutical compositions containing said aminoglycosides.
PCT/DE2005/000499 2004-04-01 2005-03-15 Novel genes from a biosynthesis gene cluster for aminoglycoside antibiotic synthesis and the thus obtained novel aminoglycoside antibiotics Ceased WO2005095591A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200410017141 DE102004017141A1 (en) 2004-04-01 2004-04-01 New genes from biosynthesis Gene clusters for the synthesis of aminoglycoside antibiotics and thus produced new aminoglycoside antibiotics
DE102004017141.6 2004-04-01

Publications (2)

Publication Number Publication Date
WO2005095591A2 WO2005095591A2 (en) 2005-10-13
WO2005095591A3 true WO2005095591A3 (en) 2006-07-20

Family

ID=35058887

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2005/000499 Ceased WO2005095591A2 (en) 2004-04-01 2005-03-15 Novel genes from a biosynthesis gene cluster for aminoglycoside antibiotic synthesis and the thus obtained novel aminoglycoside antibiotics

Country Status (2)

Country Link
DE (1) DE102004017141A1 (en)
WO (1) WO2005095591A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8440400B2 (en) 2008-06-05 2013-05-14 Meiji Seika Pharma Co., Ltd. Process for amplifying DNA in cells

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7618801B2 (en) * 2007-10-30 2009-11-17 Danison US Inc. Streptomyces protease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035770A2 (en) * 1980-03-07 1981-09-16 INTERx RESEARCH CORPORATION An orally administered drug form comprising a glycosidic antibiotic and an adjuvant
EP0204549A2 (en) * 1985-06-07 1986-12-10 Eli Lilly And Company Method of isolating antibiotic biosynthetic genes
KR20030082708A (en) * 2002-04-18 2003-10-23 주식회사 바이오홀딩스 Gene and amino acid sequences of bluensomycin biosynthesis enzyme and transformant thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035770A2 (en) * 1980-03-07 1981-09-16 INTERx RESEARCH CORPORATION An orally administered drug form comprising a glycosidic antibiotic and an adjuvant
EP0204549A2 (en) * 1985-06-07 1986-12-10 Eli Lilly And Company Method of isolating antibiotic biosynthetic genes
KR20030082708A (en) * 2002-04-18 2003-10-23 주식회사 바이오홀딩스 Gene and amino acid sequences of bluensomycin biosynthesis enzyme and transformant thereof

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
BEYER STEFAN ET AL: "The StrQ protein encoded in the gene cluster for 5'-hydroxystreptomycin of Streptomyces glaucescens GLA.0 is a alpha-D-glucose-1-phosphate cytidylyltransferase (CDP-D-glucose synthase)", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 258, no. 3, December 1998 (1998-12-01), pages 1059 - 1067, XP002349933, ISSN: 0014-2956 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; May 2001 (2001-05-01), LI T B ET AL: "[Cloning of the sugar related biosynthesis gene cluster from Streptomyces tenebrarius H6]", XP002349939, Database accession no. NLM11517612 *
DATABASE NCBI SEQUENCE DATABASE 12 July 2005 (2005-07-12), TADASHI EGUCHI: "Bacillus butirosin-biosynthetic gene cluster complete and partial cds.", XP002349940, retrieved from GENEBANK Database accession no. AB097196 *
DATABASE NCBI SEQUENCE DATABASE Washington, US; 25 November 2000 (2000-11-25), Y. OTA ET AL.: "Bacillus circulans butirosin gene cluster", XP002349783, retrieved from GENEBANK Database accession no. AB033991 *
DATABASE WPI Section Ch Week 200417, Derwent World Patents Index; Class B03, AN 2004-176937, XP002349787 *
HASKELL T H ET AL: "The preparation and biological activity of novel amino acid analogs of butirosin.", CARBOHYDRATE RESEARCH. JUN 1973, vol. 28, no. 2, June 1973 (1973-06-01), pages 263 - 280, XP002082628, ISSN: 0008-6215 *
IKENO SOUICHI ET AL: "kasT gene of Streptomyces kasugaensis M338-M1 encodes a DNA-binding protein which binds to intergenic region of kasU-kasJ in the kasugamycin biosynthesis gene cluster.", THE JOURNAL OF ANTIBIOTICS. DEC 2002, vol. 55, no. 12, December 2002 (2002-12-01), pages 1053 - 1062, XP008054360, ISSN: 0021-8820 *
JUNG YONG GYUN ET AL: "Isolation and characterization of bluensomycin biosynthetic genes from Streptomyces bluensis.", FEMS MICROBIOLOGY LETTERS. 28 FEB 2003, vol. 219, no. 2, 28 February 2003 (2003-02-28), pages 285 - 289, XP002349778, ISSN: 0378-1097 *
KHAREL MADAN KUMAR ET AL: "An approach for cloning biosynthetic genes of 2-deoxystreptamine-containing aminocyclitol antibiotics: isolation of a biosynthetic gene cluster of tobramycin from Streptomyces tenebrarius.", BIOTECHNOLOGY LETTERS. DEC 2003, vol. 25, no. 24, December 2003 (2003-12-01), pages 2041 - 2047, XP002349777, ISSN: 0141-5492 *
LYUTZKANOVA DIMITRINA ET AL: "A spectinomycin resistance determinant from the spectinomycin producer Streptomyces flavopersicus", MICROBIOLOGY (READING), vol. 143, no. 7, 1997, pages 2135 - 2143, XP008054300, ISSN: 1350-0872 *
OTA Y ET AL: "Butirosin-biosynthetic gene cluster from Bacillus circulans.", THE JOURNAL OF ANTIBIOTICS. OCT 2000, vol. 53, no. 10, October 2000 (2000-10-01), pages 1158 - 1167, XP002349775, ISSN: 0021-8820 *
PISSOWOTZKI K ET AL: "GENETICS OF STREPTOMYCIN PRODUCTION IN STREPTOMYCES-GRISEUS MOLECULAR STRUCTURE AND PUTATIVE FUNCTION OF GENES STRELMB2N", MOLECULAR AND GENERAL GENETICS, vol. 231, no. 1, 1991, pages 113 - 123, XP002349934, ISSN: 0026-8925 *
S. BUDAVARI: "The Merck Index, Twelfth Edition", 1996, MERCK &CO. INC., WHITEHOUSE STATION, NJ, US, XP002349779 *
SHENG WU GONG CHENG XUE BAO = CHINESE JOURNAL OF BIOTECHNOLOGY. MAY 2001, vol. 17, no. 3, May 2001 (2001-05-01), pages 329 - 331, ISSN: 1000-3061 *
TAMEGAI HIDEYUKI ET AL: "Identification of L-glutamine: 2-Deoxy-scyllo-inosose aminotransferase required for the biosynthesis of butirosin in Bacillus circulans", JOURNAL OF ANTIBIOTICS (TOKYO), vol. 55, no. 8, August 2002 (2002-08-01), pages 707 - 714, XP008054312, ISSN: 0021-8820 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8440400B2 (en) 2008-06-05 2013-05-14 Meiji Seika Pharma Co., Ltd. Process for amplifying DNA in cells

Also Published As

Publication number Publication date
WO2005095591A2 (en) 2005-10-13
DE102004017141A1 (en) 2005-12-01

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