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WO2004041336A1 - Dispositif de traitement par inhalation - Google Patents

Dispositif de traitement par inhalation Download PDF

Info

Publication number
WO2004041336A1
WO2004041336A1 PCT/EP2003/012404 EP0312404W WO2004041336A1 WO 2004041336 A1 WO2004041336 A1 WO 2004041336A1 EP 0312404 W EP0312404 W EP 0312404W WO 2004041336 A1 WO2004041336 A1 WO 2004041336A1
Authority
WO
WIPO (PCT)
Prior art keywords
membrane
inhalation
aerosol
valve
mixing chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/012404
Other languages
German (de)
English (en)
Inventor
Thomas Gallem
Markus Urich
Uwe Hetzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PARI GmbH Spezialisten fuer Effektive Inhalation
PARI GmbH
Original Assignee
PARI GmbH Spezialisten fuer Effektive Inhalation
PARI GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PARI GmbH Spezialisten fuer Effektive Inhalation, PARI GmbH filed Critical PARI GmbH Spezialisten fuer Effektive Inhalation
Publication of WO2004041336A1 publication Critical patent/WO2004041336A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
    • A61M15/0015—Details of inhalators; Constructional features thereof with inhalation check valves located upstream of the dispenser, i.e. not traversed by the product
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0018—Details of inhalators; Constructional features thereof with exhalation check valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A61M16/201—Controlled valves
    • A61M16/206—Capsule valves, e.g. mushroom, membrane valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/20—Valves specially adapted to medical respiratory devices
    • A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves

Definitions

  • the invention relates to an inhalation therapy device with an aerosol membrane generator and a mixing chamber and an inhalation valve.
  • Inhalation therapy devices of this type can be used to nebulize medicated liquids, liquid medications or other therapeutically usable liquids, for example salt solutions, in order to provide the patient with an aerosol for inhalation.
  • Vibration generator is set in vibration, whereby a liquid present on one side of the membrane is atomized through the membrane and released into a mixing chamber.
  • the aerosol mixes with ambient air during the inhalation process, which is fed to the mixing chamber through an annular gap formed around a liquid storage container.
  • a flat circular inhalation valve is provided in the annular gap, which releases the annular gap during the inhalation phase and closes it during the exhalation phase.
  • the problem to be solved by the invention is to provide an inhalation therapy device in which the inhalation valve is designed in such a way that the risk of contamination of the aerosol membrane generator by the patient's breathing air during the exhalation phases is reduced.
  • Liquid storage container into which a medicinal liquid can be filled, with a membrane which is connected on one side to the liquid container in such a way that one in the
  • Liquid reservoir filled liquid comes into contact with one side of the membrane, and with a vibration generator, through which the membrane can be set in vibration, so that one in the
  • Liquid reservoir filled liquid is atomized through openings in the membrane on the other side of the membrane to form an aerosol, a mixing chamber into which the aerosol membrane generator generates the aerosol, and an inhalation valve which allows the inflow of ambient air into the mixing chamber during inhalation phases and during exhalation phases prevents the aerosol from escaping from the mixing chamber, which forms a wall section of the mixing chamber which has a funnel-like area, the tapering end of which
  • Valve opening includes and extends to the aerosol membrane generator, so that an edge surrounding the valve opening in the rest position of the inhalation valve on a surface of the aerosol membrane generator is arranged surrounding the membrane.
  • the funnel-like design of the valve according to the invention has the effect that, on the one hand, a dimensionally stable and flexible valve element provides the function as an inhalation valve and, on the other hand, a favorable flow of the supply air is achieved, since the valve opening surrounds the membrane and thus the supply air the aerosol it produces.
  • the design which resembles a funnel, ensures that the aerosol is deposited to a lesser extent in the mixing chamber during inhalation phases.
  • the inhalation valve By designing the inhalation valve as a wall section, it also defines the dimensions of the mixing chamber, which immediately minimizes the space that comes into contact with aerosol.
  • the funnel-like design according to the invention in the form of a wall section avoids an area for the inhalation valve which is to be provided in addition to the mixing chamber and then also comes into contact with aerosol. The cleaning of the therapy device is correspondingly easier.
  • the funnel-like area of the inhalation valve is rounded, conical-flat, stepped or meandering.
  • the edge of the valve opening advantageously has a thickening or a bead all around.
  • the inhalation valve has an edge section next to the valve element.
  • the edge area is preferably for holding the Inhalation valve, in particular designed for clamping between the aerosol generator and the mixing chamber.
  • Inhalation valve preferably made of an elastic material.
  • FIG. 1A shows a sectional view of an inhalation device according to the invention with the inhalation valve closed;
  • IB is a sectional view of an inhalation device according to the invention with the inhalation valve open;
  • 3A and 3B are perspective views of an inhalation valve according to the invention.
  • FIGS. 1A and IB show an exemplary embodiment of an inhalation therapy device 1 according to the invention, which has an aerosol membrane generator 2 and a mixing chamber 3.
  • the two components are designed as separate units, which are connected to one another in a suitable manner in the region of the inhalation valve, so that both components as functional unit can be handled safely.
  • the aerosol generator 2 of the exemplary embodiment from FIG. 1A comprises a liquid storage container 4, into which a medicament-containing liquid 5 can be filled, and a membrane 6, which seals off the liquid storage container 4 on an open surface.
  • the membrane 6 is connected on one side to the liquid container 4 in such a way that the liquid 5 filled into the liquid storage container touches one side of the membrane 6.
  • a vibration generator 7, 'for example, a piezo element is arranged to vibrate through which the membrane 6 when the vibration generator is driven. 7
  • Vibration generator 7 is designed to be rotationally symmetrical, so that the vibration generator 7 concentrically surrounds the membrane.
  • the membrane 6 If the vibration generator 7 is excited, for example an alternating voltage is applied to the piezo element, the membrane 6 is set in vibration, so that the liquid 5 which is filled into the liquid reservoir and is present on the membrane passes through openings in the membrane to the other side of the membrane Membrane promoted and atomized there to an aerosol. The aerosol is released into the mixing chamber 3.
  • the vibration generator 7 for example an alternating voltage is applied to the piezo element, the membrane 6 is set in vibration, so that the liquid 5 which is filled into the liquid reservoir and is present on the membrane passes through openings in the membrane to the other side of the membrane Membrane promoted and atomized there to an aerosol.
  • the aerosol is released into the mixing chamber 3.
  • a mouthpiece 10 is also provided, which in the example shown is formed in one piece with the mixing chamber 3, but which, in a modified embodiment, can also be designed to be separable from the mixing chamber 3. Via the mouthpiece 10, the patient inhales that generated by the aerosol membrane generator 2 and into the mixing chamber 3 dispensed aerosol when inhaled through the mouthpiece.
  • an inhalation valve 20 is provided for controlling / checking the supply air, which in the inhalation phases detects the inflow of
  • Ambient air allows into the mixing chamber, as shown in FIG. IB, but which closes the supply air channels 9 in exhalation phases such that the exhaled breathing air does not flow through the supply air channels 9, as shown in FIG. 1A.
  • the inhalation valve 20 according to the invention thus prevents
  • the aerosol with the respiratory air by the air supply channels 9 from the mixing chamber and that breath air into the supply air ducts passes'. 9
  • the area around the liquid container 4 in the aerosol generator 2 in which there are often also other components, for example electrical connections for controlling the piezo crystal is protected from breathing air and thus from contaminants which enter the therapy device with the breathing air .
  • the inhalation valve according to the invention thus protects the interior of the aerosol generator during the exhalation phases.
  • the exhaled air is led out of the mixing chamber 3 or the mouthpiece 10 in a different way, for example via the known mouthpiece valve 32, 321, 322, the functioning of which is not discussed in detail here.
  • the valve element 21 of the inhalation valve 20 forms a wall section of the mixing chamber 3 in which it is open Closing wall area of the mixing chamber 3 supplemented.
  • the valve element 21 of the inhalation valve 20 comprises a valve opening 22, which is formed by the valve element 21, as can be seen in FIGS. 1A and IB, tapering at least in regions like a funnel.
  • a sufficiently dimensionally stable valve element 21 is created through the funnel-like region 23 of the inhalation valve 20, through the opening 22 of which the supply air can flow into the mixing chamber 3 when the patient inhales.
  • valve element 21 which resembles a funnel, is deflected out of the rest position, into which it always returns automatically due to its dimensional stability and elasticity, and, as shown in FIG. 1B, releases a gap through which the supply air passes the inhalation valve 20 can.
  • the gap is formed in the immediate vicinity of the membrane 6 and surrounds it, flow guidance of the supply air that supports aerosol generation is achieved. This is because the supply air to a certain extent encloses the aerosol emitted by the membrane 6 and thus reduces the risk that the aerosol will quickly hit a wall of the mixing chamber 3 and separate there. This is also a particular advantage of the inhalation valve according to the invention.
  • valve element 21 rests on a surface of the aerosol generator 2, as shown in FIG. 1A, so that there is no gap between the aerosol generator and the valve element 21.
  • the edge 24 of the valve opening 22 surrounds the membrane 6 of the aerosol generator, the valve opening 22 preferably being circular, in particular if the membrane 6 and the vibration generator 7 are also circular.
  • 1A and IB thus show that the tapering region 23 of the valve element 21 extends according to the invention to the aerosol membrane generator 2 in such a way that the edge 24 surrounding the opening is arranged on a surface of the aerosol generator 2 and surrounds the membrane ⁇ .
  • the surface of the aerosol generator 2 thus forms, as it were, that shown in FIG. 1A
  • valve element 21 has a circumferential bulge or thickening 24 at the edge of the valve opening 22, as a result of which the opening edge is strengthened and the dimensional stability is increased.
  • this design of the edge of the valve opening 22 makes it possible, in the case of the normally occurring breathing air flows, to reliably prevent the valve element 21 from being deflected by the breathing air flow to such an extent that it extends completely into the mixing chamber 3 and thereby assumes a new, dimensionally stable position from which it does not return to the rest position shown in FIG. 1A.
  • the bead 24 on the edge of the valve opening 22 reduces the risk that this area of the valve element 21 is damaged.
  • the funnel-like shape of the valve element 21 according to the invention can be achieved by a rounded wall profile; however, other wall shapes are also conceivable, for example the conical, flat profile shown in FIG. 2A, the stepped profile shown in FIG. 2B or the meandering profile shown in FIG. 2C.
  • the inhalation valve 20 is between a wall section 31 of the aerosol generator 2 and a wall section 31 of the mixing chamber 3 and preferably held, for example clamped, in such a way that the inhalation valve 20 is securely fixed and its valve opening 22 is exactly positioned.
  • the inhalation valve 20 has an outer edge section 25 for the
  • FIGS. 1A and IB are also particularly advantageous because the inhalation valve 20 is used to seal the connection point between the aerosol generator 2 and the mixing chamber 3.
  • the edge section 25 of the inhalation valve 20 is adapted to the end cross sections of the aerosol generator 2 and the mixing chamber 3.
  • Figures 3A and 3B show that the adjustment of the
  • Edge section 25 can go very far, but a transition to the funnel-like valve element 21 according to the invention with valve opening 22 can always be easily created.
  • this type of adaptation ensures that the material of the inhalation valve 20 which is fundamentally suitable for sealing purposes is also used for sealing the transition between the aerosol generator 2 and the mixing chamber 3. It also follows that the inhalation valve 20 according to the invention is preferably formed in one piece.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un dispositif de traitement par inhalation qui comprend un générateur d'aérosol (2) et une chambre de mélange (3). L'amenée d'air ambiant se fait par l'intermédiaire de canaux d'amenée d'air (9), sous le contrôle d'une valve d'aspiration (20) qui présente une zone (23) du type entonnoir et une ouverture de valve (22). L'ouverture de valve (22) entoure la membrane (6) du générateur d'aérosol (2), le bord (24) de la valve reposant sur une surface du générateur d'aérosol (2).
PCT/EP2003/012404 2002-11-07 2003-11-06 Dispositif de traitement par inhalation Ceased WO2004041336A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10251865A DE10251865B3 (de) 2002-11-07 2002-11-07 Inhalationstherapievorrichtung
DE10251865.3 2002-11-07

Publications (1)

Publication Number Publication Date
WO2004041336A1 true WO2004041336A1 (fr) 2004-05-21

Family

ID=32103397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/012404 Ceased WO2004041336A1 (fr) 2002-11-07 2003-11-06 Dispositif de traitement par inhalation

Country Status (2)

Country Link
DE (1) DE10251865B3 (fr)
WO (1) WO2004041336A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032630A1 (fr) * 2003-10-02 2005-04-14 Pari GmbH Spezialisten für effektive Inhalation Dispositif de traitement pas inhalation comportant une soupape
US20090025714A1 (en) * 2007-07-24 2009-01-29 Denyer Jonathan S H Drug Delivery Apparatus and Method
WO2021023522A1 (fr) * 2019-08-02 2021-02-11 Stamford Devices Limited Administration buccale d'aérosol
US11045434B1 (en) 2020-04-01 2021-06-29 UNION therapeutics A/S Niclosamide formulations for treating disease
WO2021198116A1 (fr) 2020-04-01 2021-10-07 UNION therapeutics A/S Formulation
WO2021198115A1 (fr) 2020-04-01 2021-10-07 UNION therapeutics A/S Traitement

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5813401A (en) * 1996-10-15 1998-09-29 Radcliff; Janet H. Nebulizer automatic control valve
WO2000012161A1 (fr) * 1998-08-26 2000-03-09 Otto Schill Gmbh & Co. Kg Inhalateur pour nebuliser des liquides
DE19953317C1 (de) * 1999-11-05 2001-02-01 Pari Gmbh Inhalationsvernebler

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19902847C1 (de) * 1999-01-20 2000-05-18 Kendall Med Erzeugnisse Gmbh Medikamentenvernebler zur Inhalationsbehandlung mit kombiniertem Ein-/Ausatmungsventil

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5813401A (en) * 1996-10-15 1998-09-29 Radcliff; Janet H. Nebulizer automatic control valve
WO2000012161A1 (fr) * 1998-08-26 2000-03-09 Otto Schill Gmbh & Co. Kg Inhalateur pour nebuliser des liquides
DE19953317C1 (de) * 1999-11-05 2001-02-01 Pari Gmbh Inhalationsvernebler

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005032630A1 (fr) * 2003-10-02 2005-04-14 Pari GmbH Spezialisten für effektive Inhalation Dispositif de traitement pas inhalation comportant une soupape
US9119930B2 (en) 2003-10-02 2015-09-01 Pari GmbH Spezialisten für effektive Inhalation Inhalation therapy device comprising a valve
US20090025714A1 (en) * 2007-07-24 2009-01-29 Denyer Jonathan S H Drug Delivery Apparatus and Method
WO2009013501A1 (fr) * 2007-07-24 2009-01-29 Respironics Respiratory Drug Delivery (Uk) Ltd. Appareil et procédé d'administration de médicament
CN101754781B (zh) * 2007-07-24 2013-07-17 伟康呼吸药物递送（英国）有限公司 药物递送的装置和方法
US8875697B2 (en) * 2007-07-24 2014-11-04 Ric Investments, Llc Drug delivery apparatus and method
WO2021023522A1 (fr) * 2019-08-02 2021-02-11 Stamford Devices Limited Administration buccale d'aérosol
US11045434B1 (en) 2020-04-01 2021-06-29 UNION therapeutics A/S Niclosamide formulations for treating disease
WO2021198116A1 (fr) 2020-04-01 2021-10-07 UNION therapeutics A/S Formulation
WO2021198115A1 (fr) 2020-04-01 2021-10-07 UNION therapeutics A/S Traitement
US11324708B1 (en) 2020-04-01 2022-05-10 UNION therapeutics A/S Niclosamide formulations for treating disease

Also Published As

Publication number Publication date
DE10251865B3 (de) 2004-05-13

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