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WO2003107000A3 - Ermittlung der wechselwirkung zwischen c-reaktivem protein und an c-reaktives protein bindenden komponenten - Google Patents

Ermittlung der wechselwirkung zwischen c-reaktivem protein und an c-reaktives protein bindenden komponenten Download PDF

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Publication number
WO2003107000A3
WO2003107000A3 PCT/EP2003/006038 EP0306038W WO03107000A3 WO 2003107000 A3 WO2003107000 A3 WO 2003107000A3 EP 0306038 W EP0306038 W EP 0306038W WO 03107000 A3 WO03107000 A3 WO 03107000A3
Authority
WO
WIPO (PCT)
Prior art keywords
reactive protein
interaction
hts
determining
high throughput
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/006038
Other languages
English (en)
French (fr)
Other versions
WO2003107000A2 (de
Inventor
Aimo Kannt
Antje Pommereau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to JP2004513768A priority Critical patent/JP2005529348A/ja
Priority to MXPA04012232A priority patent/MXPA04012232A/es
Priority to EP03759923A priority patent/EP1516187A2/de
Priority to BR0311709-0A priority patent/BR0311709A/pt
Priority to CA002489021A priority patent/CA2489021A1/en
Priority to AU2003250344A priority patent/AU2003250344A1/en
Publication of WO2003107000A2 publication Critical patent/WO2003107000A2/de
Publication of WO2003107000A3 publication Critical patent/WO2003107000A3/de
Anticipated expiration legal-status Critical
Priority to NO20050037A priority patent/NO20050037L/no
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4737—C-reactive protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Die vorliegende Erfindung betrifft ein HTS-fähiges Verfahren und Testsystem zur Ermittlung der Wechselwirkung zwischen C-reaktivem Protein (CRP) bzw. C1q und an CRP bzw. C1q bindenden Komponenten, zur Konzentrationsbestimmung einer CRP- bzw. C1q-haltigen Lösung sowie zur Ermittlung von Substanzen, die die Interaktion von CRP bzw. Clq und an dieses bindende Komponenten, insbesondere die Wechselwirkung zwischen CRP und C1q, beeinflussen.
PCT/EP2003/006038 2002-06-12 2003-06-10 Hts-fähiges verfahren und testsystem zur ermittlung der wechselwirkung zwischen c-reaktivem protein und an c-reaktives protein bindenden komponenten Ceased WO2003107000A2 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2004513768A JP2005529348A (ja) 2002-06-12 2003-06-10 Ｃ−反応性タンパク質と、ｃ−反応性タンパク質に結合する成分との相互作用を測定するための、ｈｔｓ可能な方法および試験システム
MXPA04012232A MXPA04012232A (es) 2002-06-12 2003-06-10 Metodo con capacidad hts y sistema de ensayo para la determinacion de la interaccion entre la proteina c-reactiva y los componentes unidos a la proteina c-reactiva.
EP03759923A EP1516187A2 (de) 2002-06-12 2003-06-10 Hts-f higes verfahren und testsystem zur ermittlung der wech selwirkung zwischen c-reaktivem protein und an c-reaktives protein bindenden komponenten
BR0311709-0A BR0311709A (pt) 2002-06-12 2003-06-10 Processo capaz de hts e sistema de teste para a determinação da interação entre proteìna reativa com relação ao c e componentes que se ligam à proteìna reativa com relação ao c
CA002489021A CA2489021A1 (en) 2002-06-12 2003-06-10 Determining the interaction between a c-reactive protein and constituents that bind to a c-reactive protein
AU2003250344A AU2003250344A1 (en) 2002-06-12 2003-06-10 Determining the interaction between a C-reactive protein and constituents that bind to a C-reactive protein
NO20050037A NO20050037L (no) 2002-06-12 2005-01-04 Fremgangsmate som er i stand til HTS og testsystem for a bestemme interaksjonen mellom et C-reaktivt protein og komponenter som binder til et C-reaktivt protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10226011A DE10226011A1 (de) 2002-06-12 2002-06-12 HTS-fähiges Verfahren und Testsystem zur Ermittlung der Wechselwirkung zwischen c-reaktivem Protein und an C-reaktives Protein bindenden Komponenten
DE10226011.7 2002-06-12

Publications (2)

Publication Number Publication Date
WO2003107000A2 WO2003107000A2 (de) 2003-12-24
WO2003107000A3 true WO2003107000A3 (de) 2004-05-27

Family

ID=29718976

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/006038 Ceased WO2003107000A2 (de) 2002-06-12 2003-06-10 Hts-fähiges verfahren und testsystem zur ermittlung der wechselwirkung zwischen c-reaktivem protein und an c-reaktives protein bindenden komponenten

Country Status (14)

Country Link
EP (1) EP1516187A2 (de)
JP (1) JP2005529348A (de)
CN (1) CN1745300A (de)
AR (1) AR040259A1 (de)
AU (1) AU2003250344A1 (de)
BR (1) BR0311709A (de)
CA (1) CA2489021A1 (de)
DE (1) DE10226011A1 (de)
MX (1) MXPA04012232A (de)
NO (1) NO20050037L (de)
RU (1) RU2005100042A (de)
TW (1) TW200411179A (de)
WO (1) WO2003107000A2 (de)
ZA (1) ZA200409199B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102721813A (zh) * 2012-07-09 2012-10-10 沃克(天津)生物科技有限公司 前列腺特异抗原均相发光免疫分析检测试剂盒及其检测方法
CN103852465A (zh) * 2012-11-30 2014-06-11 通用电气公司 检测标记蛋白的方法和装置
CA3000584A1 (en) * 2015-10-02 2017-04-27 Tgr Biosciences Pty Ltd. Analyte detection with multiple substrates
CN107976535B (zh) * 2017-11-03 2020-03-20 科美诊断技术股份有限公司 一种检测样本中目标IgM抗体的均相免疫检测试剂盒及其使用方法和应用
CN109752332A (zh) * 2017-11-07 2019-05-14 重庆中元汇吉生物技术有限公司 一种补体C1q检测试剂盒
CN108445216B (zh) * 2018-02-11 2021-10-15 科美诊断技术股份有限公司 一种人抗缪勒氏管激素测定试剂盒及其制备方法与应用
CN108169497A (zh) * 2018-02-11 2018-06-15 北京科美生物技术有限公司 人泌乳素检测试剂盒及其制备方法与应用
CN108445239B (zh) * 2018-02-11 2021-11-02 科美诊断技术股份有限公司 检测β人绒毛膜促性腺激素的均相免疫检测试剂套装及其制备方法和应用
CN108445238A (zh) * 2018-02-11 2018-08-24 北京科美生物技术有限公司 检测促黄体生成素的均相免疫检测试剂套装及其制备方法和应用
CN108490194A (zh) * 2018-02-11 2018-09-04 北京科美生物技术有限公司 检测卵泡刺激素的均相免疫检测试剂套装及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009628A1 (en) * 1988-04-04 1989-10-19 Potempa Lawrence A Binding of immune complexes by modified forms of c-reactive protein
US6140490A (en) * 1996-02-01 2000-10-31 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of complement system proteins
US5283238A (en) * 1992-04-24 1994-02-01 Immtech International, Inc. Methods of treating cancer using modified C-reactive protein
CA2170873A1 (en) * 1993-09-03 1995-03-09 Dariush Davalian Fluorescent oxygen channeling immunoassays
US6303325B1 (en) * 1998-05-29 2001-10-16 Dade Behring Inc. Method for detecting analytes

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"AlphascreenTM", PERKINELMER, 2003, XP002272309 *
AGRAWAL A ET AL: "Topology and structure of the C1q-binding site on C-reactive protein.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD.: 1950) UNITED STATES 15 MAR 2001, vol. 166, no. 6, 15 March 2001 (2001-03-15), pages 3998 - 4004, XP002272307, ISSN: 0022-1767 *
GLICKMAN J FRASER ET AL: "A comparison of ALPHAScreen, TR-FRET, and TRF as assay methods for FXR nuclear receptors", JOURNAL OF BIOMOLECULAR SCREENING, vol. 7, no. 1, February 2002 (2002-02-01), pages 3 - 10, XP008028213, ISSN: 1087-0571 *
GREPIN C ET AL: "High-throughput screening. Evolution of homogeneous time resolved fluorescence (HTRF) technology for HTS", DRUG DISCOVERY TODAY 01 MAY 2000 UNITED KINGDOM, vol. 5, no. 5, 1 May 2000 (2000-05-01), pages 212 - 214, XP002272308, ISSN: 1359-6446 *
JIANG H ET AL: "Binding and complement activation by C-reactive protein via the collagen-like region of C1q and inhibition of these reactions by monoclonal antibodies to C-reactive protein and C1q", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 146, no. 7, 1 April 1991 (1991-04-01), pages 2324 - 2330, XP002251585, ISSN: 0022-1767 *
SEETHALA R.: "Homogeneous assays", HANDBOOK OF DRUG SCREENING MARCEL DEKKER PUB., - 2001, pages 106 - 128, XP008028242 *

Also Published As

Publication number Publication date
WO2003107000A2 (de) 2003-12-24
TW200411179A (en) 2004-07-01
MXPA04012232A (es) 2005-02-25
EP1516187A2 (de) 2005-03-23
RU2005100042A (ru) 2006-07-20
AU2003250344A1 (en) 2003-12-31
BR0311709A (pt) 2005-03-15
NO20050037L (no) 2005-01-04
CN1745300A (zh) 2006-03-08
JP2005529348A (ja) 2005-09-29
AR040259A1 (es) 2005-03-23
ZA200409199B (en) 2005-05-18
CA2489021A1 (en) 2003-12-24
DE10226011A1 (de) 2004-01-08

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