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WO2003107000A3 - HIGH THROUGHPUT SCREENING METHOD (HTS) AND TEST SYSTEM FOR DETERMINING THE INTERACTION BETWEEN C-REACTIVE PROTEIN AND C-REACTIVE PROTEIN BINDING COMPONENTS - Google Patents

HIGH THROUGHPUT SCREENING METHOD (HTS) AND TEST SYSTEM FOR DETERMINING THE INTERACTION BETWEEN C-REACTIVE PROTEIN AND C-REACTIVE PROTEIN BINDING COMPONENTS Download PDF

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Publication number
WO2003107000A3
WO2003107000A3 PCT/EP2003/006038 EP0306038W WO03107000A3 WO 2003107000 A3 WO2003107000 A3 WO 2003107000A3 EP 0306038 W EP0306038 W EP 0306038W WO 03107000 A3 WO03107000 A3 WO 03107000A3
Authority
WO
WIPO (PCT)
Prior art keywords
reactive protein
interaction
hts
determining
high throughput
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/006038
Other languages
German (de)
French (fr)
Other versions
WO2003107000A2 (en
Inventor
Aimo Kannt
Antje Pommereau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to JP2004513768A priority Critical patent/JP2005529348A/en
Priority to MXPA04012232A priority patent/MXPA04012232A/en
Priority to EP03759923A priority patent/EP1516187A2/en
Priority to BR0311709-0A priority patent/BR0311709A/en
Priority to CA002489021A priority patent/CA2489021A1/en
Priority to AU2003250344A priority patent/AU2003250344A1/en
Publication of WO2003107000A2 publication Critical patent/WO2003107000A2/en
Publication of WO2003107000A3 publication Critical patent/WO2003107000A3/en
Anticipated expiration legal-status Critical
Priority to NO20050037A priority patent/NO20050037L/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4737—C-reactive protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un procédé de criblage à haut débit (HTS) ainsi qu'un système d'essai permettant de déterminer l'interaction entre la protéine C-réactive (CRP) ou la C1q et des composants se liant à la CRP ou à la C1q, de déterminer la concentration d'une solution en CRP ou en C1q, ainsi que de déterminer des substances qui influent sur l'interaction entre la CRP ou la C1q et des composants se liant à la CRP ou à la C1q, en particulier sur l'interaction entre la CRP et la C1q.A high throughput screening (HTS) method and assay system for determining the interaction between C-reactive protein (CRP) or C1q and components binding to CRP or C1q, to determine the concentration of a solution in CRP or C1q, as well as to determine substances which influence the interaction between CRP or C1q and components binding to CRP or C1q, in particular on the interaction between CRP and C1q.

PCT/EP2003/006038 2002-06-12 2003-06-10 Hts-capable method and testing system for determining the interaction between a c-reactive protein and constituents that bind to a c-reactive protein Ceased WO2003107000A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2004513768A JP2005529348A (en) 2002-06-12 2003-06-10 HTS capable method and test system for measuring the interaction between C-reactive protein and components binding to C-reactive protein
MXPA04012232A MXPA04012232A (en) 2002-06-12 2003-06-10 Hts-capable method and testing system for determining the interaction between a c-reactive protein and constituents that bind to a c-reactive protein.
EP03759923A EP1516187A2 (en) 2002-06-12 2003-06-10 Hts-capable method and testing system for determining the interaction between a c-reactive protein and constituents that bind to a c-reactive protein
BR0311709-0A BR0311709A (en) 2002-06-12 2003-06-10 Process capable of hts and test system for determining the interaction between c-reactive protein and c-reactive protein binding components
CA002489021A CA2489021A1 (en) 2002-06-12 2003-06-10 Determining the interaction between a c-reactive protein and constituents that bind to a c-reactive protein
AU2003250344A AU2003250344A1 (en) 2002-06-12 2003-06-10 Determining the interaction between a C-reactive protein and constituents that bind to a C-reactive protein
NO20050037A NO20050037L (en) 2002-06-12 2005-01-04 Method capable of HTS and test system to determine the interaction between a C-reactive protein and components that bind to a C-reactive protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10226011A DE10226011A1 (en) 2002-06-12 2002-06-12 HTS-capable method and test system for determining the interaction between c-reactive protein and components that bind to C-reactive protein
DE10226011.7 2002-06-12

Publications (2)

Publication Number Publication Date
WO2003107000A2 WO2003107000A2 (en) 2003-12-24
WO2003107000A3 true WO2003107000A3 (en) 2004-05-27

Family

ID=29718976

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/006038 Ceased WO2003107000A2 (en) 2002-06-12 2003-06-10 Hts-capable method and testing system for determining the interaction between a c-reactive protein and constituents that bind to a c-reactive protein

Country Status (14)

Country Link
EP (1) EP1516187A2 (en)
JP (1) JP2005529348A (en)
CN (1) CN1745300A (en)
AR (1) AR040259A1 (en)
AU (1) AU2003250344A1 (en)
BR (1) BR0311709A (en)
CA (1) CA2489021A1 (en)
DE (1) DE10226011A1 (en)
MX (1) MXPA04012232A (en)
NO (1) NO20050037L (en)
RU (1) RU2005100042A (en)
TW (1) TW200411179A (en)
WO (1) WO2003107000A2 (en)
ZA (1) ZA200409199B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102721813A (en) * 2012-07-09 2012-10-10 沃克(天津)生物科技有限公司 Homogeneous luminous immunoassay assay kit for prostate specific antigen and detection method therefor
CN103852465A (en) * 2012-11-30 2014-06-11 通用电气公司 Method and apparatus for detecting marker protein
CA3000584A1 (en) * 2015-10-02 2017-04-27 Tgr Biosciences Pty Ltd. Analyte detection with multiple substrates
CN107976535B (en) * 2017-11-03 2020-03-20 科美诊断技术股份有限公司 Homogeneous immunoassay kit for detecting target IgM antibody in sample and use method and application thereof
CN109752332A (en) * 2017-11-07 2019-05-14 重庆中元汇吉生物技术有限公司 A kind of C1Q detection kit
CN108445216B (en) * 2018-02-11 2021-10-15 科美诊断技术股份有限公司 Human anti-mullerian hormone determination kit and preparation method and application thereof
CN108169497A (en) * 2018-02-11 2018-06-15 北京科美生物技术有限公司 Human prolactin detection kit and preparation method and application
CN108445239B (en) * 2018-02-11 2021-11-02 科美诊断技术股份有限公司 Homogeneous phase immunoassay reagent kit for detecting beta human chorionic gonadotropin, and preparation method and application thereof
CN108445238A (en) * 2018-02-11 2018-08-24 北京科美生物技术有限公司 Detect the homogeneous immunological detection reagent suit and its preparation method and application of interstitialcellstimulating hormone (ICSH)
CN108490194A (en) * 2018-02-11 2018-09-04 北京科美生物技术有限公司 Detect the homogeneous immunological detection reagent suit and its preparation method and application of follicular stimulating hormone

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989009628A1 (en) * 1988-04-04 1989-10-19 Potempa Lawrence A Binding of immune complexes by modified forms of c-reactive protein
US6140490A (en) * 1996-02-01 2000-10-31 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of complement system proteins
US5283238A (en) * 1992-04-24 1994-02-01 Immtech International, Inc. Methods of treating cancer using modified C-reactive protein
CA2170873A1 (en) * 1993-09-03 1995-03-09 Dariush Davalian Fluorescent oxygen channeling immunoassays
US6303325B1 (en) * 1998-05-29 2001-10-16 Dade Behring Inc. Method for detecting analytes

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"AlphascreenTM", PERKINELMER, 2003, XP002272309 *
AGRAWAL A ET AL: "Topology and structure of the C1q-binding site on C-reactive protein.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD.: 1950) UNITED STATES 15 MAR 2001, vol. 166, no. 6, 15 March 2001 (2001-03-15), pages 3998 - 4004, XP002272307, ISSN: 0022-1767 *
GLICKMAN J FRASER ET AL: "A comparison of ALPHAScreen, TR-FRET, and TRF as assay methods for FXR nuclear receptors", JOURNAL OF BIOMOLECULAR SCREENING, vol. 7, no. 1, February 2002 (2002-02-01), pages 3 - 10, XP008028213, ISSN: 1087-0571 *
GREPIN C ET AL: "High-throughput screening. Evolution of homogeneous time resolved fluorescence (HTRF) technology for HTS", DRUG DISCOVERY TODAY 01 MAY 2000 UNITED KINGDOM, vol. 5, no. 5, 1 May 2000 (2000-05-01), pages 212 - 214, XP002272308, ISSN: 1359-6446 *
JIANG H ET AL: "Binding and complement activation by C-reactive protein via the collagen-like region of C1q and inhibition of these reactions by monoclonal antibodies to C-reactive protein and C1q", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 146, no. 7, 1 April 1991 (1991-04-01), pages 2324 - 2330, XP002251585, ISSN: 0022-1767 *
SEETHALA R.: "Homogeneous assays", HANDBOOK OF DRUG SCREENING MARCEL DEKKER PUB., - 2001, pages 106 - 128, XP008028242 *

Also Published As

Publication number Publication date
WO2003107000A2 (en) 2003-12-24
TW200411179A (en) 2004-07-01
MXPA04012232A (en) 2005-02-25
EP1516187A2 (en) 2005-03-23
RU2005100042A (en) 2006-07-20
AU2003250344A1 (en) 2003-12-31
BR0311709A (en) 2005-03-15
NO20050037L (en) 2005-01-04
CN1745300A (en) 2006-03-08
JP2005529348A (en) 2005-09-29
AR040259A1 (en) 2005-03-23
ZA200409199B (en) 2005-05-18
CA2489021A1 (en) 2003-12-24
DE10226011A1 (en) 2004-01-08

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