TW200411179A - HTS-capable method and assay system for determining the interaction between C-reactive protein and components binding to C-reactive protein - Google Patents
HTS-capable method and assay system for determining the interaction between C-reactive protein and components binding to C-reactive protein Download PDFInfo
- Publication number
- TW200411179A TW200411179A TW092115617A TW92115617A TW200411179A TW 200411179 A TW200411179 A TW 200411179A TW 092115617 A TW092115617 A TW 092115617A TW 92115617 A TW92115617 A TW 92115617A TW 200411179 A TW200411179 A TW 200411179A
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- TW
- Taiwan
- Prior art keywords
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- component
- components
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- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 69
- 238000009739 binding Methods 0.000 title claims abstract description 44
- 230000027455 binding Effects 0.000 title claims abstract description 30
- 230000003993 interaction Effects 0.000 title claims abstract description 15
- 108010074051 C-Reactive Protein Proteins 0.000 title abstract description 78
- 102100032752 C-reactive protein Human genes 0.000 title abstract description 78
- 238000003556 assay Methods 0.000 title abstract 2
- 239000000126 substance Substances 0.000 claims abstract description 27
- 150000001875 compounds Chemical class 0.000 claims description 67
- 108020003175 receptors Proteins 0.000 claims description 41
- 238000004458 analytical method Methods 0.000 claims description 15
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 11
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- 238000012216 screening Methods 0.000 description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
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- 208000010496 Heart Arrest Diseases 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- 101000958041 Homo sapiens Musculin Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229910052778 Plutonium Inorganic materials 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
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- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
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- 210000004369 blood Anatomy 0.000 description 1
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- 238000004925 denaturation Methods 0.000 description 1
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- 238000000502 dialysis Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- 150000004676 glycans Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
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- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 102000046949 human MSC Human genes 0.000 description 1
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- 230000007124 immune defense Effects 0.000 description 1
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- OYEHPCDNVJXUIW-UHFFFAOYSA-N plutonium atom Chemical compound [Pu] OYEHPCDNVJXUIW-UHFFFAOYSA-N 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
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- 238000000159 protein binding assay Methods 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
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- 229910052717 sulfur Inorganic materials 0.000 description 1
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- 230000000451 tissue damage Effects 0.000 description 1
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- 229940071559 trioxin Drugs 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4737—C-reactive protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10226011A DE10226011A1 (de) | 2002-06-12 | 2002-06-12 | HTS-fähiges Verfahren und Testsystem zur Ermittlung der Wechselwirkung zwischen c-reaktivem Protein und an C-reaktives Protein bindenden Komponenten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200411179A true TW200411179A (en) | 2004-07-01 |
Family
ID=29718976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW092115617A TW200411179A (en) | 2002-06-12 | 2003-06-10 | HTS-capable method and assay system for determining the interaction between C-reactive protein and components binding to C-reactive protein |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1516187A2 (de) |
| JP (1) | JP2005529348A (de) |
| CN (1) | CN1745300A (de) |
| AR (1) | AR040259A1 (de) |
| AU (1) | AU2003250344A1 (de) |
| BR (1) | BR0311709A (de) |
| CA (1) | CA2489021A1 (de) |
| DE (1) | DE10226011A1 (de) |
| MX (1) | MXPA04012232A (de) |
| NO (1) | NO20050037L (de) |
| RU (1) | RU2005100042A (de) |
| TW (1) | TW200411179A (de) |
| WO (1) | WO2003107000A2 (de) |
| ZA (1) | ZA200409199B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102721813A (zh) * | 2012-07-09 | 2012-10-10 | 沃克(天津)生物科技有限公司 | 前列腺特异抗原均相发光免疫分析检测试剂盒及其检测方法 |
| CN103852465A (zh) * | 2012-11-30 | 2014-06-11 | 通用电气公司 | 检测标记蛋白的方法和装置 |
| AU2016341539A1 (en) * | 2015-10-02 | 2018-04-26 | Tgr Biosciences Pty Ltd. | Analyte detection with multiple substrates |
| CN107976535B (zh) * | 2017-11-03 | 2020-03-20 | 科美诊断技术股份有限公司 | 一种检测样本中目标IgM抗体的均相免疫检测试剂盒及其使用方法和应用 |
| CN109752332A (zh) * | 2017-11-07 | 2019-05-14 | 重庆中元汇吉生物技术有限公司 | 一种补体C1q检测试剂盒 |
| CN108169497A (zh) * | 2018-02-11 | 2018-06-15 | 北京科美生物技术有限公司 | 人泌乳素检测试剂盒及其制备方法与应用 |
| CN108445239B (zh) * | 2018-02-11 | 2021-11-02 | 科美诊断技术股份有限公司 | 检测β人绒毛膜促性腺激素的均相免疫检测试剂套装及其制备方法和应用 |
| CN108490194A (zh) * | 2018-02-11 | 2018-09-04 | 北京科美生物技术有限公司 | 检测卵泡刺激素的均相免疫检测试剂套装及其制备方法和应用 |
| CN108445238A (zh) * | 2018-02-11 | 2018-08-24 | 北京科美生物技术有限公司 | 检测促黄体生成素的均相免疫检测试剂套装及其制备方法和应用 |
| CN108445216B (zh) * | 2018-02-11 | 2021-10-15 | 科美诊断技术股份有限公司 | 一种人抗缪勒氏管激素测定试剂盒及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0411017B1 (de) * | 1988-04-04 | 1996-03-06 | POTEMPA, Lawrence A. | Bindung von immunkomplexen durch modifizierte formen von c-reaktiven proteinen |
| US6140490A (en) * | 1996-02-01 | 2000-10-31 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands of complement system proteins |
| US5283238A (en) * | 1992-04-24 | 1994-02-01 | Immtech International, Inc. | Methods of treating cancer using modified C-reactive protein |
| JP3498960B2 (ja) * | 1993-09-03 | 2004-02-23 | デイド・ベーリング・マルブルク・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 蛍光酸素チャンネリングイムノアッセイ |
| US6303325B1 (en) * | 1998-05-29 | 2001-10-16 | Dade Behring Inc. | Method for detecting analytes |
-
2002
- 2002-06-12 DE DE10226011A patent/DE10226011A1/de not_active Withdrawn
-
2003
- 2003-06-10 BR BR0311709-0A patent/BR0311709A/pt not_active IP Right Cessation
- 2003-06-10 MX MXPA04012232A patent/MXPA04012232A/es not_active Application Discontinuation
- 2003-06-10 CA CA002489021A patent/CA2489021A1/en not_active Abandoned
- 2003-06-10 EP EP03759923A patent/EP1516187A2/de not_active Withdrawn
- 2003-06-10 CN CNA03813442XA patent/CN1745300A/zh active Pending
- 2003-06-10 TW TW092115617A patent/TW200411179A/zh unknown
- 2003-06-10 AR ARP030102067A patent/AR040259A1/es unknown
- 2003-06-10 WO PCT/EP2003/006038 patent/WO2003107000A2/de not_active Ceased
- 2003-06-10 RU RU2005100042/15A patent/RU2005100042A/ru not_active Application Discontinuation
- 2003-06-10 JP JP2004513768A patent/JP2005529348A/ja active Pending
- 2003-06-10 AU AU2003250344A patent/AU2003250344A1/en not_active Abandoned
-
2004
- 2004-11-17 ZA ZA200409199A patent/ZA200409199B/en unknown
-
2005
- 2005-01-04 NO NO20050037A patent/NO20050037L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005529348A (ja) | 2005-09-29 |
| WO2003107000A3 (de) | 2004-05-27 |
| WO2003107000A2 (de) | 2003-12-24 |
| AU2003250344A1 (en) | 2003-12-31 |
| BR0311709A (pt) | 2005-03-15 |
| AR040259A1 (es) | 2005-03-23 |
| RU2005100042A (ru) | 2006-07-20 |
| NO20050037L (no) | 2005-01-04 |
| DE10226011A1 (de) | 2004-01-08 |
| CN1745300A (zh) | 2006-03-08 |
| ZA200409199B (en) | 2005-05-18 |
| MXPA04012232A (es) | 2005-02-25 |
| EP1516187A2 (de) | 2005-03-23 |
| CA2489021A1 (en) | 2003-12-24 |
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