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WO2003030793A1 - Gel nasal hydratant et applicateur - Google Patents

Gel nasal hydratant et applicateur Download PDF

Info

Publication number
WO2003030793A1
WO2003030793A1 PCT/US2002/032606 US0232606W WO03030793A1 WO 2003030793 A1 WO2003030793 A1 WO 2003030793A1 US 0232606 W US0232606 W US 0232606W WO 03030793 A1 WO03030793 A1 WO 03030793A1
Authority
WO
WIPO (PCT)
Prior art keywords
gel
nasal
hydrating
centipoise
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/032606
Other languages
English (en)
Inventor
Jeffrey J. Fisher
Gustav R. Fenton
M. W. Anderson
Richard E. Reever
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CNS Inc
Original Assignee
CNS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CNS Inc filed Critical CNS Inc
Priority to CA002463384A priority Critical patent/CA2463384A1/fr
Priority to MXPA04003359A priority patent/MXPA04003359A/es
Priority to EP02769063A priority patent/EP1450739A4/fr
Priority to JP2003533828A priority patent/JP2005505587A/ja
Publication of WO2003030793A1 publication Critical patent/WO2003030793A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants

Definitions

  • FIG. 2 is a side view of one embodiment of the nasal gel applicator of the present invention.
  • the Brookfield viscometer is fitted with a number 4 spindle operating at 10 rpm, and at the higher end of the range, the Brookfield viscometer is fitted with a TE heliopathic spindle operating at 0.3 rpm.
  • the hydrating nasal gel of the present invention includes a controlled-release agent that physically or chemically entrains, retains or entraps water, so that moisture will be progressively released over a substantial period of time. If water is released too quickly, the product will be ineffective. If the water is released too slowly, the hydrating nasal gel will be ineffective in providing moisture to the nasal tissues. Water should preferably be released from the entraining or water binding agent at such a rate that it maintains moisture in the environment of the nasal cavity and/or in the nasal linings or tissues for a substantial period of time.
  • a hydrating nasal gel was prepared according to the formula shown in Table II. Table II

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Cette invention concerne un gel nasal hydratant exerçant un effet apaisant sur la muqueuse de la cavité nasale. Ce gel, qui reste pendant un laps de temps prolongé dans la cavité nasale, atténue la sécheresse des tissus provoquées par un état pathologique ou par un milieu ambiant très sec. Le gel peut être appliqué sur les tissus intra-nasaux au moyen de l'embout d'un applicateur, ceci sensiblement sans contact avec les voies nasales.
PCT/US2002/032606 2001-10-12 2002-10-11 Gel nasal hydratant et applicateur Ceased WO2003030793A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002463384A CA2463384A1 (fr) 2001-10-12 2002-10-11 Gel nasal hydratant et applicateur
MXPA04003359A MXPA04003359A (es) 2001-10-12 2002-10-11 Gel nasal hidratante y dispositivo aplicador.
EP02769063A EP1450739A4 (fr) 2001-10-12 2002-10-11 Gel nasal hydratant et applicateur
JP2003533828A JP2005505587A (ja) 2001-10-12 2002-10-11 含水性の点鼻ゲル及びその塗布装置

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32912201P 2001-10-12 2001-10-12
US32912301P 2001-10-12 2001-10-12
US60/329,122 2001-10-12
US60/329,123 2001-10-12

Publications (1)

Publication Number Publication Date
WO2003030793A1 true WO2003030793A1 (fr) 2003-04-17

Family

ID=26986653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/032606 Ceased WO2003030793A1 (fr) 2001-10-12 2002-10-11 Gel nasal hydratant et applicateur

Country Status (5)

Country Link
EP (1) EP1450739A4 (fr)
JP (1) JP2005505587A (fr)
CA (1) CA2463384A1 (fr)
MX (1) MXPA04003359A (fr)
WO (1) WO2003030793A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6949262B1 (en) 2003-05-27 2005-09-27 Lousal Enterprises, Inc. Skin and mucosal treatment formulation
GB2431874A (en) * 2005-11-03 2007-05-09 Cst Medical Ltd Lubricant
WO2009104966A1 (fr) * 2008-02-20 2009-08-27 Cornelis Boegem Onguent destiné pour la protection des muqueuses contre des substances allergènes présentes dans l'air, utilisation de l'onguent et applicateur pour l'onguent
CN106727277A (zh) * 2015-11-22 2017-05-31 中国人民解放军第三军医大学 一种含薄荷脑的鼻腔原位凝胶喷雾剂及其制备方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130045958A1 (en) 2011-05-13 2013-02-21 Trimel Pharmaceuticals Corporation Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US9757388B2 (en) 2011-05-13 2017-09-12 Acerus Pharmaceuticals Srl Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
US20130040923A1 (en) 2011-05-13 2013-02-14 Trimel Pharmaceuticals Corporation Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
AU2012257490A1 (en) * 2011-05-15 2013-12-19 Acerus Pharmaceuticals Srl Intranasal testosterone bio-adhesive gel formulations and use thereof for treating male hypogonadism
US11744838B2 (en) 2013-03-15 2023-09-05 Acerus Biopharma Inc. Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4781923A (en) * 1987-07-20 1988-11-01 Pellico Michael A Antiseptic gels
WO1992019275A2 (fr) * 1991-05-04 1992-11-12 The Procter & Gamble_Company Compositions cosmetiques

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863725A (en) * 1982-10-27 1989-09-05 Deckner George E Novel clear oil-free moisturizer composition
GB2133691B (en) * 1983-01-21 1986-05-21 Leo Ab Smoking substitutes for nasal administration
US4724231A (en) * 1985-04-16 1988-02-09 Nastech Pharmaceutical, Inc. Nasel compositions containing vitamin B12
JP2510052B2 (ja) * 1989-10-31 1996-06-26 コロンビア ラボラトリーズ インコーポレイテッド 組織与湿組成物及び方法
IL101056A (en) * 1992-02-24 1997-03-18 Res & Dev Co Ltd Composition for nasal treatment
FR2694189B1 (fr) * 1992-07-30 1994-09-02 Sederma Sa Nouvelle méthode destinée à augmenter la viscosité des compositions cosmétiques.
GB9218834D0 (en) * 1992-09-05 1992-10-21 Procter & Gamble Nasal spray products
GB9324250D0 (en) * 1993-11-25 1994-01-12 Minnesota Mining & Mfg Inhaler
FR2744919B1 (fr) * 1996-02-21 1998-03-27 Stoa Sa Nouvelles compositions pour le traitement et la protection des mamelles des animaux de traite
JPH09253208A (ja) * 1996-03-21 1997-09-30 Unisia Jecs Corp 鼻腔用投薬器
JPH11511180A (ja) * 1996-06-12 1999-09-28 ストア ソシエテ アノニマ 化粧品のための物理的殺菌用ゲル
US5989535A (en) * 1997-08-15 1999-11-23 Soma Technologies Polymeric bioadhesive emulsions and suspensions and methods of treatment
US6080783A (en) * 1998-09-01 2000-06-27 Gum Tech International, Inc. Method and composition for delivering zinc to the nasal membrane
WO2000044432A1 (fr) * 1999-01-27 2000-08-03 Levin Bruce H Compositions, kits, appareil et methodes d'inhibition des troubles cerebraux neurovasculaires et des cephalees musculaires
DE19961307A1 (de) * 1999-12-18 2001-07-12 Krewel Meuselbach Gmbh Medizinprodukt zur Befeuchtung und Reinigung der Nasenschleimhaut
WO2001070270A2 (fr) * 2000-03-23 2001-09-27 Collaborative Technologies, Inc. Compositions de base servant a preparer des compositions topiques exemptes de tensioactif

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4781923A (en) * 1987-07-20 1988-11-01 Pellico Michael A Antiseptic gels
WO1992019275A2 (fr) * 1991-05-04 1992-11-12 The Procter & Gamble_Company Compositions cosmetiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1450739A4 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6949262B1 (en) 2003-05-27 2005-09-27 Lousal Enterprises, Inc. Skin and mucosal treatment formulation
GB2431874A (en) * 2005-11-03 2007-05-09 Cst Medical Ltd Lubricant
WO2009104966A1 (fr) * 2008-02-20 2009-08-27 Cornelis Boegem Onguent destiné pour la protection des muqueuses contre des substances allergènes présentes dans l'air, utilisation de l'onguent et applicateur pour l'onguent
NL2002550C2 (nl) * 2008-02-20 2010-05-26 Cornelis Boegem Balsem voor het afdekken van slijmvliezen tegen in de lucht aanwezige allergene stoffen, het gebruik van de balsem en een applicator voor de balsem.
CN106727277A (zh) * 2015-11-22 2017-05-31 中国人民解放军第三军医大学 一种含薄荷脑的鼻腔原位凝胶喷雾剂及其制备方法

Also Published As

Publication number Publication date
EP1450739A4 (fr) 2008-12-17
MXPA04003359A (es) 2004-11-29
CA2463384A1 (fr) 2003-04-17
EP1450739A1 (fr) 2004-09-01
JP2005505587A (ja) 2005-02-24

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