CA2463384A1 - Gel nasal hydratant et applicateur - Google Patents
Gel nasal hydratant et applicateur Download PDFInfo
- Publication number
- CA2463384A1 CA2463384A1 CA002463384A CA2463384A CA2463384A1 CA 2463384 A1 CA2463384 A1 CA 2463384A1 CA 002463384 A CA002463384 A CA 002463384A CA 2463384 A CA2463384 A CA 2463384A CA 2463384 A1 CA2463384 A1 CA 2463384A1
- Authority
- CA
- Canada
- Prior art keywords
- gel
- nasal
- hydrating
- centipoise
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940100652 nasal gel Drugs 0.000 title claims abstract description 52
- 230000000887 hydrating effect Effects 0.000 title claims abstract description 42
- 210000003928 nasal cavity Anatomy 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 36
- 239000003795 chemical substances by application Substances 0.000 claims description 29
- 239000004615 ingredient Substances 0.000 claims description 17
- 238000013270 controlled release Methods 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 230000009974 thixotropic effect Effects 0.000 claims description 7
- 239000003755 preservative agent Substances 0.000 claims description 6
- 239000003205 fragrance Substances 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003906 humectant Substances 0.000 claims description 4
- 229920000193 polymethacrylate Polymers 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 2
- 241000723346 Cinnamomum camphora Species 0.000 claims description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 2
- 244000166124 Eucalyptus globulus Species 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- 229960000846 camphor Drugs 0.000 claims description 2
- 229930008380 camphor Natural products 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- 239000006049 herbal material Substances 0.000 claims description 2
- 229940041616 menthol Drugs 0.000 claims description 2
- 239000003607 modifier Substances 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims 2
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims 1
- 206010025482 malaise Diseases 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 45
- 230000006870 function Effects 0.000 description 12
- 230000004580 weight loss Effects 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 210000001331 nose Anatomy 0.000 description 6
- 230000002335 preservative effect Effects 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- -1 polyethylene Polymers 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 231100000344 non-irritating Toxicity 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 206010052437 Nasal discomfort Diseases 0.000 description 1
- 206010028740 Nasal dryness Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 230000001632 homeopathic effect Effects 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 206010041232 sneezing Diseases 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cette invention concerne un gel nasal hydratant exerçant un effet apaisant sur la muqueuse de la cavité nasale. Ce gel, qui reste pendant un laps de temps prolongé dans la cavité nasale, atténue la sécheresse des tissus provoquées par un état pathologique ou par un milieu ambiant très sec. Le gel peut être appliqué sur les tissus intra-nasaux au moyen de l'embout d'un applicateur, ceci sensiblement sans contact avec les voies nasales.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32912301P | 2001-10-12 | 2001-10-12 | |
| US32912201P | 2001-10-12 | 2001-10-12 | |
| US60/329,122 | 2001-10-12 | ||
| US60/329,123 | 2001-10-12 | ||
| PCT/US2002/032606 WO2003030793A1 (fr) | 2001-10-12 | 2002-10-11 | Gel nasal hydratant et applicateur |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2463384A1 true CA2463384A1 (fr) | 2003-04-17 |
Family
ID=26986653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002463384A Abandoned CA2463384A1 (fr) | 2001-10-12 | 2002-10-11 | Gel nasal hydratant et applicateur |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1450739A4 (fr) |
| JP (1) | JP2005505587A (fr) |
| CA (1) | CA2463384A1 (fr) |
| MX (1) | MXPA04003359A (fr) |
| WO (1) | WO2003030793A1 (fr) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
| US10111888B2 (en) | 2011-05-13 | 2018-10-30 | Acerus Biopharma Inc. | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| US10668084B2 (en) | 2011-05-13 | 2020-06-02 | Acerus Biopharma Inc. | Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| US11090312B2 (en) | 2013-03-15 | 2021-08-17 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testerosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
| EP2709588B1 (fr) * | 2011-05-15 | 2021-08-25 | Acerus Biopharma Inc. | Gels nasaux de testostérone à libération prolongée, méthodes associées et systèmes applicateurs multi-doses pré-remplis destinés à une administration pernasale |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6949262B1 (en) | 2003-05-27 | 2005-09-27 | Lousal Enterprises, Inc. | Skin and mucosal treatment formulation |
| GB2431874A (en) * | 2005-11-03 | 2007-05-09 | Cst Medical Ltd | Lubricant |
| NL2001342C2 (nl) * | 2008-02-20 | 2009-08-24 | Cornelis Boegem | Balsem voor het afdekken van slijmvliezen tegen in de lucht aanwezige allergene stoffen, het gebruik van de balsem en een applicator voor de balsem. |
| CN106727277A (zh) * | 2015-11-22 | 2017-05-31 | 中国人民解放军第三军医大学 | 一种含薄荷脑的鼻腔原位凝胶喷雾剂及其制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863725A (en) * | 1982-10-27 | 1989-09-05 | Deckner George E | Novel clear oil-free moisturizer composition |
| GB2133691B (en) * | 1983-01-21 | 1986-05-21 | Leo Ab | Smoking substitutes for nasal administration |
| US4724231A (en) * | 1985-04-16 | 1988-02-09 | Nastech Pharmaceutical, Inc. | Nasel compositions containing vitamin B12 |
| US4781923A (en) * | 1987-07-20 | 1988-11-01 | Pellico Michael A | Antiseptic gels |
| BR9007807A (pt) * | 1989-10-31 | 1992-09-29 | Columbia Lab Inc | Composicao e metodo para umedecimento de tecido |
| GB9109775D0 (en) * | 1991-05-04 | 1991-06-26 | Procter & Gamble | Cosmetic compositions |
| IL101056A (en) * | 1992-02-24 | 1997-03-18 | Res & Dev Co Ltd | Composition for nasal treatment |
| FR2694189B1 (fr) * | 1992-07-30 | 1994-09-02 | Sederma Sa | Nouvelle méthode destinée à augmenter la viscosité des compositions cosmétiques. |
| GB9218834D0 (en) * | 1992-09-05 | 1992-10-21 | Procter & Gamble | Nasal spray products |
| GB9324250D0 (en) * | 1993-11-25 | 1994-01-12 | Minnesota Mining & Mfg | Inhaler |
| FR2744919B1 (fr) * | 1996-02-21 | 1998-03-27 | Stoa Sa | Nouvelles compositions pour le traitement et la protection des mamelles des animaux de traite |
| JPH09253208A (ja) * | 1996-03-21 | 1997-09-30 | Unisia Jecs Corp | 鼻腔用投薬器 |
| EP0843556A1 (fr) * | 1996-06-12 | 1998-05-27 | Stoa S.A. | Compositions pharmaceutiques a base de gels de type glyceryl poly(meth)acrylate |
| US6491940B1 (en) * | 1999-01-27 | 2002-12-10 | Bruce H. Levin | Apparatus for administering composition for inhibiting cerebral neurovascular disorders and muscular headaches |
| US5989535A (en) * | 1997-08-15 | 1999-11-23 | Soma Technologies | Polymeric bioadhesive emulsions and suspensions and methods of treatment |
| US6080783A (en) * | 1998-09-01 | 2000-06-27 | Gum Tech International, Inc. | Method and composition for delivering zinc to the nasal membrane |
| DE19961307A1 (de) * | 1999-12-18 | 2001-07-12 | Krewel Meuselbach Gmbh | Medizinprodukt zur Befeuchtung und Reinigung der Nasenschleimhaut |
| AU4594601A (en) * | 2000-03-23 | 2001-10-03 | Collaborative Technologies Inc | Base compositions for preparing surfactant free topical compositions |
-
2002
- 2002-10-11 JP JP2003533828A patent/JP2005505587A/ja active Pending
- 2002-10-11 EP EP02769063A patent/EP1450739A4/fr not_active Withdrawn
- 2002-10-11 WO PCT/US2002/032606 patent/WO2003030793A1/fr not_active Ceased
- 2002-10-11 MX MXPA04003359A patent/MXPA04003359A/es unknown
- 2002-10-11 CA CA002463384A patent/CA2463384A1/fr not_active Abandoned
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
| US10111888B2 (en) | 2011-05-13 | 2018-10-30 | Acerus Biopharma Inc. | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| US10668084B2 (en) | 2011-05-13 | 2020-06-02 | Acerus Biopharma Inc. | Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
| EP2709588B1 (fr) * | 2011-05-15 | 2021-08-25 | Acerus Biopharma Inc. | Gels nasaux de testostérone à libération prolongée, méthodes associées et systèmes applicateurs multi-doses pré-remplis destinés à une administration pernasale |
| US11090312B2 (en) | 2013-03-15 | 2021-08-17 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testerosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
| US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005505587A (ja) | 2005-02-24 |
| EP1450739A4 (fr) | 2008-12-17 |
| EP1450739A1 (fr) | 2004-09-01 |
| MXPA04003359A (es) | 2004-11-29 |
| WO2003030793A1 (fr) | 2003-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |