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WO2003016331A3 - Non-mammalian gnrh analogs and uses thereof in regulation of fertility and pregnancy - Google Patents

Non-mammalian gnrh analogs and uses thereof in regulation of fertility and pregnancy Download PDF

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Publication number
WO2003016331A3
WO2003016331A3 PCT/US2002/025619 US0225619W WO03016331A3 WO 2003016331 A3 WO2003016331 A3 WO 2003016331A3 US 0225619 W US0225619 W US 0225619W WO 03016331 A3 WO03016331 A3 WO 03016331A3
Authority
WO
WIPO (PCT)
Prior art keywords
gnrh
analogs
mammalian
aza
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/025619
Other languages
French (fr)
Other versions
WO2003016331A2 (en
Inventor
Theresa M Siler-Khodr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU2002355954A priority Critical patent/AU2002355954A1/en
Publication of WO2003016331A2 publication Critical patent/WO2003016331A2/en
Publication of WO2003016331A3 publication Critical patent/WO2003016331A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Specially designed non-mammalian GnRH analog decapeptides resistant to degradation by the placental enzyme, C-ase-1, or a post-proline peptidase, are disclosed. The GnRH analogs are further defined as analogs of chicken II GnRH or salmon GnRH. These non-mammalian analogs incorporate D-arginine, D-leucine, D-tBu-Serine or D-Trp at position 6 and ethylamide or aza-Gly-amide at position 10. The D-Arg (6) chicken II GnRH ethylamide, D-Arg (6) chicken II GnRH-aza-Gly (10)-amide, the D-Arg(6) salmon GnRH ethylamide, and D-Arg(6) salmon GnRH-aza-Gly (10)-amide analogs are also provided. And demonstrate preferential binding to chorionic GnRH receptor that is greater relative to the binding of these analogs to pituitary GnRH receptor. These non-mammalian GnRH analogs may be used in pharmaceutical preparation, and specifically in various treatment methods as a contraceptive or post-coital contraceptive agent. The non-mammalian GnRH analogs are also provided in pharmaceutical preparations that may be used clinically for maintaining pregnancy when used in very low doses and administered in pulsatile fashion. In another aspect, the non-mammalian GnRH analogs may be used a luteolytic agents. The aza-Gly (10) amide non-mammalian analogs are yet other embodiments of the non-mammalian GnRH analogs provided as a part of the invention.
PCT/US2002/025619 2001-08-17 2002-08-13 Non-mammalian gnrh analogs and uses thereof in regulation of fertility and pregnancy Ceased WO2003016331A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002355954A AU2002355954A1 (en) 2001-08-17 2002-08-13 Non-mammalian gnrh analogs and uses thereof in regulation of fertility and pregnancy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93214901A 2001-08-17 2001-08-17
US09/932,149 2001-08-17

Publications (2)

Publication Number Publication Date
WO2003016331A2 WO2003016331A2 (en) 2003-02-27
WO2003016331A3 true WO2003016331A3 (en) 2003-11-20

Family

ID=25461854

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/025619 Ceased WO2003016331A2 (en) 2001-08-17 2002-08-13 Non-mammalian gnrh analogs and uses thereof in regulation of fertility and pregnancy

Country Status (2)

Country Link
AU (1) AU2002355954A1 (en)
WO (1) WO2003016331A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050043245A1 (en) * 2003-08-11 2005-02-24 Siler -Khodr Theresa M. Non-mammalian GnRH analogs and uses thereof in the immune system
EP1605962A1 (en) * 2003-08-12 2005-12-21 Theresa M. Siler-Khodr Non-mammalian gnrh analogs and uses thereof in regulation of fertility and pregnancy
US20050054576A1 (en) * 2003-08-12 2005-03-10 Siler-Khodr Theresa M. Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410514A (en) * 1982-12-06 1983-10-18 The Salk Institute For Biological Studies GnRH Agonists
GB2152059A (en) * 1983-12-23 1985-07-31 Koezponti Valto Hitelbank Gonadoliberin derivatives
GB2237571A (en) * 1989-11-01 1991-05-08 Robert Peter Millar Gonadotropin releasing hormone analogues

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410514A (en) * 1982-12-06 1983-10-18 The Salk Institute For Biological Studies GnRH Agonists
GB2152059A (en) * 1983-12-23 1985-07-31 Koezponti Valto Hitelbank Gonadoliberin derivatives
GB2237571A (en) * 1989-11-01 1991-05-08 Robert Peter Millar Gonadotropin releasing hormone analogues

Also Published As

Publication number Publication date
AU2002355954A1 (en) 2003-03-03
WO2003016331A2 (en) 2003-02-27

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