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WO2003074716A3 - Verfahren zur herstellung von ungesättigten fettsäuren - Google Patents

Verfahren zur herstellung von ungesättigten fettsäuren Download PDF

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Publication number
WO2003074716A3
WO2003074716A3 PCT/EP2003/002011 EP0302011W WO03074716A3 WO 2003074716 A3 WO2003074716 A3 WO 2003074716A3 EP 0302011 W EP0302011 W EP 0302011W WO 03074716 A3 WO03074716 A3 WO 03074716A3
Authority
WO
WIPO (PCT)
Prior art keywords
fatty acids
unsaturated fatty
production
methods
transgenic expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/002011
Other languages
English (en)
French (fr)
Other versions
WO2003074716A2 (de
Inventor
Andreas Renz
Martijn Gipmans
Ivo Feussner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Plant Science GmbH
Original Assignee
BASF Plant Science GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF Plant Science GmbH filed Critical BASF Plant Science GmbH
Priority to AU2003208769A priority Critical patent/AU2003208769A1/en
Publication of WO2003074716A2 publication Critical patent/WO2003074716A2/de
Publication of WO2003074716A3 publication Critical patent/WO2003074716A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Fats And Perfumes (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Die Erfindung betrifft Verfahren zur Herstellung von ungesättig­ten Fettsäuren, bevorzugt von konjugierten mehrfach-ungesättigten Fettsäuren wie konjugierter Linolsäure (CLA) durch transgenen Ex­pression von Desaturasen aus Insekten der Ordnung Lepidoptera. Erfindungsgemäss sind ferner transgene Expressionskassetten zur transgenen Expression von Desaturasen aus Insekten der Ordnung Lepidoptera, sowie die mit diesen transformierten transgene Orga­nismen.
PCT/EP2003/002011 2002-03-01 2003-02-27 Verfahren zur herstellung von ungesättigten fettsäuren Ceased WO2003074716A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003208769A AU2003208769A1 (en) 2002-03-01 2003-02-27 Methods for the production of unsaturated fatty acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10208812A DE10208812A1 (de) 2002-03-01 2002-03-01 Verfahren zur Herstellung von ungesättigten Fettsäuren
DE10208812.8 2002-03-01

Publications (2)

Publication Number Publication Date
WO2003074716A2 WO2003074716A2 (de) 2003-09-12
WO2003074716A3 true WO2003074716A3 (de) 2003-12-24

Family

ID=27740519

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2003/002011 Ceased WO2003074716A2 (de) 2002-03-01 2003-02-27 Verfahren zur herstellung von ungesättigten fettsäuren
PCT/US2003/005788 Ceased WO2003074715A2 (en) 2002-03-01 2003-02-27 Process for the production of unsaturated fatty acids

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2003/005788 Ceased WO2003074715A2 (en) 2002-03-01 2003-02-27 Process for the production of unsaturated fatty acids

Country Status (8)

Country Link
EP (1) EP1527182A4 (de)
JP (1) JP2006503546A (de)
CN (1) CN1656226A (de)
AU (2) AU2003208769A1 (de)
BR (1) BR0307938A (de)
CA (1) CA2477858A1 (de)
DE (1) DE10208812A1 (de)
WO (2) WO2003074716A2 (de)

Families Citing this family (22)

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JP4567047B2 (ja) * 2004-02-27 2010-10-20 ビーエーエスエフ プラント サイエンス ゲーエムベーハー トランスジェニック植物における多価不飽和脂肪酸の製造方法
DE102005052551A1 (de) * 2005-11-02 2007-05-16 Rothamsted Res Harpenden Verfahren zur Herstellung von y-Linolensäure und/oder Stearidonsäure in transgenen Brassicaceae und Linaceae
CA2628703C (en) 2005-11-30 2019-10-29 Abbott Laboratories Anti-a.beta. globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
DK1976877T4 (en) 2005-11-30 2017-01-16 Abbvie Inc Monoclonal antibodies to amyloid beta protein and uses thereof
EP2522735A3 (de) * 2006-10-20 2013-02-13 Arizona Board Of Regents For And On Behalf Arizona State University Modifizierte Cyanobakterien
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
ES2629854T3 (es) * 2008-12-01 2017-08-16 Universität des Saarlandes Producción de ácidos grasos omega-3 por mixobacterias
JP5168511B2 (ja) * 2009-08-25 2013-03-21 独立行政法人農業生物資源研究所 種子特異的プロモーターおよびその利用
CN104744591B (zh) 2010-04-15 2022-09-27 Abbvie德国有限责任两合公司 β淀粉样蛋白结合蛋白
US11236351B2 (en) 2010-05-17 2022-02-01 Dow Agrosciences Llc Production of DHA and other LC PUFAs in plants
WO2012024187A1 (en) 2010-08-14 2012-02-23 Abbott Laboratories Amyloid-beta binding proteins
TW201307553A (zh) 2011-07-26 2013-02-16 Dow Agrosciences Llc 在植物中生產二十二碳六烯酸（ｄｈａ）及其他長鏈多元不飽和脂肪酸（ｌｃ－ｐｕｆａ）之技術
KR101540746B1 (ko) * 2011-12-28 2015-08-03 대한민국 공액리놀레산(Ｃｏｎｊｕｇａｔｅｄ Ｌｉｎｏｌｅｉｃ Ａｃｉｄ, ＣＬＡ)의 생산방법
ES2789823T3 (es) 2015-06-26 2020-10-26 Univ Danmarks Tekniske Procedimiento de producción de feromonas de polilla en levadura
DK3376859T3 (da) 2015-11-18 2021-03-29 Provivi Inc Mikroorganismer til fremstilling af insektferomoner og relaterede forbindelser
US11214818B2 (en) 2016-06-06 2022-01-04 Provivi, Inc. Semi-biosynthetic production of fatty alcohols and fatty aldehydes
EP3555269B1 (de) 2016-12-16 2022-08-31 Danmarks Tekniske Universitet Herstellung von entsättigten fettalkoholen und entsättigte fettsäureacylacetate in hefe
EP3916087A1 (de) 2016-12-16 2021-12-01 Danmarks Tekniske Universitet Verfahren zur herstellung von fettalkoholen und derivaten davon in hefe
CN110914442B (zh) 2017-05-17 2025-02-18 普罗维维股份有限公司 用于产生昆虫信息素及相关化合物的微生物
EP3521439A1 (de) * 2018-01-31 2019-08-07 Commissariat à l'Energie Atomique et aux Energies Alternatives Verfahren zur herstellung von triacylglyceriden und fettsäuren
IL293960A (en) * 2019-12-20 2022-08-01 Biophero Aps Yeast cells and methods for production of e8,e10-dodecadienyl coenzyme a, codlemone and derivatives thereof
CN116064266B (zh) * 2022-11-01 2024-06-14 四川大学 盐胁迫抗性增强的重组酿酒酵母菌及其构建方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018320A1 (en) * 1995-11-14 1997-05-22 Loders Croklaan B.V. Process for the preparation of materials with a high content of long chain polyunsaturated fatty acids
WO1999047135A1 (en) * 1998-03-17 1999-09-23 Conlinco, Inc. Conjugated linoleic acid compositions
WO2001000846A2 (en) * 1999-06-30 2001-01-04 Dcv, Inc. D.B.A Bio-Technical Resources Linoleate isomerase

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Publication number Priority date Publication date Assignee Title
US5876994A (en) * 1995-11-16 1999-03-02 Cornell Research Foundation, Inc. Pheromone desaturases
CA2263794A1 (en) * 1997-05-05 1998-11-12 Dow Agrosciences Llc Insecticidal protein toxins from xenorhabdus
AU4564399A (en) * 1998-06-12 1999-12-30 Abbott Laboratories Polyunsaturated fatty acids in plants
WO2000011012A1 (en) * 1998-08-24 2000-03-02 Rutgers, The State University Of New Jersey Synthetic fatty acid desaturase gene for expression in plants
EP1190080A1 (de) * 1999-07-06 2002-03-27 BASF Plant Science GmbH $g(D)6-DESATURASEGENE EXPRIMIERENDE PFLANZEN UND PUFAS ENTHALTENDE ÖLE AUS DIESEN PFLANZEN UND EIN VERFAHREN ZUR HERSTELLUNG UNGESÄTTIGTER FETTSÄUREN
AU2001263473A1 (en) * 2000-05-26 2001-12-11 Washington State University Research Foundation Palmitate desaturase gene

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018320A1 (en) * 1995-11-14 1997-05-22 Loders Croklaan B.V. Process for the preparation of materials with a high content of long chain polyunsaturated fatty acids
WO1999047135A1 (en) * 1998-03-17 1999-09-23 Conlinco, Inc. Conjugated linoleic acid compositions
WO2001000846A2 (en) * 1999-06-30 2001-01-04 Dcv, Inc. D.B.A Bio-Technical Resources Linoleate isomerase

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CAHOON EDGAR B ET AL: "Formation of conjugated DELTA8,DELTA10-double bonds by DELTA12-oleic-acid desaturase-related enzymes. Biosynthetic origin of calendic acid.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 4, 26 January 2001 (2001-01-26), pages 2637 - 2643, XP002252846, ISSN: 0021-9258 *
CAHOON EDGAR B ET AL: "Production of fatty acid components of meadowfoam oil in somatic soybean embryos.", PLANT PHYSIOLOGY (ROCKVILLE), vol. 124, no. 1, September 2000 (2000-09-01), pages 243 - 251, XP002252847, ISSN: 0032-0889 *
FRITSCHE KATHRIN ET AL: "Isolation and characterization of a calendic acid producing (8,11)-linoleoyl desaturase.", FEBS LETTERS, vol. 462, no. 3, 3 December 1999 (1999-12-03), pages 249 - 253, XP002252849, ISSN: 0014-5793 *
KNIPPLE DOUGLAS C ET AL: "Cloning and functional expression of a cDNA encoding a pheromone gland-specific acyl-CoA DELTA11-desaturase of the cabbage looper moth, Trichoplusia ni.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 26, 22 December 1998 (1998-12-22), Dec. 22, 1998, pages 15287 - 15292, XP002252850, ISSN: 0027-8424 *
LIU WEITIAN ET AL: "Gene characterized for membrane desaturase that produces (E)-11 isomers of mono- and diunsaturated fatty acids.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 99, no. 2, 22 January 2002 (2002-01-22), http://www.pnas.org January 22, 2002, pages 620 - 624, XP002252845, ISSN: 0027-8424 *
QIU XIAO ET AL: "Identification and analysis of a gene from Calendula officinalis encoding a fatty acid conjugase.", PLANT PHYSIOLOGY (ROCKVILLE), vol. 125, no. 2, February 2001 (2001-02-01), pages 847 - 855, XP002252848, ISSN: 0032-0889 *

Also Published As

Publication number Publication date
EP1527182A2 (de) 2005-05-04
BR0307938A (pt) 2005-01-11
AU2003219899A1 (en) 2003-09-16
WO2003074715A3 (en) 2004-04-29
EP1527182A4 (de) 2005-12-21
CN1656226A (zh) 2005-08-17
DE10208812A1 (de) 2003-09-11
WO2003074716A2 (de) 2003-09-12
AU2003208769A1 (en) 2003-09-16
AU2003208769A8 (en) 2003-09-16
CA2477858A1 (en) 2003-09-12
JP2006503546A (ja) 2006-02-02
WO2003074715A2 (en) 2003-09-12

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