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WO2002026732A1 - Benzodiazepine derivative - Google Patents

Benzodiazepine derivative Download PDF

Info

Publication number
WO2002026732A1
WO2002026732A1 PCT/JP2001/008352 JP0108352W WO0226732A1 WO 2002026732 A1 WO2002026732 A1 WO 2002026732A1 JP 0108352 W JP0108352 W JP 0108352W WO 0226732 A1 WO0226732 A1 WO 0226732A1
Authority
WO
WIPO (PCT)
Prior art keywords
benzodiazepine derivative
blood coagulation
coagulation factor
activated blood
remedy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2001/008352
Other languages
English (en)
French (fr)
Inventor
Tadakiyo Nakagawa
Munetaka Tokumasu
Kazumi Tashiro
Mitsuo Takahashi
Takashi Kayahara
Shunji Takehana
Yuki Kajigaya
Kaoru Yoshida
Kuniya Sakurai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU0303074A priority Critical patent/HUP0303074A3/hu
Priority to KR10-2003-7004458A priority patent/KR20030031196A/ko
Priority to SK363-2003A priority patent/SK3632003A3/sk
Priority to AU9224101A priority patent/AU9224101A/xx
Priority to EP01972490A priority patent/EP1329450A4/en
Priority to CA002423902A priority patent/CA2423902A1/en
Priority to MXPA03002649A priority patent/MXPA03002649A/es
Priority to AU2001292241A priority patent/AU2001292241B2/en
Priority to JP2002531116A priority patent/JPWO2002026732A1/ja
Priority to IL15503501A priority patent/IL155035A0/xx
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to BR0114276-3A priority patent/BR0114276A/pt
Publication of WO2002026732A1 publication Critical patent/WO2002026732A1/ja
Priority to NO20031354A priority patent/NO20031354L/no
Priority to US10/397,219 priority patent/US6825191B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/JP2001/008352 2000-09-27 2001-09-26 Benzodiazepine derivative Ceased WO2002026732A1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP2002531116A JPWO2002026732A1 (ja) 2000-09-27 2001-09-26 ベンゾジアゼピン誘導体
SK363-2003A SK3632003A3 (en) 2000-09-27 2001-09-26 Benzodiazepine derivatives, pharmaceutical composition comprising same and their use
AU9224101A AU9224101A (en) 2000-09-27 2001-09-26 Benzodiazepine derivative
EP01972490A EP1329450A4 (en) 2000-09-27 2001-09-26 BENZODIAZEPINE DERIVATIVE
CA002423902A CA2423902A1 (en) 2000-09-27 2001-09-26 Benzodiazepine derivative
MXPA03002649A MXPA03002649A (es) 2000-09-27 2001-09-26 Derivado de benzodiazepina.
AU2001292241A AU2001292241B2 (en) 2000-09-27 2001-09-26 Benzodiazepine derivative
HU0303074A HUP0303074A3 (en) 2000-09-27 2001-09-26 Benzodiazepine derivatives and pharmaceutical compositions them
KR10-2003-7004458A KR20030031196A (ko) 2000-09-27 2001-09-26 벤조디아제핀 유도체
IL15503501A IL155035A0 (en) 2000-09-27 2001-09-26 Benzodiazepine derivatives
BR0114276-3A BR0114276A (pt) 2000-09-27 2001-09-26 Derivados de benzodiazepina ou sais destes farmaceuticamente aceitáveis, agente para inibir o fator x de coagulação do sangue ativado, composição farmacêutica, e, inibidor da coagulação sanguìnea ou um agente para prevenir ou tratar a trombose ou o embolismo
NO20031354A NO20031354L (no) 2000-09-27 2003-03-25 Benzodiazepinderivater
US10/397,219 US6825191B2 (en) 2000-09-27 2003-03-27 Benzodiazepine derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-294240 2000-09-27
JP2000294240 2000-09-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/397,219 Continuation US6825191B2 (en) 2000-09-27 2003-03-27 Benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
WO2002026732A1 true WO2002026732A1 (en) 2002-04-04

Family

ID=18776884

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/008352 Ceased WO2002026732A1 (en) 2000-09-27 2001-09-26 Benzodiazepine derivative

Country Status (18)

Country Link
US (1) US6825191B2 (ja)
EP (1) EP1329450A4 (ja)
JP (1) JPWO2002026732A1 (ja)
KR (1) KR20030031196A (ja)
CN (1) CN1476446A (ja)
AU (2) AU2001292241B2 (ja)
BR (1) BR0114276A (ja)
CA (1) CA2423902A1 (ja)
CZ (1) CZ2003893A3 (ja)
HU (1) HUP0303074A3 (ja)
IL (1) IL155035A0 (ja)
MX (1) MXPA03002649A (ja)
NO (1) NO20031354L (ja)
PL (1) PL362048A1 (ja)
RU (1) RU2003112257A (ja)
SK (1) SK3632003A3 (ja)
WO (1) WO2002026732A1 (ja)
ZA (1) ZA200302245B (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080603A1 (en) * 2002-03-27 2003-10-02 Ajinomoto Co.,Inc. Benzodiazepine derivative
WO2004056813A1 (ja) * 2002-12-19 2004-07-08 Ajinomoto Co.,Inc. ベンゾジアゼピン誘導体
US7786165B2 (en) 2004-03-15 2010-08-31 Takeda Pharmaceutical Company Limited Aminophenylpropanoic acid derivative
US8227506B2 (en) 2005-02-02 2012-07-24 Ajinomoto., Inc. Benzamidine compound
JP2018515597A (ja) * 2015-04-07 2018-06-14 イーエルエイ ファーマ リミテッドＥｌａ Ｐｈａｒｍａ Ｌｔｄ カテプシンｃおよび／またはｃｅｌａ１および／またはｃｅｌａ３ａおよび／またはそれらに構造的に関連する酵素を特異的に標的とする細胞および／または組織壊死の処置および／または防止のための組成物
CN109526220A (zh) * 2016-05-06 2019-03-26 埃斯特维制药股份公司 用于治疗疼痛和疼痛相关的状况的四氢嘧啶并二氮杂*和四氢吡啶并二氮杂*化合物
JP2020520924A (ja) * 2017-05-17 2020-07-16 デナリ セラピューティクス インコーポレイテッドＤｅｎａｌｉ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． キナーゼ阻害剤およびその使用
CN116348109A (zh) * 2020-09-17 2023-06-27 浙江海正药业股份有限公司 哌嗪类衍生物及其制备方法和用途

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2613458A1 (en) * 2005-07-12 2007-01-18 Acadia Pharmaceuticals Inc. Compounds with activity at retinoic acid receptors
EP2146722A4 (en) * 2007-05-10 2011-08-03 Amr Technology Inc ARYL AND HETEROARYL SUBSTITUTED TETRAHYDROBENZO-1,4-DIAZEPINES AND THEIR USE FOR BLOCKING THE RECOVERY OF NOREPINEPHRIN, DOPAMINE AND SEROTONINE
CN103889993B (zh) 2011-09-19 2017-05-31 吉奇亚公司 修饰的肌酸化合物
WO2024158698A1 (en) * 2023-01-23 2024-08-02 Lucy Therapeutics, Inc. Novel f-atpase hydrolase inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004057A1 (en) * 1993-07-29 1995-02-09 Genentech, Inc. TRICYCLIC INHIBITORS OF THE GPIIbIIIa RECEPTOR

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1290254A (zh) * 1998-02-05 2001-04-04 武田药品工业株式会社 氨磺酰衍生物及其制备和用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004057A1 (en) * 1993-07-29 1995-02-09 Genentech, Inc. TRICYCLIC INHIBITORS OF THE GPIIbIIIa RECEPTOR

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080603A1 (en) * 2002-03-27 2003-10-02 Ajinomoto Co.,Inc. Benzodiazepine derivative
WO2004056813A1 (ja) * 2002-12-19 2004-07-08 Ajinomoto Co.,Inc. ベンゾジアゼピン誘導体
US7786165B2 (en) 2004-03-15 2010-08-31 Takeda Pharmaceutical Company Limited Aminophenylpropanoic acid derivative
US8227506B2 (en) 2005-02-02 2012-07-24 Ajinomoto., Inc. Benzamidine compound
JP2018515597A (ja) * 2015-04-07 2018-06-14 イーエルエイ ファーマ リミテッドＥｌａ Ｐｈａｒｍａ Ｌｔｄ カテプシンｃおよび／またはｃｅｌａ１および／またはｃｅｌａ３ａおよび／またはそれらに構造的に関連する酵素を特異的に標的とする細胞および／または組織壊死の処置および／または防止のための組成物
CN109526220A (zh) * 2016-05-06 2019-03-26 埃斯特维制药股份公司 用于治疗疼痛和疼痛相关的状况的四氢嘧啶并二氮杂*和四氢吡啶并二氮杂*化合物
JP2020520924A (ja) * 2017-05-17 2020-07-16 デナリ セラピューティクス インコーポレイテッドＤｅｎａｌｉ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． キナーゼ阻害剤およびその使用
JP7064512B2 (ja) 2017-05-17 2022-05-10 デナリ セラピューティクス インコーポレイテッド キナーゼ阻害剤およびその使用
CN116348109A (zh) * 2020-09-17 2023-06-27 浙江海正药业股份有限公司 哌嗪类衍生物及其制备方法和用途

Also Published As

Publication number Publication date
ZA200302245B (en) 2004-03-23
EP1329450A1 (en) 2003-07-23
IL155035A0 (en) 2003-10-31
HUP0303074A2 (hu) 2003-12-29
JPWO2002026732A1 (ja) 2004-07-08
BR0114276A (pt) 2003-06-24
MXPA03002649A (es) 2003-09-25
NO20031354L (no) 2003-05-02
CN1476446A (zh) 2004-02-18
KR20030031196A (ko) 2003-04-18
NO20031354D0 (no) 2003-03-25
SK3632003A3 (en) 2003-09-11
US20030186969A1 (en) 2003-10-02
AU2001292241B2 (en) 2005-12-22
CA2423902A1 (en) 2003-03-26
CZ2003893A3 (cs) 2003-08-13
EP1329450A4 (en) 2005-08-31
AU9224101A (en) 2002-04-08
RU2003112257A (ru) 2004-10-27
PL362048A1 (en) 2004-10-18
US6825191B2 (en) 2004-11-30
HUP0303074A3 (en) 2007-08-28

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