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WO2002022189A1 - Pompe élastomère - Google Patents

Pompe élastomère Download PDF

Info

Publication number
WO2002022189A1
WO2002022189A1 PCT/ES2001/000333 ES0100333W WO0222189A1 WO 2002022189 A1 WO2002022189 A1 WO 2002022189A1 ES 0100333 W ES0100333 W ES 0100333W WO 0222189 A1 WO0222189 A1 WO 0222189A1
Authority
WO
WIPO (PCT)
Prior art keywords
component
elastomeric
inflatable balloon
elastomeric pump
pump according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2001/000333
Other languages
English (en)
Spanish (es)
Inventor
Jordi MARTÍN i LLORENS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leventon SA
Original Assignee
Leventon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leventon SA filed Critical Leventon SA
Priority to AU2001285957A priority Critical patent/AU2001285957A1/en
Publication of WO2002022189A1 publication Critical patent/WO2002022189A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/152Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs

Definitions

  • the invention relates to an elastomeric pump for the delivery of medications to a patient, comprising a reservoir, an inflatable balloon with a first end and a second end and defining an interior space, a valve, an anchoring zone next to said valve, said first end being mounted on said anchor zone, and said anchor zone defining a communication passage between said valve, said interior space of said inflatable balloon and an exit orifice, and fluid connection means between said balloon and said patient, wherein said reservoir has a hollow rod that extends into said reservoir.
  • Elastomeric pumps of the type indicated above are known. Certain diseases require the supply of medications on an ongoing basis for long periods of time (such as chemotherapy treatments, painkiller supplies, etc.). In these cases, the use of elastomeric pumps allows the patient to be given a high degree of mobility and independence, which may even allow him to remain at home while receiving the treatment.
  • the balloon is made of an elastomeric material in which the medicine is pressed under pressure. In some cases these balls can break or tear, with the consequent spillage of the medicine. Frequently these medications are very aggressive, so it is very important to avoid coming into contact with the skin of the patient and / or health personnel.
  • the ball is inside a tank, so that the medicine would remain inside the tank in the event of the ball breaking.
  • this deposit cannot be airtight, since during the delivery of the medication to the patient the balloon is deflated, and a depression would be generated inside the tank that would adversely affect the flow of medication being supplied. Therefore it is known to include in these tanks a membrane or filter that allows the passage of air but not of liquids.
  • these filters can never get wet, since once they are wet they are no longer permeable to air. This forces the patient to take extreme precautions to prevent the filter from getting wet.
  • the balloon is an elongated tube of elastomeric material that is fixed by each of its ends in a cylindrical projection present in the corresponding anchoring zone. Fixing is frequently done by means of a flange that presses the end of the tube against the cylindrical projection. This form of fixing is economical and allows sufficient sealing. However, a concentration of tensions is generated in the area of the tube next to the joint, which increases the amount of tears or tears of balls.
  • This improved design should reduce the risk that the skin of the patient and / or health personnel come into massive contact with the medicine in case of balloon rupture. Therefore the improved design should correct both the problem of possible exit of all the medication out of the tank, and / or reduce the risk of balloon ruptures.
  • an elastomeric pump of the type indicated at the beginning characterized in that: [a] it additionally comprises a cover, which is positioned on said rod, [b] said rod extends to approximately a central point of said tank, [ c] through said rod the passage of air between said reservoir and the outside is possible, and [d] said second end of the inflatable balloon is mounted on said cap.
  • the ends of the ball at two fixed points of the tank.
  • the medication when the medication is injected into the balloon, it deforms only transversely.
  • the balloon is deformed both transversely and longitudinally during the injection of the medication and, correspondingly, during the delivery of the medication.
  • the lid is suitable for sliding along the rod.
  • an air filter is housed inside the rod, which allows the passage of air while preventing the passage of liquids. This type of filters is known and, as already indicated above, it should be avoided that they get wet, since they cease to be permeable to air. Its accommodation inside the rod is particularly interesting, since it is extremely protected, which prevents it from accidentally getting wet.
  • the inflatable balloon is preferably an elongated tube, and advantageously has an annular flange at least one of its ends.
  • the annular flange allows reducing and / or compensating the effect produced by the concentration of stresses in the area near the flange, thereby reducing the risk of breakage or tearing.
  • fluid connection means extend that on one side are connected to the inside of the balloon, and, on the other hand, are connected to the patient's body, usually to some blood vessel of the patient.
  • These fluid connection means can be diverse, and contain various elements.
  • they comprise a first tube, connected to said outlet orifice, a particulate / air filter, connected to said first tube, and a connector.
  • the connector is standard and can be connected to any usual element, such as cannulas, catheters, needles, etc.
  • a flow regulator and a second tube are preferably added, connected to said particle / air filter and said flow regulator.
  • the flow regulator out of the tank allows direct contact with the patient's skin, allowing it to be kept at a much more constant temperature. In this way, the flow rate, which depends, among other things, on the viscosity of the medicine and, therefore, on the temperature, is regulated in a more stable way.
  • the purpose of the capillary tube is not to regulate the flow rate (function played by the flow regulator) but simply to physically separate the flow regulator from the connector.
  • the element that is partially inserted into the patient's blood vessel is less bulky, and the flow regulator is attached to the cnector via the capillary tube, which is flexible, and can be attached to the patient's skin at a point. close to the connector, but attached to it in a flexible way, which improves patient comfort.
  • the elastomeric pump may have an indicator of the volume of medication available.
  • Various solutions are possible, in particular, making use of the geometric variations that the ball experiences when deflating.
  • the lid is slidable along the rod
  • an extension that acts as a pointer and that moves with it.
  • the deposit can be transparent and can have a graduated scale marked, so that the pointer, which accompanies the end of the ball at all times in its longitudinal movement, indicates at any moment a position on the graduated scale that indicates the amount of volume of available medication.
  • the pointer is fixed in a different place, and even that it is drawn and / or marked on the outer surface of the ball itself. In any case, differences in balloon length can be appreciated and, therefore, the amount of available medication volume can be determined.
  • any magnitude related to it is indicated, such as times (both the time since the start of the supply and the time remaining until the end of the medication), capacity percentages , etc.
  • Fig. 1 a partially sectioned view of an elastomeric pump assembly.
  • Fig. 2 a view of a longitudinal section of an elastomeric pump, without fluid connection means, with the balloon deflated.
  • Fig. 3 a view of a longitudinal section of an elastomeric pump, without fluid connection means, with the balloon swollen.
  • Fig. 4 a cross-sectional view of a first component of a reservoir.
  • Fig. 5 a top plan view of the first component of a reservoir of Fig. 4.
  • Fig. 6 a top plan view of a second component of a tank.
  • Fig. 7 a view of a cross section, along the Vll-Vll line, of the second component of a reservoir of Fig. 6.
  • Fig. 8 a view of a cross section, according to line VIII-VIII, of the second component of a reservoir of Fig. 6.
  • Fig. 9, a bottom plan view of the second component of a reservoir of Fig. 6 .
  • Fig. 10 a top plan view of a balloon support.
  • Fig. 11 a view of a longitudinal section, along the line XI-XI, of the balloon support of Fig. 10.
  • Fig. 12 a bottom plan view of the balloon holder of Fig.
  • Fig. 13 a plan view of a lid.
  • Fig. 14 a view of a longitudinal section of the cover of Fig. 13.
  • Fig. 15 a view of a longitudinal section of a flange.
  • Figs. 16 and 17 views equivalent to those of Figs. 2 and 3, but in another embodiment of an elastomeric pump.
  • Fig. 18 a partial view of a longitudinal section of the anchor zone of an elastomeric pump with a flange different from that of Fig. 15.
  • FIG. 19 an elevation view of an inflatable balloon Fig. 20, a plan view of the inflatable balloon of Fig. 19
  • FIG. 21 an elevation view of the inflatable balloon of Fig. 19, inflated.
  • Fig. 22 a view of a longitudinal section of another inflatable balloon.
  • FIGs. 23 and 24 two views, partially sectioned, of two elastomeric pumps according to the invention, of different nominal capacities.
  • FIG. 1 An elastomeric pump according to the invention can be seen in Fig. 1.
  • a tank 1 houses inside an inflatable ball 3.
  • I is formed by two parts: a first component 5 and a second component 7, which are coupled together forming a substantially hollow cylindrical body.
  • the second component 7 has an anchor zone 9, with a balloon holder 10 in which a first end 11 of the inflatable balloon 3 is fixed.
  • the anchor zone 9 also has an inlet valve 13 through which it can introducing the medicine into an interior space 15 defined by the inflatable balloon 3.
  • the anchor zone 9 establishes a fluid communication between the interior space 15 of the inflatable balloon 3, the valve 13 and an outlet orifice 17.
  • the second component 7 also has an arc 19 which allows the tank 1 to be fixed to any suitable place.
  • the first component 5 has a hollow rod 21 extending into the first component 5. At its free end, the rod 21 has an outlet passage 23 that communicates the inside of the tank 1 with the outside.
  • the inflatable balloon 3 has, as already indicated, a first end
  • the cover 27 thus closes the inflatable balloon 3 by its second end 25, and in turn has a second hollow rod 29 that extends into the interior space 15 of the inflatable balloon 3, filling it mostly when the inflatable ball 3 is deflated.
  • the cover 27 can be mounted on the rod 21 of the first component 5, such that between the rod 21 and the second rod 29 the air can pass, which can thus circulate between the inside of the tank 1 and the outside, thanks to the passage of outlet 23.
  • the lid 27 can slide freely along the rod 21, so that the relative position between the lid 27 and the rod 21 varies depending on the amount of medicine present in the interior space 15.
  • the cover 27 shown in Figs. 1 to 3 has a volume indicator that basically consists of a ring 31, attached to the cover 27 through curved arms 33.
  • the ring 31 moves together with the cover 27.
  • the first component 5 of the tank 1 is of a transparent material and has a graduated scale, not shown in Figs., On its lateral surface.
  • the ring 31 at all times marks a position on the graduated scale that corresponds to the volume of medication that, at that moment, has the inflatable balloon in its inner space 3. That is, the ring 31 is like a extending the cover 27 to the lateral surface of the tank 1.
  • a cover 27 which has a slightly different volume indicator: the arms 33 have one end attached to the cover 27 and the other free end, that is, there is no ring that joins them together. .
  • the arms 33 have a certain flexibility, so that they tend to adopt a direction perpendicular to the axis of the tank 1, such that when introduced into the tank 1 they tend to be in contact with said tank 1.
  • the outlet orifice 17 is connected to a first tube 35, which in turn is connected to a particulate / air filter 37.
  • a clip 39 of conventional type, which makes it possible to throttle the First tube 35 in a sealed manner.
  • a second tube 41 which is extends to a flow regulator 43.
  • a third tube which is a flexible capillary tube 45.
  • the flexible capillary tube 45 extends to a conventional connector 47, to which any device that allows the introduction of the medicament into the human body, preferably in a blood vessel, such as a cannula, a catheter, a needle, can be attached. etc.
  • the capillary tube 45 is not to regulate the flow rate, but only to allow the assembly that is rigidly inserted into the patient's blood vessel to be as bulky as possible.
  • the rod 21 includes, at an intermediate point, an air filter 49, which allows the passage of air but prevents the passage of liquids. As can be seen in Fig. 1, the air filter 49 is in a very protected position, so it is highly unlikely that it will accidentally get wet.
  • the inflatable balloon 3 is a cylindrical tube of elastomeric material, with an annular flange 51 at each of its ends, as can be seen, for example, in Figs. 17 and 19 to 21.
  • the annular flange 51 basically consists of an end section of the tube having a wall thickness greater than the central part of the tube.
  • Each of the end sections is mounted on a cylindrical projection 53 disposed in the balloon holder 10 and in a cylindrical section 55 of the cover 27, respectively, and on the end section a flange 57 is mounted, as shown in Fig. 15, which presses the end section against the cylindrical projection 53 or the cylindrical section 55, establishing a tight seal.
  • Both the cylindrical projection 53 and the cylindrical section 55 may have a surface with a geometry that improves the seal.
  • the cylindrical projection 53 and the cylindrical section 55 have a serrated surface.
  • the flange 57 of Fig. 15 is substantially a ring that is capable of being mounted on the annular flange 51 of the inflatable balloon 3. It is possible to use any other type of fixation, provided that it is compatible with the invention. Thus, in Fig. 18 another type of flange 57 is shown. In this case, flange 57 is totally conventional and consists substantially of a head 63 with a hole and a serrated tail 65. The free end of tail 65 is introduced in the hole, in which there is an internal projection that allows the introduction of the tail 65 in a single direction, so that once the tail 65 is introduced it is no longer possible to extract it again. This flange 57 can be tightened on the annular flange 51 until a tight seal is achieved. The annular flange 51 may have additional reliefs, for example for a better positioning of this flange 57. It is also not necessary that the flanges 57 placed at the two ends of the inflatable balloon 3 be equal to each other.
  • the annular flange 51 can be external, that is, in such a way that the internal diameter of the balloon 3 is constant, or internal, that is, such that the external diameter of the balloon 3 is constant. It is also possible that the annular flange 51 is a combination of the above cases, so that the balloon 3 comprises a tubular central section of constant outer and inner diameter and annular flanges 51 where both the outer diameter and the inner diameter have variations.
  • a container is coupled with the medicament capable of subjecting the medicament to a certain pressure, for example a syringe, in the upper part of the pump, in which there is another conventional connector 67, conical in shape.
  • the pressure opens the valve 13, and the medicine is introduced into the inner space 15 of the inflatable balloon 3.
  • the pressure causes the balloon 3 to swell.
  • the balloon 3 also increases its length (although there are other technical solutions in which the length of the balloon 3 remains constant).
  • the cover 27 moves along the rod 21. The air dislodged by the balloon when it swells outwards through the exit passage 23.
  • the clip 39 is removed, and The medicine is pushed by the elastic force of the balloon 3 along an existing duct in the anchoring zone 9 to the outlet orifice 17 and, subsequently, through the first tube 35, the particulate / air filter 37 and the second tube 41 at a high speed, since the passage sections are relatively large. In this way, a large part of the circuit is purged quickly.
  • the medication reaches the flow regulator 43, the medication velocity is reduced to a flow rate close to the flow rate required for delivery to the patient.
  • the capillary tube 45 is of reduced length and therefore its filling is not excessively slow. In some cases it is convenient to take into account the loss of pressure that takes place in the various sections of the course of the medication, in order to calculate more accurately the loss of pressure needed in the flow regulator 43.
  • various elements of the elastomeric pump are manufactured by means of plastic injection technology.
  • the cover 27 is preferably manufactured by plastic injection technology.
  • the surfaces of the second rod 29 have a non-zero demolding angle, in order to facilitate the demolding of the injected part. Therefore, it is preferable that the second rod 29 has an intermediate section 69 whose outer surface is conical. This intermediate section 69 may be, in the extreme case, the entire second rod 29.
  • the inflatable balloon 3 has a central part 71 whose inner surface is also frustoconical.
  • This central part 71 can be, in an extreme case, the entire inflatable balloon 3. This reduces the amount of air housed inside the inflatable balloon 3 before being filled with the medicine, and reduces the amount of residual medicine that remains inside the inflatable balloon 3.
  • Fig. 22 an inflatable balloon 3 can be seen having a central part 71 whose inner surface is conical.
  • the central part 71 includes the second end 25.
  • Another advantage of the elastomeric pump according to the invention is that it is possible to manufacture elastomeric pumps of different nominal capacities while retaining most of the elements that form it. That is, only by changing some element can a pump of different capacity be obtained. This has obvious advantages of a productive and logistic type, by reducing the amount of different elements that must be manufactured.
  • Figs. 23 and 24 two elastomeric pumps according to the invention, of different nominal capacities have been represented (specifically, in the examples of Figs. 23 and 24 it is a 150 ml elastomeric pump and a 250 ml elastomeric pump, respectively).
  • the reservoir 1 of these elastomeric pumps is formed by a first component 5 and a second component 7, as already described in the previous examples.
  • These two elastomeric pumps have all the same elements, with the sole exception of the first component 5, which is specific for each elastomeric pump. Specifically, its length is shorter and the length of the rod 21 is also shorter.
  • the inflatable balloon 3 can be the same, since by introducing more liquid inside it will stretch more longitudinally, but will not significantly increase its diameter.
  • the inflatable balloon 3 of Fig. 22 is suitable to be mounted on both an elastomeric pump of 150 ml of nominal capacity and one of 250 ml of nominal capacity.
  • the second component 7 and the cover 27 are the same in both elastomeric pumps.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne une pompe élastomère destinée à l'administration de médicaments à un patient. Cette pompe comprend un dépôt, un ballonnet gonflable pourvu d'une première extrémité et d'une seconde extrémité et définissant un espace intérieur, une soupape et une zone d'ancrage située à proximité de ladite soupape, la première extrémité étant montée sur la zone d'ancrage, laquelle définit un passage de communication entre la soupape, l'espace intérieur du ballonnet gonflable et un orifice de sortie. Cette pompe comprend également un dispositif de communication fluidique entre le ballonnet et le patient. Le dépôt présente une tige creuse qui s'étend jusqu'à un point central du dépôt et à travers laquelle s'établit un passage d'air entre l'intérieur et l'extérieur du dépôt. Le dépôt comprend en outre un couvercle disposé sur la tige sur lequel est montée la seconde extrémité du ballonnet gonflable.
PCT/ES2001/000333 2000-09-07 2001-08-31 Pompe élastomère Ceased WO2002022189A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001285957A AU2001285957A1 (en) 2000-09-07 2001-08-31 Elastomeric pump

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200002195A ES2165820B1 (es) 2000-09-07 2000-09-07 Bomba elastomerica.
ESP200002195 2000-09-07

Publications (1)

Publication Number Publication Date
WO2002022189A1 true WO2002022189A1 (fr) 2002-03-21

Family

ID=8494870

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2001/000333 Ceased WO2002022189A1 (fr) 2000-09-07 2001-08-31 Pompe élastomère

Country Status (3)

Country Link
AU (1) AU2001285957A1 (fr)
ES (1) ES2165820B1 (fr)
WO (1) WO2002022189A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064897A1 (fr) * 2003-01-15 2004-08-05 I-Flow Corporation Ensemble d'etancheite pour pompe a perfusion elastomere
CN104001231A (zh) * 2014-05-15 2014-08-27 上海金塔医用器材有限公司 安全泵留置针
CN104998323A (zh) * 2015-07-20 2015-10-28 北京伏尔特技术有限公司 一种新型持续缓慢给液装置及其安装和使用方法
US11253644B2 (en) * 2017-02-20 2022-02-22 Avent, Inc. Bladder for an infusion assembly
EP4260889A1 (fr) 2022-04-13 2023-10-18 Centre national de la recherche scientifique Dispositif d éjection contrôlée d'une solution liquide

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9925333B2 (en) * 2013-06-18 2018-03-27 Enable Injections, Inc. Vial transfer and injection apparatus and method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3961725A (en) * 1974-04-09 1976-06-08 Clark Richard A Method and apparatus for dispensing fluids under pressure
EP0464761A1 (fr) * 1990-07-05 1992-01-08 Nissho Corporation Dispositif d'infusion de liquides
US5529214A (en) * 1994-08-12 1996-06-25 Secure Medical Products, Inc. Infusion pump
EP0885620A2 (fr) * 1997-06-19 1998-12-23 Young Gyu Lee Dispositif pour injecter des médicaments liquides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3961725A (en) * 1974-04-09 1976-06-08 Clark Richard A Method and apparatus for dispensing fluids under pressure
EP0464761A1 (fr) * 1990-07-05 1992-01-08 Nissho Corporation Dispositif d'infusion de liquides
US5529214A (en) * 1994-08-12 1996-06-25 Secure Medical Products, Inc. Infusion pump
EP0885620A2 (fr) * 1997-06-19 1998-12-23 Young Gyu Lee Dispositif pour injecter des médicaments liquides

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064897A1 (fr) * 2003-01-15 2004-08-05 I-Flow Corporation Ensemble d'etancheite pour pompe a perfusion elastomere
US7322961B2 (en) 2003-01-15 2008-01-29 I-Flow Corporation Seal assembly for elastomeric infusion pump
CN104001231A (zh) * 2014-05-15 2014-08-27 上海金塔医用器材有限公司 安全泵留置针
WO2015172423A1 (fr) * 2014-05-15 2015-11-19 上海金塔医用器材有限公司 Aiguille à demeure de pompe de sécurité
CN104998323A (zh) * 2015-07-20 2015-10-28 北京伏尔特技术有限公司 一种新型持续缓慢给液装置及其安装和使用方法
CN104998323B (zh) * 2015-07-20 2019-02-05 北京伏尔特技术有限公司 一种持续缓慢给液装置及其安装方法
US11253644B2 (en) * 2017-02-20 2022-02-22 Avent, Inc. Bladder for an infusion assembly
EP4260889A1 (fr) 2022-04-13 2023-10-18 Centre national de la recherche scientifique Dispositif d éjection contrôlée d'une solution liquide
WO2023198832A1 (fr) 2022-04-13 2023-10-19 Centre National De La Recherche Scientifique Dispositif d'éjection commandée d'une solution liquide

Also Published As

Publication number Publication date
ES2165820B1 (es) 2003-03-16
AU2001285957A1 (en) 2002-03-26
ES2165820A1 (es) 2002-03-16

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